MX2008006337A - Closing system for containers - Google Patents

Abstract

The invention relates to a closing system for containers for storing or administering liquid, pasty or powdery materials, consisting of a cap (81, 82) provided with a through-hole (85) and a closing element (60), the cap holding the closing element on the container (10, 50) in a non-positive or positive manner, in the region of the opening (12) to be closed, by means of a rear grip (37) on the container. To this end, the front surface (21) surrounding the container opening and on which the closing element is arranged comprises a recess (24, 25). The closing element is a virus-tight, bacteria-tight and spore-tight film which lies on the front surface and at least partially over the recess. An elastomer or adhesive ring (71, 72) filling the recess is arranged between the closing element and the recess for the positioning of the cap. The invention provides a closing system for containers which enables the container to be closed in a virus-tight, bacteria-tight, spore-tight and lastingly secure manner.

Description

CLOSURE SYSTEM FOR CONTAINERS DESCRIPTIVE MEMORY The invention relates to a closure system for containers used to store or administer substances in the form of liquids, pastes or powders, system which is composed of a cover, provided with a through hole, and a closure element, said cover holds the closing element with a force adjustment and / or shape adjustment on the container, in the area of the opening to be closed, by means of a lower cut present in the container. Aluminum caps for dental carpules are known from DIN ISO 1 1 040 part 3 of 1993. These caps are used to securely close glass cylinders, for example, by means of piston plugs or sealing discs. For this purpose, after the piston plugs or sealing discs have been applied, the caps are fixed on the glass cylinder by means of a deformation procedure performed on the cap. Part 2 of the standard describes, among other things, thin sealing discs made of an elastomeric material. The object of the present invention is, therefore, to develop a closure system for containers which, without the application of thermal energy, and in a mechanically simple manner, allow the container Closes safely and permanently in a virus-proof, bacteria-proof and spore-proof manner. This objective is achieved through the characteristics of the main claim. For this purpose, the end face surrounding the opening of the container, and on which the closure element is held, comprises a depression. The closure element is a virus, bacteria and spore-proof film that extends over the end face and, at least in some areas, over the depression. When the cap is adjusted in place, an elastomeric ring or adhesive ring is disposed between the closure element and the depression and fills the depression. Alternatively, the closure element is supported on an end face provided with an elevation. In this case, an elastomeric ring is disposed in the closure member, and the elevation presses this elevation when the cap is adjusted in place. In addition, a closure system is provided in which the lid, on its inner face directed towards the closure element, has at least one closed, elastic sealing rim that rests elastically on the closure element. Moreover, a closure system without a lid is also conceived. In this case, the elastomeric ring, fixedly connected to the closing element, is held radially on a radial outer profile of the container, for example located in the area of the opening to be closed.

