MX2014002343A - Parp inhibitors. - Google Patents

Parp inhibitors.

Info

Publication number
MX2014002343A
MX2014002343A MX2014002343A MX2014002343A MX2014002343A MX 2014002343 A MX2014002343 A MX 2014002343A MX 2014002343 A MX2014002343 A MX 2014002343A MX 2014002343 A MX2014002343 A MX 2014002343A MX 2014002343 A MX2014002343 A MX 2014002343A
Authority
MX
Mexico
Prior art keywords
parp
compounds
parp inhibitors
inhibitors
formula
Prior art date
Application number
MX2014002343A
Other languages
Spanish (es)
Inventor
Nancy-Ellen Haynes
Nathan Robert Scott
Nicholas John Silvester Huby
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2014002343A publication Critical patent/MX2014002343A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/18—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

The present application disclosed compounds of Formula I wherein variables R1 and R2 are defined as described herein, which are inhibitors of PARP and provides compounds and compositions containing the compounds of Formula I. The present application further provides methods of using the disclosed PARP inhibitors for the treatment of PARP-mediated diseases and disorders.
MX2014002343A 2011-09-01 2012-08-29 Parp inhibitors. MX2014002343A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161529942P 2011-09-01 2011-09-01
PCT/EP2012/066721 WO2013030205A1 (en) 2011-09-01 2012-08-29 Parp inhibitors

Publications (1)

Publication Number Publication Date
MX2014002343A true MX2014002343A (en) 2014-04-30

Family

ID=46796563

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014002343A MX2014002343A (en) 2011-09-01 2012-08-29 Parp inhibitors.

Country Status (9)

Country Link
EP (1) EP2758370A1 (en)
JP (1) JP2014531416A (en)
KR (1) KR20140062096A (en)
CN (1) CN103906730A (en)
BR (1) BR112014005011A2 (en)
CA (1) CA2846429A1 (en)
MX (1) MX2014002343A (en)
RU (1) RU2014110624A (en)
WO (1) WO2013030205A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5441864A (en) * 1977-09-02 1979-04-03 Sankyo Co Ltd Beta-lactam homolog and its preparation
US7642277B2 (en) * 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
WO2007144652A2 (en) * 2006-06-15 2007-12-21 Kudos Pharmaceuticals Limited Parp inhibitors
EP2438052A1 (en) * 2009-06-05 2012-04-11 Oslo University Hospital HF Azole derivatives as wtn pathway inhibitors

Also Published As

Publication number Publication date
RU2014110624A (en) 2015-10-10
WO2013030205A1 (en) 2013-03-07
EP2758370A1 (en) 2014-07-30
BR112014005011A2 (en) 2017-05-30
KR20140062096A (en) 2014-05-22
JP2014531416A (en) 2014-11-27
CN103906730A (en) 2014-07-02
CA2846429A1 (en) 2013-03-07

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