MX2016016079A - Sistema de hidroalcoholico para el tratamiento de las uñas. - Google Patents
Sistema de hidroalcoholico para el tratamiento de las uñas.Info
- Publication number
- MX2016016079A MX2016016079A MX2016016079A MX2016016079A MX2016016079A MX 2016016079 A MX2016016079 A MX 2016016079A MX 2016016079 A MX2016016079 A MX 2016016079A MX 2016016079 A MX2016016079 A MX 2016016079A MX 2016016079 A MX2016016079 A MX 2016016079A
- Authority
- MX
- Mexico
- Prior art keywords
- nail treatment
- mixtures
- hydroalcoholic system
- hydroalcoholic
- poloxamer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
La presente invención se refiere a una composición farmacéutica que comprende (i) poloxámero 407, (ii) al menos un potenciador de la penetración, (iii) al menos un agente solubilizante seleccionado del grupo que consiste en ciclodextrinas, polímeros hidrófilos y mezclas de los mismos, (iv) al menos una sustancia biológicamente activa y (v) un vehículo que comprende agua y un alcohol C1-C3, o mezclas de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14382215.3A EP2952208A1 (en) | 2014-06-04 | 2014-06-04 | Hydroalcoholic system for nail treatment |
PCT/EP2015/062413 WO2015185647A1 (en) | 2014-06-04 | 2015-06-03 | Hydroalcoholic system for nail treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016016079A true MX2016016079A (es) | 2017-07-28 |
Family
ID=50942639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016016079A MX2016016079A (es) | 2014-06-04 | 2015-06-03 | Sistema de hidroalcoholico para el tratamiento de las uñas. |
Country Status (17)
Country | Link |
---|---|
US (1) | US20170224669A1 (es) |
EP (2) | EP2952208A1 (es) |
JP (1) | JP6742920B2 (es) |
KR (1) | KR102394176B1 (es) |
CN (1) | CN106456781B (es) |
AU (1) | AU2015270537B2 (es) |
BR (1) | BR112016028412B1 (es) |
CA (1) | CA2950478C (es) |
ES (1) | ES2831973T3 (es) |
HU (1) | HUE051352T2 (es) |
LT (1) | LT3151863T (es) |
MX (1) | MX2016016079A (es) |
PL (1) | PL3151863T3 (es) |
PT (1) | PT3151863T (es) |
RU (1) | RU2730010C2 (es) |
SI (1) | SI3151863T1 (es) |
WO (1) | WO2015185647A1 (es) |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3162081D1 (en) | 1980-04-29 | 1984-03-08 | Lucas Ind Plc | Brake master cylinder |
DE3544983A1 (de) | 1985-12-19 | 1987-06-25 | Hoechst Ag | Antimykotisch wirksamer nagellack |
DE3720147A1 (de) | 1987-06-16 | 1988-12-29 | Hoechst Ag | Antimykotisch wirksamer nagellack sowie verfahren zu dessen herstellung |
CA2008775C (en) | 1989-02-24 | 1998-12-22 | Alberto Ferro | Nail lacquer |
DE4212105A1 (de) | 1992-04-10 | 1993-10-14 | Roehm Pharma Gmbh | Nagellack zur Behandlung von Onychomykosen |
US5464610A (en) | 1992-10-15 | 1995-11-07 | Schering-Plough Healthcare Products, Inc. | Method for treating onychomycosis |
FR2705563B1 (fr) | 1993-05-26 | 1995-07-07 | Oreal | Vernis à ongles aqueux, incolore ou coloré, contenant un polymère filmogène à l'état dispersé et un composé perfluoroalkyle hydrosoluble. |
US5391367A (en) | 1993-07-28 | 1995-02-21 | Pfizer Inc. | Antifungal nail solution |
FR2711059B1 (fr) | 1993-10-15 | 1996-02-02 | Oreal | Composition cosmétique sous forme de vernis à ongles aqueux, coloré ou incolore, contenant en tant que substance filmogène des particules de polyester-polyuréthanne anionique à l'état dispersé. |
JPH07223942A (ja) * | 1994-02-03 | 1995-08-22 | Ildong Pharm Co Ltd | プロピオン酸系非ステロイド性薬物を有効成分として含有する新規消炎鎮痛外用ゲル製剤 |
US5487776A (en) | 1994-03-17 | 1996-01-30 | Nimni; Marcel | Anti-fungal nail lacquer and method therefor |
US5696164A (en) | 1994-12-22 | 1997-12-09 | Johnson & Johnson Consumer Products, Inc. | Antifungal treatment of nails |
US5696105A (en) | 1996-03-14 | 1997-12-09 | Hackler; Walter A. | Antifungal nail composition |
KR100220403B1 (ko) * | 1997-03-25 | 1999-09-15 | 박성원 | 각질 투과 증가제를 기제성분으로 함유하는 항진균성 손.발톱 와니스 |
US6224887B1 (en) | 1998-02-09 | 2001-05-01 | Macrochem Corporation | Antifungal nail lacquer and method using same |
FR2775593B1 (fr) | 1998-03-09 | 2002-06-14 | Oreal | Composition filmogene comprenant un polyurethane en dispersion aqueuse et un agent plastifiant |
US6159977A (en) | 1998-11-16 | 2000-12-12 | Astan, Inc. | Therapeutic anti-fungal nail preparation |
