MXPA00011800A - Pre-filled container - Google Patents

Abstract

A pre-filled plastic syringe (1) which includes:a) a barrel (1a);b) a moveable stopper(3) which seals the barrel at one end;c) a needle fitting (13) which is integral with the barrel and which is located at the end of the syringe remote from the moveable stopper;and d) a closure (9) which seals the syringe at its needle fitting end;wherein an injectable liquid (10) is housed within the barrel between the moveable stopper and the closure and wherein the closure is located within the needle fitting and/or the barrel of the syringe.

Description

PRELIMINARY CONTAINER This invention concerns pre-filled containers, cartridges and syringes. It relates more particularly to a new form of syringe that can be prefilled, fitted to a hypodermic needle and packaged as a ready-to-use product. The applicant has previously proposed several designs for the manufacture of injection molded plastic syringes. For example, reference is made to the prior patent applications of the applicant PPCT / AU92 / 00007 and PCT / AU95 / 00723. In both cases the prefilled syringes were sealed at the end of the needle by an enclosure in the form of a rod that separated from the syringe. Although the applicant's previous proposals were significant improvements over the pre-filled products that were available before these developments, the use of a separable rod to seal the syringe caused certain difficulties to arise. First, a rod protruding from the end of the syringe is susceptible to accidental knocks, both in production and in use and this can lead to contamination or an inadvertent opening of the unit. Secondly, in a system such as that described in PCT / AU / PP723 it is necessary to remove the stem from the needle attachment before a hypodermic needle can be fixed. This means that the needle must be adjusted in a separate step immediately before use. This can be inconvenient and there is the possibility of contamination during the operation of fixing the needle. It is an object of the present invention to provide a pre-filled syringe that is sealed in a manner that addresses, at least to some extent, the inherent difficulties of the above units described herein. In accordance with the present invention, a plastic syringe is provided which includes: (a) a barrel; (b) a movable plug that seals the barrel at one end; (c) a needle attachment that is integrated into the barrel and located at the remote end of the syringe from the movable plug; and (d) an enclosure that seals the syringe at the end of the needle attachment; where an injectable liquid is lodged inside the barrel between the movable plug and the enclosure and where the enclosure is located within the attachment for the needle and / or barrel of the syringe.

Preferably, the needle attachment includes a truncated hollow cone, the interior of which is in liquid communication with the interior of the barrel. More preferably, the needle attachment is in the form of a truncated cone surrounded by a peripheral wall spaced from the cone. An example of this accessory for "luer lock" needle. The luer lock accessory incorporates a threaded screw on the inner surface of the peripheral wall to facilitate threading the screw thread of a hypodermic needle into the needle attachment. The hypodermic needles used in conjunction with the luer lock needle are fixed at one end to a support that is conical, hollow and sized to fit over the central cone of the luer lock fitting. The base of the needle holder includes a flange which is shaped to engage with the thread of the screw on the inner surface of the peripheral wall so that when the hypodermic needle is rotated relative to the needle attachment, the screwing is facilitated. It is more preferred that the syringe of this invention uses a luer lock attachment for a needle and that the syringe be used in conjunction with a hypodermic needle fixed to a conical holder as described above.

The enclosure may be a separate component located within the barrel or the needle attachment so that a friction is adjusted or by other suitable means. In this case it is preferred that the enclosure be formed of a material and have a thickness that can be punctured without difficulty. However, the enclosure is preferably a wall portion that is connected with brittleness to the inner surface of the barrel or to the inner surface of the needle attachment and extending through the opening in the barrel or the needle attachment. It is more preferred that the enclosure be located completely within the needle attachment of the syringe. In the embodiment of the invention where the needle attachment includes a truncated hollow cone in communication with the interior of the barrel it is preferred that the enclosure be an integral wall portion which is connected to the inner surface of the cone and extends to through its opening. In this embodiment of the invention, the portion of the wall can be located at any position along the interior wall of the needle attachment. Preferably, it is fixed in a brittle manner to the inner surface of the truncated cone and located at least 2.0 mm and more preferably at least 4.0 mm from the open end of the truncated cone to reduce the leaflet of the portion of the wall that has been broken away from the inside wall and (thus breaking the seal created by the portion of the wall) inadvertently. In order that the syringe can be opened without difficulty when it is desired to apply the injectable liquid it is desirable that the enclosure can be punctured by the rear part of the needle of a standard two-sided hypodermic needle (in which case the enclosure is placed near the open end of the needle attachment) or alternatively that is fragile so that it can be detached or broken in part away from the inner surface of the truncated cone or barrel when using a suitable tool. In a particularly preferred embodiment of the invention the syringe includes an accessory for truncated conical needle and the enclosure is a portion of the wall that extends through the internal passage of the cone and is fixed in a fragile manner to the interior surface of the cone. cone. In this embodiment it is desirable that the portion of the wall includes a weakened circumferential section at or adjacent to its connection with the inner surface of the cone. The weakened section thus waxes a "line of rupture" along which the enclosure can be detached (at least in part) from the interior surface of the cone. Preferably the portion of the wall is between 0.8 mm to 1.5 mm in thickness except in the weakened section where it is preferably between 0.05 to 0.2 mm in thickness. Although it is possible to use a weakened section extending all the way around the portion of the wall this is not preferred as the application of a force against the portion of the wall in such an embodiment can result in a complete separation of the enclosure from the wall. Needle accessory. Although this does not adversely affect the operation of the syringe, it is considered undesirable to cause the enclosure to float freely in the injectable liquid. Thus, it is preferred that the weakened section extends circumferentially through about 330-350 ° so that when the enclosure is broken away from the inner surface the cone along the weakened section the enclosure still remains fixed into the needle attachment and having the ability to have hinge movement around that section at or adjacent to the inner surface of the cone that is not weakened.