Through the invention, a closure system is obtained which is easy and safe to handle and with which substances in the form of liquids, pastes or powders, in particular medicines, for example pharmaceutical liquids containing proteins, are permanently enclosed in a sealed way in a container. The additional details of the invention will be clarified from the dependent claims and from the following descriptions of illustrative embodiments which are schematically illustrated in the figures, wherein: Figure 1 shows a medicament chamber with lid and sealing film; Figure 2 shows an elongated partial cross section of Figure 1; Figure 3 shows the same view as figure 2, but without guide cone; Figure 4 shows the same view as Figure 2, but with a slot-like depression for receiving the elastomeric ring; Figure 5 shows a carpule with lid and sealing film; Figure 6 shows a medicament chamber with a lid that is resilient with respect to the sealing film; Figure 7 shows a detail of Figure 6; Figure 8 shows the same view as Figure 6, but with at least one other film contact element; Figure 9 shows the same view as Figure 4, but with an edge elevation and a flat elastomeric ring; Figure 10 shows a medicament chamber with clamping ring; and Figure 1 1 shows a medicament chamber without a clamping ring and without a lid. Figure 1 shows a container 10 with a piston 40 and a closing system. Hereinafter, container 10 is designated as a drug chamber. The drug chamber 10, in combination with the piston 40, is a group of assemblies of an injection system. The medicament that will be administered initially is stored, for example in liquid form, in the drug chamber 10. For this purpose, the medicament has to be enclosed in the cylinder 1 1 of the chamber 10 in a way that is virus-proof, bacteria-free and spores. For example, the conical cylinder 1 has two openings 1 1, 13. A front opening 13 is the outlet nozzle. A rear nozzle 12 is used inter alia to fill the cylinder 1 1. When the chamber 10 is filled, the piston 40 is placed in the rear area of the cylinder 1 1. Located directly behind the piston 40, there is a cover 81 which, with the aid of a closing element 60, closes the rear opening 12 in a manner that is resistant to viruses, bacteria and spores. Of course, the container 10, 50 can also be provided with only one opening 12, especially the opening that is closed by the proposed closure system. If convenient, the closure system can also be gas impermeable. To fix the elastic cover 81, the rear area of the chamber 10, made for example of COC plastic, has a defined profile (see figure 2). The chamber 10 has an end piece in the form of an almost cylindrical tube 20 with an end face 21, which is flat for example, and with a cylindrical outer profile 28. In front, the end piece 20 terminates in a housing collar 35. An additional housing collar 31 is located in the transition area between the end face 21 and the cylindrical outer profile 28. The width of this housing collar 31 is, for example, 50% of the wall thickness of the workpiece. end 20. The depth of this housing collar 31 is slightly greater than its width. The radial flank 32 of the housing collar 31 is cylindrical, while the axial flank 34 is flat. Located under the housing collar 31, there is a circumferential capture elevation 37, for example with two flanks. Its length corresponds to approximately 50% of the length of the end piece located between the two housing collars 31, 35. In this illustrative embodiment, the circumferential catch elevation 37, which is centrally positioned for example, has no interruption. The capture elevation 37 has a front flank 38 and a rear flank 39. The angle of the rear flank is for example 17 ± 3 angular degrees, while the angle of the frontal flank is for example 51 ± 3 angular degrees. The capture elevation 37 is round in the area of the contact zone of the flanks 38, 39. According to FIG. 2, the closure element 60 and an elastomer ring 71 are seated on the rear end face of the piece of end 20. The closure element 60 is, for example, a sealing film having a thickness of 0.15 millimeters and is made of an aluminum alloy. The film material can also be Tyvek®, PE, PET or a mixed material. The sealing film 60 is a round, flat and flexible disc. The elastomeric ring 71 is made, for example, of silicone rubber, chlorinated rubber or butyl rubber. It is a closed ring with an individual cross section at least approximately round. It is flattened in the area through which it adhesively bonds or burns on the sealing film 60. The cover 81 is formed of two portions, especially an assurance area 91 and a base area 95. The securing area 91 it is a portion in the form of a substantially cylindrical tube. It engages around the end piece 20 in the area of the capture elevation 37 provided therein. Its inner profile is configured exactly in such a way that after the cover 81 is put in place, sits free of play on the end piece 20, at least in the flank area 38. The inner profile does not rest on the other flank 39, or is held on the latter only in some areas.

The base area 95, which according to FIG. 2 partially rests with a flat base surface 96 on the sealing film 60, has a frustoconical exterior profile 97 and a funnel-shaped central recess 98. The central recess 98 , which corresponds to the through hole 85, has a minimum diameter slightly smaller than the diameter of the rear opening 12 of the cylinder 1 1. The area of the recess 98 adjacent to the base surface 96 has a cylindrical shape. The remaining area of the gap 98 widens backward in a funnel shape. This funnel shape facilitates the insertion of a plunger (not shown) through which the piston 40 in the cylinder 1 moves when the injector is triggered. After the drug chamber 10 has been filled and the piston 40 has been inserted, the sealing film 60 together with the elastomeric ring 71, fit over the end face 21 of the chamber 11. The elastomeric ring 71 that adheres to the sealing film 60 engages centrally around the radial flank 32 of the housing collar 31. When the lid 81 snaps into place, it slides with its lower cut 92 over the capture lift 37. As soon as the lower cut 92 is held in the front flank 38, the lid 81 reaches its end position. The base surface 96 is then firmly held in the sealing film 60. At the same time, the elastomeric ring 71 in the area of the housing collar 31 is seated in a sealed manner between the cover 81 and the end piece 20. In the axial direction, the elastomeric ring 72 is forced between the axial flank 34 and the sealing film 60 pressed firmly on the base surface 96. Here the clamping force of the lid 81 is generated, for example, by means of the annular clamping force of the securing area 91. The housing collar 35 serves as an auxiliary splice when the cover 81 snaps into place. In small containers in particular, it is also conceivable that the lid fits around the entire container. In this case, the lid is then locked on the base of the container acting as a capture element 37. Figure 3 shows a closure system with a simplified lid 82. This lid 82 does not have the insertion funnel 98. An additional variant of figure 2 is shown in figure 4. In this variant, a depression 25 in the form of an annular channel that has been worked radially on the end face 21. The annular channel 21, whose individual cross section is composed of a rectangle surface and a semicircle surface, receives the elastomeric ring 72 secured in the sealing film 60. The closed areas of the end face 21 are located on both sides of the annular channel 21. In these areas, the sealed film 60 is held firmly on the end face 21 of the chamber 10. If convenient, in this variant, an adhesive may be introduced into the annular channel 25 instead of a ring elastomeric 72. This adhesive then bonds the applied sealing film 60 to the chamber 10.

