MX2016007653A - Combinaciones de trametinib, panitumumab y dabrafenib para el tratamiento del cancer. - Google Patents

Combinaciones de trametinib, panitumumab y dabrafenib para el tratamiento del cancer.

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Publication number
MX2016007653A
MX2016007653A MX2016007653A MX2016007653A MX2016007653A MX 2016007653 A MX2016007653 A MX 2016007653A MX 2016007653 A MX2016007653 A MX 2016007653A MX 2016007653 A MX2016007653 A MX 2016007653A MX 2016007653 A MX2016007653 A MX 2016007653A
Authority
MX
Mexico
Prior art keywords
panitumumab
cancer
combinations
treatment
dabrafenib
Prior art date
Application number
MX2016007653A
Other languages
English (en)
Inventor
David Greshock Joel
Hoos Axel
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2016007653A publication Critical patent/MX2016007653A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una nueva combinación que comprende un inhibidor de la B-Raf, particularmente N-{3-[5-(2-Amino-4-pirimidinil)-2-(1,1-dimetiletil )-1,3-tiazol-4-il]-2-fluorofenil}-2,6-difluorobencenosulfonamida o una sal farmacéuticamente aceptable del mismo, y/o el inhibidor de MEK N-{3-[3-ciclopropil-5-(2-fluoro-4-iodo-fenilamino)6,8-dimet il;-2,4,7-trioxo-3,4,6,7-tetrahidro-2H-pirido[4,3-d]pirimidin-1-i l]fenil}acetamida, o una sal farmacéuticamente aceptable o solvato del mismo, y panitumumab (Vectibix); composiciones farmacéuticas que comprenden los mismos y métodos de uso de tales combinaciones y composiciones en el tratamiento de condiciones en las que la inhibición de MEK y/o B-Raf y/o EGFR es beneficiosa, por ejemplo, cáncer.
MX2016007653A 2013-12-12 2014-12-11 Combinaciones de trametinib, panitumumab y dabrafenib para el tratamiento del cancer. MX2016007653A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361915041P 2013-12-12 2013-12-12
US201462004579P 2014-05-29 2014-05-29
PCT/IB2014/066814 WO2015087279A1 (en) 2013-12-12 2014-12-11 Combinations of trametinib, panitumumab and dabrafenib for the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2016007653A true MX2016007653A (es) 2016-10-13

Family

ID=52146562

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016007653A MX2016007653A (es) 2013-12-12 2014-12-11 Combinaciones de trametinib, panitumumab y dabrafenib para el tratamiento del cancer.

Country Status (10)

Country Link
US (1) US20160367662A1 (es)
EP (1) EP3079698A1 (es)
JP (1) JP2017500307A (es)
KR (1) KR20160088884A (es)
CN (1) CN106029074A (es)
AU (1) AU2014362995A1 (es)
BR (1) BR112016011222A2 (es)
CA (1) CA2933311A1 (es)
MX (1) MX2016007653A (es)
WO (1) WO2015087279A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017066664A1 (en) * 2015-10-16 2017-04-20 Millennium Pharmaceuticals, Inc. Combination therapy including a raf inhibitor for the treatment of colorectal cancer
WO2017070475A1 (en) * 2015-10-22 2017-04-27 Merrimack Pharmaceuticals, Inc. Methods of treating cancer by administering a mek inhibitor and a combination of anti-egfr antibodies
MX2018009581A (es) 2016-02-06 2019-05-06 Epimab Biotherapeutics Inc Inmunoglobulina con fabs en tandem y sus usos.
CR20190002A (es) * 2016-06-03 2019-06-10 Zhu Alexander Cao Combinaciones farmacéuticas
CN106539777A (zh) * 2016-11-25 2017-03-29 佳木斯大学 一种甲磺酸达拉非尼缓释片及其制备方法
EP3846799A1 (en) 2018-07-24 2021-07-14 Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Combined therapy inhibiting expression, activity and/or function of epidermal growth factor receptor and c-raf against cancer
EP3598973A1 (en) 2018-07-24 2020-01-29 Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Combined therapy against cancer
KR102192576B1 (ko) 2019-03-21 2020-12-17 경북대학교 산학협력단 다브라페닙을 유효성분으로 포함하는 알레르기 질환 예방, 치료 또는 개선용 조성물
KR102275782B1 (ko) * 2019-06-18 2021-07-09 주식회사 스탠다임 대사성 간질환의 예방 또는 치료용 조성물
CN115490640A (zh) * 2021-06-17 2022-12-20 深圳市塔吉瑞生物医药有限公司 取代的苯并咪唑类化合物及包含该化合物的组合物及其用途

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US5681835A (en) 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
EP0947478B1 (en) 1998-02-13 2005-07-13 Central Glass Company, Limited Water-repellent solution and method of forming water-repellent film on substrate by using the solution
US7378423B2 (en) 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
CN101006086B (zh) 2004-06-11 2010-09-29 日本烟草产业株式会社 用于治疗癌症的5-氨基-2,4,7-三氧代-3,4,7,8-四氢-2H-吡啶并[2,3-d]嘧啶衍生物和相关化合物
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
SI2488033T1 (sl) * 2009-10-16 2019-10-30 Novartis Ag Kombinacija, ki vsebuje inhibitor MEK in inhibitor B-RAF
BR112015009134A2 (pt) * 2012-10-25 2017-07-04 Glaxosmithkline Llc combinação

Also Published As

Publication number Publication date
CA2933311A1 (en) 2015-06-18
US20160367662A1 (en) 2016-12-22
EP3079698A1 (en) 2016-10-19
WO2015087279A1 (en) 2015-06-18
KR20160088884A (ko) 2016-07-26
JP2017500307A (ja) 2017-01-05
CN106029074A (zh) 2016-10-12
BR112016011222A2 (pt) 2017-09-19
AU2014362995A1 (en) 2016-05-26

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