HUP0200774A2 - Aminopyridine and aminoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates - Google Patents

Aminopyridine and aminoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates

Info

Publication number
HUP0200774A2
HUP0200774A2 HU0200774A HUP0200774A HUP0200774A2 HU P0200774 A2 HUP0200774 A2 HU P0200774A2 HU 0200774 A HU0200774 A HU 0200774A HU P0200774 A HUP0200774 A HU P0200774A HU P0200774 A2 HUP0200774 A2 HU P0200774A2
Authority
HU
Hungary
Prior art keywords
alkyl
halo
alkoxy
optionally substituted
aminoquinoline
Prior art date
Application number
HU0200774A
Other languages
Hungarian (hu)
Inventor
Péter Arányi
László Balázs
Mária Balogh
Imre Bata
Sándor Bátori
NAGY Lajos T.
Géza Tímári
Kinga Boér
Olivier Finance
Zoltán Kapui
Endre Mikus
Zsuzsanna Szamosvölgyi
Gábor Szeleczky
Katalin Urbán-Szabó
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Priority to HU0200774A priority Critical patent/HUP0200774A2/en
Priority to TW091110975A priority patent/TWI328581B/en
Priority to NZ529966A priority patent/NZ529966A/en
Priority to EP02732985A priority patent/EP1390349B1/en
Priority to AU2002304358A priority patent/AU2002304358B2/en
Priority to BR0209719-2A priority patent/BR0209719A/en
Priority to MXPA03010870A priority patent/MXPA03010870A/en
Priority to PCT/HU2002/000048 priority patent/WO2002096879A1/en
Priority to KR1020037015646A priority patent/KR100745307B1/en
Priority to EA200301317A priority patent/EA006854B1/en
Priority to US10/478,721 priority patent/US6969723B2/en
Priority to YUP-950/03A priority patent/RS95003A/en
Priority to RU2003137836/04A priority patent/RU2278112C2/en
Priority to PL02366516A priority patent/PL366516A1/en
Priority to CA2448561A priority patent/CA2448561C/en
Priority to CZ20033510A priority patent/CZ20033510A3/en
Priority to SK1414-2003A priority patent/SK14142003A3/en
Priority to CNB02810840XA priority patent/CN1257160C/en
Priority to EEP200300574A priority patent/EE05304B1/en
Priority to JP2003500059A priority patent/JP4409935B2/en
Priority to MEP-186/08A priority patent/MEP18608A/en
Priority to IL15885402A priority patent/IL158854A0/en
Publication of HUP0200774D0 publication Critical patent/HUP0200774D0/hu
Priority to ARP020102036A priority patent/AR036074A1/en
Priority to TNPCT/HU2002/000048A priority patent/TNSN03117A1/en
Priority to MA27388A priority patent/MA26236A1/en
Priority to IS7052A priority patent/IS2773B/en
Priority to NO20035300A priority patent/NO327710B1/en
Priority to CO03107462A priority patent/CO5550457A2/en
Priority to BG108477A priority patent/BG108477A/en
Priority to HRP20031091AA priority patent/HRP20031091B1/en
Publication of HUP0200774A2 publication Critical patent/HUP0200774A2/en

Links

Abstract

Aminoquinoline and aminopyridine derivatives (I) are new. Aminoquinoline and aminopyridine derivatives of formula (I), their optically active isomers, salts and solvates are new. [Image] R 1>, R 2>H or 1-4C alkyl; R 3>phenyl, thienyl, furyl (all optionally substituted by at least one 1-4C alkyl, 1-4C alkoxy or halo), 5-6 membered heteroaromatic ring (optionally substituted by 1-4C alkyl, 1-4C alkoxy or halo and containing either 1-3 N, N or S, or N or O atoms), H or R 1>; R 4>, R 5>H; or R 4>+R 5>1,3-butadienyl group optionally substituted by methylenedioxy, 1-4C alkyl, 1-4C alkoxy, halo or OH; R 6>H, CN, aminocarbonyl, 1-4C alkoxycarbonyl or carboxy; R 7>phenyl, benzyl, thienyl, furyl (all optionally substituted by at least one 1-4C alkyl, 1-4C alkoxy, halo, methylenedioxy, OH, CF 3 or CN), 5-6 membered heteroaromatic ring (optionally substituted by 1-4C alkyl, 1-4C alkoxy or halo and containing either 1-3 N, N or S, or N or O atoms) or H; X : -CH 2, -NH, -NR 8>, S, O, sulfo or sulfoxy group; R 8>1-4C alkyl or 3-6C cycloalkyl; and n : 0-2. Independent claims are also included for: (1) preparation of (I); and (2) intermediate compounds of formula (II)-(IV) (structures not given in the specification. ACTIVITY : Antiinflammatory; Antiallergic; Hypotensive; Dermatological; Antiarthritic; Immunosuppressive; Antipsoriatic; Ophthalmological; Antidiabetic; Antirheumatic; Vasotropic; Antiarrhythmic; Antiasthmatic; Cardiant; Nephrotropic; Antitumor. MECHANISM OF ACTION : Adenosine A3 Antagonist In tests, compounds (I) displayed K i values of 0.14-0.15 nM. No specific data given.
HU0200774A 2001-05-31 2002-03-01 Aminopyridine and aminoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates HUP0200774A2 (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
HU0200774A HUP0200774A2 (en) 2002-03-01 2002-03-01 Aminopyridine and aminoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates
TW091110975A TWI328581B (en) 2002-03-01 2002-05-24 New compounds
CZ20033510A CZ20033510A3 (en) 2001-05-31 2002-05-29 Aminoquinoline and aminopyridine derivatives and their use as adenosine A3 ligands
CNB02810840XA CN1257160C (en) 2001-05-31 2002-05-29 Aimoquinoline and aminopyridine derivatives and their use as adenosine A3 ligands
EP02732985A EP1390349B1 (en) 2001-05-31 2002-05-29 Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands
BR0209719-2A BR0209719A (en) 2001-05-31 2002-05-29 Aminoquinoline and aminopyridine derivatives and their use as a3 adenosine ligands
MXPA03010870A MXPA03010870A (en) 2001-05-31 2002-05-29 Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands.
PCT/HU2002/000048 WO2002096879A1 (en) 2001-05-31 2002-05-29 Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands
KR1020037015646A KR100745307B1 (en) 2001-05-31 2002-05-29 Aminoquinoline derivatives and their use as adenosine a3 ligands
EA200301317A EA006854B1 (en) 2001-05-31 2002-05-29 Aminoquinoline derivatives and their use as adenosine as ligands
US10/478,721 US6969723B2 (en) 2001-05-31 2002-05-29 Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands
YUP-950/03A RS95003A (en) 2001-05-31 2002-05-29 Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands
RU2003137836/04A RU2278112C2 (en) 2001-05-31 2002-05-29 Derivatives of aminoquinoline and aminopyridine and their using as adenosine ligands a3
PL02366516A PL366516A1 (en) 2001-05-31 2002-05-29 Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands
CA2448561A CA2448561C (en) 2001-05-31 2002-05-29 Aminoquinoline derivatives and their use as adenosine a3 ligands
NZ529966A NZ529966A (en) 2001-05-31 2002-05-29 Aminoquinoline and aminopyridine derivatives and their use as adenosine A3 ligands
SK1414-2003A SK14142003A3 (en) 2001-05-31 2002-05-29 Aminoquinoline and aminopyridine derivatives and their use as adenosine A3 ligands
AU2002304358A AU2002304358B2 (en) 2001-05-31 2002-05-29 Aminoquinoline and aminopyridine derivatives and their use as adenosine A3 ligands
EEP200300574A EE05304B1 (en) 2001-05-31 2002-05-29 Aminoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and their use as adenosine A3 receptor ligands
JP2003500059A JP4409935B2 (en) 2001-05-31 2002-05-29 Aminoquinoline and aminopyridine derivatives and their use as adenosine A3 ligands
MEP-186/08A MEP18608A (en) 2001-05-31 2002-05-29 Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands
IL15885402A IL158854A0 (en) 2001-05-31 2002-05-29 Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands
ARP020102036A AR036074A1 (en) 2001-05-31 2002-05-31 DERIVATIVES OF AMINOQUINOLINE, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, THE USE OF THE SAME FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION, A PROCEDURE FOR THEIR PREPARATION AND THE INTERMEDIARIES USED IN SUCH PREPARATION PROCEDURE
TNPCT/HU2002/000048A TNSN03117A1 (en) 2001-05-31 2003-07-08 Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands
MA27388A MA26236A1 (en) 2001-05-31 2003-11-10 AMINOQUINOLINE AND AMINOPYRRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS
IS7052A IS2773B (en) 2001-05-31 2003-11-26 Aminoquinoline derivatives and their use as adenosine A3 ligands
NO20035300A NO327710B1 (en) 2001-05-31 2003-11-28 Aminoquinoline derivatives and their use as adenosine A <N> 3 </N> ligands
CO03107462A CO5550457A2 (en) 2001-05-31 2003-12-05 AMINOQUINOLINE DERIVATIVES
BG108477A BG108477A (en) 2001-05-31 2003-12-19 Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands
HRP20031091AA HRP20031091B1 (en) 2001-05-31 2003-12-29 Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0200774A HUP0200774A2 (en) 2002-03-01 2002-03-01 Aminopyridine and aminoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates

Publications (2)

Publication Number Publication Date
HUP0200774D0 HUP0200774D0 (en) 2002-05-29
HUP0200774A2 true HUP0200774A2 (en) 2005-10-28

Family

ID=89575035

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0200774A HUP0200774A2 (en) 2001-05-31 2002-03-01 Aminopyridine and aminoquinoline derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates

Country Status (2)

Country Link
HU (1) HUP0200774A2 (en)
TW (1) TWI328581B (en)

Also Published As

Publication number Publication date
HUP0200774D0 (en) 2002-05-29
TWI328581B (en) 2010-08-11

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Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished