MD4485B1 - Procedeu de obţinere a 9-butilamino-3,3-dimetil-3,4-dihidroacridin-1(2H)-onei clorhidrat - Google Patents
Procedeu de obţinere a 9-butilamino-3,3-dimetil-3,4-dihidroacridin-1(2H)-onei clorhidrat Download PDFInfo
- Publication number
- MD4485B1 MD4485B1 MDA20150115A MD20150115A MD4485B1 MD 4485 B1 MD4485 B1 MD 4485B1 MD A20150115 A MDA20150115 A MD A20150115A MD 20150115 A MD20150115 A MD 20150115A MD 4485 B1 MD4485 B1 MD 4485B1
- Authority
- MD
- Moldova
- Prior art keywords
- dimethyl
- dihydroacridine
- producing
- hydrochloride
- butylamino
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- JCJITGOVWIQPIC-UHFFFAOYSA-N 9-(butylamino)-3,3-dimethyl-2,4-dihydroacridin-1-one;hydrochloride Chemical compound Cl.C1=CC=C2C(NCCCC)=C(C(=O)CC(C)(C)C3)C3=NC2=C1 JCJITGOVWIQPIC-UHFFFAOYSA-N 0.000 title abstract 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 2
- -1 2-[(5,5-dimethyl-3-oxacyclohex-1-enyl)amino]benzonitrile hydrochloride Chemical class 0.000 abstract 1
- 150000005027 9-aminoacridines Chemical class 0.000 abstract 1
- 150000004996 alkyl benzenes Chemical class 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- BADXJIPKFRBFOT-UHFFFAOYSA-N dimedone Chemical compound CC1(C)CC(=O)CC(=O)C1 BADXJIPKFRBFOT-UHFFFAOYSA-N 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Invenţia se referă la industria chimico-farmaceutică, şi anume la un procedeu de obţinere a unui derivat al 9-aminoacridinei, mai exact a 9-butilamino-3,3-dimetil-3,4-dihidroacridin-1(2H)-onei clorhidrat.Procedeul, conform invenţiei, include etapele de interacţiune a nitrilului acidului antranilic cu dimedona, ciclizare a 2-[(5,5-dimetil-3-oxaciclohex-1-enil)amino]benzonitrilului clorhidrat substituit obţinut şi alchilare a 9-amino-3,3-dimetil-3,4-dihidroacridin-1(H)-onei. Procedeul de obţinere a compuşilor intermediari este realizat în mediu de alchilbenzeni.Procedeul permite obţinerea produsului cu un randament înalt.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2014150132/04A RU2567388C1 (ru) | 2014-12-10 | 2014-12-10 | Способ получения 9-бутиламино-3,3-диметил-3,4-дигидроакридин-1(2н)-она гидрохлорида |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD20150115A0 MD20150115A0 (ro) | 2016-02-29 |
| MD4485B1 true MD4485B1 (ro) | 2017-05-31 |
| MD4485C1 MD4485C1 (ro) | 2017-12-31 |
Family
ID=54537009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20150115A MD4485C1 (ro) | 2014-12-10 | 2015-11-16 | Procedeu de obţinere a 9-butilamino-3,3-dimetil-3,4-dihidroacridin-1(2H)-onei clorhidrat |
Country Status (3)
| Country | Link |
|---|---|
| EA (1) | EA201501038A1 (ro) |
| MD (1) | MD4485C1 (ro) |
| RU (1) | RU2567388C1 (ro) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE63903T1 (de) * | 1984-10-25 | 1991-06-15 | Hoechst Roussel Pharma | 9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel. |
| US4695573A (en) * | 1984-10-25 | 1987-09-22 | Hoechst-Roussel Pharmaceuticals Inc. | 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds |
| DK569087A (da) * | 1986-10-31 | 1988-05-01 | Sumitomo Pharma | Quinolin-derivater, deres fremstilling og anvendelse |
| FI91401C (fi) * | 1987-03-17 | 1994-06-27 | Hoechst Roussel Pharma | Menetelmä terapeuttisesti aktiivisten substituoitujen 9-aminotetrahydroakriinien ja niille läheisten yhdisteiden valmistamiseksi |
| GB8827704D0 (en) * | 1988-11-28 | 1988-12-29 | Fujisawa Pharmaceutical Co | New acridine derivatives & processes for their production |
