MD57C2 - Process for obtaining compound ethers of the 5-chlor-3-chlorsukphonyl-2-thiophencarbonic acid. - Google Patents
Process for obtaining compound ethers of the 5-chlor-3-chlorsukphonyl-2-thiophencarbonic acid.Info
- Publication number
- MD57C2 MD57C2 MD94-0070A MD940070A MD57C2 MD 57 C2 MD57 C2 MD 57C2 MD 940070 A MD940070 A MD 940070A MD 57 C2 MD57 C2 MD 57C2
- Authority
- MD
- Moldova
- Prior art keywords
- iron
- chlor
- mol
- ether
- dissolvant
- Prior art date
Links
Abstract
The invention relates to the thiophenocarbonic acids derivatives, as well as to the obtaining of C1-C4-alkyl ethers of the 5-chlor-3-chlorsukphonyl-2-thiophencarbonic acid - semiproducts for medicinal remedies synthesis. The purpose consists in increasing the efficiency of the product having a special destination and simplification of the process. It is realized by chlorization in the 5 position of the corresponding ether of the indicated acid by means of chlor (which is directed in the amount of 5-50 g/hour to the initial mol (of ether) into the dissolvant medium), CH2Cl2, CHCl3, CCl4 or their mixture iron presence. The latter is obtained by treatment of metallic iron chlor (the iron amount 1-10 mol to mol of initial ether) in 0,5-5,0 l of dissolvant CHCl3, CCl4, CH2Cl2 or their mixture (the amount of chlor being 100-1500 g to iron mol) during 1-5 hours at 10-40°C or by holding the iron during 12-48 hours at 0-50°C in the chromium medium.Besides it is better to effectuate the iron intensification in the dissolvant suspension with gaseons chlor with the ratio evidence of one of the initial ether mols and suspension of 0,2-0,4 iron mol in 1-3 l of CH2Cl2, CHCl3, CCl4 or their mixture with passage of 200-300 g of chlor to the iron mol during 2-3 hours. The chlorization of the ether is realized till the formation of a monochloric compound with the concentration of 50-70% controlling the process by gaseous chromatography. The obtained product contains a monochloric compound having a concentration of 04,6%.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0112388A AT390060B (en) | 1988-05-02 | 1988-05-02 | METHOD FOR PRODUCING 5-CHLORINE-3CHLORESULFONYL-2-THIOPHENICARBONIC ACID ESTERS |
| SU894613917A SU1704632A3 (en) | 1988-05-02 | 1989-04-25 | Method for preparation of esters of 5-chloro-3-chlorosulphonyl-2-thiophene carboxylic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD57B1 MD57B1 (en) | 1994-08-31 |
| MD57C2 true MD57C2 (en) | 1995-03-31 |
Family
ID=25594965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0070A MD57C2 (en) | 1988-05-02 | 1994-03-25 | Process for obtaining compound ethers of the 5-chlor-3-chlorsukphonyl-2-thiophencarbonic acid. |
Country Status (3)
| Country | Link |
|---|---|
| LT (1) | LT2533B (en) |
| LV (1) | LV5702A3 (en) |
| MD (1) | MD57C2 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2159156A (en) * | 1984-05-24 | 1985-11-27 | Du Pont | Process for the preparation of alkyl 3-chlorosulfonylthiophene-2-carboxylate |
-
1993
- 1993-09-28 LT LTRP1204A patent/LT2533B/en not_active IP Right Cessation
- 1993-11-12 LV LV931216A patent/LV5702A3/en unknown
-
1994
- 1994-03-25 MD MD94-0070A patent/MD57C2/en active IP Right Grant
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2159156A (en) * | 1984-05-24 | 1985-11-27 | Du Pont | Process for the preparation of alkyl 3-chlorosulfonylthiophene-2-carboxylate |
Also Published As
| Publication number | Publication date |
|---|---|
| LV5702A3 (en) | 1995-02-20 |
| MD57B1 (en) | 1994-08-31 |
| LT2533B (en) | 1994-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20090324 |
|
| MK4A | Patent for invention expired |