MX2007003427A - Sintesis eficiente de 4,5-dihidro-pirazolo[3,4-c]pirid-2-onas. - Google Patents

Sintesis eficiente de 4,5-dihidro-pirazolo[3,4-c]pirid-2-onas.

Info

Publication number
MX2007003427A
MX2007003427A MX2007003427A MX2007003427A MX2007003427A MX 2007003427 A MX2007003427 A MX 2007003427A MX 2007003427 A MX2007003427 A MX 2007003427A MX 2007003427 A MX2007003427 A MX 2007003427A MX 2007003427 A MX2007003427 A MX 2007003427A
Authority
MX
Mexico
Prior art keywords
pyrid
pyrazolo
dihydro
ones
efficient synthesis
Prior art date
Application number
MX2007003427A
Other languages
English (en)
Inventor
Jing Liang
Bang-Chi Chen
Rulin Zhao
Boguslaw M Mudryk
Nicolas Cuniere
Dau-Ming Hsieh
Huiping Zhang
Lucius Rossano
Bei Wang
Adrian David
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2007003427A publication Critical patent/MX2007003427A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describe un proceso novedoso y compuestos intermedios del mismo para fabricar 4,5-dihidro-pirazolo[3,4-c]parid-2-onas del tipo mostrado posteriormente a partir de las fenil hidracinas apropiadas. (Ver Formula I). Estos compuestos puede ser utiles como inhibidores del factor Xa.
MX2007003427A 2004-09-28 2005-09-27 Sintesis eficiente de 4,5-dihidro-pirazolo[3,4-c]pirid-2-onas. MX2007003427A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61375404P 2004-09-28 2004-09-28
US63762304P 2004-12-20 2004-12-20
US11/235,647 US7304157B2 (en) 2004-09-28 2005-09-26 Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
PCT/US2005/034511 WO2006036926A2 (en) 2004-09-28 2005-09-27 Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones

Publications (1)

Publication Number Publication Date
MX2007003427A true MX2007003427A (es) 2007-05-10

Family

ID=36100112

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007003427A MX2007003427A (es) 2004-09-28 2005-09-27 Sintesis eficiente de 4,5-dihidro-pirazolo[3,4-c]pirid-2-onas.

Country Status (11)

Country Link
US (3) US7304157B2 (es)
EP (1) EP1805176A2 (es)
JP (1) JP2008514710A (es)
KR (1) KR20070067176A (es)
AU (1) AU2005289598A1 (es)
BR (1) BRPI0516172A (es)
CA (1) CA2582222A1 (es)
IL (1) IL182147A0 (es)
MX (1) MX2007003427A (es)
NO (1) NO20071634L (es)
WO (1) WO2006036926A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI331526B (en) * 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
TW200738672A (en) * 2001-12-10 2007-10-16 Bristol Myers Squibb Co Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
TWI322813B (en) * 2002-01-21 2010-04-01 Organon Nv Process for the preparation of 7alpha-methylsteroids
US20060069085A1 (en) * 2004-09-28 2006-03-30 Rulin Zhao Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
US7388096B2 (en) * 2004-09-28 2008-06-17 Bristol-Myers Squibb Company Crystalline forms of a factor Xa inhibitor
US7371864B2 (en) * 2004-12-15 2008-05-13 Bristol-Myers Squibb Company Crystalline forms of a factor Xa inhibitor
FI20070471A0 (fi) * 2007-06-13 2007-06-13 Glykos Finland Oy Ravinnelisäkompositiota
CN105384739B (zh) * 2014-09-02 2020-03-20 石药集团中奇制药技术（石家庄）有限公司 吡唑并[3,4-c]吡啶类衍生物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5423698A (en) * 1994-03-30 1995-06-13 Molex Incorporated Electrical connector system for a video display tube yoke
TWI331526B (en) 2001-09-21 2010-10-11 Bristol Myers Squibb Pharma Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
CN104744461A (zh) * 2001-09-21 2015-07-01 百时美施贵宝公司 含有内酰胺的化合物及其衍生物作为Xa因子的抑制剂
TW200738672A (en) 2001-12-10 2007-10-16 Bristol Myers Squibb Co Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
US20060069085A1 (en) 2004-09-28 2006-03-30 Rulin Zhao Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
US20060069260A1 (en) 2004-09-28 2006-03-30 Huiping Zhang Preparation of N-aryl pyridones
US7396932B2 (en) 2004-09-28 2008-07-08 Bristol-Myers Squibb Company Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
US7388096B2 (en) 2004-09-28 2008-06-17 Bristol-Myers Squibb Company Crystalline forms of a factor Xa inhibitor

Also Published As

Publication number Publication date
IL182147A0 (en) 2007-07-24
JP2008514710A (ja) 2008-05-08
EP1805176A2 (en) 2007-07-11
AU2005289598A1 (en) 2006-04-06
NO20071634L (no) 2007-06-21
WO2006036926A2 (en) 2006-04-06
WO2006036926B1 (en) 2007-03-15
BRPI0516172A (pt) 2008-08-26
US20070282106A1 (en) 2007-12-06
US20060069119A1 (en) 2006-03-30
KR20070067176A (ko) 2007-06-27
US7435821B2 (en) 2008-10-14
WO2006036926A3 (en) 2007-01-18
US20080009626A1 (en) 2008-01-10
CA2582222A1 (en) 2006-04-06
US7304157B2 (en) 2007-12-04
US7579472B2 (en) 2009-08-25

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