MA59295A1 - TRACELESS LINKERS AND RELATED PROTEIN CONJUGATES - Google Patents
TRACELESS LINKERS AND RELATED PROTEIN CONJUGATESInfo
- Publication number
- MA59295A1 MA59295A1 MA59295A MA59295A MA59295A1 MA 59295 A1 MA59295 A1 MA 59295A1 MA 59295 A MA59295 A MA 59295A MA 59295 A MA59295 A MA 59295A MA 59295 A1 MA59295 A1 MA 59295A1
- Authority
- MA
- Morocco
- Prior art keywords
- protein conjugates
- compounds
- related protein
- traceless
- traceless linkers
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000003676 Glucocorticoid Receptors Human genes 0.000 abstract 3
- 108090000079 Glucocorticoid Receptors Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003862 glucocorticoid Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 229940037128 systemic glucocorticoids Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
Abstract
L'invention concerne des composés, des composés comprenant des lieurs sans trace, des conjugués protéiques associés, et des compositions associées. L'invention concerne également des méthodes de traitement de maladies, de troubles et d'états, et/ou la gestion de leurs symptômes, associés à des maladies inflammatoires et des troubles auto-immuns associés en outre au récepteur des glucocorticoïdes, à la liaison aux glucocorticoïdes et/ou à la signalisation des récepteurs des glucocorticoïdes, comprenant l'administration des composés ou de charges utiles par l'intermédiaire de charges utiles de lieurs sans trace, et des conjugués protéiques associés.Compounds, compounds comprising traceless linkers, related protein conjugates, and related compositions are provided. Also provided are methods of treating diseases, disorders and conditions, and/or managing their symptoms, associated with inflammatory diseases and autoimmune disorders further associated with the glucocorticoid receptor, binding to glucocorticoids and/or glucocorticoid receptor signaling, including delivery of the compounds or payloads via traceless linker payloads, and associated protein conjugates.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/243,020 US20190209702A1 (en) | 2018-01-08 | 2019-01-08 | Steroids and antibody-conjugates thereof |
US201962872229P | 2019-07-09 | 2019-07-09 | |
US201962937721P | 2019-11-19 | 2019-11-19 | |
PCT/US2020/012798 WO2020146541A2 (en) | 2019-01-08 | 2020-01-08 | Traceless linkers and protein-conjugates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MA59295A1 true MA59295A1 (en) | 2023-07-31 |
Family
ID=71521936
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA59295A MA59295A1 (en) | 2019-01-08 | 2020-01-08 | TRACELESS LINKERS AND RELATED PROTEIN CONJUGATES |
MA53772A MA53772B1 (en) | 2019-01-08 | 2020-01-08 | TRACELESS LINKERS AND RELATED PROTEIN CONJUGATES |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA53772A MA53772B1 (en) | 2019-01-08 | 2020-01-08 | TRACELESS LINKERS AND RELATED PROTEIN CONJUGATES |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP3908323A2 (en) |
JP (1) | JP2022517767A (en) |
KR (1) | KR20210114008A (en) |
CN (1) | CN113905767A (en) |
AU (1) | AU2020205662A1 (en) |
BR (1) | BR112021013464A2 (en) |
CA (1) | CA3125998A1 (en) |
CL (1) | CL2021001790A1 (en) |
CO (1) | CO2021010315A2 (en) |
IL (1) | IL284673A (en) |
MA (2) | MA59295A1 (en) |
MX (1) | MX2021008114A (en) |
SG (1) | SG11202107212QA (en) |
WO (1) | WO2020146541A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL266353B2 (en) | 2016-11-08 | 2024-03-01 | Regeneron Pharma | Steroids and protein-conjugates thereof |
US11491237B2 (en) | 2017-05-18 | 2022-11-08 | Regeneron Pharmaceuticals, Inc. | Cyclodextrin protein drug conjugates |
CA3098453A1 (en) | 2018-05-09 | 2019-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-msr1 antibodies and methods of use thereof |
US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
WO2023079362A1 (en) * | 2021-11-03 | 2023-05-11 | Ripple Therapeutics Corporation | Processable compositions and use for the same |
US20230287138A1 (en) | 2022-01-12 | 2023-09-14 | Regneron Pharmaceuticals, Inc. | Protein-drug conjugates comprising camptothecin analogs and methods of use thereof |
TW202340252A (en) * | 2022-01-29 | 2023-10-16 | 大陸商上海盛迪醫藥有限公司 | Drug conjugates of glucocorticoids |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
US20070258987A1 (en) | 2000-11-28 | 2007-11-08 | Seattle Genetics, Inc. | Recombinant Anti-Cd30 Antibodies and Uses Thereof |
US20050276812A1 (en) | 2004-06-01 | 2005-12-15 | Genentech, Inc. | Antibody-drug conjugates and methods |
AR048098A1 (en) | 2004-03-15 | 2006-03-29 | Wyeth Corp | CALIQUEAMYCIN CONJUGATES |
EP1817341A2 (en) | 2004-11-29 | 2007-08-15 | Seattle Genetics, Inc. | Engineered antibodies and immunoconjugates |
US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
WO2008122039A2 (en) | 2007-04-02 | 2008-10-09 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Selenocysteine mediated hybrid antibody molecules |
WO2008153744A2 (en) | 2007-05-23 | 2008-12-18 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
EP2276506A4 (en) | 2008-04-30 | 2014-05-07 | Immunogen Inc | Potent conjugates and hydrophilic linkers |
KR101000067B1 (en) | 2008-12-30 | 2010-12-10 | 엘지전자 주식회사 | Laser Firing Apparatus For High Efficiency Sollar Cell And Fabrication Method For High Efficiency Sollar Cell |
PE20130342A1 (en) | 2010-04-15 | 2013-04-20 | Spirogen Sarl | PIRROLOBENZODIACEPINES AND CONJUGATES OF THE SAME |
US20130244905A1 (en) | 2010-07-06 | 2013-09-19 | Ed Grabczyk | Reporter for RNA Polymerase II Termination |
EP3170821B1 (en) | 2011-05-27 | 2021-09-15 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
MX341523B (en) | 2011-10-14 | 2016-08-24 | Medimmune Ltd | Pyrrolobenzodiazepines. |
JP6393617B2 (en) | 2011-10-14 | 2018-09-19 | シアトル ジェネティクス,インコーポレーテッド | Pyrrolobenzodiazepine and target conjugates |
EA029046B1 (en) | 2011-10-14 | 2018-02-28 | Медимьюн Лимитед | Pyrrolobenzodiazepines and intermediates for the preparation thereof, synthesis methods thereof |
EP2753178B1 (en) | 2011-10-14 | 2017-12-06 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
WO2013068874A1 (en) | 2011-11-11 | 2013-05-16 | Pfizer Inc. | Antibody-drug conjugates |
CN110201186A (en) | 2012-10-23 | 2019-09-06 | 西纳福克斯股份有限公司 | Modified antibody, antibody-conjugate and preparation method thereof |
AU2014283185B2 (en) * | 2013-06-21 | 2019-05-02 | Innate Pharma | Enzymatic conjugation of polypeptides |
TWI641620B (en) | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | Anti-prlr antibodies and uses thereof |
KR102127623B1 (en) * | 2014-04-10 | 2020-06-29 | 다이이찌 산쿄 가부시키가이샤 | Anti-her3 antibody-drug conjugate |
CR20180594A (en) * | 2016-06-02 | 2019-07-29 | Abbvie Inc | GLUCOCORTICOID RECEPTOR AGONIST AND IMMUNOCONJUGATES THEREOF |
MX2019003325A (en) | 2016-09-23 | 2019-08-05 | Regeneron Pharma | Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof. |
EP3625209A1 (en) * | 2017-05-18 | 2020-03-25 | Regeneron Pharmaceuticals, Inc. | Bis-octahydrophenanthrene carboxamides and protein conjugates thereof |
US11491237B2 (en) * | 2017-05-18 | 2022-11-08 | Regeneron Pharmaceuticals, Inc. | Cyclodextrin protein drug conjugates |
CN109106951A (en) * | 2017-08-18 | 2019-01-01 | 四川百利药业有限责任公司 | A kind of camptothecine-antibody coupling matter |
WO2019034177A1 (en) * | 2017-08-18 | 2019-02-21 | 四川百利药业有限责任公司 | Antibody drug conjugate having two different drugs |
MX2020006994A (en) * | 2018-01-08 | 2020-11-06 | Regeneron Pharma | Steroids and antibody-conjugates thereof. |
EP3764830B1 (en) | 2018-05-08 | 2021-07-21 | Nike Innovate C.V. | Bonding to polyolefin plates and articles of footwear formed therefrom |
CA3098453A1 (en) | 2018-05-09 | 2019-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-msr1 antibodies and methods of use thereof |
-
2020
- 2020-01-08 MX MX2021008114A patent/MX2021008114A/en unknown
- 2020-01-08 BR BR112021013464-6A patent/BR112021013464A2/en unknown
- 2020-01-08 AU AU2020205662A patent/AU2020205662A1/en active Pending
- 2020-01-08 CN CN202080019317.3A patent/CN113905767A/en active Pending
- 2020-01-08 EP EP20702563.6A patent/EP3908323A2/en active Pending
- 2020-01-08 CA CA3125998A patent/CA3125998A1/en active Pending
- 2020-01-08 MA MA59295A patent/MA59295A1/en unknown
- 2020-01-08 MA MA53772A patent/MA53772B1/en unknown
- 2020-01-08 KR KR1020217024347A patent/KR20210114008A/en unknown
- 2020-01-08 SG SG11202107212QA patent/SG11202107212QA/en unknown
- 2020-01-08 JP JP2021539640A patent/JP2022517767A/en active Pending
- 2020-01-08 WO PCT/US2020/012798 patent/WO2020146541A2/en unknown
-
2021
- 2021-07-06 CL CL2021001790A patent/CL2021001790A1/en unknown
- 2021-07-07 IL IL284673A patent/IL284673A/en unknown
- 2021-08-04 CO CONC2021/0010315A patent/CO2021010315A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2022517767A (en) | 2022-03-10 |
WO2020146541A2 (en) | 2020-07-16 |
EP3908323A2 (en) | 2021-11-17 |
MA53772B1 (en) | 2023-08-31 |
MA53772A1 (en) | 2022-10-31 |
KR20210114008A (en) | 2021-09-17 |
SG11202107212QA (en) | 2021-07-29 |
CN113905767A (en) | 2022-01-07 |
CO2021010315A2 (en) | 2021-08-19 |
IL284673A (en) | 2021-08-31 |
BR112021013464A2 (en) | 2021-09-21 |
CL2021001790A1 (en) | 2022-07-01 |
WO2020146541A3 (en) | 2020-08-13 |
CA3125998A1 (en) | 2020-07-16 |
AU2020205662A1 (en) | 2021-07-22 |
MX2021008114A (en) | 2021-08-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA53772B1 (en) | TRACELESS LINKERS AND RELATED PROTEIN CONJUGATES | |
MA47392A1 (en) | Bis-octahydrophenanthrene carboxamides and their protein conjugates | |
MA31016B1 (en) | DIAZEPAN COMPOUNDS SUBSTITUTED AS ANTAGONISTS OF OREXIN RECEPTORS. | |
MA32804B1 (en) | ISONICOTINAMIDE ANTAGONISTS OF OREXIN RECEPTORS | |
MA34517B1 (en) | PRODRUGS COMPRISING AN EXTERNAL-RELIEF CONJUGATE | |
MA32131B1 (en) | Diphenyl n-diphenyls, d2b prostaglandin receptors | |
MA44312A (en) | ANTIBODIES AND THEIR METHODS OF USE | |
MA40801A1 (en) | Anti-cd3 antibody, anti-cd123 antibody and bispecific antibodies binding specifically to cd3 and / or cd123 | |
MA31403B1 (en) | POLYPEPTIDES, VARIOUS DOMAINS OF ANTIBODIES AND ANTAGONISTS | |
MA53455A1 (en) | Bis-octahydrophenanthrene carboxamide derivatives and their protein conjugates for use as lxr agonists | |
MA52492B1 (en) | RIP1 INHIBITORY COMPOUNDS, METHODS OF PREPARATION AND USE THEREOF | |
MA29931B1 (en) | INHIBITORS OF 5-LIPOXYGENASE ACTIVATION PROTEIN (FLAP) | |
TN2010000230A1 (en) | NEW AGONISTS OF GLUCOCORTICOID RECEPTORS | |
MA34287B1 (en) | COMPOSITIONS AND METHODS OF USING LOW DENSITY THERAPEUTIC MULTIVALENT ANTIBODIES OF LIPOPROTEIN 6-RELATED PROTEIN (LRP6) | |
MA31437B1 (en) | POLYPEPTIDES, VARIOUS DOMAINS OF ANTIBODIES AND ANTAGONISTS | |
BRPI0514259A (en) | binding domain fusion protein | |
WO2004091510A3 (en) | Recombinant il-9 antibodies and uses thereof | |
MA31764B1 (en) | Components and formulations as activity rates gpr119 | |
MA30906B1 (en) | COMPOUNDS AND COMPOSITIONS AS QUINHIBITORS OF PROTEINS KINASES | |
MA37761A1 (en) | Proteins for binding to a double receptor antagonist antigen and their uses | |
MA53765A1 (en) | Tubulysins and tubulysins-protein conjugates | |
MA34053B1 (en) | DR5 BINDING AGONIST POLYPEPTIDES | |
MA43113A (en) | ANTI-HTR A1 ANTIBODIES AND METHODS OF USING THEM | |
MA33758B1 (en) | STABLE ANTI-TNFR1 POLYPEPTIDES, VARIOUS DOMES OF ANTIBODY, AND ANTAGONISTS | |
MA30901B1 (en) | SEQUENTIAL COMBINATION THERAPY |