MX2008003522A - Catheter type iontophoresis apparatus - Google Patents

Abstract

Catheter type iontophoresis apparatus (10) comprising endoscope unit (20) and, disposed at a distal end of flexible cable (18) thereof, small working-side electrode structure (12) and non-working-side electrode structure (14). Pin-point infiltration of drug solution can be accomplished by closely adhering first ion exchange membrane (44) and fourth ion exchange membrane (54) provided at the distal end thereof to, for example, a cancer site of the digestive organ and carrying out iontophoresis. The working-side electrode structure (12) and non-working-side electrode structure (14) are mounted at a distal end of rodlike member (16), and the rodlike member (16) is freely attachable to or detachable from the distal end of the flexible cable (18), being replaceable integrally.

Description

CATHETER TYPE IONTOPHORESIS DEVICE TECHNICAL FIELD The present invention relates to an iontophoresis device for administering a drug ion to an organism.

BACKGROUND OF THE INVENTION That iontophoresis device as described above is intended to cause a drug solution to infiltrate a skin or mucosa, and its objective has conventionally been a skin or mucosa having a relatively large area of at least about 20 mm. diameter . On the other hand, the direct injection of a drug in: a region as a goal of endoscopic surgery; part of a region such as a mucosa in a nasal cavity, a mucosa in an oral cavity, an esophagus, a stomach, a small intestine, a large intestine, or an anus; an affected area after a laparoscopic operation in a lung cancer therapy; or part of an organism exposed in laparotomy or similar (punctual) can increase a therapeutic effect. In that case, the infiltration of a drug by means of iontophoresis rather than the injection is non-invasive and preferable. In addition, after photodynamic therapy (PDT), after a photosensitizing reaction substance has been administered, light is applied so that anticancer action can be expected. However, a patient should not be irradiated with sunlight because the photosensitizing reaction substance circulates through his body. In addition, the substance can circulate through any portion other than the affected area to provide a lateral effect. Therefore, in a PDT, the administration of a photosensitizing reaction substance only to an affected area has been desirable.