The seal provided by the portion of the wall can be broken by applying a force against the portion of the wall. A tool that incorporates a push rod of a smaller diameter from the inner diameter of the cone and that is of sufficient length to reach the portion of the wall can be used for this purpose. Preferably this tool has a flat end face dimensioned to make contact with most of the surface area of the enclosure. Once the closure comes off, the hypodermic needle can be attached to the needle attachment making the syringe ready for immediate use. Alternatively, and more preferably where the enclosure is fragile connected, the needle attachment, the pre-filled syringe of the invention also includes a hollow duct for opening the enclosure, a hypodermic needle and a needle holder having an internal cavity , in which the hypodermic needle is fixed to one of the ends of the needle holder and this support is placed on (but not completely hooked) the needle attachment, where a first end of the opening opening duct is placed inside the internal cavity and a second end of the opening opening duct is placed inside the needle fitting, the The opening conduit of the enclosure is in liquid communication with the hypodermic needle and is of such length that the movement of the needle holder towards the end of the movable syringe cap will cause the opening conduit of the enclosure to break the seal provided by the enclosure. Desirably the length of the opening conduit of the enclosure is such that the screwing of the needle holder on the needle attachment provides sufficient movement of the needle holder, (and therefore to the closing duct of the enclosure) to break the seal provided by the enclosure. Preferably the cavity in the needle holder includes an end face in which the centrally disposed opening is located. The hypodermic needle can be adjusted and secured at one end inside the opening so that it extends away from the cavity. The opening opening of the enclosure is preferably located within the cavity with the first end embedded in the face of the end of the box with the internal passage there in alignment with the opening in the end face of the needle holder. The other end of the opening opening of the enclosure is preferably adjacent or embedded to the surface of the enclosure. In this way, the movement of the needle holder towards the end of the movable needle cap will cause the end face to press against the first end of the opening opening of the enclosure and in turn apply pressure to the enclosure. When moving the support completely on the needle attachment the opening opening of the enclosure will move sufficiently to break the fragile connection of the enclosure with the needle attachment and in this way facilitate direct liquid communication from the barrel to the syringe by passing the hypodermic needle through the enclosure open and through the conduit of the opening of the enclosure. The opening opening of the enclosure can be integral and extend from the needle holder but preferably is a separate component. Preferably the duct of the opening of the enclosure includes a central duct and fins or ribs that extend outward therefrom to minimize contact between the duct of the opening of the enclosure and the internal surface of the needle attachment. This reduces the friction between the surfaces. As an alternative other closing opening element, it can be used when it does not incorporate a duct but simply has the shape to allow the passage of the liquid. For example, the closure opening elements may be a solid rod having a diameter smaller than the smallest diameter of the passage in the needle fitting with the guide ribs that are configured to make contact with the interior surface of the fitting. of the needle. Desirably the prefilled syringe also includes a cap placed on the hypodermic needle. An evident violation band can be provided around the base of the cap to recognize the anterior removal of the cap due to absence of the band or fracture. The embodiment of the invention utilizes an enclosure opening conduit that provides significant advantages in ease of use and avoids contamination. In particular, it is possible to make a mold by injection of the components, assembly and filling of the needle in an aseptic environment. The filling and assembly of the needle can also be hermetically sealed inside a clear plastic wrap like cellophane before delivering the product out of the clean environment. The pre-filled product can be delivered to the doctors with the hypodermic needle in position on the needle attachment but not completely screwed. During use, the hypodermic needle can be pushed or turned on the needle attachment while the product is in the hermetically sealed package. The complete seating of the hypodermic needle in the needle attachment causes a seal to be formed by the closure that will break so that when the packing is open the removal of the hypodermic needle cover (if present) provides a pre-filled syringe open ready for use and not susceptible to contamination by the application of additional parts or products to the syringe after the package has been opened. The pre-filled plastic syringe of the invention is preferably made of a thermoplastic material such as polypropylene. Other suitable materials include translucent and transparent plastics such as PET, polyamides or TPX. Other suitable materials are well known to those skilled in the art. The examples of the invention are now described by reference to preferred embodiments particularly in which pre-filled syringes are injection molded, assembled and packaged in a sterile environment and available for immediate use. The embodiments are shown in the following drawings in which: Figure 1 is a schematic diagram illustrating a prefilled syringe packaged inside an outer envelope; Figure 2 is a schematic diagram illustrating the prefilled syringe shown in Figure 1 with the wrap removed and before the syringe is opened; Figure 3 is an end view of the prefilled syringe shown in Figure 2 seen from the end of the plunger; Figure 4 is an elongated schematic view of the needle attachments and closure of the prefilled syringe shown in Figure 2; Figure 5 is an enlarged view of the central cone of the needle attachment shown in Figure 4 and the associated enclosure; Figure 6 is a schematic diagram illustrating the end of the needle attachment of the prefilled syringe shown in Figure 2 with the hypodermic needle and the needle holder placed over the end of the needle attachment of the syringe but before being screwed totally; Figure 7 is a schematic diagram illustrating the needle attachment and the hypodermic needle assembly as shown in Figure 6, after the hypodermic needle and needle holder have been firmly placed on the needle attachment of the syringe; Figure 8 is a schematic diagram illustrating the end of the needle attachment of the prefilled syringe and the passage through which the injectable liquid can flow once the closure is opened. Figure 9 is a schematic representation of the conduit of the opening of the enclosure; Figure 10 is a sectional sectional view of a removable band that is intended to be used to hold the cap in position over the hypodermic needle before use; Figure 11 is a schematic diagram illustrating an alternative embodiment of the invention using a two-sided hypodermic needle; Figure 12 is a schematic representation of the end of the needle attachment of the pre-filled syringe illustrated in Figure 11; Figure 13 is a schematic diagram of the end of the truncated cone in the needle attachment illustrated in Figure 12; and Figure 14 is a schematic representation of the two-sided hypodermic needle with holder and cap. Figure 1 is a schematic representation illustrating how a preferred embodiment of the invention can be presented for distribution to doctors and other medical practitioners. The pre-filled syringe 1 is preferably manufactured by injection molding all the components in an aseptic environment, assembling and filling the syringe in an aseptic environment and sealing within an outer envelope 17. The syringe 1 illustrated without the protective packing in figure 2, it includes a barrel la and a plunger rod 2 fixed to a movable plug 3. The movable plug 3 seals the barrel at one end - the other end of the barrel is sealed by an enclosure 9 which is integrated to the central truncated cone 13a of the needle attachment 13 and on the other side of the syringe. The barrel is filled with an injectable liquid 10 and this injectable liquid is drawn into the barrel between the movable plug 3 and the enclosure 9.