US6495124B1 (en) | 2000-02-14 | 2002-12-17 | Macrochem Corporation | Antifungal nail lacquer and method using same |
DE10035991A1 (de) | 2000-07-24 | 2002-02-14 | Polichem Sa | Nagellackzusammensetzung |
US20030049320A1 (en) * | 2000-12-18 | 2003-03-13 | Wockhardt Limited | Novel in-situ forming controlled release microcarrier delivery system |
US6881726B2 (en) * | 2001-12-24 | 2005-04-19 | Dow Pharmaceutical Sciences | Aqueous compositions containing metronidazole |
PL2106805T3 (pl) * | 2003-03-21 | 2011-10-31 | Nexmed Holdings Inc | Przeciwgrzybicza powłoka na paznokcie |
EP1491202A1 (en) * | 2003-06-23 | 2004-12-29 | Polichem S.A. | Nail restructuring compositions for topical application |
RU2238722C1 (ru) * | 2003-06-25 | 2004-10-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Фармацевтическая композиция с обезболивающим и противовоспалительным действием |
US20050238672A1 (en) * | 2004-04-27 | 2005-10-27 | Nimni Marcel E | Antifungal drug delivery |
EP1970076A4 (en) | 2005-12-28 | 2012-12-12 | Teikoku Seiyaku Kk | PHARMACEUTICAL COMPOSITION FOR APPLYING TO A NAIL |
GB0613925D0 (en) * | 2006-07-13 | 2006-08-23 | Unilever Plc | Improvements relating to nanodispersions |
GB0720716D0 (en) * | 2007-10-23 | 2007-12-05 | York Pharma Plc | Novel formulation |
US20090175810A1 (en) * | 2008-01-03 | 2009-07-09 | Gareth Winckle | Compositions and methods for treating diseases of the nail |
US20090175945A1 (en) | 2008-01-08 | 2009-07-09 | Jie Zhang | Systems, Methods, and Formulations for Topically Treating Nail Fungal Infections and Nail Psoriasis |
CA2712120A1 (en) * | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
AU2010336441B2 (en) * | 2009-12-23 | 2015-02-05 | Nuvo Research Inc. | Highly permeating terbinafine formulation for treating onychomycosis |
ES2369101B2 (es) * | 2010-05-07 | 2012-08-02 | Universidade De Santiago De Compostela | Sistema farmacéutico acuoso para la administración de fármacos en las uñas. |
JP2012017318A (ja) * | 2010-06-07 | 2012-01-26 | Nikko Chemical Co Ltd | 液晶及びそれを含有する皮膚外用剤 |
-
2014
- 2014-06-04 EP EP14382215.3A patent/EP2952208A1/en not_active Withdrawn
-
2015
- 2015-06-03 SI SI201531410T patent/SI3151863T1/sl unknown
- 2015-06-03 WO PCT/EP2015/062413 patent/WO2015185647A1/en active Application Filing
- 2015-06-03 US US15/315,314 patent/US20170224669A1/en not_active Abandoned
- 2015-06-03 CA CA2950478A patent/CA2950478C/en active Active
- 2015-06-03 KR KR1020167033922A patent/KR102394176B1/ko active IP Right Grant
- 2015-06-03 LT LTEP15725664.5T patent/LT3151863T/lt unknown
- 2015-06-03 MX MX2016016079A patent/MX2016016079A/es active IP Right Grant
- 2015-06-03 CN CN201580030022.5A patent/CN106456781B/zh active Active
- 2015-06-03 BR BR112016028412-7A patent/BR112016028412B1/pt active IP Right Grant
- 2015-06-03 JP JP2016570778A patent/JP6742920B2/ja active Active
- 2015-06-03 HU HUE15725664A patent/HUE051352T2/hu unknown
- 2015-06-03 PL PL15725664T patent/PL3151863T3/pl unknown
- 2015-06-03 EP EP15725664.5A patent/EP3151863B1/en active Active
- 2015-06-03 RU RU2016147020A patent/RU2730010C2/ru active
- 2015-06-03 PT PT157256645T patent/PT3151863T/pt unknown
- 2015-06-03 ES ES15725664T patent/ES2831973T3/es active Active
- 2015-06-03 AU AU2015270537A patent/AU2015270537B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
PL3151863T3 (pl) | 2021-03-08 |
AU2015270537B2 (en) | 2019-12-05 |
ES2831973T3 (es) | 2021-06-09 |
AU2015270537A1 (en) | 2016-12-15 |
CN106456781B (zh) | 2020-07-10 |
LT3151863T (lt) | 2021-08-10 |
RU2016147020A (ru) | 2018-05-30 |
JP2017523135A (ja) | 2017-08-17 |
RU2016147020A3 (es) | 2018-12-26 |
EP3151863A1 (en) | 2017-04-12 |
EP3151863B1 (en) | 2020-08-12 |
KR20170008763A (ko) | 2017-01-24 |
RU2730010C2 (ru) | 2020-08-14 |
BR112016028412A2 (pt) | 2017-08-22 |
CA2950478C (en) | 2022-04-12 |
WO2015185647A1 (en) | 2015-12-10 |
EP2952208A1 (en) | 2015-12-09 |
SI3151863T1 (sl) | 2021-03-31 |
BR112016028412B1 (pt) | 2023-05-02 |
HUE051352T2 (hu) | 2021-03-01 |
KR102394176B1 (ko) | 2022-05-03 |
US20170224669A1 (en) | 2017-08-10 |
PT3151863T (pt) | 2020-11-19 |
CN106456781A (zh) | 2017-02-22 |
CA2950478A1 (en) | 2015-12-10 |
JP6742920B2 (ja) | 2020-08-19 |
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