Instead of a drug chamber, it is also possible to use a glass jar or a carpule 50 (see figure 5). In this case, a cover 83 engages around the neck 51 of the carpule 50 with a shape fit. The lower cut 92 has an individual cross section in the shape of a prong. In the carpule 50, as well as in the drug chamber 10, the end face 21 can be designed with downward inclination towards the outside. Accordingly, the end face 21 describes for example a truncated cone, with a cone angle of 150 + 4 angular degrees for example. The tip of the imaginary cone extends out of the carpule 50 or out of the drug chamber 10. Figure 6 shows a closure system that does not require an elastomeric ring. In contrast, the cover 83 has for example two sealing flanges 87, 88 which press the sealing film 60 elastically against the end face 21 of the drug chamber 10 (see also figure 7). The first outer sealing lip 87 is directed towards the atmosphere. Press the sealing film 60 into the edge area of the opening 12 against the end face 21. In its individual cross-section the sealing flange 87 is inclined approximately 45 angular degrees with respect to the sealing film 60. Its wall thickness is greater than that of the second inner sealing flange 88. The second inner sealing flange 88 is seated in a protected position under the first sealing flange 87. Press the area of outer edge of the sealing film 60 against the end face 21. It is also inclined approximately 45 angular degrees with respect to the sealing film 60. Both sealing flanges 87, 88 are made of a permanently elastic material. To ensure that the sealing film 60 can be placed at least more or less centrally on the end face 21 at the time of assembling the closure system, this variant includes a splice edge 22 whose height corresponds to at least twice the film thickness of the sealing film 60. Figure 7 shows an enlarged detail of Figure 6. This enlargement shows that the sealing film 60, in the edge area of the opening 12, has a circumferential score 62. in the form of a notch in the upper surface 61. The circumferential bead 62 represents a mechanical weakening of the sealing film 60. It is intended to make it easier to detach the film 60 at the time of administering the medicament. Fig. 8 shows a variant of Fig. 6. The inner sealing lip 88 and the end face 21 have another configuration. The end face 21 according to figure 8 has a channel 23 extending along the splice edge 22. When the cover 84 is adjusted in place, the sealing film 60 is pressed with the aid of the flange inner seal 88 towards this channel 23. The individual cross-section of seal flange 88 is substantially biased, so that the front area 89 of the sealing flange 88 presses almost at right angles onto the sealing film 60. The rear area of the sealing flange 88 serves as an elastic zone. When the cap 84 snaps into place, the inner sealing lip 88 presses the sealing film 60 towards the channel 23. In doing so, the sealing film 60 is tensioned, so that it extends flat. If convenient, the front area 89 of the sealing flange 88 can also point outwards. In this case, the front area is part of a cone surface, the tip of which extends over the upper surface 61 of the sealing film 60 in the continuous center line of the chamber 10. Here, for example, the channel can be omitted 23. Figure 9 shows a closure system which has an elevation 27, instead of a circumferential depression, on the end face 21 of the chamber 10 or carpule 50. The elevation 27 extends approximately centrally on the surface ring of the end face 21. According to FIG. 9, the elevation 27 is formed, for example, by two truncated cone surfaces that appear as a triangle in individual cross section. The elevation can have almost any desired individual cross section. If it is convenient, also several elevations extend one next to the other. Furthermore, the individual elevation does not have to be arranged concentrically with respect to the centerline of the chamber 10. Nor does it have to be round in the plan view.

The sealing film 60 is held on the end face 21 through the elastomeric ring 63 which is fixedly disposed thereon. The elastomeric ring 73 has the shape of a perforated disc. In the compressed state in which it is installed, its material thickness is at least 30% greater than the height of the elevation 27. The elastomeric ring 73 reaches here as much as the wall of the cylinder 1 1. In this variant, the clamping force of the cover 81 is determined by the elasticity of the elastomeric ring 73. Figures 10 and 11 show a variant of the closure system without a cover. This solution is based on a radial clamping force of the corresponding elastomeric ring 74, 75. The elastomeric ring 74, 75 which adheres to the underside of the elastic sealing film 60, has a smaller average diameter in the state when it is not installed Only after assembly, it is applied with elastic expansion on the end piece 20 and from there, for example, on the radial flank 32, 33. In this case, the radial flank may have a cylindrical profile 32 or a non-cylindrical profile 33. In the figure 10, profile 33 is shown with dashed lines. Starting from the end face 21, its diameter decreases linearly downward. Accordingly, the flank 33 has the shape of a truncated cone surface whose theoretical tip extends, for example, in the central area of the chamber 10. According to FIG. 10, the elastomeric ring 74 is radially supported and held by a clamping ring 79. The ring of The holder 79 is supported on the elastomeric ring 74 and also on the outer profile 28 of the end piece 20. Only by way of example is it shown here fixed through the capture elevation 37. The clamping ring 79 ends level with the sealing film 60 at the rear end of the chamber. If necessary, the clamping ring 79 engages only around the elastomeric ring 74. Figure 1 1 shows a closure system in which the assembled joint located between the profile 33 and the elastomeric ring 75 forms a lower cut. If convenient, the elastomeric ring 75, in the non-installed state, already has a shape that coincides with the profile 33. Here, for example, it is possible to dispense with a clamping ring. Solutions are also possible in which the variants of FIGS. 1, 4, 6, 8, 10 and 1 1 overlap at least partially. The sealing films 60 and, if convenient, also the elastomeric rings 71-73, can of course have self-adhesive, virus-proof coatings in the areas where they touch the end face 21 and the depressions 24, 25 or elevations 27.

Claims (10)

NOVELTY OF THE INVENTION CLAIMS

1 .- A closure system for containers used to store or administer substances in the form of liquids, pastes or powders, system which is composed of a cover (81, 82), provided with a through hole (85), and an element of closure (60), the lid (81, 82) supports the closure element (60) with a force adjustment and / or shape adjustment in the container (10, 50), in the area of the opening (12) which will be closed, by means of a capture element (37) present in the container (10, 50), characterized in that the end face (21) which surrounds the opening of the container (12) and on which the closure element (60), comprises a depression (24, 25), the closure element (60) is a film resistant to viruses, bacteria and spores that extends on the end face (21) and at least in some areas, over the depression (24, 25), and when the cover (81, 82) is adjusted in place, an elastomeric ring or adhesive ring (71, 72) is disposed in between the closing element (60) and the depression (24, 25) and filling the depression (24, 25).

2. The closure system according to claim 1, further characterized in that the closure element (60) is a disk-shaped film.

3. - The closure system according to claim 2, further characterized in that the film (60) has a material thickness of 50 to 300 micrometers.

4. - The closure system according to claim 2, further characterized in that the film (60) is made of an aluminum alloy.

5. - The closure system according to claim 2, further characterized in that in the area of the opening (12) of the container (10, 50), the film (60) has, on its upper surface (61), a account (62) that weakens the film (60).

6. - The closure system according to claim 1, further characterized in that the depression (24) extends on the outer edge of the end face (21).

7. - A closure system for containers used to store or administer substances in the form of liquids, pastes or powders, system which is composed of a cover (83, 84), provided with a through hole (85), and an element of closure (60), the lid (83, 84) holds the closure element (60) with a force adjustment and / or shape adjustment in the container (10, 50) in the area of the opening (12) that it will be closed, by means of a capture element (37) present in the container (10, 50) characterized in that the closing element (60) is a film resistant to viruses, bacteria and spores and at least one sealing flange elastic, closed (87, 88) is disposed resiliently on the inside face (16) of the cover facing the closure element (60).

8. - The closure system according to claim 7, further characterized in that an inner sealing rim (88) and an outer sealing rim (87) are disposed on the inner face (86) of the lid.

9. - The closure system according to claim 8, further characterized in that in at least one elastic seal flange (88), the area in contact with the sealing film (60), and that holds the sealing film (60), is oriented towards the outside and its individual cross section encloses an angle of 30 to 60 angular degrees with respect to the central line of the container (10, 50).

10. - A closure system for containers used to store or administer substances in the form of liquids, pastes or powders, system which is composed of a cover (81, 82), provided with a through hole (85), and an element of closure (60), the lid (81, 82) holds the closing element (60) with force adjustment and / or shape adjustment in the container (10, 50), in the area of the opening (12) that will be closed, by means of a capture element (37) present in the container (10, 50), characterized in that the end face (21) which surrounds the opening of the container (12), and on which the closing element (60), has an elevation (27) that surrounds the opening of the container (12), the closing element (60) is a film resistant to viruses, bacteria and spores that extends on the end face ( 21) and in the elevation (27), and a ring elastomeric (73) is disposed in the closure element (60), and the elevation (27) presses said elastomeric ring (73) when the cover (81, 82) is adjusted in place. eleven . - A closure system for containers used to store or administer substances in the form of liquids, pastes or powders, which system comprises a film-like closing element (60) on the edge of which is disposed an elastomeric ring (71, 74) of a fixed manner, and the closure element (60) is supported on the container (10, 50), in the area of an opening (12) to be closed, especially on an end face (21) that surrounds the opening of the container (12), and the elastomeric ring (74, 75) is elastically supported on an outer radial profile (32, 33) of the container (10, 50). 12. - The closure system according to claim 1 1, further characterized in that the diameter of the radial outer profile (32, 33) decreases as the distance from the end face (21) of the container (10, 50) increases. ), thus forming a lower cut. 13. - The closure system according to claim 1, further characterized in that the elastomeric ring (74, 75) is pressed against the radial outer profile (32, 33) by means of a clamping ring (79) that encloses radially said elastomeric ring (74, 75).