A hypodermic needle 5 is secured to the needle holder 7. The needle holder 7 includes an internal cavity 7a (better seen in Figure 6) and is placed over the end of the truncated cone 13a of the needle attachment 13. hypodermic needle 5 is hollow and is in liquid communication with cavity 7a. An opening duct of the enclosure is of the nature of a separate tube 21 (again better seen in Figure 6) is placed between the needle support 7 and the enclosure 9 and the use of this had in conjunction with the support of the needle 7 in the peel-off enclosure 9 is described below. The hypodermic needle 5 is protected by a cover 6 which is held in place with a circumferential band 4 which is shown in full detail in Figure 10. The needle attachment 13 also includes an outer peripheral wall 15. Figure 3 illustrates the syringe from the end of the plunger rod of the syringe, showing pressure with the thumbs 12, finger support flanges 16 and ribs for fastening 18. These features are shown simply to exemplify the particular embodiment of the invention but it will be appreciated that any type of plunger rod mechanism or movable plug, as is known in the art, may be suitable for the purposes of the present invention. Figure 4 illustrates the end of the needle attachment of the prefilled syringe shown in Figure 2. The needle attachment includes a central truncated cone 13a and a peripheral outer wall 15. This is in the nature of the standard needle accessory type "luer lock" and in this way is suitable to be used in conjunction with a hypodermic needle and a needle holder of the type shown in Figure 2. The peripheral wall 15 includes a spiral rib 20 which facilitates the screwing of the threaded screw of the needle holder 7 into the needle attachment 13. The needle attachment 13 has an opening 22 between the peripheral wall 15 and the central truncated cone 13a. Different from the standard luer lock there is a provision for an enclosure 9 in the form of an integrated end of the portion of the wall located within the central truncated cone 13a. The enclosure 9 although integrated with the inner surface of the truncated central cone 13a is brittlely connected thereto as best shown in Figure 5. Adjacent to the inner surface of the truncated cone 13a the enclosure 9 includes a break line 8 which is a circumferential portion of the reduced thickness so that the application of a force against the enclosure 9 towards the end of the movable plug of the pre-filled syringe will cause the enclosure to break away from the inner surface of the truncated cone 13a along the line of breaking 8 of reduced thickness. In the embodiment shown the syringe is made of polypropylene and the enclosure 9 is approximately 1.2 mm thick. The line of rupture is around 0.1 mm thick. Preferably, the line of rupture 8 does not extend around the entire circumference of the enclosure 9 so that when force is applied against the enclosure, at least part of the enclosure remains fixed to the interior surface of the truncated cone 13a to leave the enclosure 9 fixed to the portion of the inner surface of the truncated cone 13a. The inner passage diameter of the central truncated cone 13a is slightly larger on the side of the barrel of the enclosure 9 to accommodate the enclosure when it is detached and bent backwards by the tube 21. The operation of the syringe is shown in greater detail in Figures 6, 7 and 8. In Figure 6, the end of the needle attachment of the syringe is shown with the enclosure 9 sealing the syringe. This is the way in which the product will be delivered to the end users. The needle holder 7 is placed on a central truncated cone 13a but the flange 7b of the needle holder 7 has not been screwed with the portion of the threaded screw 20 of the peripheral wall 15. The Tube 21 is located with a first end embedded against the end of the cavity 7a and with the other end embedded against the face of the enclosure 9. The tube 21 has a central passage 21a which is aligned so as to be in direct fluid communication with the passage 5a in the hypodermic