MX2009013778A - Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing. - Google Patents

Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing.

Info

Publication number
MX2009013778A
MX2009013778A MX2009013778A MX2009013778A MX2009013778A MX 2009013778 A MX2009013778 A MX 2009013778A MX 2009013778 A MX2009013778 A MX 2009013778A MX 2009013778 A MX2009013778 A MX 2009013778A MX 2009013778 A MX2009013778 A MX 2009013778A
Authority
MX
Mexico
Prior art keywords
probe
test apparatus
dissolution test
vessel
calibration
Prior art date
Application number
MX2009013778A
Other languages
Spanish (es)
Inventor
Laurence Dwayne Chin
Archibald Williams
Martin Schwalm
Brett Andrew Feeney
Original Assignee
Varian Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Varian Inc filed Critical Varian Inc
Publication of MX2009013778A publication Critical patent/MX2009013778A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/15—Preventing contamination of the components of the optical system or obstruction of the light path
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/006—Dissolution of tablets or the like
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/15—Preventing contamination of the components of the optical system or obstruction of the light path
    • G01N2021/154—Ultrasonic cleaning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • G01N2021/8528—Immerged light conductor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction

Abstract

A dissolution test apparatus includes an optical probe, an automated actuator. The probe takes an optics-based measurement in dissolution media contained in a test vessel and transmits the measurement to an analytical instrument situated remotely from the vessel. The optical probe is movable by the actuator into and out from the vessel. The dissolution test apparatus may include a bubble removal apparatus that communicates with the optical probe and is configured for transmitting a variable vibrating force to the probe, wherein bubbles are removed from a light path gap of the probe. In another dissolution test apparatus, the bubble removal apparatus rotates the probe to remove bubbles. Another dissolution test apparatus includes a movable cleaning mechanism, a movable calibration mechanism, or both mechanisms.
MX2009013778A 2007-06-20 2008-06-18 Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing. MX2009013778A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93625707P 2007-06-20 2007-06-20
PCT/US2008/067302 WO2008157584A2 (en) 2007-06-20 2008-06-18 Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing

Publications (1)

Publication Number Publication Date
MX2009013778A true MX2009013778A (en) 2010-02-17

Family

ID=40156950

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013778A MX2009013778A (en) 2007-06-20 2008-06-18 Apparatus and methods for automatic insertion, debubbling, cleaning and calibration of a spectral probe during dissolution testing.

Country Status (8)

Country Link
EP (1) EP2162725A4 (en)
JP (1) JP2010530542A (en)
KR (1) KR20100023963A (en)
CN (1) CN101688825A (en)
BR (1) BRPI0813135A2 (en)
DE (1) DE08771330T1 (en)
MX (1) MX2009013778A (en)
WO (1) WO2008157584A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010094341A1 (en) * 2009-02-20 2010-08-26 Erweka Gmbh Decay time measurement device
JP5861010B2 (en) * 2013-12-11 2016-02-16 オリンパス株式会社 Calibrator and calibration device
CN104492365A (en) * 2014-12-29 2015-04-08 常州市龙道电子商务有限公司 Reaction kettle
CN104492364A (en) * 2014-12-29 2015-04-08 常州市龙道电子商务有限公司 Reaction kettle with rotary defoaming device
EP3176565B1 (en) * 2015-12-04 2021-04-28 Atten2 Advanced Monitoring Technologies S.L.U. Fluid monitoring system based on near-infrared spectroscopy
US9945830B2 (en) * 2016-01-21 2018-04-17 Rosemount Inc. Standard solution with cleaning reagent for wet chemistry analyzer
CN113388488B (en) * 2020-03-12 2023-09-29 迪必尔智能科技(深圳)有限公司 Probe type biomass on-line detection device capable of achieving high-temperature sterilization
JP7446614B2 (en) 2020-10-23 2024-03-11 富山産業株式会社 Collapse test basket and collapse detection device
WO2024091881A1 (en) * 2022-10-24 2024-05-02 Thermo Scientific Portable Analytical Instruments Inc. Self centering vial holder for immersion probes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH636200A5 (en) * 1979-03-20 1983-05-13 Zellweger Uster Ag Method and device for removing gas bubbles and other deposits from cuvettes (cells)
US6174497B1 (en) * 1997-06-04 2001-01-16 Euro-Celtique, S.A. Detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form
US6762841B1 (en) * 2000-02-22 2004-07-13 Spectraalliance, Inc. Method of performing spectral analysis in a pharmaceutical dissolution process
AR031557A1 (en) * 2000-03-10 2003-09-24 Textron Systems Corp OPTICAL PROBE AND METHODS FOR SPECTRAL ANALYSIS.
US6580506B2 (en) * 2001-02-10 2003-06-17 Leap Technologies, Inc. Fiber optic probes apparatus for spectrophotometry
US6962674B2 (en) * 2001-02-28 2005-11-08 Varian, Inc. Dissolution test apparatus
US6764651B2 (en) * 2001-11-07 2004-07-20 Varian, Inc. Fiber-optic dissolution systems, devices, and methods
AU2003243246A1 (en) * 2002-05-17 2003-12-02 Delphian Technology, Inc. In situ methods for measuring the release of a substance from a dosage form

Also Published As

Publication number Publication date
WO2008157584A3 (en) 2009-03-05
DE08771330T1 (en) 2010-09-30
BRPI0813135A2 (en) 2014-12-23
EP2162725A4 (en) 2010-06-09
CN101688825A (en) 2010-03-31
KR20100023963A (en) 2010-03-04
JP2010530542A (en) 2010-09-09
EP2162725A2 (en) 2010-03-17
WO2008157584A2 (en) 2008-12-24

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