MX2010007989A - Alfavirus recombinantes atenuados incapaces de replicarse en mosquitos y usos de estos. - Google Patents

Alfavirus recombinantes atenuados incapaces de replicarse en mosquitos y usos de estos.

Info

Publication number
MX2010007989A
MX2010007989A MX2010007989A MX2010007989A MX2010007989A MX 2010007989 A MX2010007989 A MX 2010007989A MX 2010007989 A MX2010007989 A MX 2010007989A MX 2010007989 A MX2010007989 A MX 2010007989A MX 2010007989 A MX2010007989 A MX 2010007989A
Authority
MX
Mexico
Prior art keywords
ires
veev
alphavirus
virus
cells
Prior art date
Application number
MX2010007989A
Other languages
English (en)
Spanish (es)
Inventor
Ilya V Frolov
Scott C Weaver
Elena Frolova
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of MX2010007989A publication Critical patent/MX2010007989A/es

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    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04Inactivation or attenuation; Producing viral sub-units
    • C12N7/045Pseudoviral particles; Non infectious pseudovirions, e.g. genetically engineered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/36011Togaviridae
    • C12N2770/36111Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/36011Togaviridae
    • C12N2770/36111Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36161Methods of inactivation or attenuation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/36011Togaviridae
    • C12N2770/36111Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36171Demonstrated in vivo effect
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/20Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MX2010007989A 2008-01-24 2009-01-23 Alfavirus recombinantes atenuados incapaces de replicarse en mosquitos y usos de estos. MX2010007989A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6222908P 2008-01-24 2008-01-24
PCT/US2009/000458 WO2009131604A2 (en) 2008-01-24 2009-01-23 Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof

Publications (1)

Publication Number Publication Date
MX2010007989A true MX2010007989A (es) 2010-12-21

Family

ID=41217313

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2014010258A MX367792B (es) 2008-01-24 2009-01-23 Alfavirus recombinantes atenuados incapaces de replicarse en mosquitos y usos de estos.
MX2010007989A MX2010007989A (es) 2008-01-24 2009-01-23 Alfavirus recombinantes atenuados incapaces de replicarse en mosquitos y usos de estos.
MX2019010530A MX378503B (es) 2008-01-24 2009-01-23 Alfavirus recombinantes atenuados incapaces de replicarse en mosquitos y usos de estos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2014010258A MX367792B (es) 2008-01-24 2009-01-23 Alfavirus recombinantes atenuados incapaces de replicarse en mosquitos y usos de estos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019010530A MX378503B (es) 2008-01-24 2009-01-23 Alfavirus recombinantes atenuados incapaces de replicarse en mosquitos y usos de estos.

Country Status (15)

Country Link
US (3) US8426188B2 (enExample)
EP (2) EP3085787B1 (enExample)
JP (1) JP5758632B2 (enExample)
KR (2) KR101913790B1 (enExample)
CN (1) CN102083986B (enExample)
AU (1) AU2009238667A1 (enExample)
CA (2) CA2713165C (enExample)
CO (1) CO6290702A2 (enExample)
IL (2) IL207167A (enExample)
MX (3) MX367792B (enExample)
MY (1) MY178870A (enExample)
NZ (2) NZ603790A (enExample)
SG (2) SG187513A1 (enExample)
WO (1) WO2009131604A2 (enExample)
ZA (1) ZA201005943B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5602624B2 (ja) * 2007-06-21 2014-10-08 アルファバックス, インコーポレイテッド αウイルス構造タンパク質の発現のためのプロモーターレスカセット
SG187513A1 (en) 2008-01-24 2013-02-28 Univ Texas Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof
US8961995B2 (en) 2012-09-20 2015-02-24 Uab Research Foundation Methods and compositions for alphavirus replicons
BR112015006840A2 (pt) 2012-09-27 2017-11-21 Res Found Dev vírus chikungunya atenuado
CN111729077A (zh) 2013-03-14 2020-10-02 武田疫苗股份有限公司 减毒活甲病毒制剂的组合物和方法
CN109195625A (zh) * 2016-03-31 2019-01-11 武田疫苗股份有限公司 活减毒甲病毒构建体及其方法和用途
WO2017201579A1 (en) * 2016-05-27 2017-11-30 Griffith University Arthrogenic alphavirus vaccine
CN110612116A (zh) 2017-05-08 2019-12-24 磨石肿瘤生物技术公司 甲病毒新抗原载体
EP3830109A4 (en) * 2018-08-03 2022-05-18 Uab Research Foundation METHODS AND COMPOSITIONS FOR ALPHAVIRUS VACCINATION
CN109536464B (zh) * 2018-12-10 2022-06-10 中国科学院武汉病毒研究所 一种缺失衣壳蛋白基因的基孔肯雅病毒感染性克隆及构建方法和在制备减毒疫苗中的应用
TW202523847A (zh) 2019-05-30 2025-06-16 美商磨石生物公司 經修飾之腺病毒
WO2021138447A1 (en) 2019-12-31 2021-07-08 Elixirgen Therapeutics, Inc. Temperature-based transient delivery of nucleic acids and proteins to cells and tissues
EP4192496A4 (en) 2020-08-06 2025-01-01 Gritstone bio, Inc. MULTIEPITOP VACCINE CASSETTES

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451592B1 (en) * 1996-04-05 2002-09-17 Chiron Corporation Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
CA2327189A1 (en) 2000-12-21 2002-06-21 The Minister Of National Defence Novel dna-based vaccine against the encephalitis alphaviruses
NZ542353A (en) * 2003-03-20 2008-07-31 Alphavax Inc Improved alphavirus replicons and helper constructs
AU2005256112B9 (en) 2004-07-30 2008-09-25 Blackberry Limited Method and system for coordinating device setting between a communications client and its host device
US7332322B2 (en) 2004-09-14 2008-02-19 Ilya Frolov Venezuelan equine encephalitis virus replicons with adaptive mutations in the genome and uses thereof
CA2579507C (en) 2006-03-15 2017-06-13 Institut Pasteur Novel isolated and purified strains of chikungunya virus and polynucleotides and polypeptides sequences, diagnostic and immunogenical uses thereof
SG187513A1 (en) * 2008-01-24 2013-02-28 Univ Texas Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof

Also Published As

Publication number Publication date
EP2250269B1 (en) 2016-03-16
EP3085787B1 (en) 2020-10-28
KR101913790B1 (ko) 2018-12-28
KR20160124255A (ko) 2016-10-26
WO2009131604A3 (en) 2009-12-23
JP5758632B2 (ja) 2015-08-05
US8426188B2 (en) 2013-04-23
US10533186B2 (en) 2020-01-14
CA2910235C (en) 2021-07-06
US20140010841A1 (en) 2014-01-09
US20170240919A1 (en) 2017-08-24
US9580690B2 (en) 2017-02-28
MX367792B (es) 2019-09-05
WO2009131604A2 (en) 2009-10-29
CN102083986A (zh) 2011-06-01
SG187513A1 (en) 2013-02-28
AU2009238667A1 (en) 2009-10-29
MX2019010530A (es) 2019-10-15
ZA201005943B (en) 2011-04-28
CA2713165A1 (en) 2009-10-29
CN102083986B (zh) 2014-06-18
MX378503B (es) 2025-03-11
JP2011523347A (ja) 2011-08-11
KR20100106599A (ko) 2010-10-01
EP2250269A4 (en) 2012-01-04
KR101668849B1 (ko) 2016-10-24
EP3085787A1 (en) 2016-10-26
CA2713165C (en) 2015-12-29
IL232032A0 (en) 2014-05-28
CA2910235A1 (en) 2009-10-29
IL207167A0 (en) 2010-12-30
EP2250269A2 (en) 2010-11-17
IL207167A (en) 2014-04-30
CO6290702A2 (es) 2011-06-20
US20110052634A1 (en) 2011-03-03
NZ587502A (en) 2012-12-21
MY178870A (en) 2020-10-21
NZ603790A (en) 2014-08-29
SG10201606111XA (en) 2016-09-29

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