MD4886C1 - (m2-Бромо)-{m2-2,2'-[(5-трет-бутил-2-оксидо-1,3-фенилен)диметанилиден]бис(N-метилгидразин-1-карботиоамидо)}-ди-медь(II), проявляющий противогрибковую активность в отношении Candida albicans - Google Patents
(m2-Бромо)-{m2-2,2'-[(5-трет-бутил-2-оксидо-1,3-фенилен)диметанилиден]бис(N-метилгидразин-1-карботиоамидо)}-ди-медь(II), проявляющий противогрибковую активность в отношении Candida albicans Download PDFInfo
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- MD4886C1 MD4886C1 MDA20220041A MD20220041A MD4886C1 MD 4886 C1 MD4886 C1 MD 4886C1 MD A20220041 A MDA20220041 A MD A20220041A MD 20220041 A MD20220041 A MD 20220041A MD 4886 C1 MD4886 C1 MD 4886C1
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- Moldova
- Prior art keywords
- bis
- tert
- copper
- butyl
- methylhydrazine
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- -1 5-tert-butyl-2-oxido-1,3-phenylene Chemical group 0.000 title claims abstract description 26
- 241000222122 Candida albicans Species 0.000 title claims abstract description 15
- 230000000843 anti-fungal effect Effects 0.000 title claims abstract description 8
- 229940095731 candida albicans Drugs 0.000 title claims description 6
- 230000001747 exhibiting effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 19
- 239000003814 drug Substances 0.000 abstract description 10
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract description 3
- 208000031888 Mycoses Diseases 0.000 abstract description 3
- 239000002184 metal Substances 0.000 abstract description 3
- 229910052751 metal Inorganic materials 0.000 abstract description 3
- 238000011282 treatment Methods 0.000 abstract description 3
- 241000233866 Fungi Species 0.000 abstract description 2
- 229910052802 copper Inorganic materials 0.000 abstract description 2
- 239000010949 copper Substances 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract 1
- QTMDXZNDVAMKGV-UHFFFAOYSA-L copper(ii) bromide Chemical compound [Cu+2].[Br-].[Br-] QTMDXZNDVAMKGV-UHFFFAOYSA-L 0.000 description 8
- 230000001857 anti-mycotic effect Effects 0.000 description 7
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 6
- 229960004884 fluconazole Drugs 0.000 description 6
- PTVZQOAHCSKAAS-UHFFFAOYSA-N 4-methyl-3-thiosemicarbazide Chemical compound CNC(=S)NN PTVZQOAHCSKAAS-UHFFFAOYSA-N 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- WQNTWZJPCLUXQC-UHFFFAOYSA-N 5-tert-butyl-2-hydroxybenzene-1,3-dicarbaldehyde Chemical compound CC(C)(C)C1=CC(C=O)=C(O)C(C=O)=C1 WQNTWZJPCLUXQC-UHFFFAOYSA-N 0.000 description 4
- 229910021590 Copper(II) bromide Inorganic materials 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 238000011321 prophylaxis Methods 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 238000003775 Density Functional Theory Methods 0.000 description 1
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010022678 Intestinal infections Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 229920002535 Polyethylene Glycol 1500 Polymers 0.000 description 1
- 229920002571 Polyethylene Glycol 4500 Polymers 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001032 anti-candidal effect Effects 0.000 description 1
- 239000002543 antimycotic Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 150000003851 azoles Chemical class 0.000 description 1
- 238000012925 biological evaluation Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 238000000126 in silico method Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 238000001254 matrix assisted laser desorption--ionisation time-of-flight mass spectrum Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000013110 organic ligand Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- OIASAVWSBWJWBR-UKTHLTGXSA-N trans-2-[3-(4-tert-butylphenyl)-2-methyl-2-propenylidene]malononitrile Chemical compound N#CC(C#N)=CC(/C)=C/C1=CC=C(C(C)(C)C)C=C1 OIASAVWSBWJWBR-UKTHLTGXSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Изобретение относится к химии и медицине, в частности к биологически активному биядерному координационному соединению меди, класса бис-тиосемикарбазонатов металлов, которое может найти применение в медицине и ветеринарии для профилактики и лечения микозов. Согласно изобретению, заявляется координационное соединение (µ2-бромо)-{µ2-2,2'-[(5-трет-бутил-2-оксидо-1,3-фенилен)диметанилиден]бис(N-метилгидразин-1-карботиоамидо)}-ди-медь(II)формулы: Упомянутое координационное соединение проявляет высокую противогрибковую активность в отношении грибов вида Candida albicans.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20220041A MD4886C1 (ru) | 2022-09-14 | 2022-09-14 | (m2-Бромо)-{m2-2,2'-[(5-трет-бутил-2-оксидо-1,3-фенилен)диметанилиден]бис(N-метилгидразин-1-карботиоамидо)}-ди-медь(II), проявляющий противогрибковую активность в отношении Candida albicans |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20220041A MD4886C1 (ru) | 2022-09-14 | 2022-09-14 | (m2-Бромо)-{m2-2,2'-[(5-трет-бутил-2-оксидо-1,3-фенилен)диметанилиден]бис(N-метилгидразин-1-карботиоамидо)}-ди-медь(II), проявляющий противогрибковую активность в отношении Candida albicans |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD4886B1 MD4886B1 (ru) | 2024-02-29 |
| MD4886C1 true MD4886C1 (ru) | 2024-09-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20220041A MD4886C1 (ru) | 2022-09-14 | 2022-09-14 | (m2-Бромо)-{m2-2,2'-[(5-трет-бутил-2-оксидо-1,3-фенилен)диметанилиден]бис(N-метилгидразин-1-карботиоамидо)}-ди-медь(II), проявляющий противогрибковую активность в отношении Candida albicans |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD4886C1 (ru) |
-
2022
- 2022-09-14 MD MDA20220041A patent/MD4886C1/ru active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| MD4886B1 (ru) | 2024-02-29 |
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