MX2010006926A - 4-imidazolidinones as kv1.5 potassium channel inhibitors. - Google Patents

4-imidazolidinones as kv1.5 potassium channel inhibitors.

Info

Publication number
MX2010006926A
MX2010006926A MX2010006926A MX2010006926A MX2010006926A MX 2010006926 A MX2010006926 A MX 2010006926A MX 2010006926 A MX2010006926 A MX 2010006926A MX 2010006926 A MX2010006926 A MX 2010006926A MX 2010006926 A MX2010006926 A MX 2010006926A
Authority
MX
Mexico
Prior art keywords
imidazolidinones
potassium channel
channel inhibitors
present teachings
selective
Prior art date
Application number
MX2010006926A
Other languages
Spanish (es)
Inventor
Shengde Wu
Benjamin E Blass
John M Janusz
James M Ii Ridgeway
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of MX2010006926A publication Critical patent/MX2010006926A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present teachings relate to 4-imidazolidinones of Formula (Ia) or (Ib) which are useful as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic activity. The present teachings further relate to compositions and methods for treating atrial-selective antiarrhythmia.
MX2010006926A 2007-12-19 2008-12-18 4-imidazolidinones as kv1.5 potassium channel inhibitors. MX2010006926A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1493707P 2007-12-19 2007-12-19
PCT/US2008/087459 WO2009079630A1 (en) 2007-12-19 2008-12-18 4-imidazolidinones as kv1.5 potassium channel inhibitors

Publications (1)

Publication Number Publication Date
MX2010006926A true MX2010006926A (en) 2010-08-02

Family

ID=40379648

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010006926A MX2010006926A (en) 2007-12-19 2008-12-18 4-imidazolidinones as kv1.5 potassium channel inhibitors.

Country Status (8)

Country Link
EP (1) EP2234983A1 (en)
JP (1) JP2011507887A (en)
AU (1) AU2008338374A1 (en)
BR (1) BRPI0821394A2 (en)
CA (1) CA2709187A1 (en)
MX (1) MX2010006926A (en)
WO (1) WO2009079630A1 (en)
ZA (1) ZA201005086B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO3175985T3 (en) 2011-07-01 2018-04-28
AU2013203252B2 (en) 2012-01-27 2015-08-20 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2014134419A1 (en) 2013-03-01 2014-09-04 Gilead Sciences, Inc. Use of ikach blockers for the treatment of cardiac diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY125533A (en) * 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
JP2009541342A (en) * 2006-06-20 2009-11-26 ワイス Kv1.5 potassium channel inhibitor

Also Published As

Publication number Publication date
WO2009079630A1 (en) 2009-06-25
JP2011507887A (en) 2011-03-10
BRPI0821394A2 (en) 2015-06-16
AU2008338374A1 (en) 2009-06-25
ZA201005086B (en) 2011-03-30
CA2709187A1 (en) 2009-06-25
EP2234983A1 (en) 2010-10-06

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal