MX2007003427A - Sintesis eficiente de 4,5-dihidro-pirazolo[3,4-c]pirid-2-onas. - Google Patents
Sintesis eficiente de 4,5-dihidro-pirazolo[3,4-c]pirid-2-onas.Info
- Publication number
- MX2007003427A MX2007003427A MX2007003427A MX2007003427A MX2007003427A MX 2007003427 A MX2007003427 A MX 2007003427A MX 2007003427 A MX2007003427 A MX 2007003427A MX 2007003427 A MX2007003427 A MX 2007003427A MX 2007003427 A MX2007003427 A MX 2007003427A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrid
- pyrazolo
- dihydro
- ones
- efficient synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se describe un proceso novedoso y compuestos intermedios del mismo para fabricar 4,5-dihidro-pirazolo[3,4-c]parid-2-onas del tipo mostrado posteriormente a partir de las fenil hidracinas apropiadas. (Ver Formula I). Estos compuestos puede ser utiles como inhibidores del factor Xa.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61375404P | 2004-09-28 | 2004-09-28 | |
US63762304P | 2004-12-20 | 2004-12-20 | |
US11/235,647 US7304157B2 (en) | 2004-09-28 | 2005-09-26 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
PCT/US2005/034511 WO2006036926A2 (en) | 2004-09-28 | 2005-09-27 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007003427A true MX2007003427A (es) | 2007-05-10 |
Family
ID=36100112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007003427A MX2007003427A (es) | 2004-09-28 | 2005-09-27 | Sintesis eficiente de 4,5-dihidro-pirazolo[3,4-c]pirid-2-onas. |
Country Status (11)
Country | Link |
---|---|
US (3) | US7304157B2 (es) |
EP (1) | EP1805176A2 (es) |
JP (1) | JP2008514710A (es) |
KR (1) | KR20070067176A (es) |
AU (1) | AU2005289598A1 (es) |
BR (1) | BRPI0516172A (es) |
CA (1) | CA2582222A1 (es) |
IL (1) | IL182147A0 (es) |
MX (1) | MX2007003427A (es) |
NO (1) | NO20071634L (es) |
WO (1) | WO2006036926A2 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI331526B (en) * | 2001-09-21 | 2010-10-11 | Bristol Myers Squibb Pharma Co | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
TW200738672A (en) * | 2001-12-10 | 2007-10-16 | Bristol Myers Squibb Co | Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones |
TWI322813B (en) * | 2002-01-21 | 2010-04-01 | Organon Nv | Process for the preparation of 7alpha-methylsteroids |
US20060069085A1 (en) * | 2004-09-28 | 2006-03-30 | Rulin Zhao | Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
US7388096B2 (en) * | 2004-09-28 | 2008-06-17 | Bristol-Myers Squibb Company | Crystalline forms of a factor Xa inhibitor |
US7371864B2 (en) * | 2004-12-15 | 2008-05-13 | Bristol-Myers Squibb Company | Crystalline forms of a factor Xa inhibitor |
FI20070471A0 (fi) * | 2007-06-13 | 2007-06-13 | Glykos Finland Oy | Ravinnelisäkompositiota |
CN105384739B (zh) * | 2014-09-02 | 2020-03-20 | 石药集团中奇制药技术(石家庄)有限公司 | 吡唑并[3,4-c]吡啶类衍生物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5423698A (en) * | 1994-03-30 | 1995-06-13 | Molex Incorporated | Electrical connector system for a video display tube yoke |
TWI331526B (en) | 2001-09-21 | 2010-10-11 | Bristol Myers Squibb Pharma Co | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
CN104744461A (zh) * | 2001-09-21 | 2015-07-01 | 百时美施贵宝公司 | 含有内酰胺的化合物及其衍生物作为Xa因子的抑制剂 |
TW200738672A (en) | 2001-12-10 | 2007-10-16 | Bristol Myers Squibb Co | Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones |
US20060069085A1 (en) | 2004-09-28 | 2006-03-30 | Rulin Zhao | Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
US20060069260A1 (en) | 2004-09-28 | 2006-03-30 | Huiping Zhang | Preparation of N-aryl pyridones |
US7396932B2 (en) | 2004-09-28 | 2008-07-08 | Bristol-Myers Squibb Company | Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
US7388096B2 (en) | 2004-09-28 | 2008-06-17 | Bristol-Myers Squibb Company | Crystalline forms of a factor Xa inhibitor |
-
2005
- 2005-09-26 US US11/235,647 patent/US7304157B2/en active Active
- 2005-09-27 MX MX2007003427A patent/MX2007003427A/es not_active Application Discontinuation
- 2005-09-27 KR KR1020077009650A patent/KR20070067176A/ko not_active Application Discontinuation
- 2005-09-27 JP JP2007534699A patent/JP2008514710A/ja not_active Withdrawn
- 2005-09-27 EP EP05805626A patent/EP1805176A2/en not_active Withdrawn
- 2005-09-27 WO PCT/US2005/034511 patent/WO2006036926A2/en active Application Filing
- 2005-09-27 CA CA002582222A patent/CA2582222A1/en not_active Abandoned
- 2005-09-27 AU AU2005289598A patent/AU2005289598A1/en not_active Abandoned
- 2005-09-27 BR BRPI0516172-0A patent/BRPI0516172A/pt not_active Application Discontinuation
-
2007
- 2007-03-22 IL IL182147A patent/IL182147A0/en unknown
- 2007-03-28 NO NO20071634A patent/NO20071634L/no not_active Application Discontinuation
- 2007-08-15 US US11/838,932 patent/US7435821B2/en active Active
- 2007-08-15 US US11/838,926 patent/US7579472B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
IL182147A0 (en) | 2007-07-24 |
JP2008514710A (ja) | 2008-05-08 |
EP1805176A2 (en) | 2007-07-11 |
AU2005289598A1 (en) | 2006-04-06 |
NO20071634L (no) | 2007-06-21 |
WO2006036926A2 (en) | 2006-04-06 |
WO2006036926B1 (en) | 2007-03-15 |
BRPI0516172A (pt) | 2008-08-26 |
US20070282106A1 (en) | 2007-12-06 |
US20060069119A1 (en) | 2006-03-30 |
KR20070067176A (ko) | 2007-06-27 |
US7435821B2 (en) | 2008-10-14 |
WO2006036926A3 (en) | 2007-01-18 |
US20080009626A1 (en) | 2008-01-10 |
CA2582222A1 (en) | 2006-04-06 |
US7304157B2 (en) | 2007-12-04 |
US7579472B2 (en) | 2009-08-25 |
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Legal Events
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FA | Abandonment or withdrawal |