MX2007014803A - Cell nucleus-entering compositions. - Google Patents

Cell nucleus-entering compositions.

Info

Publication number
MX2007014803A
MX2007014803A MX2007014803A MX2007014803A MX2007014803A MX 2007014803 A MX2007014803 A MX 2007014803A MX 2007014803 A MX2007014803 A MX 2007014803A MX 2007014803 A MX2007014803 A MX 2007014803A MX 2007014803 A MX2007014803 A MX 2007014803A
Authority
MX
Mexico
Prior art keywords
cell nucleus
entering
amino acid
acid sequence
compositions
Prior art date
Application number
MX2007014803A
Other languages
Spanish (es)
Inventor
Allan L Goldstein
Ewald Hannappel
Thomas Huff
David Crockford
Original Assignee
Regenerx Biopharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regenerx Biopharmaceuticals filed Critical Regenerx Biopharmaceuticals
Publication of MX2007014803A publication Critical patent/MX2007014803A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2292—Thymosin; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

A pharmaceutically acceptable composition and method for entering a cell nucleus utilizes a cell nucleus-entering polypeptide including at least one of amino acid sequence LKKTET, amino acid sequence LKKTNT or amino acid sequence KSKLKK, or a conservative variant thereof, linked to a physiologically active agent having at least one of therapeutic or diagnostic application in the cell nucleus.
MX2007014803A 2005-05-27 2005-10-03 Cell nucleus-entering compositions. MX2007014803A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68499305P 2005-05-27 2005-05-27
PCT/US2005/035716 WO2006130171A1 (en) 2005-05-27 2005-10-03 Cell nucleus-entering compositions

Publications (1)

Publication Number Publication Date
MX2007014803A true MX2007014803A (en) 2008-04-21

Family

ID=37481967

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007014803A MX2007014803A (en) 2005-05-27 2005-10-03 Cell nucleus-entering compositions.

Country Status (9)

Country Link
EP (1) EP1904076A4 (en)
JP (1) JP2008542265A (en)
KR (1) KR20080016675A (en)
CN (1) CN101184498A (en)
AU (1) AU2005332297A1 (en)
CA (1) CA2607701A1 (en)
IL (1) IL187217A0 (en)
MX (1) MX2007014803A (en)
WO (1) WO2006130171A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102037133B (en) * 2008-03-17 2016-01-13 雷金纳克斯生物制药公司 The β thymosin fragments improved
CN110790821B (en) * 2019-11-19 2022-09-02 南阳师范学院 Cell nucleus penetrating peptide and application thereof
CN115266995B (en) * 2022-08-02 2023-10-13 兆科（广州）眼科药物有限公司 Analysis method of related substances in pilatory peptide preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6919208B2 (en) * 2000-05-22 2005-07-19 The Children's Hospital Of Philadelphia Methods and compositions for enhancing the delivery of a nucleic acid to a cell
CN1852727A (en) * 2003-03-31 2006-10-25 雷金纳克斯生物制药公司 Compositions and methods for delivering thymosin beta 4, analogues, isoforms and other derivatives
WO2004099768A1 (en) * 2003-05-05 2004-11-18 Regenerx Biopharmaceuticals, Inc. Method for detecting development of a physiological disorder in a subject
JP2007523878A (en) * 2003-07-18 2007-08-23 リジェナークス・バイオファーマスーティカルズ・インコーポレイテッド Treatment or prevention of damage from radiation exposure

Also Published As

Publication number Publication date
AU2005332297A1 (en) 2006-12-07
IL187217A0 (en) 2008-02-09
EP1904076A4 (en) 2009-12-09
KR20080016675A (en) 2008-02-21
CN101184498A (en) 2008-05-21
WO2006130171A1 (en) 2006-12-07
EP1904076A1 (en) 2008-04-02
CA2607701A1 (en) 2006-12-07
JP2008542265A (en) 2008-11-27

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal