MD369Z - Metodă de pronostic al riscului de recidivare sau malignizare a procesului precanceros al colului uterin - Google Patents

Metodă de pronostic al riscului de recidivare sau malignizare a procesului precanceros al colului uterin

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Publication number
MD369Z
MD369Z MDS20110007A MDS20110007A MD369Z MD 369 Z MD369 Z MD 369Z MD S20110007 A MDS20110007 A MD S20110007A MD S20110007 A MDS20110007 A MD S20110007A MD 369 Z MD369 Z MD 369Z
Authority
MD
Moldova
Prior art keywords
malignization
recurrence
risk
uterus
neck
Prior art date
Application number
MDS20110007A
Other languages
English (en)
Russian (ru)
Inventor
Лилиан ШАРТЕФРАЦЬ
Анатол ЧЕРНЫЙ
Виталие МАЗУРУ
Валериу ДАВИД
Лилиан ГУЦУ
Корина КАРДАНЮК
Еуджен АНКУЦА
Кодрина АНКУЦА
Original Assignee
Лилиан ШАРТЕФРАЦЬ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лилиан ШАРТЕФРАЦЬ filed Critical Лилиан ШАРТЕФРАЦЬ
Priority to MDS20110007A priority Critical patent/MD369Z/ro
Publication of MD369Y publication Critical patent/MD369Y/ro
Publication of MD369Z publication Critical patent/MD369Z/ro

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  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Invenţia se referă la medicină, în special la morfopatologia oncologică şi poate fi utilizată pentru pronosticul riscului de recidivare sau malignizare a procesului precanceros al colului uterin cu utilizarea imunocolorării duble cu anticorpii anti-CD105 şi anti-Ki67.Esenţa invenţiei constă în aceea că după conizarea procesului precanceros al colului uterin se pregătesc secţiuni histologice din bioptate cu grosimea de 3 µm, se colorează cu hematoxilină-eozină, după care se efectuează reacţiile de imunocolorare cu anticorpul anti-CD105, clona SN6h, cu colorarea în brun a endoteliului activat al vaselor, apoi cu anticorpul anti-Ki67, clona MIB1, cu colorarea în roşu a nucleilor celulelor endoteliale şi dacă se determină 0...4 vase cu reacţie pozitivă la ambii anticorpi, se pronostichează un risc minor de recidivare sau malignizare a procesului precanceros, iar dacă se determină mai mult de 4 vase, se pronostichează un risc sporit de recidivare sau malignizare a procesului precanceros.
MDS20110007A 2011-01-03 2011-01-03 Metodă de pronostic al riscului de recidivare sau malignizare a procesului precanceros al colului uterin MD369Z (ro)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDS20110007A MD369Z (ro) 2011-01-03 2011-01-03 Metodă de pronostic al riscului de recidivare sau malignizare a procesului precanceros al colului uterin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDS20110007A MD369Z (ro) 2011-01-03 2011-01-03 Metodă de pronostic al riscului de recidivare sau malignizare a procesului precanceros al colului uterin

Publications (2)

Publication Number Publication Date
MD369Y MD369Y (ro) 2011-05-31
MD369Z true MD369Z (ro) 2011-12-31

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ID=45815147

Family Applications (1)

Application Number Title Priority Date Filing Date
MDS20110007A MD369Z (ro) 2011-01-03 2011-01-03 Metodă de pronostic al riscului de recidivare sau malignizare a procesului precanceros al colului uterin

Country Status (1)

Country Link
MD (1) MD369Z (ro)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD726Z (ro) * 2013-07-23 2014-08-31 Адриан КИШКА Metodă de pronostic al evoluţiei stărilor precanceroase gastrice la bărbaţi

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD2653G2 (ro) * 2003-07-25 2005-09-30 Институт Генетики И Физиологии Растений Академии Наук Молдовы Procedeu de cultivare a tutunului
  • 2011

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
Davidson B., Goldberg I., Kopolovic J. Angiogenesis in uterine cervical intraepithelial neoplasia and squamous cell carcinoma: an *
Davidson B., Goldberg I., Kopolovic J. Angiogenesis in uterine cervical intraepithelial neoplasia and squamous cell carcinoma: an immunohistochemical study. Int J. Gynecol. Pathol., 1997, № 16, p. 335-338 *
evaluating angiogenesis in cervical cancer. Pathol. Res. Pract., 2005, № 201, p. 34, 313-318 *
Graflund M., Sorbe B., Hussein A., Bryne M., Karlsson M. The prognostic value of histopathologic grading parameters and microvessel density in *
Graflund M., Sorbe B., Hussein A., Bryne M., Karlsson M. The prognostic value of histopathologic grading parameters and microvessel density in patients with early squamous cell carcinoma of the uterine cervix. Int J. Gynecol. Cancer, 2002, №12, p. 32-41 *
immunohistochemical study. Int J. Gynecol. Pathol., 1997, № 16, p. 335-338 *
patients with early squamous cell carcinoma of the uterine cervix. Int J. Gynecol. Cancer, 2002, №12, p. 32-41 *
Vieira S.C., Silva B.B., Pinto G.A., Vassallo J., Moraes N.G., Santana J.O., Santos L.G., Carvasan G.A., Zeferino L.C. CD34 as a marker for *
Vieira S.C., Silva B.B., Pinto G.A., Vassallo J., Moraes N.G., Santana J.O., Santos L.G., Carvasan G.A., Zeferino L.C. CD34 as a marker for evaluating angiogenesis in cervical cancer. Pathol. Res. Pract., 2005, № 201, p. 34, 313-318 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD726Z (ro) * 2013-07-23 2014-08-31 Адриан КИШКА Metodă de pronostic al evoluţiei stărilor precanceroase gastrice la bărbaţi

Also Published As

Publication number Publication date
MD369Y (ro) 2011-05-31

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KA4Y Short-term patent lapsed due to non-payment of fees (with right of restoration)
MM4Y Short-term patent definitely lapsed due to non-payment of fees