The Invention An objective to be achieved by the present invention is to provide an iontophoresis device suitably used for the infiltration of a drug solution in part of an organism as a site with cancer in the case of a therapy or treatment by means of an endoscope or a laparoscope. The objectives described above are achieved by the following embodiments of the present invention. (1) A catheter-type iontophoresis device that includes a work-side electrode assembly and an idle-side electrode assembly each used to deliver an ionic drug for iontophoresis and a DC power source to be connected to the electrode assembly of the working side and the electrode assembly of the non-working side with opposite polarities, characterized in that it includes: a member similar to a rod to support the electrode assembly of the working side and the electrode assembly of the non-working side; and an endoscopic device for releasably supporting a rod-like member, with the working-side electrode assembly and the work-side electrode assembly positioned on the tip of the rod-like member, at a predetermined amount of separation that is provided between the electrode assembly of the working side and the electrode assembly of the non-working side, and the stick-like member being removably supported at the tip of a flexible cable flexibly supported by a flexible tube of the endoscopic device. (2) The catheter-type iontophoresis device according to item (1), characterized in that the ionic drug is a photosensitized reactive material to be activated by the absorption of light, and the endoscopic device has an optical irradiation system for applying light from the vicinity of a tip of the electrode assembly from the working side via a flexible tube. (3) The catheter-type iontophoresis device according to item (2), characterized in that the endoscopic device has an endoscopic optical system that includes an optical fiber for irradiated light to irradiate the interior of an organism with light and an optical fiber for light reflected to introduce the radiated light reflected towards the outside, and the optical irradiation system is the optical fiber for the irradiated light. (4) The catheter-type iontophoresis device according to any of items (1) to (3), characterized in that the flexible cable includes a working electrode terminal on the side of the electric power source and an electrode terminal without work on the side of the electric power source connected via wires from the electric power source of CD to the electric power source of CD with opposite polarities, the wires being housed in the flexible cable, the member similar to the rod has on a proximal end on one side of the flexible cable, a contact on the side of the working electrode and a contact on the side of the electrode without work, which are connected to or are separated from the terminal of the working electrode on the side of the source electrical power and the electrode terminal without work on the side of the electrical power source when connecting or disconnecting the flexible cable, and the contact of the side of the working electrode and contact of the electrode side without work are connected to an electrode of the working side and an electrode of the non-working side in an electrode assembly of the working side and the electrode assembly of the non-working side, respectively . (5) The catheter-type iontophoresis device according to point (4), characterized in that the endoscopic device includes a controller for adjusting at least one current value outside a current value during energization and the energization time as the time of administration, being in controller placed in a circuit of the electric power source between each of the terminal of the working electrode on the side of the electric power source and the terminal of the electrode without work on the side of the electric power source and the power source of CD. (6) The catheter-type iontophoresis device according to any of items (1) to (5), characterized in that the electrode assembly of the working side and the electrode assembly of the non-working side are positioned so that the axes central of them are parallel to each other. (7) The catheter-type iontophoresis device according to any of the points (1) to (5), characterized in that the electrode assembly of the working side and the electrode assembly of the non-working side are positioned so that the axes central ones propagate in a direction towards the tip. (8) The cathode-type iontophoresis device according to any of points (1) to (5), characterized in that the electrode assembly of the working side and the electrode assembly of the non-working side are positioned so that the axes central ones intersect each other in the direction of the tip. (9) The cathode-type iontophoresis device according to any of items (1) to (8), characterized in that the work-side electrode assembly includes: the working-side electrode connected to the electric power source of the electrode. CD that has the same polarity as that of a charged ion of the ionic drug; a containment portion of electrolytic solution containing an electrolyte solution, the portion containing the electrolyte solution placed on a front surface of a working electrode; a second ion exchange membrane that selects an ion having a polarity opposite to that of the charged ion of the ionic drug, the second ion exchange membrane being positioned on a front surface of the portion containing the electrolyte solution; a portion containing a drug solution containing an ionic drug, the portion containing the drug solution placed on a front surface of the second ion exchange membrane; and a first ion exchange membrane which is the ion exchange membrane which selects an ion having the same polarity as that of the charged ion of the ionic drug, the first ion exchange membrane being placed on a front surface of the portion containing the drug solution, and the electrode assembly of the non-working side includes: the electrode on the non-working side connected to the DC electric power source with a polarity opposite to that of the charged ion of the ionic drug; a second portion containing electrolytic solution containing a second electrolytic solution, the second portion containing the electrolytic solution placed on a front surface of the electrode on the non-working side; a third ion exchange membrane that selects an ion having a polarity equal to that of the charged ion of the ionic drug, the third ion exchange membrane being positioned on a front surface of the second portion containing the electrolyte solution; a third portion containing electrolytic solution containing a third electrolytic solution, the third portion containing the electrolytic solution placed on a front surface and the third ion exchange membrane, and a fourth ion exchange membrane which is the exchange membrane ion that selects an ion having a polarity opposite that of an ion charged with the ionic drug, the fourth ion exchange membrane being placed on a frontal surface to that of the third portion containing the electrolytic solution.

BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a plan view showing an iontophoresis device according to an embodiment of the present invention. Figure 2 is a sectional view, amplified, showing a main portion of each of an electrode assembly of the working side and an electrode assembly of the non-working side. Figure 3 is a plan view showing another example of an arrangement of the work side electrode assembly and an electrode assembly of the work side. Figure 4 is a plan view showing another example of the arrangement of the electrode assembly on the working side and the electrode assembly on the non-working side.

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the best mode for carrying out the present invention will be described, in detail, with reference to Figures 1 to 4. As shown in each of Figures 1 and 2, the catheter-type iontophoresis device 10 according to the best mode includes: an electrode assembly of the working side 12 and an electrode assembly of the non-working side 14 each used to administer an ionic drug; and member similar to a rod 16 to support them integrally; and a DC power source 30 connected to the work side electrode assembly 12 and the work side electrode assembly 14 with different polarities. Each of the electrode assembly of the working side 12 and the electrode assembly of the non-working side 14 is attached to the tip of the member similar to a rod 16. The rod-like member 16 is detachably supported by the tip of the rod. a flexible cable 18. As a result, the electrode assembly of the working side 12 and the electrode assembly of the non-working side 14 are integrally interchangeable with the rod-like member 16. The flexible cable 18 is supported by a flexible tube 22 of an endoscopic device 20, so that the cable can bend freely. The member is similar to a rod 16 being similar to a peel-off rod to a tip projecting from a flexible tube 22. The endoscopic device 20 has an endoscopic optical system that includes an optical fiber 24 for irradiating light and an optical fiber 26 for the reflected light, each of which passes through the flexible tube 22. The optical fiber 24 for radiating light emits light that radiates from its tip, and the optical fiber 26 for the reflected light captures the reflected light generated by the light of irradiation emitted from the optical fiber 24 to irradiate light to, for example, an affected area in an organism and guide the reflected light to the outside. The white light is adapted to impinge from a laser light source 58 to be described later on the optical fiber 24 for irradiation light. The work electrode assembly 12 and the workless electrode assembly 14 are connected to different polarities of the CD power source 30 via a circuit of the electrical power source (not shown). The tip of the rod-like member 16 on the side of the flexible cable 18 is provided with an electrode terminal on the working side 32 to be connected to the work-side electrode assembly 12 and an electrode terminal on the non-working side 34. to be connected to the electrode assembly of the non-working side 14. The electrode terminal of the working side 32 and the electrode terminal of the non-working side 34 are adapted to be connected to a working electrode terminal on the source side of the electrode. electrical power 33 and a non-working electrode terminal on the side of the electrical power source 35 on the side of the flexible cable 18, respectively, when the member is similar to a rod 16 is connected to the flexible cable 18. The electrode terminal work on the side of the electric power source 33 and the electrode terminal without work on the side of the electric power source 35 are connected to the DC power source 30 arranged further out of the endoscopic device 20 via the electric power source circuit 28. The rod-like member 16 is a cylindrical member having the same diameter as the cable flexible member 18. The member 16 is adapted to threadably connect a male screw portion 16A in a female screw portion 18A to the tip of the flexible cable 18 and to detach by rotating the male threaded portion 16A in a direction opposite to the moment of the thread.

Figure 2 is an amplified view showing a state where the electrode assembly of the working side 12, and the electrode assembly of the non-working side 14 are arranged so that the lines of their central axes are parallel to each other. In addition, the mounting of the working side electrode 12 is constituted by laminating a working side electrode 36, a portion containing electrolytic solution 38, a second ion exchange membrane 40, a portion containing drug solution 42, and a first ion exchange membrane 44 in the order established on the side of the member similar to a rod 16, and is formed in the form of a disk of about 2 to 6 mm in diameter. The working side electrode 36 is desirably constituted by a conductive paint applied to a surface of the base sheet 13 and mixed with a non-metallic conductive filler such as a carbon paste. The working side electrode 36 can be constituted by a copper plate or a thin film of metal, but an eluted metal of a plate or the thin film can be transferred to an organism after the administration of the drug. Therefore, the working electrode 36 is preferably non-metallic. The portion containing the electrolytic solution 38 is constituted by, for example, an electrolytic paint applied to the working side electrode 36. The electrolytic paint is a paint that contains an electrolyte, and an electrolyte that is oxidized or reduced more easily than the electrolyte. The electrolytic reaction of water (oxidation on a positive pole and reduction on a negative pole) is particularly preferably used. Examples of that electrolyte include: medical agents such as ascorbic acid (vitamin C) and sodium ascorbate, and organic acids such as lactic acid, oxalic acid, melic acid, succinic acid, and fumaric acid and / or salts thereof. The use of that electrolyte can suppress the generation of an oxygen gas or a hydrogen gas. In addition, mixing a plurality of electrolyte types that serve as a combination of electrolytic buffer solutions when dissolved in a solvent can suppress a change in pH during energization. The electrolytic paint is mixed with a hydrophilic polymer such as polyvinyl alcohol, polyacrylic acid, polyacrylamide, or polyethylene glycol to improve the property of application and property of film formation of the paint, and mixed with an appropriate amount of solvent such as water, ethanol or propanol to adjust the viscosity of the electrolytic paint. The paint can be mixed with an appropriate additional component such as a thickener, a thixotropic agent, a defoaming agent, a pigment, a flavor, or a coloring agent. The second ion exchange membrane 40 is formed by applying a second ion exchange paint to the portion containing the electrolytic solution 38. The second ion exchange paint is a paint containing an ion exchange resin into which a group of ion exchange resin is introduced. ion exchange using, as a counter ion, an ion having a type of conductivity opposite to that of the drug ion in the portion containing the drug solution 42 to be described later. In the case where a drug is used whose pharmaceutical component is dissociated to positive drug ions in the portion containing the drug solution 42, the paint is mixed with an anion exchange resin. On the other hand, in the case where a drug whose pharmaceutical component is dissociated to negative drug ions is used, the paint is mixed with a cation exchange resin. The portion containing the drug solution 42 is composed of a drug paint applied to the second ion exchange membrane 40. The paint is a paint containing a drug (which includes a precursor for the drug) whose pharmaceutical component is dissociated from the drug. positive or negative ions (drug ions) as a result of, for example, dissolution in a solvent such as water. Examples of drug whose pharmaceutical component dissociates to positive ions may include lidocaine hydrochloride as an anesthetic drug and morphine hydrochloride as an anesthetic drug. Examples of drugs whose pharmaceutical component dissociates to negative ions may include ascorbic acid as a vitamin agent. The first ion exchange membrane 44 is formed of a first ion exchange paint applied to the portion containing the drug solution 42. The first ion exchange paint is a paint that contains an ion exchange resin in which an ion exchange resin is introduced. ion exchange group using, as a counter ion, an ion having the same conductivity type as the drug ion in the portion containing the drug solution 42. In the case where a drug whose pharmaceutical component is dissociated to ion positive / negative drug in the portion containing the drug solution 42, the paint is mixed with an anion / cation exchange resin. An anion exchange resin obtained by introducing a cation exchange group (an exchange group using a cation as a counter ion) as a sulphonic group, a carboxyl group, or a phosphoric group in a polymer having a three-dimensional network structure such as a resin based on hydrocarbons (for example, a polystyrene resin or an acrylic resin) or a fluorine-based resin having a perfluorocarbon skeleton can be used as the cation exchange resin without any limitation. An ion exchange resin obtained by introducing an anion exchange group (an exchange group using an anion as counterion) as a primary amino group, a secondary amino group, a tertiary amino group, a quaternary ammonium group, a pyridyl group, a imidazole group, a quaternary pyridinium group, a quaternary imidazolium group in a polymer having a three-dimensional network structure similar to that of the cation exchange resin case can be used as the anion exchange resin without any limitation. The electrode assembly of the non-working side 14 is constituted by laminating a non-working electrode 46, a second portion containing electrolytic solution 48, a third ion exchange membrane 50, a third portion containing electrolytic solution 52, and a fourth exchange membrane Ionic 54 in the order established on one side of the base sheet of the non-working side 15, and is formed in the form of a disc as in the case of the electrode assembly of the working side 12.

The electrode on the non-working side 46 has the same constitution as the electrode on the working side 36 in the assembly of the working-side electrode 12, and the constitutions and components of the second portion containing the electrolytic solution 48 and the third portion that contains the electrolytic solution 52 are the same as those of the portion containing the electrolytic solution 38. The third ion exchange membrane 50 is formed of an ion exchange paint applied to the second portion containing the electrolytic solution 48. The paint of ion exchange is the same as the first ion exchange paint from which the first ion exchange membrane 44 was formed, and functions as an anion exchange membrane similar to the first ion exchange membrane 44. The fourth ion exchange membrane 54 is formed of the same second ion exchange paint as described above Applied to the third portion containing the electrolytic solution 52. The fourth ion exchange membrane 54 functions as an ion exchange membrane similar to the second ion exchange membrane 40. A plate on the working side electrode terminal 32A is arranges on the other surface of the base sheet 13, and the conduction is established between the electrode terminal plate of the working side 32A and the working side electrode 36 of the electrode assembly of the working side 12 through a through hole formed on the base sheet 13, and the end plate of the working side electrode 32A is connected to the electrode end of the working side 32 through the through hole. Similarly, a plate on the electrode terminal of the non-working side 34A is arranged on the other surface of the base sheet of the non-working side 15, and the conduction is established between the electrode terminal plate on the non-working side 34A and the work-side electrode 46 of the work-side electrode assembly 14 through a through hole formed on the work-free base sheet 15, and the work-side electrode terminal plate 34A is connected to the terminal of the electrode on the non-working side 34 through the through hole. The first ion exchange membrane 44 and the fourth ion exchange membrane 54 at the tips of the working side electrode assembly 12 and the electrode assembly of the non-working side 14 are exposed to be able to come into contact with the side of an organism , respectively.

The electrical power source of CD 30 is comprised of, for example, an AC / DC converter, and the circuit of electrical power source 28 between the electrical power source of CD 30 and the working electrode terminal of the side. of the electric power source 33 and the electric power source of CD 30 and the electrode terminal without work on the side of the electric power source 35 is provided with a controller 56 to adjust, or of a current value during energization and an energization time as the administration time, at least the current value. As a result, each of the current values and the administration time can be adjusted in a certain range. Here, a predetermined amount of separation S is provided between the first ion exchange membrane 44 and the fourth ion exchange membrane 54 at each of the tips of the electrode assembly of the working side 12 and of the electrode assembly of the non-working side. 14 to prevent the current from flowing directly between the membranes after energization. The spacing S has substantially the same size as the diameter of each of the first ion exchange membrane 44 and the fourth ion exchange membrane 54. After therapy, only the following procedure has been performed. White light is applied from the optical fiber 24 to irradiate light. The reflected light (image) is guided to the outside by means of the optical fiber for the reflected light 26. An affected area is identified while it is observed in reflected light (image). The electrode assembly of the working side 12 is pressed against the affected area. No illumination is performed during iontophoresis. In the previous mode, the assembly of the work side electrode 12 and the work side assembly 14 are connected so that the central axes thereof are parallel to each other. However, the present invention is not limited thereto. For example, as shown in Figure 4, the electrode assembly of the working side 12 and the electrode assembly of the non-working side 14 can be positioned so that the central axes thereof intersect each other in a direction of the tip with a 60 ° angle between the axes. Alternatively, as shown in Figure 4, the electrode assembly of the working side 12 and the electrode assembly of the non-working side 14 can be positioned so that the central axes thereof are dispersed outwards in a direction of the tip. In each of those embodiments, the electrode assembly of the working side 12 and the electrode assembly of the non-working side 14 are arranged in the tip of the flexible cable 18 in the endoscopic device 20 with a space S between the mounts. Thus, for example, when a drug solution is made to infiltrate a site with cancer of a digestive organ, a physician attached to the endoscopic device 20 carries the first ion exchange membrane 44 at the tip of the electrode assembly. on the working side 12 at the tip of the flexible cable 18 in close contact with the site with cancer, and at the same time, placing the fourth ion exchange membrane 54 at the tip of the work side electrode assembly 14 in close contact with a mucosa or similar near the site with cancer for energization. In this way, a white drug solution can be made to easily infiltrate a white site on a point basis. In addition, the electrode assembly of the working side 12 and the electrode assembly of the non-working side 14 can be detached together with the rod-like member 16 of the flexible cable 18, so that the drug solution can be easily exchanged. The catheter-type iontophoresis device 10 can be used for therapy from within a body by means of a PDT as the anticancer means which involves: applying a photosensitizing reaction substance, to, for example, a cancer cell; and irradiate the substance with light to make the substance absorb light. For example, the device 10 can be used for the therapy of a superficial esophageal cancer, a superficial gastric cancer, or a cervical cancer. In addition, the device 10 can be used for therapy from within the body, for example, gastric ulcer therapy or colitis by means of a PDT method. In the case of a PDT, the portion containing the drug solution 42 in the electrode assembly of the working side 12 contains a photosensitizing reaction substance, and a light having a wavelength to be absorbed by the reaction substance. photosensitizing as an ultraviolet light is supplied from the laser light source 58 while controlled by the controller 56 for the optical fiber 24 for the irradiation of light, so that an affected area can be irradiated with the light. The light having a wavelength at which the photosensitizing reaction substance is sensitive is used for PDT. In this case, a light source that emits light having the wavelength is arranged separately, and the white light and the light has the wavelength are selectively changed using means to change the input to the optical fiber for irradiation of light 24 (not shown). In addition, the filter that passes only light that has a wavelength of white light can be used without the use of a new light source.

INDUSTRIAL APPLICABILITY In the present invention, each of the working electrode assembly and electrode assembly without work in the catheter-type iontophoresis device is arranged at the tip of the flexible cable in the endoscopic device. An anti-cancer agent is made to infiltrate to a site such as a site with cancer in, for example, a digestive organ so that efficient therapy with few side effects can be effected. In addition, immediately after a PDT, each of the working electrode assembly and the jobless electrode assembly are exchanged and then an anticancer agent is administered. As a result, recurrence prevention therapy can be performed simultaneously.

Claims (9)

1. CLAIMS 1. Catheter-type iontophoresis device comprising an electrode assembly of the working side and an electrode assembly of the non-working side, each used to administer an ionic drug by iontophoresis and a DC electric power source to be connected to the assembly of the working side electrode and assembly of the electrode on the non-working side with opposite polarities, characterized in that it comprises: a member similar to a rod for supporting the assembly of the electrode on the working side and the assembly of the electrode on the non-working side; and an endoscopic device for releasably supporting the rod-shaped member, with the work-side electrode assembly and the work-side electrode assembly positioned on a tip of the rod-shaped member, a predetermined amount being provided of separation between the assembly of the working-side electrode and the assembly of the electrode of the non-working side, and the stick-like member being detachably supported to the tip of a flexible cable supported in a flexible manner by a flexible tube of the device endoscopic. A catheter-type iontophoresis device according to claim 1, characterized in that the ionic drug comprises a photosensitized reactive material to be activated by absorbing light, and the endoscopic device comprises an optical irradiation system for applying light from a vicinity of a tip of the working side electrode via the flexible tube. 3. Catheter-type iontophoresis device according to claim 2, characterized in that the endoscopic device comprises an endoscopic optical system that includes an optical fiber to irradiate light to irradiate the interior of an organism with light and an optical fiber for the reflected light to introduce the irradiated light reflected outwards, and the optical irradiation system comprises the optical fiber for the irradiated light. 4. Catheter-type iontophoresis device according to any of claims 1 to 3, characterized in that the flexible cable comprises a working electrode terminal on the side of the electric power source and a non-working electrode terminal on the side of the power source electrical connected via wires from the CD electric power source to the DC electric power source with opposite polarities with the wires housed in the flexible cable, the rod-like member comprises a proximal end of a cable-detachable side of the cable flexible from a contact from the side to the working electrode and a contact from the electrode side without work which are connected or separated from the terminal of the working electrode on the side of the electric power source and the electrode terminal without work from the the source of electrical power when connecting or disconnecting from the flexible cable, and the contact of the or from the working electrode and the electrode-side contact without work are connected to a work-side electrode and an electrode on the non-working side of the work-side electrode assembly and the work-side electrode assembly, respectively. A catheter-type iontophoresis device according to claim 4, characterized in that the endoscopic device comprises a controller for adjusting a current value outside a current value during energization and the energization time as the administration time, the controller being placed in a circuit of the source of electrical energy between each of the terminal of the working electrode on the side of the electric power source and the electrode terminal without work on the side of the electric power source and the electric power source of CD in at least one current value. 6. Catheter-type iontophoresis device according to any of claims 1 to 5, characterized in that the assembly of the working side electrode and the electrode assembly of the non-working side are positioned so that the central axes thereof are parallel to each other. 7. Catheter-type iontophoresis device according to any of claims 1 to 5, characterized in that the assembly of the electrode on the working side and the assembly of the electrode on the non-working side are arranged so that the central axes thereof are separated in a direction towards the tip. A catheter-type iontophoresis device according to any of claims 1 to 5, characterized in that the electrode assembly of the working side and the electrode assembly of the non-working side are connected so that the central axes thereof intersect each other in one direction of the tip. A catheter-type iontophoresis device according to any one of claims 1 to 8, characterized in that the assembly of the working-side electrode comprises: the working-side electrode connected to the DC electric power source having the same polarity as the electrode. ion charged with the ionic drug; a portion containing electrolytic solution containing an electrolyte solution, the portion containing the electrolyte solution placed on a front surface of the working electrode; a second ion exchange membrane that selects an ion having a polarity opposite to that of the charged ion of the ionic drug, the second ion exchange membrane being positioned on a front surface of the portion containing the electrolyte solution; a portion containing drug solution containing the ionic drug, the portion containing the drug solution placed on a front surface of the second ion exchange membrane; and a first ion exchange membrane which is the ion exchange membrane which selects an ion having the same polarity as that of the charged ion of the ionic drug, the first ion exchange membrane being placed on a front surface of the portion containing the solution of the drug, and the electrode assembly of the non-working side comprises: the electrode of the non-working side connected to the DC electric power source with a polarity opposite to that of the charged ion of the ionic drug; a second portion containing electrolytic solution containing a second electrolytic solution, the second portion containing electrolytic solution placed on a front surface of the electrode on the non-working side; a third ion exchange membrane that selects an ion having a polarity equal to that of the charged ion of the ionic drug, the third ion exchange membrane being positioned on a front surface of the second portion containing the electrolyte solution; a third portion containing electrolytic solution containing a third electrolytic solution, the third portion containing the electrolytic solution placed on the front surface of the third ion exchange membrane; and a fourth ion exchange membrane which is the ion exchange membrane which selects an ion having a polarity opposite to that of the charged ion of the ionic drug, the fourth ion exchange membrane being on the front surface of the third portion containing the electrolytic solution.