MX2015016093A - Trans-clomifeno y sus analogos como agentes que aumentan la densidad mineral osea. - Google Patents

Trans-clomifeno y sus analogos como agentes que aumentan la densidad mineral osea.

Info

Publication number
MX2015016093A
MX2015016093A MX2015016093A MX2015016093A MX2015016093A MX 2015016093 A MX2015016093 A MX 2015016093A MX 2015016093 A MX2015016093 A MX 2015016093A MX 2015016093 A MX2015016093 A MX 2015016093A MX 2015016093 A MX2015016093 A MX 2015016093A
Authority
MX
Mexico
Prior art keywords
clomiphene
trans
mineral density
analogues
agents
Prior art date
Application number
MX2015016093A
Other languages
English (en)
Inventor
Joseph S Podolski
Ronald D Wiehle
Kuang Hsu
Greg Fontenot
Jaye Thompson
Original Assignee
Repros Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Repros Therapeutics Inc filed Critical Repros Therapeutics Inc
Publication of MX2015016093A publication Critical patent/MX2015016093A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)

Abstract

La presente invención se refiere a la administración de composiciones que comprenden trans-clomifeno o un análogo o sal del mismo, para inhibir la resorción ósea y recambio óseo en un sujeto. La invención también se refiere a métodos para aumentar la densidad mineral ósea en un sujeto y prevenir o tratar un trastorno relacionado con los huesos en un sujeto, que comprenden administrar al sujeto una cantidad efectiva de trans-clomifeno o un análogo o sal del mismo.
MX2015016093A 2013-06-05 2014-06-03 Trans-clomifeno y sus analogos como agentes que aumentan la densidad mineral osea. MX2015016093A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361831542P 2013-06-05 2013-06-05
PCT/US2014/040704 WO2014197477A1 (en) 2013-06-05 2014-06-03 Trans-clomiphene and its analogues as agents that increase bone mineral density

Publications (1)

Publication Number Publication Date
MX2015016093A true MX2015016093A (es) 2016-03-21

Family

ID=52008535

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015016093A MX2015016093A (es) 2013-06-05 2014-06-03 Trans-clomifeno y sus analogos como agentes que aumentan la densidad mineral osea.

Country Status (10)

Country Link
US (1) US9616034B2 (es)
EP (1) EP3003487A4 (es)
JP (1) JP6417409B2 (es)
KR (1) KR20160016792A (es)
CN (1) CN105473183A (es)
AU (1) AU2014275101B2 (es)
CA (1) CA2914503A1 (es)
HK (1) HK1223318A1 (es)
MX (1) MX2015016093A (es)
WO (1) WO2014197477A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017123577A1 (en) * 2016-01-12 2017-07-20 Repros Therapeutics Inc. Trans-clomiphene and progesterone receptor antagonist combination therapy for treating hormone-dependent conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970237A (en) * 1987-03-20 1990-11-13 Yale University Use of clomiphene to increase bone mass in premenopausal women
WO2006102232A2 (en) * 2005-03-22 2006-09-28 Repros Therapeutics Inc. Dosing regimes for trans-clomiphene
CA2607901C (en) 2005-06-13 2016-08-16 Rigel Pharmaceuticals, Inc. Methods and compositions for treating degenerative bone disorders using a syk inhibitory 2,4-pyrimidinediamine
CA2865234A1 (en) * 2012-02-29 2013-09-06 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency

Also Published As

Publication number Publication date
WO2014197477A1 (en) 2014-12-11
JP6417409B2 (ja) 2018-11-07
AU2014275101A1 (en) 2015-12-03
JP2016520657A (ja) 2016-07-14
US9616034B2 (en) 2017-04-11
HK1223318A1 (zh) 2017-07-28
CN105473183A (zh) 2016-04-06
AU2014275101B2 (en) 2019-10-24
KR20160016792A (ko) 2016-02-15
EP3003487A4 (en) 2017-01-25
US20160128953A1 (en) 2016-05-12
EP3003487A1 (en) 2016-04-13
CA2914503A1 (en) 2014-11-12

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