MX2013002048A - Conjugates, particles, compositions, and related methods. - Google Patents

Conjugates, particles, compositions, and related methods.

Info

Publication number
MX2013002048A
MX2013002048A MX2013002048A MX2013002048A MX2013002048A MX 2013002048 A MX2013002048 A MX 2013002048A MX 2013002048 A MX2013002048 A MX 2013002048A MX 2013002048 A MX2013002048 A MX 2013002048A MX 2013002048 A MX2013002048 A MX 2013002048A
Authority
MX
Mexico
Prior art keywords
conjugates
particles
compositions
related methods
methods
Prior art date
Application number
MX2013002048A
Other languages
Spanish (es)
Inventor
Sonke Svenson
Scott Eliasof
Oliver S Fetzer
Jungyeon Hwang
Patrick Lim Soo
Pei-Sze Ng
Donald E Bergstrom
Original Assignee
Cerulean Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerulean Pharma Inc filed Critical Cerulean Pharma Inc
Publication of MX2013002048A publication Critical patent/MX2013002048A/en

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    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/35Nature of the modification
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

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Abstract

Particles and conjugates for delivering nucleic acid agents. Compositions containing the particles, the conjugates, or both. Methods of using the particles, the conjugates, and the compositions.
MX2013002048A 2010-08-20 2011-08-18 Conjugates, particles, compositions, and related methods. MX2013002048A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37578310P 2010-08-20 2010-08-20
US38788210P 2010-09-29 2010-09-29
US201161443972P 2011-02-17 2011-02-17
US201161475923P 2011-04-15 2011-04-15
PCT/US2011/048305 WO2012024526A2 (en) 2010-08-20 2011-08-18 Conjugates, particles, compositions, and related methods

Publications (1)

Publication Number Publication Date
MX2013002048A true MX2013002048A (en) 2013-07-03

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Application Number Title Priority Date Filing Date
MX2013002048A MX2013002048A (en) 2010-08-20 2011-08-18 Conjugates, particles, compositions, and related methods.

