MX2007001714A

MX2007001714A - Cannula device

Info

Publication number: MX2007001714A
Application number: MX/A/2007/001714A
Authority: MX
Inventors: Wesseltoft Mogensen Lasse; Walter Goransson Magnus
Original assignee: Goeransson Magnus Walter; Mogensen Lasse; Unomedical A/S
Priority date: 2004-08-10
Filing date: 2007-02-09
Publication date: 2008-10-03

Abstract

A cannula device suitable as a component in a base part of an infusion set. The cannula device comprises a housing and at least one membrane together defining at least one cavity adapted to receive a piercing member of a connector, the cannula device further comprising a cannula mounted in said housing and being in fluid communication with said at least one cavity, wherein the device can receive the piercing member of a connector from more than one direction, and the housing has such a geometry that the cannula can extend from the base part in more than one direction.

Description

CELLULAR DEVICE DESCRIPTION OF THE INVENTION The present invention relates to a cannula device, especially for use in infusion equipment. Such a device can be used in several versions of infusion equipment. Normally an infusion set for intermittent or continuous administration of a therapeutic substance, such as insulin, is in the form of a two-part device. A traditional infusion set comprises a base part having a cannula for insertion into a patient wherein the base part has means for receiving a connector cannula extending from a connector and for placing the connector cannula in fluid communication with the cannula of the base part. Frequently, the connector needle is in fluid communication with a drug delivery device, such as an insulin pump. Different types of infusion equipment are described in WO 02/068014 A2, EP 0 956 879 Al, US 5 522 803, US 2003/0225373 Al and WO 03/026728 Al. US 2003/0176852 A1 discloses an infusion set in the wherein a base part comprises a pivot member, the base part comprises a cannula for insertion into a patient and the pivot member has an internal cavity with a receiving end adapted to receive an inserter needle or a connector cannula and two connection ends (3161 and 320) for additional connection with the cannula of the base part. During the insertion of the pivot member it is positioned orthogonal to the base part and an inserter needle penetrates the membrane at the receiving end and the needle passes through a channel and through the first connecting end into the cannula which then can insert After insertion the needle is removed and the pivot member is connected with a connector. The connector and the pivot member are connected from the same direction as the connection between the pivot member and the inserter. The pivot member is then rotated in order to align the second connection end with the cannula. This device has the disadvantage that it is very sensitive to the movement of the pivot member since a small adjustment will close the distribution of the drugs. WO 02/094352 A2 describes an infusion set having such a construction in the base part that it can receive an insertion needle from one direction and a connector needle from a second direction. This design does not allow the patient to choose from which direction to connect the connector with the base part. In those prior art infusion kits the construction of the cannula and the means to provide Fluid communication between the cannula and the cannula of the connector is unique for each equipment. Normally each infusion set also uses a specific equipment of guidance and / or blocking means thus allowing to couple only a specific connector with the base part. It would be very desirable both from the production and practical use point if a universal part having a cannula and means adapted to receive the cannula from the connector and fit most / all common infusion sets would be available. The invention is intended to cover both infusion sets as described above and variants thereof when such universal parts are used therein. Normally the connector and the base part are connected in the plane essentially parallel to the surface of the skin of the wearer or in the direction essentially perpendicular to the skin of the wearer. Moreover, in the infusion sets of the prior art, the connector and the base part must be replaced if the person carrying the base part for some reason wishes to change to a different base part. It could be advantageous if different types of connectors could be used with the same base part and vice versa, and also if the connection from different angles was possible. The object of the present invention is therefore provide a cannula device which can be used as a component in most / all common infusion sets and which allows connection from more than one direction. According to the invention there is provided a cannula device for mounting on a base part for infusion equipment comprising a housing and at least one membrane that together define at least one cavity adapted to receive a piercing member of a connector, the cannula device further comprises a cannula mounted in the housing and in fluid communication with at least one cavity, the device can receive the piercing member of a connector from a first receiving direction and additionally can receive the piercing member from a connector from a second receiving direction that is different from the first direction providing fluid communication between the piercing member of a connector and that at least one cavity of the device is characterized in that the cannula device has means for joining the cannula device to the corresponding means of the base part and that the housing has a geometry such that the cannula can extend from the base part in more than one direction. The advantage of such a part is that it can be used as a key component in infusion equipment with connections parallel and orthogonal between the connector and the base part seen in relation to the skin of the potador. Thus this key component can be mass produced and can be used as a serial component of desired designs for infusion sets. This results in lower manufacturing costs, a more flexible production line and more flexible product. Appropriate geometries that allow the cannula to extend from the base part in more than one direction are for example an essential cubic housing or a housing with at least two sides of a cube. The cubic housing can be oriented with the cannula pointing to several directions in the same hole. Another appropriate geometry is a segment of a sphere defined by two cuts in a sphere or segment of an ellipsoid defined by two cuts in an ellipsoid. Preferably the angle between the cuts in the sphere and the ellipsoid is between 60 and 120 degrees especially preferred is an angle of essentially 90 degrees. Additionally an appropriate housing could be cylindrical or in the form of a box which could be attached to the base in a way that allows it to rotate. It should be emphasized that it is not mandatory that the various note addresses can be obtained when joining the base part, this could also result from the possibility of multiple joining addresses. In a preferred embodiment, the device cannula is attached to the base part in a releasable manner, thus allowing the exchange thereof. The exchange can be done by taking the cannula device for example, by sliding it out of the base part guided by a group of guide means. Then another cannula device can be provided on the same base part by sliding it into place by the same group of guide means or by using a different group of guide means in case a different orientation of the flexible cannula is desired. By this means the advantage is obtained in that the base part can be reused several times by the patient thus saving medical expenses. It also provides the option to use different cannula devices in the same base part for example having cannula devices with different cannula sizes ie different lengths and / or diameters, thus making infusion equipment tailored for the patient using standard component. The invention also relates to a base part having multiple groups of guide means in such a way that they allow it to be coupled with a cannula device of the aforementioned type in such a way that the cannula device has more than one possible orientation of its axis. principal. In a preferred embodiment the base part also has stops that allow the cannula device to stop at multiple weights and / or distances from a lower position, thus allowing an infusion set with multiple exposed cannula lengths (the part of the cannula which penetrates the patient) using the same cannula device. In a preferred embodiment, the cannula device can be mounted on the base part at different levels thereby offering the option of varying the insertion depth of the cannula. This gives the advantage that a cannula device and a base part together can be used for more than one depth of insertion, in addition to then adapting the infusion set to the individual patient, and further how the infusion set can for example be used for child as for adults. In addition, different insertion angles can be used with the same base part. By changing from a cannula device having a first angle between the cannula and the housing to a cannula device having a second and different angle between the cannula and the housing, more than one insertion angle is possible using the same base part . In another preferred embodiment, the cannula device is provided with guide means for guiding the connection with the connector and / or for guiding the assembly with a base part. In an even more preferred embodiment the cannula device has more than one type of guide means and / or subjection. This allows the patient to use their preferred mating directions, for example some patients prefer a link in which the connection is parallel with the skin and other patients prefer that the links be orthogonal to the skin. The guide means described above are for guiding the coupling, thus securing the needle and / or the end of the cannula in the correct position and place, or for guiding the connection of the cannula device to the base part. In a preferred embodiment, the guide means guide the cannula device assembly with a base part, and the coupling with a connector and / or an inserter. Preferably, the cannula device is adapted to removably attach to a base part of an infusion set. Preferably, the piercing member of the connector is in the form of a cannula. In a preferred embodiment, the securing means is for holding the connector and the base part together in a releasable manner. Infusion sets with a cannula device of the type mentioned above provide a unique option for patients. It is now possible to insert the cannula using a traditional inserter, perpendicular relative to the skin giving the advance of a depth of Prefixed penetration, and connect with the connector parallel to the surface of the skin, giving the lowest profile of the infusion set. In a preferred embodiment, the cannula device cannula is a flexible cannula, preferably a flexible cannula made of plastic material. The preferred plastic materials for the flexible cannula are materials which are flexible enough to bend, when the patient moves and stiff enough to avoid interruption of the drug delivery by twisting. In addition, the material must be compatible with medical use, that is, skin irritation must be kept to a minimum and must be non-toxic, must not be broken down in the body, etc. Thermoplastic elastomers (TPE) are a type of materials that meet these requirements. Examples of such useful elastomers are: polyester ethers, ECDEL, styrene-based TPE, olefin-based TPE, urethane-based TPE, ester-based TPE, TPE based on amides, olefins and silicone gums. In a preferred embodiment, the material is selected from the group consisting of polypropylene, C-FLEX ™ blends of C-FLEX ™, and polypropylene, LUPOLEN ™ 1840H, LUPOLEN ™ 3020D, PELLETHANE ™ 2363-75D, PELLETHANE ™ 2363-55D, TECOTHANE ™ and CARBOTHANE ™ In a preferred embodiment, accommodation is made of a plastic material, preferably polypropylene. In a preferred embodiment, there is an angle of at least 45 ° between the first and second directions of reception of the needle and / or the piercing member, more preferably there are at least 60 ° between the directions, even more preferably there is at minus 75 ° between addresses, and more preferably there is at least 85 ° between addresses. In an even more preferred embodiment, the cannula device can in addition to the two directions set above receive the piercing member from additional directions, the additional directions preferably have angles at the first direction ranging from 5 ° to 175 °, more than preference angles from 30 ° to 150 °. In a preferred embodiment of the cannula device, there is a membrane in the cannula device whose membrane can be penetrated by and sealed around a piercing member of a connector to allow fluid communication with at least one cavity for each of the receiving directions . In another preferred embodiment, there is a membrane through which the connector cannula and / or insertion needle enters / enters, no matter which of the possible reception angles is used. In a preferred embodiment, the device The cannula comprises a plurality of wells for receiving the piercing member of the connector. These wells are in fluid communication with the cannula device cannula. In another preferred modality, the cannula device is rotatable relative to the base part, in this way, which allows the return of the subsequent insertion of the base part without movement of the inserted cannula. Alternatively, the base part is rotated toward a desired angle relative to the cannula, and then the cannula is preferably inserted using an inserter. In a preferred embodiment, the cannula device is joined to the base part by means of articulations. In a preferred embodiment, the cannula device comprises a chamber which, when a connector is connected to the base part, is in fluid communication with the piercing member of a connector and which is also in fluid communication with the cannula of the device of cannula Having a camera makes it easier to adjust the connection between the connector and the base part. In another preferred embodiment, the piercing member of the connector is in direct fluid communication with the cannula device cannula, i.e. without a chamber. This gives the advantages of a smaller waste volume. In a preferred embodiment, the membrane is made of silicone, and even more preferred of self-sealable silicone. In a preferred embodiment, the membrane crosses the axis of the cannula. Another embodiment of the invention relates to an infusion set comprising a cannula device of the type mentioned above. The cannula device can be attached to the base part by, for example, mechanical means, such as edges, slits or caps; by adhesives such as glues or by friction, for example, the cannula device fits into a hole in the base part, and the friction between the sides of the hole and the cannula device keeps the cannula device in place. In a preferred embodiment, the base part has a first group of fastening means, and the cannula device has a second group of fastening means for securing the cannula device in the base part. Preferably, the fastening means also have a decoupling member for releasing the cannula device from the base portion. In a preferred embodiment, of the infusion set, the connector comprises a cannula which can be broken at a predetermined location. This gives the possibility of using the connector as an inserter to insert the cannula device cannula. After insertion, the cannula of the The connector breaks at the desired point, and the connector is used in a traditional way. A second aspect of the invention relates to an infusion set comprising a base part which comprises a cannula device of the type mentioned above for insertion into a patient and a connector for connecting the base part with a medical device through a conduit, the connector comprises a piercing member of a connector that is in fluid communication with the tube; the base part optionally comprises a first group of guide means and a first group of fastening means for securing the connector to the base part; the connector optionally comprises a second group of guide means adapted to fit the first group of guide means and a second group of attachment means adapted to engage with the first group of clamping means in a releasable manner. According to another aspect of the present invention, an infusion set is provided. The infusion set includes a base part and a cannula device removably connected to the base part. The cannula device includes a housing having at least one membrane secured thereto, and a cannula mounted in the housing. The cannula device is adapted to receive a piercing member of a connector from a first direction of receiving and from a second receiving direction different from the first direction, providing fluid communication between the piercing member and the cannula device cannula. BRIEF DESCRIPTION OF THE DRAWINGS The cannula device will be described in more detail with reference to the figures. FIGURE 1 is a perspective view of one embodiment of the cannula device of the present invention; FIGURE 2 is an enlarged view of the housing of the cannula device shown in FIGURE 1; FIGURE 3 is a sectional view of the cannula device shown in FIGURE 2; FIGURE 4 is a perspective view of the cannula device coupled with an inserter; FIGURE 5 is a perspective view of the cannula device mounted on a base part of an infusion set; FIGURE 6 is an exploded perspective view of the cannula device mounted on a base part; FIGURE 7 is a top view of the cannula device mounted on a base part and encapsulated by protection members; FIGURE 8 is an exploded top perspective view showing the cannula device mounted on a base part in which a cannula is essentially orthogonal to the main plane of the base part; FIGURE 9 is a side view of an inserter coupled with the embodiment shown in FIGURE 8; FIGURE 10 is a perspective view showing the assembly of the cannula device in the base part; FIGURE 11 is an exploded side view showing another position for the cannula device mounted on the base part; FIGURE 12 is an exploded view showing the embodiment of FIGURE 11 from a different angle; FIGURE 13 is an exploded view of the cannula device mounted on a second type of base part including an inserter and a protection member; FIGURE 14 is an exploded view of the cannula device mounted on the base portion shown in FIGURE 13 wherein the cannula device is mounted in an orthogonal direction. FIGURE 15 is a top perspective view of the cannula device in the base part with a protection member; FIGURE 16 is a sectional view of the embodiment shown in FIGURE 15; FIGURE 17 is an exploded view of the mode shown in FIGURE 14 having a different protection member; FIGURE 18 is a perspective view of one embodiment of the cannula device, the base part and an inserter; FIGURE 19 is a perspective view of the embodiment shown in FIGURE 18 with the inserter inserted in an orthogonal direction; FIGURE 20 is a perspective view of the embodiment shown in FIGURE 18 with the inserter removed; FIGURE 21 is a top perspective view of the embodiment shown in FIGURE 18 with the protection member coupled with the base part; FIGURE 22A shows the cannula device of FIGURE 1; FIGURES 22B-D show the cannula device of FIGURE 22A having several protection members; FIGURE 23A-D shows side views of embodiments shown in FIGS. 22A-D; FIGURE 24A-D shows top views of the modalities shown in FIGURES 22A-D; FIGURE 25 is a perspective view of an embodiment of the present invention having a protection member; FIGURE 26 is a sectional view of the embodiment shown in FIGURE 25; FIGURE 27 is an exploded view of one embodiment of the present invention that includes an adhesive layer; FIGURE 28 is an exploded bottom view of the embodiment shown in FIGURE 27; FIGURE 29A is another embodiment of the cannula device of the present invention; FIGURE 29B is a partial sectional view of the embodiment shown in FIGURE 29A; FIGURE 30A is a front perspective view of the cannula device and a connector; FIGURE 30B is a top perspective view of the embodiment shown in FIGURE 30A; FIGURE 31A is an exploded top view of the cannula device, the base and the connector; FIGURE 31B is a perspective view of the cannula device and the base part of the embodiment shown in FIGURE 31A; FIGURE 32A is a sectional view of the embodiment shown in FIGURE 31A; FIGURE 32B is a sectional view of the embodiment shown in FIGURE 31B; FIGURE 32C is a side view of the modality shown in FIGURE 31B; FIGURE 32D is a top view of the embodiment shown in FIGURE 3IB; FIGURE 33A is a perspective view of the cannula device shown in FIGURE 31B with the cannula device in an orthogonal direction; FIGURE 33B is a perspective view of the cannula device shown in FIGURE 31A with the cannula device in an orthogonal direction; FIGURES 33C and D show top views of the embodiments shown in FIGURES 33A and B respectively; FIGURE 34A is a front perspective view of one embodiment of the cannula device; FIGURE 34B is a perspective view of one embodiment of the cannula device, the base part and the adhesive layer; FIGURE 35 is a sectional view of the embodiment shown in FIGURE 34B; FIGURES 36A-E are top and perspective views of one embodiment of the present invention; FIGURE 37A is a top perspective view of the cannula device and the connector showing the cannula in an orthogonal direction; FIGURE 37B is a side perspective view of the embodiment shown in FIGURE 37A; FIGURE 37C is a top view of the embodiment shown in FIGURE 37; FIGURE 38A is a side perspective view of the cannula device and the connector showing the cannula in a parallel direction; FIGURE 38B is a top view of the embodiment shown in FIGURE 38A; FIGURE 39 is a perspective view showing an inserter with the cannula device; FIGURES 40A and B are perspective views showing a cannula device mounted on the connector in different positions; FIGURES 41A and B are sectional views of the embodiment shown in FIGURES 41A and B respectively; FIGS. 42A and B are side views of the embodiment shown in FIGS. 41A and B respectively; FIGURE 43 is a sectional view of one embodiment of the cannula device of the present invention showing the connector in communication with the cannula; FIGURE 44 is a top perspective view of the cannula device, base part and connector showing the clamping members; FIGURE 45 is a top view of one embodiment of the present invention; FIGURE 46 is a top perspective view of the cannula device, base part and inserter; FIGURE 47 is a perspective view of the cannula device and the inserter mounted on the base part in an orthogonal direction; FIGURE 48 shows the inserter that can be mounted on the cannula device; FIGURE 49 is a perspective view of one embodiment of the present invention showing an angled base portion; FIGURE 50 is a top view of the cannula device mounted on an angled base portion; FIGURE 51 is a sectional view of the embodiment shown in FIGURE 50; FIGURE 52 is a front perspective view of the embodiment shown in FIGURE 50; FIGURE 53 is a top perspective view of the embodiment shown in FIGURE 50; FIGURE 54 is a perspective view of the embodiment shown in FIGURE 50; FIGURE 55 is a perspective view of the embodiment shown in FIGURE 50; FIGURE 56 is a perspective view of the embodiment shown in FIGURE 50; FIGURE 57 is a front perspective view of the modality shown in FIGURE 50; FIGURE 58 is an exploded perspective view of another embodiment of the present invention; FIGURE 59 is an exploded perspective view of the cannula device and the base portion shown in FIGURE 58; FIGURE 60 is a perspective view of the embodiment shown in FIGURE 59 with the cannula device in an orthogonal direction; FIGURE 61 is a perspective view of the embodiment shown in FIGURE 60 with the cannula device in a parallel direction; FIGURE 62 is an exploded perspective view of the embodiment shown in FIGURE 61; FIGURE 63 is an exploded perspective view of the embodiment shown in FIGURE 61; and FIGURE 64 is a sectional view of the cannula device shown in FIGURE 58. FIGURE 65 shows a segment of a sphere defined by two cuts. FIGURE 1 shows a first embodiment of the present invention. In this embodiment, the cannula device 1 includes a housing 2 and a membrane 3 which together define a cavity 6 which is adapted to receive a piercing member extending from a connector A cannula 4 is mounted in the housing 2 and is in fluid communication with the cavity 6. The membrane 3 can have an oval or elongated shape covering at least a portion of the two sides 8, 10 of the cannula device 1. Alternatively, the membrane 3 may cover at least a portion of one or more sides different from that of the two sides 8, 10. The membrane 3 may also be configured in an alternative form, for example, but not limited to, circular, rectangular, triangular and others. This allows connection with a connector from more than one angle. The membrane 3 is shown as a single membrane that curves around the cavity 6. Alternatively, more than one membrane may be provided for the entry of a piercing member in different directions of reception as described in the following. In the embodiment shown in FIGURE 1, guide members 5 are provided in housing 2, thereby guiding the connection with a device such as the connector, the inserter, or both. This helps to ensure that the cannula from the connector, the needles of the connector or both, are properly aligned as described in the following. As shown in FIGURES 1 and 2, and as described in the following, the guide members 5 can guide the connection from at least two angles that are essentially orthogonal to one another.

FIGURE 2 shows the cavity 6 defined by the housing 2 and the membrane 3. The cavity 6 can be in fluid communication with the cannula 4. As shown, a pair of guide member 5 extend from the housing 2, opposite one another on the sides 9, 11 of the housing 2. Each guide member 5 may include a pair of elongated rail members 12 adapted to slidely engage with a device such as a connector or an inserter as described in the following. Each rail member 12 may further include a notch 14 defined in the rail member 12 to be removably coupled to another or the same device. Additional guide members 5 are possible to remove the coupling with the device such as the connector, for example, from an infusion set, or an inserter, as will be apparent to one skilled in the art. A sectional view of the cannula device 1 shown in FIGURE 3 shows the cavity 6 in greater detail. The cavity 6 defines a chamber 16 which is in fluid communication with the cannula 4. A piercing member (such as the piercing member 580, 680 described in the following) can penetrate the membrane 3 at any position in the membrane 3 and communicate with the camera 16. Thus, the piercing member such as a piercing member can be in fluid communication with the cannula 4 or the device 1, and make it possible to connect the connector to the cannula device 1 from different angles. As shown in FIGURE 3, cannula device 1 can further include canals 17 and 19 of cannula inlet 4. Inlet channels 17 and 19 can enter fluid communication with chamber 16 for the reception of a therapeutic substance through the piercing member. Alternatively, the inlet channels 17 and 19 can directly receive the piercing member for the release of the therapeutic substance as described in the following. As shown in FIGURE 4, the cannula device 1 is connected to an inserter 50. A needle 51 extends from the inserter 50, penetrating the membrane 3 in a first position and extending outwardly through the cannula 4. inserter 50 is used to place cannula 4 of device 1 subcutaneously in the patient. After insertion, the inserter 50 is removed and the cannula 4 is left in the patient for the release of a therapeutic substance and subsequent removal, for example, when a base part (shown in FIGURE 5), the cannula device 1 , or both, are removed. FIGURE 4 shows that the inserter 50 can be connected to the cannula device 1 from a first insertion direction 18 which can be generally parallel to or aligned with the axis 103 of the cannula 4. A portion of the membrane 3 remains accessible and thus illustrates it's possible connecting to a connector from a second direction 20 which is different from the first direction 18. As shown, there is approximately a 90 ° angle between the two directions 18, 20. The first direction 18 and the second direction 20 can be predetermined by the location of the entry chambers 17 and 19 for direct reception of the piercing member. Alternatively, any direction of reception can be used with the camera 16 that allows fluid communication between the piercing member and the cannula 4 of the cannula device for the release of the therapeutic substances. By way of example, additional angles between the first direction 18 and the second direction 20 are possible. Preferably, the angle between the first direction 18 and the second direction 20 is in the range from about 5 or about 175 °, more preferably from about 30 ° to about 150 °. Preferably, the angle between the first direction 18 and the second direction 20 is at least about 45 °, more preferably about 60 °, 75 °, 85 °, most preferably about 90 °. One skilled in the art will understand that additional connection directions are possible and from many different angles. As shown in FIGURE 5, the cannula device 1 is assembled in a base part 100 of an equipment 90 of infusion. In this embodiment, the base part 100 includes base guide members 101 which fit in conjunction with the guide members 5 mounted in the housing 2 of the cannula device 1. The guide members 5 in the cannula device 1 can be used to guide and align the cannula device 1 in the base guide members 101 of the base part 100 and to guide the connection to a connector. An opening 102 in a portion of the base guide members 101 of the base portion 100 allows the connection of the guide members 5 of the cannula device 1 or a device, such as a connector or an inserter from a second and different direction. that the first direction 18 which is parallel to the axis 103 of the cannula 4. The guide members 5 may be elongated rectangular rails, as shown in this embodiment, or pins, or other types of known alignment mechanisms. The protection members 104, 105 are also shown in FIGURE 5. The protection members 104, 105 secure and at least partially enclose, and cover the cannula device 1 on a plurality of sides. The protection member 105 includes guide arms 106 and clamping arms 107 similar to the guide and clamping arms that can be provided in a connector. The exemplary coupling of the clamping arms of a connector with an infusion set is described in detail in U.S. 5,522,803 which is incorporated herein by reference in its entirety. The guide arms 106 are adapted to fit slidably with splice openings 110 formed in the inserter 50 as shown in FIGS. 5 and 6. FIGURE 6 illustrates an alternative view, in perspective of the embodiment shown in FIGURE 5. Alternatively , the guide arms 106 can be slidably adjusted with the guide members 101 of the base 100 as shown in FIGURE 8 showing the inserter 50 removed. The holding arms 107 can releasably couple openings 114 formed in the base 100. The releasable coupling of the cannula device 1 with the base part 100 allows exchange of the base part 100 and the cannula device 1. For example, but not limited to the following, the cannula device 1 can be removed from the base part 100 by sliding the cannula device 1 out of the base part 100. Another cannula device 1 can slide in the same base part 100. using the same guide arms 106 of the base part 100. An advantage of the present invention is that the same base part can be reused several times by the patient, thus saving medical expenses. Additionally, the interchangeable cannula device and the base part allows the use of different cannula devices in the same base part, for example, but not limited to, having a cannula 4 of different size with the cannula device 1, ie, the length or diameter of the cannula 4. This exchange allows the infusion sets to be configured in equipment that is custom-made for the patient using these modular components. FIGURE 7 illustrates the cannula device 1 releasably mounted on the base part 100 and the cannula device 1 and the base 100 are covered by protection members 104 and 105. FIGURE 8 shows the cannula device 1 mounted on the base part 100 in an alternative position to that shown in FIGS. 5-7. In particular, the cannula device 1 is mounted in the second direction 20 where the cannula 4 is mounted on the base part 100 substantially orthogonal to the main plane 118 of the base part 100. The base part 100 includes multiple guide members 105 and openings 102 to allow the removable attachment of the cannula device 1 in at least these multiple orientations. As shown in FIGURE 8, the guide members 5 of the housing 2 are releasably adapted with the opening 102 in the base portion 100. Changing the orientation of the guide members 5 of the housing 2 with respect to the guide members 101 and the openings 102 in the base part 100 allow that the angle between the cannula and the base part 100 has been changed, which may be desired in certain circumstances. The protection members 104, 105 may also be coupled with the same base member 100 when the guide members 5 of the housing 2 are slidably received in the openings 102 of the base part 100. As shown in FIGURE 9, in combination with FIGURE 8, the inserter 50 including the needle 51 extending through the cannula 4 is connected to the cannula device 1 when the cannula device 1 is slidably received in the opening 102 in the base part 100. The members 104 , 105 of protection are also coupled with the base part 100. Alternatively, a connector (eg, a connector 450, 550, 650, described in the following) may be coupled with the base part 100 in the position shown for the inserter 50 or in the position shown for the protection member 105 and connected to the cannula device 1. As shown in FIGURE 9, the cannula device 1 and the inserter 50 engage the base part 100 in an orthogonal direction compared to the parallel direction shown in FIGURE 7. In FIGURE 10, the cannula device 1 is mounts in the base part 100 in the first direction 18 where the cannula 4 is substantially parallel with the main plane 118 of the base part 100. The cannula device 1 can be slidably retained in the base part 100 by the friction between the members 5 of 1 device guide cannula and the guide members 101 of the base part 100. The guide arms 106 of the guard member 105 can be slidably engaged in an opening 122 formed in the base 100 when the cannula device 1 is coupled with the base 100. The device The cannula 1 can also be coupled to the base part 100 using various methods known to the person skilled in the art. For example, but not limited to, mechanical means, such as notches, slits or lids; by adhesives such as glue or by friction such as the cannula device 1 adapted with the opening 102 in the base part 100 and being retained therein by the friction between the sides of the guide means 5 of the cannula device 1 and the sides of the opening 102. The base portion 100 may further include fastening members that removably secure the cannula device 1 to the base part 100. In addition, the cannula device 1 may have a holding member, such as the coupling hinge 14, shown in FIGURE 2, to secure the cannula device 1 to the base part 100. The fastening members can further include decoupling members to release the fastening members. FIGURES 11 and 12 show how the clamping arms of the protection member 105, or alternatively, a connector having similar clamping arms (as shown in FIGS. 52-57), can be coupled in an aperture. 107 in the base part 100. The cannula 4 is shown extended in the parallel direction, similar to FIGURE 7. Preferably, the cannula device 1 of the present invention is made of the following materials, but is not limited to the materials described in the present. One skilled in the art will recognize that other materials are possible and are within the scope of the present invention. The housing 2 of the cannula device 1 of the present invention is preferably made of a plastic material, more preferably polypropylene. The membrane of the present invention is preferably made of silicone, more preferably of self-sealable silicone. The membrane is preferably adapted to be penetrated by and sealed around a piercing member to allow fluid communication with the cannula device cannula or with at least one cavity for each of the receiving directions. The cannula 4 of the cannula device 1, as shown, is preferably a flexible cannula. Preferably, the cannula 4 is made of a plastic material. The preferred plastic materials for flexible cannula 4 are also materials that are flexible enough to bend when the patient moves and stiff enough to prevent twisting and closing of the drug supply. In addition, the material must be compatible with the use medical, that is, minimal skin irritation, non-toxic, non-decomposable in the body, etc. Thermoplastic elastomers (TPE) are a type of materials that meet these requirements. Examples of such elastomers include, but are not limited to: polyester ethers, ECDEL, styrene-based TPE, olefin-based TPE, urethane-based TPE, ester-based TPE, TPE based on amides, olefins and silicone gum. In a preferred embodiment, the material is selected from the group consisting of polypropylene, C-FLEX ™ blends of C-FLEX ™, and polypropylene, LUPOLENTM 1840H, LUPOLENTM 3020D, PELLETHANE T 2363-75D, PELLETHANETM 2363-55D, TECOTHANE ™ and CARBOTHANETM. An alternative embodiment of the present invention is shown in FIGS. 13-25 illustrating the same cannula device 1 mounted on a different type of base part 200. FIGS. 13-25 show how the cannula device of FIGURES 1-2 It can be mounted on different types of infusion equipment. Illustrating an advantage of the cannula device of the present invention. As shown in FIGURE 13, the cannula device 1 engages with the base part 200 in the first direction 18 where the cannula 4 is generally parallel to a main plane 218 of the base part 200. FIGURE 13 also shows the inserter 50 with the needle 51 connected to the cannula device 1 and extending through the cannula The projections 22 extend from the inserter 50 and slidably engage with the guide members 5 of the cannula device 1. In this embodiment, the base portion 200 includes guide members 201 which are adapted together with the guide members 5 in the cannula device 1 as described above. The cannula 4 extends through an opening 203 in the base part 200, the opening 203 having the size to receive an annular ring 210 of the cannula device 1. The base part 200 further includes straight guide members 206, 207 adapted for sliding reception of the corresponding guide members 208, 209 of a protection member 204 once the inserter 50 is removed from the cannula device 1. The protection member 204 can cover the cannula device 1 while the cannula 4 is secured to the skin of the patient and is capable of releasing therapeutic substances to the patient through the cannula 4. The guide members 208, 209 can best be seen in FIG. FIG. 16 wherein the base guide members 206, 207 and guide members 208, 209 of the guard member 204 are rotatably adapted to fit together to removably secure the guard member 204 to the base part 200. Preferably , the guide members 207, 208 may further include toothed projections 211 to facilitate coupling. The guide members 206, 209 they can also include 111 toothed projections. As shown in FIGURE 13, the base portion 200 preferably includes two straight guide members 206, 207 on opposite sides of the base portion 200. Alternatively, any number of guide members 206, 207 or only the guide member 207 it can be used to couple the corresponding guide members 208, 209 or the guide member 208 respectively, and the guide members 206, 207 and 208, 209 can be of sufficient size to removably secure the guard member 204 to the base 200. Another mechanism of alignment, clamping and / or guidance can be implemented. The protection member 204 may include an opening 212 as best seen in FIGURE 15. The tubing (not shown) for delivering a therapeutic substance to the cannula device 201 may be inserted through the opening 212 such that the therapeutic substance the patient can be released through the cannula 4 while the cover is in position at the base part 200. The protection member 204 can further include elongated openings 214 on opposite sides of the protection member 204. Preferably, the openings 214 extend from the periphery 216 of the member 204 inward and generally follow the contour of the periphery 216. The sides 218 of the protective member adjacent the openings 214 provide partially flexible surfaces for fastening and turning the protection member 204 to engage or release the base member 200. However, one skilled in the art will recognize that alternative coupling and release can be achieved by any mechanism commonly known to the person skilled in the art. FIGURE 14 illustrates the cannula device 1 coupled with the base part 200 in the second direction 20 where the cannula 4 is generally perpendicular to the main plane 218 of the base part 200. FIGURE 14 also shows the inserter 50 with the needle 51 connected to the cannula device 1 and extending through the cannula 4. The coupling of the inserter 50 and the protection member 204 is as described above in FIGURE 13. Once the inserter 50 is removed from the cannula device 1 and the Base part 200, the protection member 204 can be engaged with the guide members 206, 207 of the base part 200 as shown in FIGURE 15. In some embodiments, the protection members can be coupled with the base part while an inserter is also coupled with the base part as described in the following. In the embodiment shown in FIGURE 15, the cannula 4 extends from the bottom of the base 200. As discussed above, the tubing may extend from the opening 212. FIGURE 16 illustrates a sectional view of the device shown in FIG. FIGURE 15 where member 204 of protection is coupled to the base part 200 and the cannula device 1 is placed in the base part 200 with the cannula 4 projecting from the base part perpendicular to the main plane 218 of the base part 200. The protection member 204 has size and shape to adapt with the base part 200. The guide member 207 of the base part 200 and the guide member 208 of the protection member 204 having toothed projections 211 in the inner pair of the guide members 207, 208 are shown secured together rotatably As discussed above and shown in FIGURE 16, the outer pair of guide members 207, 208 do not include toothed projections 211, however, one skilled in the art will recognize that each of the guide members 207, 208 may include guide projections 211. The inlet channels 17 and 19 of the cannula device 1 are below the membrane 3 which is protected by the protection member 204. FIGURE 17 illustrates the same cannula device 1 coupled with the same base part 200 by the guide members 105 of the cannula device 1 inserted in the base guide members 201 where the cannula 4 extends in the first direction 18 generally parallel to the plane 218 of the base part 200. FIGURE 17 illustrates a pair of protection members 250, 252 that can be coupled with the base part 200 to cover the cannula device 1 and the base part 200. The protection members 250, 252 They are sized and shaped to adapt in conjunction with the base part 200 to cover the base part 200. As discussed above, alternative forms for the base part 200 and the protection members 250, 252 are possible. Other structures for coupling these multiple members together can also be used. The protection member 250 includes a pair of guide members 254 that can be adapted to engage the guide members 207 of the base portion 200. As described above, the base portion 200 can include guide members 206. The guide members 206 can slide together with projections 256 on the periphery 258 of the protection member 250. The protection member 250 may further include a notch 260 for coupling an edge 270 of the base portion 200. The protection member 250 covers a portion of the membrane 3 of the cannula device 1 and may also engage the protection member 252 for protection. covering the base part 200 when the base part 200 adheres to the skin of the patient and the cannula 4 is placed transcutaneously for the release of the therapeutic substance. As shown in FIGURE 17, the protection member may include a portion 264 to cover the membrane 3 of the cannula device 1 and the portion 264 may be made of a material that is different from the remaining protection member and penetrable by a needle , such as the needle 51 of the inserter 50. For example, the portion 264 may be integrally molded to the member 250 and formed of an elastomer. The protection member 252 can be slidably coupled with the protection member 250. FIGURE 18 shows the protection member 250 coupled with the base portion 200 as described above for FIGURE 17. While the protection member 250 engages the base portion 200, the protection member 252 can be removed from the protection member 250 and the base part 200. The needle 51 of the inserter 50 can be inserted in the membrane 3 of the cannula device 1 and extend through the cannula 4 in the first direction 18. The inserter 50 can be removed and replaced with the limb 252 protection or alternatively with a connector, such as a connector 450, 550, 650 described in the following, for the delivery of a therapeutic substance. FIGURE 19 illustrates the cannula device 1 (below the protection members 250, 252) coupled with the base part 200 in the second direction 20 and the inserter 50 having the needle 51 inserted in the cannula device 1 through cannula 4 in the second direction. FIGURE 19 shows the needle 51 penetrating the portion 254 of the protection member 250. When the cannula device 1 engages with the base part 200 in the second direction 20, the protection members 250, 252 can remain coupled with the base part 200, protecting the base part 200 and the cannula device 1 while the needle 51 of the inserter 50 extends through the cannula 4. FIGURE 20 illustrates the embodiment described above for FIGURE 17 showing the member 250 of protection coupled with the base part 200 and the protection member 252 not yet engaged. As shown, the shielding member 252 can be coupled parallel to the direction of the cannula 4 extending from the base portion 200. FIGURE 21 illustrates the compact size of the device when the shielding member 252 engages with the shielding member 250 and the base part 200. In this configuration, the most sensitive parts of the device are covered and protected, and the assembly itself is easily transported or packaged. As described above, the protection member 252 can be removed and a connector can be inserted in place of the protection member 252, having a similar compact size. FIGURE 22 illustrates perspective views of the cannula device 1 and includes various assembly configurations including the base portions 100, 200 and the protection members 104, 105, 204, 250, 252. FIGURE 22A shows the cannula device 1 itself. FIGURE 22B shows the cannula device 1 inserted in the base part 100. The protection members 104, 105 cover the base part 100 and the cannula device 1 with at least a part of the membrane 3 accessible for the insertion of a needle of an inserter or a connector for the release of the therapeutic substance. FIGURE 22C shows the cannula device 1 coupled with the base part 200. The protection member 204 is shown covering the cannula device 1 and the base part 200 and has been described above. FIGURE 22D shows the cannula device 1 coupled with the base part 200 and protection members 250, 252 covering the device 1 and the base part 200. FIGURES 23A-D illustrate side views of the cannula device 1 coupled with the different ones corresponding embodiments shown in FIGURES 22B-D. FIGURES 24A-D illustrate top views of the embodiments shown in FIGS. 22B-D respectively. FIGURE 25 illustrates another embodiment of the present invention. As shown, a base part 300 engages protection members 350, 352 to form a compact device. An adhesive layer 310 for adhering the base part 300 to the skin of the patient is shown connected to the base portion 300. FIGURE 26 illustrates a sectional view of the embodiment shown in FIGURE 25. The base portion 300 includes a plurality of projections 320 having bottom surfaces 322 that together form the bottom surface 324 of the base part 300 as shown in FIGURES 26 and 28. A Inlet port 328 can be formed in base part 300 where inlet port 328 is connected to a channel 330 which fluidly connects to a cannula 304 extending from base part 300. Protection member 352 can be removed and a connector such as connector 450, 550, 650, described in the following, can be inserted in the same position for the release of the therapeutic substance. The adhesive layer 310 adheres to the bottom surfaces 322 of the base portion 300 and can be formed of a material that can be penetrated by a needle of an inserter (not shown) that extends through the cannula 304. Alternatively, the layer 310 The adhesive can include an opening through which the cannula 304 can extend. FIGURE 27 shows an exploded view of the embodiment shown in FIGURE 25. As shown, the protection member 352 includes guide arms 306 and holding arms 307 for engagement of the guard member 352 with the base part 300. The holding arms 307 can couple the base part 300 through the corresponding openings 314 in the base part 200 as described above in FIGS. 5 and 6. FIGURE 28 shows an exploded bottom view of the embodiment shown in FIG. 25. The projections 320 having lower surfaces 322 on the base part 300 are shown. The base part 300 can also include a peripheral surface 332 extending around the periphery of the base part 300 to which the adhesive layer 310 can adhere in addition to the surface 322. As shown in FIGS. 25-28, the general form of the embodiment is cylindrical having the adhesive layer 310, base portion 300 and protection members 350, 352 formed to be accommodated together to form a compact device. One skilled in the art will recognize that alternative forms are possible, including but not limited to oval, rectangular and square shapes, preferably where the modal assembly can form a compact device. FIGURES 29A and 29B show an alternative embodiment of a cannula device 401. The cannula device 401 includes a housing 402, a membrane 403 and openings 405, 407. Preferably, the housing 402 can be essentially cylindrical in shape, although other shapes are possible. In the present embodiment, the cylindrical shape includes radially extending projections 413 (or tabs) defining openings 405 and 407 and can be used as guides when placed on a base part, such as a base part 400, shown in FIGURE. 30A. As shown in the sectional view in FIGURE 29B, the membrane 403, together with the housing 402 define a cavity 406 within the housing 402 for receiving a perforator from a connector (described in the following). A 404 cannula extends from the housing 402 under the cavity 406 as shown in FIGURE 29B. In this embodiment, the housing 402 may be rotatably attached to the base portion 400, shown in FIGURE 30, so that the rotatable attachment allows the housing 402 to rotate in the base portion 400 after the insertion of the cannula 404 into the skin. of the patient, without movement of the cannula 404 and therefore minimizing the pain to the patient. Alternatively, the base part 400 can be changed to a desired angle relative to the cannula 404 and then insert the cannula 404 using an inserter such as the inserter 50 shown in FIGURE 4. As shown in FIGURE 29A, the final portions 412 Preferably, the end portions 412 may be generally circular in shape to provide rotation within the base portion 400. However, the end portions 412 may be of any size and shape that is movable within the portion 412. base 400 known to one skilled in the art. In Figures 30A and B, the cannula 404 of the cannula device 401 can be seen connected to the base portion 400 and a connector 450. In this embodiment the base portion 400 includes connection members 446 adapted to receive the end portions 412 of the housing 402. The connecting members 446 and the final portions 412 can be shaped and sized to facilitate the rotation of the housing 402 with respect to the base portion 400. The device 401 further includes an adhesive layer 410 for adhering the base portion 400 to the skin of the patient. The adhesive layer 410 is shown connected to the base part 400 and the adhesive layer 410 can include a cut 448 for the cannula 404 when the end portion 412 of the housing 402 is rotated in the connecting member 446 of the base part 400 to change the angle of the cannula 404 with respect to the skin. The connector 450 is connected to the cannula device housing 402 through openings 405, 407 in the housing 402. (Also shown and described in the following with reference to FIGURE 31?). The connector 450 may further include tubing 452 for the delivery of a therapeutic substance to the cannula 404 for delivery to the patient. The connector 450 may include a button 454 for releasing the connector 450 from the housing 402. Alternatively, any method for releasing the connector 450 from the housing 402 may be used, including, but not limited to, pressure on an outer portion 456 on each side of the connector. 450 to release the clamping arms 458 (shown in FIGURE 31A). FIGURE 31A illustrates connector 450 prior to connection to housing 402. Connector 450 may include clamping arms 458 and guide members 470 similar to the clamping arms and guide members described above for the protection member with the cannula device 1. The clamping arms 458 allow the connector 450 to be inserted into the openings 405 of the housing 402 and removably held in place for the release of the therapeutic substance. The connector 450 may further include a piercing member 480 that connects the connector 450 to the cannula 404. The piercing member 480 can be inserted through the membrane 403 and into the cannula 404 or into the chamber 406 to connect fluidly with the the cannula 404. The piercing member 480 can be adapted to break at a predetermined location. This allows the connector 450 to be used as an inserter to insert the cannula 404 of the cannula device 401. Then the piercing member 480 can be broken at the desired point and the connector 450 used in the traditional way. The piercing member 480 extends through the membrane and can put a piece to the membrane, but does not necessarily have to pierce the membrane. For example, the piercing member can be inserted through a preformed hole in the membrane. The term "piercing member" as used herein may include a cannula, which includes a rigid cannula or needle, a semi-rigid cannula, or a flexible cannula or any member suitable for piercing the membrane. As shown in FIGURES 31A and B, the part base 400 of this embodiment can be flexible or articulated to facilitate rotation of the housing 402 in the base portion 401. FIGURE 31B illustrates the cannula 404 turned toward the skin and the base portion 400 flexed for rotation. The base portion 401 may further include hinges 472 attached to the connection members 446. The hinges 472 can be used to rotate the cannula 404 from parallel to the skin until angled towards the skin. The rotation of the housing 402 also allows the cannula 404 to be placed on the skin with an injection needle, such as the needle 51 shown with the cannula device 1. The connector 450 can be connected at any angle and the insertion device 480 can be inserted into the membrane 403 from a plurality of directions. FIGURE 32A shows the cavity 406 formed in the housing 402 and the cannula 404 extending from the cavity 406. FIGURE 32B shows a portion of the housing 402 cut off from the base portion 400. The connection member 446 is shown in a circular configuration having a raised circumference 474 and a central depression 476 adapted to receive the end portion 412 of the housing 402. A portion of the base portion 400 is shown extended from the connection member 446. FIGURE 32C shows cannula 404 rotated from the direction parallel to the skin. FIGURE 32D shows a top view of the cannula device 401. FIGURES 33A-D illustrate the cannula device 401 having the cannula 404 extending in a different direction as previously shown in FIGURES 30-32. The cannula 404 is shown substantially orthogonally exceeded with respect to the cannula 404 shown in FIGURES 31-32. FIGURE 33B shows the cannula device 401 with the cannula 404 extending vertically from the base portion 400. The connector 450 is shown removably connected to the housing 402 in the openings 405, 407 of the housing 402. An opening 482 in the layer 410 adhesive is shown in FIGURE 33B so that the cannula 404 extends through and into the patient's skin. FIGURES 33C and D show top views of the cannula device 401 shown in FIGURES 33A and B, respectively. FIGURE 34A illustrates housing 402 having openings 405, 407. Membrane 403 is shown in the center of housing 402 for receiving an insertion device to fluidly release a therapeutic substance through cannula 404. End portion 412 it is shown to have a generally rectangular shape for engaging a similarly connecting member 446 of the base portion 400 shown in FIGURE 34B. The housing 402 is rotatable in the base portion 400 as described in FIG. previous FIGURE 35 shows the cavity 406 formed inside the housing 402. The membrane 403 can cover a portion of the cavity 406. An upper portion 484 of the cannula 404 connects with the cavity 406 in the housing 402. The cavity 406 allows a piercing member of a connector is inserted in the membrane 403 in any direction of reception and having the cannula 404 in fluid communication with the connector for the release of the therapeutic substance. In this embodiment, the cannula 404 is shown extending vertically from the housing 402 relative to the plane 418 of the base portion 400. A pair of openings 486 is shown in the housing 402 for receiving a connector or a protective member in two different directions. The base part 400 also includes the connecting member 446 in a generally square shape for receiving the final portion 412 of the housing 402. The adhesive layer 410 may adhere to the skin of the patient. FIGURES 36A-E show the cannula device 401 from different angles. FIGURE 36A shows a top view of cannula device 401 with connector 450 connected to housing 402. Cannula 404 is shown extending in a direction generally parallel to base portion 400. Tubing 452 extends from the connector 450 for connection to a medical device (not shown) for the delivery of a therapeutic substance. FIGURE 36B shows the cannula device 401 of FIGURE 36A with the connector 450 removed. FIGURE 36C shows a perspective view of the cannula device 401 of FIGURE 36A. FIGURE 36D shows a rear perspective view of the cannula device 401 and FIGURE 36E shows a rear perspective view of the cannula device 401 with the connector 450 connected to the housing 402. FIGURES 37A-C illustrate the cannula device 401 with the cannula 404 extending in a generally vertical direction to the plane 418 of the base part 400. FIGURE 37A shows the connector 450 connected in a group of the openings 484 in the housing 402 where the connection is parallel to the plane of the base part 400. The second group of the pair of openings 488 are shown open in a second direction such that the connector 450 can be inserted inside wherein the connection is generally orthogonal to the plane 418 of the base part 400. FIGURE 37B shows a perspective view lateral of the cannula device 401 and the cannula 404 extending below the base part 400. FIGURE 37C shows a top view of the device shown in FIGURE 37A. FIGURE 38A shows the cannula device of FIGURE 37A with housing 402 repositioned in the part base 400 such that the cannula 404 extends generally parallel to the main plane 418 of the base part 400. The connector 450 is shown connected to the housing 402 in a direction parallel to the plane 418 of the base part 400. FIGURE 38B is a top view of cannula device 401 shown in FIGURE 38? wherein the guide arms 470 and the clamping arms 458 of the connector 450 can be seen connected to the housing 402 for removable connection. FIGURE 39 illustrates a cannula device 501 connected to an inserter 550. The cannula device 501 is shown removed from a base portion to show the connection of the inserter 560 to the guide members 505 of the cannula device 501. As shown in FIGS. 0A and B, the cannula device 501 can be connected to a connector 550 at different heights and distances from the skin of the patient such that the cannula 504 can extend into the skin of the patient at various depths. A position member 507 is shown in FIGS. 40A and 41A placed below the cannula device 501. The position member 507 can be positioned between a base member 500 (shown in FIGURE 43) and the cannula device 501 to change the height and distance at which the cannula 501 can be inserted into the skin. The position member 507 allows the cannula device 501 to be placed higher in the connector 550 in the FIGURE 40A when compared to the position of the cannula device in connector 550 in FIGURE 40B without a position member (see also FIGURES 41A and 41B). The cannula device can also be placed at multiple heights with respect to the base portion using multiple guide members. Multiple positions of the cannula device with respect to the base part allow a cannula device and a base part together to be used for more than one depth of insertion by adapting the infusion set to the individual patient and also in such a way that the infusion set can also be used for children and adults. The cannula device 501 also includes a membrane 503 that is adapted to receive a piercing member 580, such as a cannula, from the connector 550 to fluidly connect the connector 550 to the cannula 504 for delivery of a therapeutic substance. As will be understood by one skilled in the art, the cannula may be rigid, for example, but not limited to a needle, semi-rigid, or flexible. FIGURES 41A and B show a partial view of the modalities shown in FIGURES 40A and B, respectively. FIGURE 41A illustrates a modality that allows the connection of the cannula device 501 with the connector 550 from two different directions. As shown, the membrane 503 is a single membrane mounted in the housing 502. As described in the following, multiple 503 membranes are possible. The piercing member 580 shown as a cannula, can extend from the connector 550 and penetrate the membrane 503 and depend on the direction from which the piercing member 580 is received in the cannula device 501, the piercing member 580 can terminate in one of two cavities 512 formed in the cannula device 501. The two cavities 512 may be in fluid communication with one another through a channel 514 formed in the cannula device 501. Preferably the channel 514 is provided within the housing 502. This embodiment allows the piercing member 580 to be in fluid communication with the cannula 504 regardless of the direction from which the insertion device is inserted through the membrane 503. As shown in FIGURE 41A, piercing member 580 may be essentially orthogonal with cannula 504 of cannula device 501 and cavity 512, in which piercing member 580 is inserted and terminated, fluidly connects channel 514 and a cavity 516 connected to the cannula 504. One skilled in the art will recognize that the piercing member 580 can also be inserted into the membrane 503 from a direction essentially parallel to the cannula 504 from the top of the cannula device 501. The piercing member 580 can also be inserted through the membrane 503 and the member 580 of The perforation can terminate in the cannula 504 and thus the piercing member 580 can connect fluidly and directly to the cannula 504 without connecting through a cavity 512 or a channel 514. FIGURE 41B illustrates the cannula device 501 that can be connected to the member 580 of drilling from two directions and in which the piercing member 580 is connected to an individual cavity 522 from any direction through the membrane 503. When the piercing member 580 is inserted through the membrane 503 in the direction orthogonal to the In the direction of the cannula 504, the insertion device can enter the cavity 522 from a hole 524 in a wall 523 of the cavity 522. FIGURES 41A and B also illustrate the cannula device 501 connected at different heights in the connector 550. FIGS. 42A and B illustrate side views of the cannula device 501 connected to the cannula device 501 at different heights in the connector 550. The FIGURE 43 illustrates the connector 550 connected to the cannula device 501 and the cannula device 501 can be mounted on a base part 500. As shown, the connector 550 is connected in a direction parallel to the main plane of the base part 500. The connector 550 includes piercing member 580 shown connected through membrane 503 directly with cannula 504.

FIGURE 44 shows the cannula device 501 connected to the connector 550 and mounted on the base part 500. The cannula 504 extends in the direction parallel to the plane 518 of the base part 500, orthogonal to the direction shown in FIGS. 42A and B . The connector 550 includes guide arms 506 and holding arms 507. As described above, the guide arms assist in positioning the cannula device 501 in the base part 500 and the holding arms 507 removably hold the connector 550 with the base part 500. The holding arms 507 are shown extended within and holding a portion of the base portion 500 and within an aperture 511 in the base portion 500. The side portions 513 of the gripper arms 507 may include folds 517 to assist the patient in grasping the grasping arms 507 and pushing them slidably together with the connector 550 and the base part 500 for removably attaching the connector 550 with the base part 500. The holding arms 507 can also be flexible so that the patient can press inward on the holding arms 507 to free the arms for holding the base part 500. A portion of the membrane 503 remains exposed on top of the cannula device 501. FIGURE 45 shows the cannula device 501 together with the connector 550 and the tubing 552 and the base part 500. An adhesive layer 510 is also shown to have a cutting portion 515 for cannula 504. FIGURE 46 illustrates cannula device 501 mounted on base part 500 with cannula 504 extending in the direction parallel to the main plane of base part 500. An inserter 560 can be connected to the base part 500 and the cannula device 501. A needle 561 extends from the inserter 560 through the membrane 503 of the cannula device and through the cannula 504. FIGURE 47 illustrates the cannula device 501 shown in FIGURE 46 that can be rotated orthogonally to the direction shown in FIG. FIGURE 46 and mounted on the same base part 500 shown in FIGURE 46. The cannula 504 extends downward from the base portion 500. The inserter 560 is also shown connected to the base portion 500 and the cannula 501 in the orthogonal direction to the shown in FIGURE 46. FIGURE 48 shows the inserter 560. The needle 561 extends from the inserter 560 and the guide arms 563 can extend on both sides of the needle 561 for slidable connection with the guide members of the cannula device. (described and shown in the above) to guide the inserter 560 in position in the cannula device 501. FIGURE 49 shows a modality similar to the embodiment shown in FIGURE 45 having an angled base portion 600. The angled base portion 600 can best be seen in the side view shown in FIGURE 51, where the connector 650 is shown inserted into the base portion 600 at an angle to the main plane of the base portion 618. A cannula device 601 may be mounted to the base portion 600 in several directions including as shown in FIGURE 49 having a cannula 604 which extends from the base portion 600 in a direction generally parallel to the plane 618 of the base portion 600. A connector 650 may be connected to the base portion 600 and the cannula device 601. The connector 650 may include a piercing member 680 that is inserted through the membrane 603 of the cannula device 601 for fluid connection between the tubing 652 and the cannula 604 for delivery of a therapeutic substance to the skin of a patient. The connector 650 may also include gripping arms 607 that extend through an opening 611 in the connector 650 to removably attach the connector 650 to the base portion 600. An adhesive layer 610 is also shown connected to the base portion 600 and the Adhesive layer 610 may include a cutting portion 615 for cannula 604. FIGURE 50 shows a top view of the embodiment shown in FIGURE 49. FIGURE 52 shows cannula device 601 having an angled base portion 600. As described above, the connector 650 can be connected to the base part 600. The connector 650 further includes guide arms to assist in positioning the cannula device 601 in the base 600 (not shown, described in the foregoing, for example, in FIGURE 6). The clamping arms 607 removably engage the base part 600 through the opening 611 in the base part 600. The clamping arms 607 are shown extended in and removably holding with a portion of the base part 600 within the opening 611 in the base portion 600. The side portions 613 of the grasping arms 607 may include folds 617 to assist the patient in securing the grasping arms and removably attaching the connector 650 to the base portion 600. the grasping arms 607 may also be flexible from such that the patient can press inwardly into the holding arms 607 to release the holding arms 607 from the base portion 600. FIGURES 53-57 illustrate perspective views of the cannula device 601 shown in FIGURE 52. FIGS. FIGURES 58-65 illustrate another preferred embodiment of the present invention. In FIGS. 58 and 59, a cannula device 701 is cubically formed and placed on a base portion 700 such that a cannula 704 of the cannula device 701 is orthogonal to essentially a major surface 705 of the base portion 700. As In the foregoing, other forms of the cannula device 701 are possible. The cannula device 701 can receive an inserter needle from an inserter (as described above and was shown, for example, in the FIGURE 4) and a connector 750 having a cannula 751 from a direction that is essentially parallel with the cannula 704. The cannula device 701 includes at least one membrane 703 through which the insertion needle or the piercing member 751 is inserted. FIGURES 58 and 59 illustrate cannula device 701 having two membranes 703, although one skilled in the art will understand that more membranes 703 are possible. A protection member or inserter may also be used with the cannula device 701 and the base portion 700 in place of the connector 750 as described above. Furthermore, FIGS. 58 and 59 show that it is possible for the connector 750 to connect with the base part 700 from a direction that is essentially orthogonal to the direction of the cannula 704 and