MD503C2 - Pentapeptyd derivatives - Google Patents
Pentapeptyd derivativesInfo
- Publication number
- MD503C2 MD503C2 MD95-0391A MD950391A MD503C2 MD 503 C2 MD503 C2 MD 503C2 MD 950391 A MD950391 A MD 950391A MD 503 C2 MD503 C2 MD 503C2
- Authority
- MD
- Moldova
- Prior art keywords
- derivatives
- pentapeptyd
- dna synthesis
- independently
- under
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K7/067—Hemoregulatory peptides based on sequence Glp-Glu-Asp-Cys-Lys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The present invention relates to the pentapeptyd derivatives and particularly to the pentapeptidic compounds which manifest suppressive influence upon the DNA synthesis and mythotic rate under the liver regeneration, and also upon the DNA synthesis and hepatoma malignant cells line growth in vitro and in vivo. Peptapeptyd derivatives of general formula I:where X1, X2 and X3 represents independently one from another OH or NH2 under the condition that X2 and X3 both are not NH2; or X1 is OH, X2 is NH2 and X3 is OH; or X1, X2 and X3 each reprezents independently OH.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO884054A NO884054D0 (en) | 1988-09-13 | 1988-09-13 | NEW PENTAPEPTIME AND PROCEDURE FOR PREPARING THEREOF. |
| PCT/NO1989/000093 WO1990002754A1 (en) | 1988-09-13 | 1989-09-12 | New pentapeptide and a process for the preparation thereof |
| SU914895028A RU2010799C1 (en) | 1988-09-13 | 1991-03-12 | Derivatives of pentapeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD503B1 MD503B1 (en) | 1996-03-29 |
| MD503C2 true MD503C2 (en) | 1996-07-31 |
Family
ID=19891239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD95-0391A MD503C2 (en) | 1988-09-13 | 1994-12-29 | Pentapeptyd derivatives |
Country Status (19)
| Country | Link |
|---|---|
| EP (2) | EP0434722A1 (en) |
| JP (1) | JPH04501710A (en) |
| KR (1) | KR900701830A (en) |
| CN (1) | CN1041158A (en) |
| AT (1) | ATE102215T1 (en) |
| AU (1) | AU623687B2 (en) |
| DE (1) | DE68913411T2 (en) |
| DK (1) | DK43891A (en) |
| ES (1) | ES2062024T3 (en) |
| FI (1) | FI911219A0 (en) |
| HU (2) | HU206373B (en) |
| LV (1) | LV10289B (en) |
| MD (1) | MD503C2 (en) |
| MY (1) | MY104912A (en) |
| NO (2) | NO884054D0 (en) |
| NZ (1) | NZ230625A (en) |
| RU (1) | RU2010799C1 (en) |
| WO (1) | WO1990002754A1 (en) |
| ZA (1) | ZA896944B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5620957A (en) * | 1989-07-14 | 1997-04-15 | Smithkline Beecham Corporation | Hemoregulatory peptides |
| TW222280B (en) * | 1991-11-26 | 1994-04-11 | Smithkline Beecham Corp | |
| IL104323A0 (en) * | 1992-01-10 | 1993-05-13 | Smithkline Beecham Corp | Hemoregulatory peptides |
| RU2297239C1 (en) * | 2006-05-30 | 2007-04-20 | Общество С Ограниченной Ответственностью "Сиа Пептайдс" | Peptide stimulating regeneration of liver tissue, pharmaceutical composition based on thereof and method for its using |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2591748A (en) | 1949-12-23 | 1952-04-08 | Hercules Powder Co Ltd | Amphoteric cellulose derivatives |
| FR2110268B1 (en) | 1970-10-07 | 1976-06-04 | Minnesota Mining & Mfg | |
| US4237253A (en) | 1977-04-21 | 1980-12-02 | L'oreal | Copolymers, their process of preparation, and cosmetic compounds containing them |
| NO860752L (en) * | 1985-06-26 | 1986-12-29 | Bio Tech As | PENTAPEPTIDES WITH CELL GROWTH REGULATORY EFFECTS AND PROCEDURES FOR PRODUCING THEREOF. |
| GB8626539D0 (en) * | 1986-11-06 | 1986-12-10 | Nycomed As | Peptide compounds |
-
1988
- 1988-09-13 NO NO884054A patent/NO884054D0/en unknown
-
1989
- 1989-09-11 CN CN89107061A patent/CN1041158A/en active Pending
- 1989-09-12 AU AU42240/89A patent/AU623687B2/en not_active Ceased
- 1989-09-12 WO PCT/NO1989/000093 patent/WO1990002754A1/en active Application Filing
- 1989-09-12 HU HU9057Q patent/HU206373B/en not_active IP Right Cessation
- 1989-09-12 ES ES89309237T patent/ES2062024T3/en not_active Expired - Lifetime
- 1989-09-12 NZ NZ230625A patent/NZ230625A/en unknown
- 1989-09-12 AT AT89309237T patent/ATE102215T1/en not_active IP Right Cessation
- 1989-09-12 JP JP1509645A patent/JPH04501710A/en active Pending
- 1989-09-12 HU HU895790A patent/HU895790D0/en unknown
- 1989-09-12 MY MYPI89001244A patent/MY104912A/en unknown
- 1989-09-12 KR KR1019900700995A patent/KR900701830A/en not_active Application Discontinuation
- 1989-09-12 EP EP89910214A patent/EP0434722A1/en active Pending
- 1989-09-12 EP EP89309237A patent/EP0360481B1/en not_active Expired - Lifetime
- 1989-09-12 ZA ZA896944A patent/ZA896944B/en unknown
- 1989-09-12 DE DE68913411T patent/DE68913411T2/en not_active Expired - Fee Related
-
1991
- 1991-03-08 NO NO910933A patent/NO910933D0/en unknown
- 1991-03-12 DK DK043891A patent/DK43891A/en not_active Application Discontinuation
- 1991-03-12 RU SU914895028A patent/RU2010799C1/en active
- 1991-03-12 FI FI911219A patent/FI911219A0/en not_active Application Discontinuation
-
1993
- 1993-06-15 LV LVP-93-590A patent/LV10289B/en unknown
-
1994
- 1994-12-29 MD MD95-0391A patent/MD503C2/en active IP Right Grant
Non-Patent Citations (2)
| Title |
|---|
| Brevet nr.WO 87/00180, Int. Cl. C 07 K 7/06, 1987. * |
| Ян Эрик Паульсен, Карл-Л. Рейхельт, Анна К. Петерсен, Purification and characterization of a growth inhibitory hepatic peptide, apreliminary note, Virehows Arch B. 54, 152-154, 1987. * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR900701830A (en) | 1990-12-04 |
| LV10289A (en) | 1994-10-20 |
| NZ230625A (en) | 1991-06-25 |
| ES2062024T3 (en) | 1994-12-16 |
| CN1041158A (en) | 1990-04-11 |
| EP0434722A1 (en) | 1991-07-03 |
| EP0360481A1 (en) | 1990-03-28 |
| FI911219A0 (en) | 1991-03-12 |
| DK43891D0 (en) | 1991-03-12 |
| JPH04501710A (en) | 1992-03-26 |
| LV10289B (en) | 1995-04-20 |
| HU895790D0 (en) | 1991-11-28 |
| ZA896944B (en) | 1990-06-27 |
| MY104912A (en) | 1994-06-30 |
| WO1990002754A1 (en) | 1990-03-22 |
| EP0360481B1 (en) | 1994-03-02 |
| DE68913411T2 (en) | 1994-06-23 |
| AU623687B2 (en) | 1992-05-21 |
| RU2010799C1 (en) | 1994-04-15 |
| DK43891A (en) | 1991-03-12 |
| HUT58766A (en) | 1992-03-30 |
| ATE102215T1 (en) | 1994-03-15 |
| NO884054D0 (en) | 1988-09-13 |
| HU206373B (en) | 1992-10-28 |
| DE68913411D1 (en) | 1994-04-07 |
| NO910933L (en) | 1991-03-08 |
| NO910933D0 (en) | 1991-03-08 |
| AU4224089A (en) | 1990-04-02 |
| MD503B1 (en) | 1996-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20110312 |