needle 5. Rape indicator bands 4 hold lid 6 in position. Figure 7 shows the end of the needle attachment of the pre-filled syringe after part of the closure 9 has been detached from the inner surface of the central truncated cone 13a. Preferably, this is achieved by applying a force to the lid 6 or the circumferential band 4 in the direction of the end of the movable plug of the pre-filled syringe. Instead, this force will move the needle holder 7 further into the truncated cone 13a. Screwing on the screw thread 20 is more preferable than the force used in conjunction with a rotating action for screwing the needle holder 7 into the central cone 13a and towards the end of the movable plug of the syringe. This support movement 7 causes a force to be applied to the tube 21 which in turn applies a force to the enclosure 9 causing a force to be applied to the tube 21, which in turn applies a force to the enclosure 9 causing it to break away from the enclosure 9. inner surface of the central truncated cone 13a together with the line of rupture 8. In the preferred embodiment shown in Figure 7, the line of rupture 8 does not extend around the entire circumference of the enclosure and thus has a movement of hinge to one side as can be clearly seen in Figure 7. Preferably tube 21 is beveled at the end. This facilitates easy insertion of the tube 21 into the truncated cone 13a when the product is assembled but also means that the tube 21 is less likely to detach completely from the enclosure 9 from the inner surface of the truncated cone 13a. The open enclosure 9 is held between the inner surface of the truncated cone 13a and the outer surface of the tube 21 once the needle holder 7 has been screwed tightly into the needle attachment 13. In Figure 8, the end of the Needle attachment of prefilled syringe 1 is shown ready to use. The rape evidence band 4 has been removed together with the cover 6 (contrast with figure 7). the injectable liquid 10 can now be applied outside the syringe 1 in the direction of the arrow shown in Figure 8 by moving the rod of the plunger 2 toward the end of the needle attachment of the syringe. The liquid 10 will move in the direction of the arrow in Figure 8 through the passage 21a and subsequently through the hollow hypodermic needle 5. Figure 9 is a schematic representation showing the tube 21 and Figure 10 is a section elongated crusade of the rape evidence band 4. This band includes an inner rib 11 and an end flange 14a adapted to a latch around the flange 6a of the cover 6. An alternative embodiment of the invention is shown in FIGS. Figures 11 to 14. In this embodiment, the characteristics similar to those described with respect to the first embodiment of the invention numbered in a similar manner are numbered. The primary difference between the embodiment of the invention shown in Figures 11 to 14 with those shown in Figures 1 to 10, concerns the position of the enclosure 9 and the use of a two-sided hypodermic needle. Turning to Figure 11, a pre-filled syringe 1 having a barrel la, a plunger rod 2 and a removable plug 3 is shown. The needle attachment 13 includes a central truncated cone 13a and a peripheral wall 15. The hypodermic needle 5 is fitted to the needle holder 7. in contrast to the embodiment shown in Figures 1 to 10, the hypodermic needle 5 extends through the needle holder 7 or has a pointed end 5b of the hypodermic needle 5 which is located near but not in contact with the enclosure 9. The accessory of the needle 13 and the central truncated cone 13a are shown in greater detail in Figures 12 and 13. In order to ensure the correct perforation of the enclosure 9 a Through the pointed end 5b of the hypodermic needle 5 when the needle holder 7 fits completely in the needle fitting 13, it is important that the closure 9 is located near the end of the central cone 13a. Although it can be completely located at the end of the central cone 13a, it is preferred that it be located at a short distance within the cone, for example 0.5 mm from the end of the cone 13a.

It will be appreciated that in use, securing the needle holder 7 completely in the needle attachment 13 will cause a movement of the pointed end 5b of the hypodermic needle 5 towards and through the enclosure 9 thus breaking the seal formed by the enclosure 9. so that the injectable liquid 10 can be applied from the syringe in a manner similar to that described with respect to the first embodiment. Figure 14 is an elongated representation of the hypodermic needle 5, needle holder 7 and lid 6. It will be apparent from the foregoing that the preferred embodiments of the invention in the manner illustrated and described above can be manufactured, assembled and sealed in an all in an aseptic and clean environment. This product can be transported and stored if the minimum risk of contamination and the envelope can protect the syringe from any contamination and be removed only when the syringe is in use. Since the opening mechanism of the syringe is activated by screwing the needle holder 7 into the needle attachment 13 there is no need for the needle attachment or the needle holder to be exposed to the environment and to a possible contamination before use. The consequent advantages in ease of use will be simple for those people qualified in technology. Various modifications and / or additions can be made to the embodiment described herein without departing from the spirit or scope of the present invention as defined in the following claims.

Claims (18)

1. CLAIMS 1. A pre-filled plastic syringe that includes: (a) a barrel (b) a movable plug that seals the barrel at one end; (c) a needle attachment that is integrated with the barrel and that is located at the remote end of the syringe from the movable plug; and (d) an enclosure that seals the syringe at the end of the syringe fitting. where an injectable liquid is housed inside the barrel between the movable plug and the enclosure and where the enclosure is located within the needle attachment and / or barrel of the syringe.
2. 2. A pre-filled plastic syringe as described in Claim 1 wherein the needle attachment includes a hollow truncated cone, the interior of which is in liquid communication with the interior of the barrel.
3. 3. A prefilled plastic syringe as described in Claim 1 or Claim 2 wherein the needle attachment is in the form of a truncated cone surrounded by a peripheral wall spaced from the cone.
4. 4. A prefilled plastic syringe as described in any of Claims 1 to 3 wherein the enclosure is made of such material and with such a thickness that it can be punctured without difficulty.
5. 5. A pre-filled plastic syringe as described in any one of Claims 1 to 4 wherein the enclosure is a separate component that is located within the barrel or within the needle attachment.
6. 6. A pre-filled plastic syringe as described in any one of Claims 1 to 4 wherein the enclosure is a wall portion that is brittlely connected to the interior surface of the barrel or to the interior surface of the needle attachment and that extends through the barrel opening of the needle attachment.
7. 7. A pre-filled plastic syringe as described in any of the preceding Claims where the enclosure is located fully within the needle attachment of the syringe.
8. 8. A prefilled plastic syringe as described in Claim 7 wherein the needle attachment includes an open end of the hollow truncated cone in liquid communication with the interior of the barrel and the enclosure is an integrated portion of the wall that is connected to the inner surface of the truncated cone and extending through its opening.
9. 9. A pre-filled plastic syringe as described in Claim 8 wherein the portion of the wall is located at any position along the length of the interior wall of the needle attachment. A pre-filled plastic syringe as described in Claim 8 wherein the enclosure is a portion of the wall that is fragilely attached to the interior surface of the truncated cone and located at least 2 mm from its end open. 11. A prefilled plastic syringe as described in Claim 10 wherein the portion of the wall is fragilely attached to the inner surface of the truncated cone and is located at least at 4. 0 mm from its open end. 12. A pre-filled plastic syringe as described in any of the preceding claims in which the needle attachment is a luer lock needle fitting. 13. A pre-filled plastic syringe as described in any of the preceding claims wherein the enclosure is pierceable by the rear needle of a two-sided hypodermic needle. 14. A pre-filled plastic syringe as described in any of the preceding claims wherein the enclosure can be detached or broken away from the inner surface of the needle or barrel fit when using a suitable tool. 15. A pre-filled plastic syringe as described in claims 8 to 14 wherein the enclosure is a portion of the wall that extends through the internal passage of the trickling cone and that is fixed in a fragile manner to the internal surface of the concave. same. 16. A plastic syringe as described in Claim 15 wherein the portion of the wall includes a weakened circumferential section or adjacent to its connection with the inner surface of the truncated cone. 17. A pre-filled plastic syringe as described in Claim 16 where the wall portion is between 0.8 mm to 1.5 mm thick except in the weakened section where it is between 0.05 to 0.2 mm thick. 18. A prefilled plastic syringe as described in Claim 17 wherein the weakened section extends in circumference through between 330 to 350 ° so that when the enclosure is broken from the inner surface of the needle attachment along the the weakened section the closure will remain fixed to the inner surface of the needle attachment and will have a hinge motion around that section at or adjacent to the inner surface of the needle attachment that is not weakened. 20. A pre-filled plastic syringe as described in any of the preceding claims that also includes a hollow opening duct of the enclosure, a hypodermic needle and a needle holder having an internal cavity, the hypodermic needle is attached to one end of the needle holder and the needle holder is placed over the needle attachment, where the first end of the aperture tube of the enclosure is placed inside the internal cavity of the needle holder and a second end of the conduit of the opening of the enclosure is placed inside the needle attachment, where the conduit of the opening of the enclosure is in liquid communication with the hypodermic needle and has a length that the movement of the needle support towards the end of the movable plug of the syringe will cause the duct of the closing opening to break the seal provided by the enclosure. 21. A pre-filled plastic syringe as described in Claim 20 wherein the length of the opening opening duct is such that the complete threading of the needle holder on the needle fitting provides sufficient movement of the opening opening duct for the closure. break the seal provided by the enclosure. 22. A prefilled plastic syringe as described in Claim 21 wherein the cavity in the needle holder includes an end face where an opening is centrally disposed. 23. A prefilled plastic syringe as described in Claim 22 wherein the hypodermic needle is fitted and secured to one end within the opening in the needle holder and extends away from the cavity. 24. A pre-filled plastic syringe as described in Claim 23 wherein the opening conduit of the enclosure is located within the cavity with the first end embedded to the end face of the cavity with the internal passage there in alignment with the opening on the end face of the needle holder. 25. A pre-filled plastic syringe as described in Claim 24 where one end of the enclosure opening conduit is adjacent or embedded to the enclosure surface. 26. A prefilled plastic syringe as described in one of claims 20 to 25 wherein the enclosure opening conduit is integrated and extends from the needle holder. 27. A pre-filled plastic syringe as described in Claim 26 wherein the duct of the opening of the enclosure is a separate component. 28. A pre-filled plastic syringe as described in any of claims 20 to 27, wherein the duct of the opening of the enclosure includes a central duct and ribs or ribs that extend outwardly. 29. A pre-filled plastic syringe as described in any of claims 20 to 28 which further includes a cap located on the hypodermic needle. 30. A prefilled plastic syringe as claimed in any of the preceding claims wherein the filled and assembled syringe is hermetically sealed with a clear plastic wrap. 31. A method for using a pre-filled plastic syringe as described in any of claims 20 to 29 wherein the hypodermic needle is pushed or rotated on the needle attachment while the product is in a hermetically sealed package. 32. A method as described in Claim 31 wherein the movement of the hypodermic needle in the needle attachment causes the opening duct of the closure to break the seal provided by the closure. 33. A pre-filled plastic syringe as described in any of the preceding claims made of a thermoplastic material. 34. A plastic syringe pre-filled substantially as described herein with reference to what is shown in any of the drawings.