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Priority claimed from AT88390Aexternal-prioritypatent/ATA39088A/en
Application filed by Chemisch Pharmazeutische Forschungsgesellschaft M.B.H.filedCriticalChemisch Pharmazeutische Forschungsgesellschaft M.B.H.
Publication of MD266B1publicationCriticalpatent/MD266B1/en
Publication of MD266C2publicationCriticalpatent/MD266C2/en
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur
(AREA)
Abstract
The invention relates to the heterocyclic materials and, particularly, to the preparation of the 5-haloid theienoisothiazoles-3-(2H)-on-1,1-dioxides derivatives or pharmaceutically supportable acidic additive salts of formulawhere R is haloid, possessing the anxiolytic activity, which may be used in the medicine.The aim of the invention - cleation of new more active substances of the indicated class. the syntehesis is conductes by the reaction of 1-(2-pyrimidinylpiperazine with the compound of formulawhere X - haloid in the absolute dimetilhylformamide medium at 60°C during 45 min at further desired product isolation in the free form or in the form of the required salt. The new materials are low-toxic (more then 2000 mg/kg) and possesse a high antxiolytic activity.
MD94-0300A1988-02-181994-09-14Process for preparation of 5-haloid thienoisothiazole-3(2H)-on-1,1-dioxides derivatives
MD266C2
(en)
Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions.
Process for producing 3-piperidinole-indazole derivatives and pharmaceutical preparations having effect against high blood pressure containing these compounds as active substance
Process for producing ether derivatives and thioether derivatives, as well as pharmaceutical compositions comprising these compounds as active ingredient