MX168098B - ADHESIVE TRANSDERMIC DOSAGE LAYER - Google Patents

ADHESIVE TRANSDERMIC DOSAGE LAYER

Info

Publication number
MX168098B
MX168098B MX206357A MX20635785A MX168098B MX 168098 B MX168098 B MX 168098B MX 206357 A MX206357 A MX 206357A MX 20635785 A MX20635785 A MX 20635785A MX 168098 B MX168098 B MX 168098B
Authority
MX
Mexico
Prior art keywords
pharmaceutically active
component layer
skin
linked
sheet
Prior art date
Application number
MX206357A
Other languages
Spanish (es)
Inventor
Steven Sablotsky
John M Questel
James Thompson
Original Assignee
Key Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Key Pharma filed Critical Key Pharma
Priority to MX206357A priority Critical patent/MX168098B/en
Publication of MX168098B publication Critical patent/MX168098B/en

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  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a un sistema de dosificación transdérmica, adhesivo, de capa doble, para la liberación sostenida de un medicamento farmacéuticamente activo a la piel de un paciente humano, que comprende: (i) una primera capa componente formada de una lámina esencialmente plana que contiene un medicamento farmacéuticamente activo de un adhesivo acrílico, sensible a la presión, al menos parcialmente eslabonado transversalmente, la lámina esencialmente plana comprendiendo un polímero de adrilato eslabonado transversalmente, de auto-sostén, flexible, de sificiente adhesividad, durabilidad y resistencia mediante el cual se mantiene contacto difusional íntimo con la piel del paciente por un período de al menos 24 horas sin destrucción de la integridad física de la lámina, la lámina esencialmente plana siendo capaz de retener ahí disperso suficiente medicamento farmacéuticamente activo para suministrar a la piel una cantidad farmacéuticamente activa del medicamento farmacéuticamente activo en un intervalo de 24 horas, sin disolución del adhesivo acrílico sensible a la presión, al menos parcialmente eslabonado transversalmente, y (ii) una segunda capa componente íntimamente adherida a un lado de la primera capa componente, la segunda capa componente siendo resistente al paso del medicamento farmacéuticamente activo desde la primera capa componente.The present invention relates to a double-layer, adhesive, transdermal dosing system for the sustained release of a pharmaceutically active drug to the skin of a human patient, comprising: (i) a first component layer formed of essentially a sheet flat containing a pharmaceutically active medicament of a pressure-sensitive acrylic adhesive, at least partially cross-linked, the essentially flat sheet comprising a flexible, self-supporting, cross-linked adrylate polymer of sufficient adhesiveness, durability and strength by which maintains intimate diffusion contact with the patient's skin for a period of at least 24 hours without destruction of the physical integrity of the sheet, the essentially flat sheet being able to retain there dispersed enough pharmaceutically active medication to supply the skin with a pharmaceutically active amount of m pharmaceutically active edicament within 24 hours, without dissolution of the pressure sensitive acrylic adhesive, at least partially cross-linked, and (ii) a second component layer closely adhered to one side of the first component layer, the second component layer being resistant to the passage of the pharmaceutically active drug from the first component layer.

MX206357A 1985-08-19 1985-08-19 ADHESIVE TRANSDERMIC DOSAGE LAYER MX168098B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MX206357A MX168098B (en) 1985-08-19 1985-08-19 ADHESIVE TRANSDERMIC DOSAGE LAYER

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MX206357A MX168098B (en) 1985-08-19 1985-08-19 ADHESIVE TRANSDERMIC DOSAGE LAYER

Publications (1)

Publication Number Publication Date
MX168098B true MX168098B (en) 1993-05-03

Family

ID=19749056

Family Applications (1)

Application Number Title Priority Date Filing Date
MX206357A MX168098B (en) 1985-08-19 1985-08-19 ADHESIVE TRANSDERMIC DOSAGE LAYER

Country Status (1)

Country Link
MX (1) MX168098B (en)

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