MX2009011022A - Uso de sustratos como chaperonas farmacologicas. - Google Patents
Uso de sustratos como chaperonas farmacologicas.Info
- Publication number
- MX2009011022A MX2009011022A MX2009011022A MX2009011022A MX2009011022A MX 2009011022 A MX2009011022 A MX 2009011022A MX 2009011022 A MX2009011022 A MX 2009011022A MX 2009011022 A MX2009011022 A MX 2009011022A MX 2009011022 A MX2009011022 A MX 2009011022A
- Authority
- MX
- Mexico
- Prior art keywords
- substrates
- pharmacological chaperones
- chaperones
- pharmacological
- enhancing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporciona un método para mejorar la actividad de enzimas lisosomales utilizando sustratos que son derivados de sustratos naturales como chaperonas farmacológicas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91171007P | 2007-04-13 | 2007-04-13 | |
PCT/US2008/060094 WO2008128089A1 (en) | 2007-04-13 | 2008-04-11 | Use of substrates as pharmacological chaperones |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009011022A true MX2009011022A (es) | 2010-01-13 |
Family
ID=39864340
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009011022A MX2009011022A (es) | 2007-04-13 | 2008-04-11 | Uso de sustratos como chaperonas farmacologicas. |
Country Status (7)
Country | Link |
---|---|
US (1) | US20100197018A1 (es) |
EP (1) | EP2137204A4 (es) |
JP (1) | JP2010523160A (es) |
AU (1) | AU2008240205A1 (es) |
CA (1) | CA2684042A1 (es) |
MX (1) | MX2009011022A (es) |
WO (1) | WO2008128089A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010022461A1 (en) * | 2008-08-29 | 2010-03-04 | Children, Youth And Women's Health Service | Sulphated sugars to increase activity of sulphatases en lysosomal storage disorders |
AU2010254092B2 (en) * | 2009-05-26 | 2015-11-12 | Amicus Therapeutics, Inc. | Utilization of pharmacological chaperones to improve manufacturing and purification of biologics |
US9206457B2 (en) * | 2009-05-26 | 2015-12-08 | Amicus Therapeutics, Inc. | Utilization of pharmacological chaperones to improve manufacturing and purification of biologics |
WO2012027612A1 (en) * | 2010-08-25 | 2012-03-01 | Michael Gelb | Mass spectrometric compositions and methods for lysosomal storage disease screening |
JP2017195786A (ja) * | 2016-04-25 | 2017-11-02 | 国立大学法人 熊本大学 | 細胞内酵素タンパク質の構造異常の正常化方法、細胞内酵素タンパク質の構造異常の検出方法、及び、遺伝性代謝病の治療方法ならびにその治療効果の予測・評価方法 |
US20220184185A1 (en) | 2018-07-25 | 2022-06-16 | Modernatx, Inc. | Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6274597B1 (en) * | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
US7927587B2 (en) * | 1999-08-05 | 2011-04-19 | Regents Of The University Of Minnesota | MAPC administration for the treatment of lysosomal storage disorders |
AU2004293115A1 (en) * | 2003-11-25 | 2005-06-09 | Mount Sinai School Of Medicine Of New York University | Chaperone-based therapy for Niemann-Pick disease |
-
2008
- 2008-04-11 EP EP08745655A patent/EP2137204A4/en not_active Withdrawn
- 2008-04-11 WO PCT/US2008/060094 patent/WO2008128089A1/en active Application Filing
- 2008-04-11 US US12/595,081 patent/US20100197018A1/en not_active Abandoned
- 2008-04-11 JP JP2010503246A patent/JP2010523160A/ja not_active Withdrawn
- 2008-04-11 MX MX2009011022A patent/MX2009011022A/es active IP Right Grant
- 2008-04-11 AU AU2008240205A patent/AU2008240205A1/en not_active Abandoned
- 2008-04-11 CA CA002684042A patent/CA2684042A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2008128089A1 (en) | 2008-10-23 |
CA2684042A1 (en) | 2008-10-23 |
US20100197018A1 (en) | 2010-08-05 |
JP2010523160A (ja) | 2010-07-15 |
AU2008240205A1 (en) | 2008-10-23 |
EP2137204A1 (en) | 2009-12-30 |
EP2137204A4 (en) | 2010-05-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |