MD120C2 - Method of obtaining of macrocycle compounds - Google Patents

Abstract

The invention relates to the obtaining of macrocycle compounds with general formulawherein R1 represents methyl, ethyl or isoprophyl; R2 and R3 represent hydrogen atoms.OR4 represents hydroxy group, methoxy group, alkanoiloxy group, with a fragment C1-C6-alkyl without an indispensable substitution by phenoxy group, or-OCOOR5 group in which R5-C1-C5-alkyl, characterized by the fact that the compound with general formula II:wherein R1 and OR4 have the above indicated meanings, except of OR4 which represents hyperoxy group, 1-R11OCSO group,wherein R11 represents (C1-C6alkyl)-phenyl or phenyl is submissive to restoring through the action of tinhydroalkyl, for example, tri-n-hydrobutyltin in the presence of radical intiators, for example, azobisisobutyronitrile, or under the light action and chemical compound obtained with formula 1, wherein OR4 is a methoxy group or alkanoiloxy group with C1-C6-alkyl fragment, without an indispensable substitution, in case of necessary transforming in chemical compound with formula 1, wherein OR4 represents hydroxigroup which in case of necessity through the action of acid halide transforms in compound with formula 1, wherein OR4 is OCOOR5 group. New compounds according to the invention possess an antibiotic activity and/or are used as intermediar products at the obtaining of another active compounds.