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Country Link
US (4) US20120225129A1 (en)
EP (1) EP2605799A4 (en)
JP (1) JP5756858B2 (en)
CN (1) CN103080313A (en)
AU (1) AU2011291582A1 (en)
BR (1) BR112013003825A2 (en)
CA (1) CA2808901A1 (en)
EA (1) EA201390145A1 (en)
MX (1) MX2013002048A (en)
WO (1) WO2012024526A2 (en)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101661746B1 (en) 2008-08-13 2016-09-30 캘리포니아 인스티튜트 오브 테크놀로지 Carrier nanoparticles and related compositions, methods and systems
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CA2821992A1 (en) 2010-10-01 2012-04-05 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
DE12722942T1 (en) 2011-03-31 2021-09-30 Modernatx, Inc. RELEASE AND FORMULATION OF MANIPULATED NUCLEIC ACIDS
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3492109B1 (en) 2011-10-03 2020-03-04 ModernaTX, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
US9579338B2 (en) * 2011-11-04 2017-02-28 Nitto Denko Corporation Method of producing lipid nanoparticles for drug delivery
PL2790675T3 (en) * 2011-12-14 2019-12-31 Abraxis Bioscience, Llc Use of polymeric excipients for lyophilization or freezing of particles
PL2796150T3 (en) * 2011-12-15 2021-08-30 Bioneer Corporation Novel oligonucleotide conjugates and use thereof
JP2015501844A (en) 2011-12-16 2015-01-19 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. Modified nucleosides, nucleotides and nucleic acid compositions
CN107988227A (en) 2012-01-05 2018-05-04 株式会社百奥尼 Efficient nanoparticle form double helix widow RNA structures and preparation method thereof
EP2833923A4 (en) 2012-04-02 2016-02-24 Moderna Therapeutics Inc Modified polynucleotides for the production of proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
LT2922554T (en) 2012-11-26 2022-06-27 Modernatx, Inc. Terminally modified rna
US9545447B2 (en) * 2013-01-04 2017-01-17 The Texas A&M University System Polymer-drug systems
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
EP2971010B1 (en) 2013-03-14 2020-06-10 ModernaTX, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
CA2911344C (en) 2013-05-14 2022-08-30 California Institute Of Technology Method of delivering therapeutics and imaging agents by nanoparticles that cross the blood brain barrier
EP3041934A1 (en) 2013-09-03 2016-07-13 Moderna Therapeutics, Inc. Chimeric polynucleotides
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
WO2015048744A2 (en) 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
EP3052521A1 (en) 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
WO2015057847A1 (en) * 2013-10-16 2015-04-23 Cerulean Pharma Inc. Conjugates, particles, compositions, and related methods
WO2015175545A1 (en) * 2014-05-12 2015-11-19 The Johns Hopkins University Highly stable biodegradable gene vector platforms for overcoming biological barriers
WO2015184326A1 (en) * 2014-05-30 2015-12-03 Cerulean Pharma Inc. Conjugates, particles, compositions, and related methods
WO2016011226A1 (en) 2014-07-16 2016-01-21 Moderna Therapeutics, Inc. Chimeric polynucleotides
EP3171895A1 (en) 2014-07-23 2017-05-31 Modernatx, Inc. Modified polynucleotides for the production of intrabodies
EP3317323B1 (en) 2015-07-01 2021-05-26 California Institute of Technology Cationic mucic acid polymer-based delivery systems
MA43072A (en) * 2015-07-22 2018-05-30 Wave Life Sciences Ltd COMPOSITIONS OF OLIGONUCLEOTIDES AND RELATED PROCESSES
WO2017070613A1 (en) 2015-10-22 2017-04-27 Modernatx, Inc. Human cytomegalovirus vaccine
DK3394093T3 (en) 2015-12-23 2022-04-19 Modernatx Inc PROCEDURES FOR USING OX40 LIGAND CODING POLYNUCLEOTIDES
WO2017120612A1 (en) 2016-01-10 2017-07-13 Modernatx, Inc. Therapeutic mrnas encoding anti ctla-4 antibodies
KR20190068570A (en) * 2016-10-10 2019-06-18 아브락시스 바이오사이언스, 엘엘씨 Nanoparticle formulations, and methods of making and using them
US11446393B2 (en) * 2017-06-13 2022-09-20 Monash University Non-viral gene delivery agent comprising lipopeptide (LP) compounds
US10463746B2 (en) 2017-11-09 2019-11-05 International Business Machines Corporation Macromolecular chemotherapeutics
EP3714048A1 (en) 2017-11-22 2020-09-30 Modernatx, Inc. Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders
JP7423521B2 (en) 2017-11-22 2024-01-29 モダーナティエックス・インコーポレイテッド Polynucleotide encoding phenylalanine hydroxylase for the treatment of phenylketonuria
MA52709A (en) 2018-05-23 2021-03-31 Modernatx Inc DNA ADMINISTRATION
CA3099440A1 (en) 2018-06-13 2019-12-19 California Institute Of Technology Nanoparticles for crossing the blood brain barrier and methods of treatment using the same
MA53545A (en) 2018-09-02 2021-07-14 Modernatx Inc POLYNUCLEOTIDES ENCODED FOR VERY LONG CHAIN ACYL-COA DEHYDROGENASE FOR THE TREATMENT OF VERY LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY
CN113164561A (en) 2018-09-13 2021-07-23 摩登纳特斯有限公司 Polynucleotides encoding glucose-6-phosphatase for the treatment of glycogen storage disease
MA53652A (en) 2018-09-19 2021-07-28 Modernatx Inc HIGH PURITY PEG LIPIDS AND THEIR USES
US20220047518A1 (en) 2018-09-19 2022-02-17 Moderna TX, Inc. Peg lipids and uses thereof
CN109880021B (en) * 2019-02-20 2020-03-27 河南大学 Polymer and preparation method thereof, ROS response type siRNA nano micelle and application thereof
DK4013385T3 (en) 2019-08-14 2024-09-02 Acuitas Therapeutics Inc Improved lipid nanoparticles for delivery of nucleic acids
CA3150452A1 (en) 2019-09-06 2021-03-11 Generation Bio Co. Lipid nanoparticle compositions comprising closed-ended dna and cleavable lipids and methods of use thereof
BR112022007481A2 (en) 2019-11-22 2022-07-12 Generation Bio Co IONIZABLE LIPIDS AND NANOPARTICLE COMPOSITIONS THEREOF
JP2023506703A (en) 2019-12-04 2023-02-20 ダンタリ インコーポレイテッド Methods and compositions for synthesizing therapeutic nanoparticles
CN111560432A (en) * 2020-04-27 2020-08-21 上海大学 Application of ICAM-1 as lung squamous carcinoma marker and treatment target
MX2023014855A (en) 2021-06-14 2024-01-31 Generation Bio Co Cationic lipids and compositions thereof.
IL312490A (en) 2021-11-08 2024-07-01 Orna Therapeutics Inc Lipid nanoparticle compositions for delivering circular polynucleotides
WO2023161350A1 (en) 2022-02-24 2023-08-31 Io Biotech Aps Nucleotide delivery of cancer therapy
WO2023172547A1 (en) * 2022-03-11 2023-09-14 National Health Research Institutes Nucleic acid-lipid nanoparticle and method using the same
WO2023239756A1 (en) 2022-06-07 2023-12-14 Generation Bio Co. Lipid nanoparticle compositions and uses thereof
WO2024102762A1 (en) 2022-11-08 2024-05-16 Orna Therapeutics, Inc. Lipids and lipid nanoparticle compositions for delivering polynucleotides
WO2024102730A1 (en) 2022-11-08 2024-05-16 Orna Therapeutics, Inc. Lipids and nanoparticle compositions for delivering polynucleotides
TW202428289A (en) 2022-11-08 2024-07-16 美商歐納醫療公司 Circular rna compositions
WO2024119074A1 (en) 2022-12-01 2024-06-06 Generation Bio Co. Stealth lipid nanoparticle compositions for cell targeting
WO2024119051A1 (en) 2022-12-01 2024-06-06 Generation Bio Co. Novel polyglycerol-conjugated lipids and lipid nanoparticle compositions comprising the same
WO2024119039A2 (en) 2022-12-01 2024-06-06 Generation Bio Co. Stealth lipid nanoparticles and uses thereof
WO2024119103A1 (en) 2022-12-01 2024-06-06 Generation Bio Co. Lipid nanoparticles comprising nucleic acids and lipid-anchored polymers
WO2024129982A2 (en) 2022-12-15 2024-06-20 Orna Therapeutics, Inc. Circular rna compositions and methods
WO2024205657A2 (en) 2023-03-29 2024-10-03 Orna Therapeutics, Inc. Lipids and lipid nanoparticle compositions for delivering polynucleotides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990013361A1 (en) * 1989-05-04 1990-11-15 Southern Research Institute Improved encapsulation process and products therefrom
EP1373185B1 (en) * 2001-01-08 2017-03-01 Aminex Therapeutics, Inc. Hydrophobic polyamine analogs and methods for their use
US8137699B2 (en) * 2002-03-29 2012-03-20 Trustees Of Princeton University Process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use
JP2005530695A (en) * 2002-02-15 2005-10-13 ザイコス インク. Electroporation method for introducing physiologically active substances into cells
EP1877103A4 (en) * 2005-04-20 2010-11-03 Dendritic Nanotechnologies Inc Dendritic polymers with enhanced amplification and interior functionality
JP2007099631A (en) * 2005-09-30 2007-04-19 Hosokawa Funtai Gijutsu Kenkyusho:Kk Method for producing anionic medicine-encapsulated nanoparticle and pharmaceutical formulation using the same
EP1973608A1 (en) * 2005-12-14 2008-10-01 Cytos Biotechnology AG Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity

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