| US5053513A (en) * | 1990-03-29 | 1991-10-01 | Hoechst-Roussel Pharmaceuticals Incorporated | Method of reducing a carbonyl containing acridine |
| RU2017730C1 (ru) * | 1990-09-17 | 1994-08-15 | Химический факультет МГУ им.М.В.Ломоносова | Способ получения 6-нитро-9-амино-2-этоксиакридина |
| RU2024509C1 (ru) * | 1991-05-07 | 1994-12-15 | Всероссийский научный центр по безопасности биологически активных веществ | Производные 9-аминоакридина или их соли с органическими или неорганическими кислотами, проявляющие психотропную, антиамнестическую и липидрегулирующую активность |
-
2014
- 2014-12-10 RU RU2014150132/04A patent/RU2567388C1/ru not_active IP Right Cessation
-
2015
- 2015-11-16 MD MDA20150115A patent/MD4485C1/ro not_active IP Right Cessation
- 2015-11-19 EA EA201501038A patent/EA201501038A1/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2567388C1 (ru) | 2015-11-10 |
| EA201501038A1 (ru) | 2016-06-30 |
| MD4485C1 (ro) | 2017-12-31 |
| MD20150115A0 (ro) | 2016-02-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB2558335B (en) | Novel processes for the production of oligonucleotides | |
| TW201613886A (en) | 3-amino-1,5,6,7-tetrahydro-4h-indol-4-ones | |
| GB2550003B (en) | Process for the production of formaldehyde-stabilised urea | |
| SG11201702657RA (en) | Process for the production of high value chemicals from biologically produced materials | |
| PL3221264T3 (pl) | Proces i aparatura do produkcji kalcynowanych związków do wytwarzania produktów kalcynowanych | |
| ZA201901641B (en) | Process for the production of glycolic acid | |
| HUE059279T2 (hu) | Eljárás alkének elõállítására és azok felhasználása 1,3-butadién elõállításához | |
| ZA201707822B (en) | Process for the biological production of methacrylic acid and derivatives thereof | |
| ZA201902125B (en) | Process for the production of 2-alkylalkanol | |
| HUE061332T2 (hu) | Eljárás aminobenzoesav vagy aminobenzoesav-származék elõállítására | |
| PL3606871T3 (pl) | Sposób wytwarzania mocznika stabilizowanego formaldehydem | |
| SG11201608513WA (en) | Novel purification process of gonadotropin | |
| EP3447042A4 (en) | PRODUCTION PROCESS OF 1,2-DICHLOROHEXAFLUORCYCLOPENTEN | |
| GB201621609D0 (en) | Process for the production of commercial grade silicon | |
| PL3355870T3 (pl) | Sposób wytwarzania kompresowanych tabletek | |
| SG10201914018UA (en) | Process of omega-hydroxyl fatty acid production | |
| IT201600130642A1 (it) | Processo per la produzione di 2(3 alchilmorfolino)-etan-1-olo | |
| HUE060286T2 (hu) | Eljárás kémiai termékek elõállítására az eljárás megszakítása mellett | |
| MX381604B (es) | Proceso para preparar de temozolomida y un intermediario. | |
| MD4485B1 (ro) | Procedeu de obţinere a 9-butilamino-3,3-dimetil-3,4-dihidroacridin-1(2H)-onei clorhidrat | |
| ZA201807761B (en) | Amide derivatives of polycaffeoylquinic acids, process for producing same and uses thereof | |
| MX2019003255A (es) | Proceso para la preparacion de 3-fluoroalquil-5-pirazolcarboxilato s y acidos 3-fluoroalquil-5-pirazolcarboxilicos. | |
| MX2016012936A (es) | Proceso para la preparacion de n-[3-(bencilcarbamoil)fenil]-1h-pir azol-5-carboxamidas. | |
| LT3250555T (lt) | Kondensuotų imidazolo darinių gamybos būdas | |
| PT3371277T (pt) | Método para produzir um gás sintético. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |