MX2016000306A - Multiple proteases deficient filamentous fungal cells and methods of use thereof. - Google Patents

Multiple proteases deficient filamentous fungal cells and methods of use thereof.

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Publication number
MX2016000306A
MX2016000306A MX2016000306A MX2016000306A MX2016000306A MX 2016000306 A MX2016000306 A MX 2016000306A MX 2016000306 A MX2016000306 A MX 2016000306A MX 2016000306 A MX2016000306 A MX 2016000306A MX 2016000306 A MX2016000306 A MX 2016000306A
Authority
MX
Mexico
Prior art keywords
filamentous fungal
fungal cells
methods
multiple proteases
deficient filamentous
Prior art date
Application number
MX2016000306A
Other languages
Spanish (es)
Inventor
Markku Saloheimo
Anne Kanerva
Jukka Hiltunen
Anne Huuskonen
Christopher Landowski
Ann Westerholm-Parvinen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2016000306A publication Critical patent/MX2016000306A/en

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
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    • C12P21/00—Preparation of peptides or proteins
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485—Exopeptidases (3.4.11-3.4.19)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01258—Dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase (2.4.1.258)
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    • C12Y303/02—Ether hydrolases (3.3.2)
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/17—Metallocarboxypeptidases (3.4.17)
    • C12Y304/17021—Glutamate carboxypeptidase II (3.4.17.21)
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
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    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21062—Subtilisin (3.4.21.62)
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21078—Granzyme A (3.4.21.78)
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/23—Aspartic endopeptidases (3.4.23)
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    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23018—Aspergillopepsin I (3.4.23.18)
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    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)

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  • Life Sciences & Earth Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
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  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
MX2016000306A 2013-07-10 2014-07-10 Multiple proteases deficient filamentous fungal cells and methods of use thereof. MX2016000306A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13176001 2013-07-10
PCT/EP2014/064820 WO2015004241A2 (en) 2013-07-10 2014-07-10 Multiple proteases deficient filamentous fungal cells and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2016000306A true MX2016000306A (en) 2016-08-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016000306A MX2016000306A (en) 2013-07-10 2014-07-10 Multiple proteases deficient filamentous fungal cells and methods of use thereof.

Country Status (13)

Country Link
US (4) US10435731B2 (en)
EP (1) EP3019602B1 (en)
JP (1) JP2016523552A (en)
KR (1) KR20160035587A (en)
CN (1) CN105980552A (en)
AU (1) AU2014289183A1 (en)
CA (1) CA2916905A1 (en)
DK (1) DK3019602T3 (en)
IL (1) IL243276A0 (en)
MX (1) MX2016000306A (en)
RU (1) RU2016104064A (en)
SG (1) SG11201600115SA (en)
WO (1) WO2015004241A2 (en)

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