MX2013006163A - Compuestos y metodos para la reparación de la piel. - Google Patents
Compuestos y metodos para la reparación de la piel.Info
- Publication number
- MX2013006163A MX2013006163A MX2013006163A MX2013006163A MX2013006163A MX 2013006163 A MX2013006163 A MX 2013006163A MX 2013006163 A MX2013006163 A MX 2013006163A MX 2013006163 A MX2013006163 A MX 2013006163A MX 2013006163 A MX2013006163 A MX 2013006163A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- use according
- alkenyl
- skin
- composition
- Prior art date
Links
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Landscapes
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
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| US41911510P | 2010-12-02 | 2010-12-02 | |
| PCT/US2011/062691 WO2012075174A2 (en) | 2010-12-02 | 2011-11-30 | Compounds and methods for skin repair |
Publications (1)
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| MX2013006163A true MX2013006163A (es) | 2013-10-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| MX2013006163A MX2013006163A (es) | 2010-12-02 | 2011-11-30 | Compuestos y metodos para la reparación de la piel. |
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| Country | Link |
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| US (1) | US20120142684A1 (https=) |
| EP (2) | EP2646017B1 (https=) |
| JP (1) | JP2013544842A (https=) |
| KR (1) | KR20130119958A (https=) |
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| CA (1) | CA2819471A1 (https=) |
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| TW (1) | TW201307313A (https=) |
| WO (1) | WO2012075174A2 (https=) |
| ZA (1) | ZA201303949B (https=) |
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| BR112013003600A2 (pt) * | 2010-08-17 | 2016-08-16 | Allergan Inc | agonistas ep2 ou ep4 para o tratamento de névoa da córnea |
| US8900571B2 (en) * | 2010-08-19 | 2014-12-02 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8894992B2 (en) * | 2010-08-19 | 2014-11-25 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8697057B2 (en) | 2010-08-19 | 2014-04-15 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8889123B2 (en) * | 2010-08-19 | 2014-11-18 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8926963B2 (en) * | 2010-08-19 | 2015-01-06 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8883139B2 (en) * | 2010-08-19 | 2014-11-11 | Allergan Inc. | Compositions and soft tissue replacement methods |
| US9005605B2 (en) * | 2010-08-19 | 2015-04-14 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| CA2890034A1 (en) * | 2012-11-16 | 2014-05-22 | Allergan, Inc. | Skin wound healing and scar reduction with prostaglandin ep4 agonist combinations |
| US20140142092A1 (en) * | 2012-11-16 | 2014-05-22 | Allergan, Inc. | Compounds and methods for skin repair |
| US9546162B2 (en) * | 2013-09-27 | 2017-01-17 | Allergan, Inc. | Compounds and methods for skin repair |
Family Cites Families (24)
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| US5811446A (en) * | 1997-04-18 | 1998-09-22 | Cytos Pharmaceuticals Llc | Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor |
| US5877211A (en) * | 1997-11-21 | 1999-03-02 | Allergan | EP2 receptor agonists as neuroprotective agents for the eye |
| TWI249520B (en) * | 1998-07-15 | 2006-02-21 | Ono Pharmaceutical Co | 5-Thia-omega-substituted phenyl prostaglandin E derivatives, method for producing the same and medicines containing the same as the active ingredient |
| US6586468B1 (en) * | 1998-09-14 | 2003-07-01 | Ono Pharmaceutical Co., Ltd. | ω-substituted phenyl-prostaglandin E derivatives and drugs containing the same as the active ingredient |
| RU2296122C2 (ru) * | 2001-07-16 | 2007-03-27 | Ф.Хоффманн-Ля Рош Аг | Производные 2-пирролидона в качестве простаноидных агонистов и фармацевтическая композиция |
| NZ530885A (en) * | 2001-07-23 | 2007-09-28 | Ono Pharmaceutical Co | Remedies for diseases with bone mass loss having EP4 agonist as the active ingredient |
| US20040058313A1 (en) * | 2002-04-24 | 2004-03-25 | Abreu Marcio Marc | Compositions, targets, methods and devices for the therapy of ocular and periocular disorders |
| ES2584606T3 (es) * | 2002-10-10 | 2016-09-28 | Ono Pharmaceutical Co., Ltd. | Microesferas que comprenden ONO-1301 |
| RU2311409C2 (ru) * | 2003-01-10 | 2007-11-27 | Ф.Хоффманн-Ля Рош Аг | Производные 2-пиперидона в качестве агонистов простагландина |
| US7855226B2 (en) | 2003-02-11 | 2010-12-21 | Allergan, Inc. | Treatment of inflammatory bowel disease |
| US6875787B2 (en) | 2003-02-11 | 2005-04-05 | Allergan, Inc. | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
| WO2005027931A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and an ep2 or ep4 selective agonist |
| JP4985400B2 (ja) * | 2005-06-24 | 2012-07-25 | 大正製薬株式会社 | プロスタグランジン誘導体 |
| US20070232660A1 (en) * | 2006-04-04 | 2007-10-04 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
| US7439372B2 (en) * | 2006-05-03 | 2008-10-21 | Allergan, Inc. | Therapeutic compounds |
| AU2007331471C1 (en) * | 2006-12-15 | 2013-07-25 | Glaxo Group Limited | Benzamide derivatives as EP4 receptor agonists |
| EP2120962A1 (en) * | 2006-12-18 | 2009-11-25 | Allergan, Inc. | Methods and compositions for treating gastrointestinal disorders |
| WO2008092860A1 (en) * | 2007-01-30 | 2008-08-07 | Janssen Pharmaceutica N.V. | Bicyclic derivatives as ep4 agonists |
| WO2008092862A1 (en) * | 2007-01-30 | 2008-08-07 | Janssen Pharmaceutica N.V. | Bicyclic derivatives as ep4 agonists |
| WO2008092861A1 (en) * | 2007-01-30 | 2008-08-07 | Janssen Pharmaceutica N.V. | Bicyclic derivatives as ep4 agonists |
| GB0810615D0 (en) * | 2008-06-10 | 2008-07-16 | Glaxo Group Ltd | Novel pharmaceutical |
| US20110111031A1 (en) * | 2009-04-20 | 2011-05-12 | Guang-Liang Jiang | Drug Delivery Platforms Comprising Silk Fibroin Hydrogels and Uses Thereof |
| US20120136011A1 (en) * | 2010-07-30 | 2012-05-31 | Allergan, Inc. | Compounds and methods for skin repair |
| WO2012024072A1 (en) * | 2010-08-19 | 2012-02-23 | Allergan, Inc. | Compositions comprising adipose tissue and a pge2 analogue and their use in the treatment of a soft tissue condition |
-
2011
- 2011-11-29 US US13/306,637 patent/US20120142684A1/en not_active Abandoned
- 2011-11-30 EP EP11794357.1A patent/EP2646017B1/en not_active Not-in-force
- 2011-11-30 JP JP2013542143A patent/JP2013544842A/ja active Pending
- 2011-11-30 AU AU2011336582A patent/AU2011336582A1/en not_active Abandoned
- 2011-11-30 RU RU2013129262/15A patent/RU2013129262A/ru not_active Application Discontinuation
- 2011-11-30 KR KR1020137017027A patent/KR20130119958A/ko not_active Withdrawn
- 2011-11-30 MX MX2013006163A patent/MX2013006163A/es unknown
- 2011-11-30 SG SG2013042171A patent/SG190947A1/en unknown
- 2011-11-30 EP EP16198852.2A patent/EP3195863A1/en not_active Withdrawn
- 2011-11-30 WO PCT/US2011/062691 patent/WO2012075174A2/en not_active Ceased
- 2011-11-30 BR BR112013015781A patent/BR112013015781A2/pt not_active Application Discontinuation
- 2011-11-30 CN CN2011800627436A patent/CN103282033A/zh active Pending
- 2011-11-30 CA CA2819471A patent/CA2819471A1/en not_active Abandoned
- 2011-12-02 TW TW100144475A patent/TW201307313A/zh unknown
- 2011-12-02 AR ARP110104524A patent/AR084144A1/es unknown
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2013
- 2013-05-30 ZA ZA2013/03949A patent/ZA201303949B/en unknown
- 2013-05-31 CL CL2013001579A patent/CL2013001579A1/es unknown
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|---|---|
| SG190947A1 (en) | 2013-07-31 |
| RU2013129262A (ru) | 2015-01-10 |
| TW201307313A (zh) | 2013-02-16 |
| EP3195863A1 (en) | 2017-07-26 |
| AR084144A1 (es) | 2013-04-24 |
| EP2646017B1 (en) | 2016-11-16 |
| KR20130119958A (ko) | 2013-11-01 |
| EP2646017A2 (en) | 2013-10-09 |
| CN103282033A (zh) | 2013-09-04 |
| ZA201303949B (en) | 2014-08-27 |
| US20120142684A1 (en) | 2012-06-07 |
| CA2819471A1 (en) | 2012-06-07 |
| JP2013544842A (ja) | 2013-12-19 |
| BR112013015781A2 (pt) | 2018-11-06 |
| WO2012075174A2 (en) | 2012-06-07 |
| CL2013001579A1 (es) | 2013-12-27 |
| WO2012075174A3 (en) | 2012-07-26 |
| AU2011336582A1 (en) | 2013-07-11 |
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