MEP18608A - Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands - Google Patents
Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligandsInfo
- Publication number
- MEP18608A MEP18608A MEP-186/08A MEP18608A MEP18608A ME P18608 A MEP18608 A ME P18608A ME P18608 A MEP18608 A ME P18608A ME P18608 A MEP18608 A ME P18608A
- Authority
- ME
- Montenegro
- Prior art keywords
- adenosine
- ligands
- aminoquinoline
- aminopyridine derivatives
- branched
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 title 1
- 229960005305 adenosine Drugs 0.000 title 1
- 150000003927 aminopyridines Chemical class 0.000 title 1
- 150000005010 aminoquinolines Chemical class 0.000 title 1
- -1 1,3-butadienyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 102000008161 Adenosine A3 Receptor Human genes 0.000 abstract 1
- 108010060261 Adenosine A3 Receptor Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Jedinjenja opšte formule (I), gdje R4 i R5 označavaju atom vodonika ili zajedno formiraju 1,3-butadienil grupu, opciono supsti tuisanu meti lendioksi grupom ili sa jednom ili više pravolančanih ili razgranati h C1-4 alkil grupa, pravolančanim ili razgranati m C1-4 alkoksi grupama, hidroksi grupom ili atomom halogena; predstavljaju snažne ligande adenozinskog A3 receptora i poželjno su antagonosti.Compounds of the general formula (I), where R4 and R5 represent a hydrogen atom or together form a 1,3-butadienyl group, optionally substituted with a methylenedioxy group or with one or more straight-chain or branched C1-4 alkyl groups, straight-chain or branched m C1 - 4 alkoxy groups, a hydroxy group or a halogen atom; are strong ligands of the adenosine A3 receptor and are preferably antagonists.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0102279A HUP0102279A3 (en) | 2001-05-31 | 2001-05-31 | A3 antagonist amino-quinoline-derivatives, process for their preparation, pharmaceutical compositions containing them and their use |
| HU0200774A HUP0200774A2 (en) | 2002-03-01 | 2002-03-01 | Aminopyridine and aminoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates |
| YUP-950/03A RS95003A (en) | 2001-05-31 | 2002-05-29 | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands |
| PCT/HU2002/000048 WO2002096879A1 (en) | 2001-05-31 | 2002-05-29 | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MEP18608A true MEP18608A (en) | 2010-10-10 |
Family
ID=89575036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-186/08A MEP18608A (en) | 2001-05-31 | 2002-05-29 | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands |
Country Status (1)
| Country | Link |
|---|---|
| ME (1) | MEP18608A (en) |
-
2002
- 2002-05-29 ME MEP-186/08A patent/MEP18608A/en unknown
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