the piercing member 751 can pierce the membrane 703 from a direction orthogonal to the direction of the connector 750 shown in FIGURE 58. The cannula device 701 is constructed in such a way that the cannula 704 is in fluid communication with the piercing member 751 when received regardless of the direction from which the piercing member 751 it is received. In the embodiment shown in FIGS. 58 and 59, the cannula device includes a cavity 706 similar to the cavity 6 described above for the cannula device 1. Alternatively, the cannula device 701 may not including a cavity 706 in which the piercing member 751 fluidly connects with the cannula 704, similar to receiving the piercing member without having a cavity 706, similar to the device described in the foregoing in FIGURE 4IB. FIGS. 58 and 59 also illustrate an alternative mechanism for removably attaching the connector 750 to the base portion 700. The connector 750 includes holding arms 707 for removably attaching the base portion 700 to the connector 750. The attachment arms 707 also include projections 720 notched to engage the angled projections 722 on the base part 700. The notched projections 720 of the connector 750 slidably engage the angled projections 722 of the base part 700. The projections 720 clasp together with the projections 722 and the projections 720 are adjusted to a slit in the base part 700 for releasably attaching the base part 700 to the connector 750. The base part 700 can be released from the connector 750 by pressing on the projections 720. The connector 750 can also include guide arms 706 for slidably coupling guide members 705 of the cannula device 701. Of course, alternative fastening means can be used to releasably couple the base portion 700 with the connector 751. FIGURES 58-60 illustrate the cannula 704 which is extends essentially perpendicular to the main surface 705 of the base portion 700 such that the cannula 704 penetrates the patient's skin essentially perpendicular to the main surface 705 of the base portion 700. The base portion 700 includes an opening 709 through the which cannula 704 of cannula device 701 can be extended. FIGURE 61 illustrates the cannula 704 extending essentially parallel to the main surface 705 of the base portion 700 through the opening 709 in the base portion 700. FIGURES 62 and 63 illustrate the cannula device 701 prior to connection to the part base 700 where the cannula 704 will extend through the opening 709 essentially parallel to the main surface 705 of the base part 700. FIGURE 64 shows an example of an inner portion 713 of the cannula device 701. In this embodiment, the piercing member 751 will be inserted directly into a channel 715 without having a cavity for fluidly connecting the piercing member 751 to the cannula 704 as described above. The cannula connector 751 can pierce the membranes 703 from any direction shown and enter directly into the channels 715 to connect fluidly with the cannula 704. Although the invention therein has been described in connection with a preferred embodiment thereof, it is It will be appreciated by those skilled in the art that additions, modifications, substitutions and eliminations not specifically described may be made without departing from the spirit and scope of the invention as defined in the appended claims. It is therefore intended that the present detailed description be considered as illustrative rather than limiting, and that it will be understood that the following claims, including all equivalents, are intended to define the spirit and scope of this invention. FIGURE 65 shows a segment of a sphere defined by two planes that intersects the sphere in different segments where the two planes have a line of intersection within the sphere. The shape of this segment is useful as a form of housing of the cannula device. Instead of a segment of a sphere a segment of an ellipsoid defined in the same way could be used ie a segment of an ellipsoid defined by two planes that intersects the ellipsoid in different segments and where the two planes have a line of intersection within of the ellipsoid.

Claims

CLAIMS 1. A cannula device for mounting on a base part for infusion equipment; the cannula device comprises a housing and at least one membrane which together define at least one cavity adapted to receive a piercing member of a connector. The cannula device further comprises a cannula mounted in the housing and in fluid communication with at least one cavity, wherein the device can receive the piercing member of a connector from a first receiving direction and additionally can receive the piercing member of a connector from a second receiving direction that is different from the first direction providing fluid communication between the piercing member of a connector and at least one cavity, the cannula device has means for joining the cannula device to the corresponding means of the base part, the device is characterized in that the housing has a geometry so that the cannula can extend from the base part in more than one direction.
2. The cannula device according to claim 1, characterized in that the cannula device comprises a membrane for each of the receiving directions.
3. The cannula device according to claim 1 or 2, characterized in that the device of cannula comprises two membranes.
The cannula device according to any of the preceding claims, characterized in that the angle between the first and the second direction is at least 45 °, preferably at least 60 °, even more preferably 75 °, and more preferably at least 85 °.
5. The cannula device according to any of the preceding claims, characterized in that the cannula device is adapted to receive the cannula from a further direction.
The cannula device according to any of the preceding claims, characterized in that the angle between the first direction and the additional direction is between 5 ° and 175 °, preferably from 30 ° to 150 °.
7. The cannula device according to any of the preceding claims, characterized in that the membrane is self-sealing.
The cannula device according to claim 7, characterized in that the membrane is made of silicone.
9. The cannula device according to any of the preceding claims, characterized in that the housing of the cannula device comprises guide means.
10. The cannula device according to any of the preceding claims, characterized in that the housing of the cannula device comprises clamping means.
11. The cannula device according to claim 10, characterized in that the means for securing the cannula device further comprises releasing means for decoupling the clamping means.
12. The cannula device according to claim 9, characterized in that the guide means (guide the assembly of the cannula device with the base part) and the coupling with a connector and / or an inserter.
The cannula device according to any of the preceding claims, characterized in that the housing of the cannula device comprises a plurality of wells.
14. The cannula device according to any of the preceding claims, characterized in that the cannula device has a cylindrical shape.
15. The cannula device according to any of the preceding claims, characterized in that the cannula device comprises a cavity which is closed by a membrane
16. A base part wherein a device of cannula for an infusion set is mounted in which the cannula device comprises a housing and at least one membrane which together define at least one cavity adapted to receive a piercing member of a connector, the cannula device further comprises a cannula mounted in the housing and in fluid communication with at least one cavity, wherein the device can receive the piercing member of a connector from a first receiving direction and additionally can receive the piercing member of a connector from a second receiving direction that is different from the first direction providing fluid communication between the piercing member of a connector and at least one cavity, the cannula device has means for attaching the cannula device to the corresponding means of the base part, the device is characterized in that the housing has a geometry so that the cannula can extend from the base part in more than one direction.
17. The base part according to claim 16, characterized in that the cannula device can be attached to the base part at different levels.
18. The base part according to claim 16 or 17, characterized in that the base part has means for joining the cannula device having the central axis of the cannula devices in more than one address to the base part.
19. The base part according to any of claims 16 to 18, characterized in that it comprises guide means adapted to be coupled with the guide means of the cannula device.
20. The base part according to any of claims 16 to 19, characterized in that it comprises fastening means.
21. The base part according to claim 20, characterized in that the clamping means are for clamping the cannula device to the base part.
22. The base part according to claim 20, characterized in that the fastening means are for fastening a connector to the base part.
23. The base part according to any of claims 16 to 22, characterized in that the cannula device can revolve relatively to the rest of the base part.
24. The base part according to claim 23, characterized in that the cannula device is joined to the base part by means of articulations.
25. The infusion set characterized in that it comprises a base part comprising a cannula device according to any of the claims 1 to 15 for insertion into a patient and a connector for connecting the base part with a medical device through a conduit, the connector comprises a piercing member of a connector that is in fluid communication with the tube; the base part optionally comprises a first group of guide means and a first group of fastening means for securing the connector to the base part; the connector optionally comprises a second group of guide means adapted to fit the first group of guide means and a second group of attachment means adapted to engage with the first group of fastening means in a releasable manner.
26. The use of a cannula device according to any of claims 1 to 15 in an infusion set.