CL2021001790A1 - Non-trace linkers, protein conjugates thereof and compositions thereof - Google Patents
Non-trace linkers, protein conjugates thereof and compositions thereofInfo
- Publication number
- CL2021001790A1 CL2021001790A1 CL2021001790A CL2021001790A CL2021001790A1 CL 2021001790 A1 CL2021001790 A1 CL 2021001790A1 CL 2021001790 A CL2021001790 A CL 2021001790A CL 2021001790 A CL2021001790 A CL 2021001790A CL 2021001790 A1 CL2021001790 A1 CL 2021001790A1
- Authority
- CL
- Chile
- Prior art keywords
- compositions
- protein conjugates
- trace
- linkers
- trace linkers
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 abstract 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
COMPUESTOS ENLAZADORES SIN TRAZAS; CONJUGADOS DE PROTEÍNAS DE LOS MISMOS; COMPOSICIONES FARMACÉUTICAS Y SU USO EN EL TRATAMIENTO DE UNA ENFERMEDAD ASOCIADA CON LA SEÑALIZACIÓN DEL RECEPTOR DE GLUCOCORTICOIDES.NON-TRACE LINKING COMPOUNDS; PROTEIN CONJUGATES THEREOF; PHARMACEUTICAL COMPOSITIONS AND THEIR USE IN THE TREATMENT OF A DISEASE ASSOCIATED WITH GLUCOCORTICOID RECEPTOR SIGNALING.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2019/012786 WO2019136487A2 (en) | 2018-01-08 | 2019-01-08 | Steroids and antibody-conjugates thereof |
US16/243,020 US20190209702A1 (en) | 2018-01-08 | 2019-01-08 | Steroids and antibody-conjugates thereof |
US201962872229P | 2019-07-09 | 2019-07-09 | |
US201962937721P | 2019-11-19 | 2019-11-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021001790A1 true CL2021001790A1 (en) | 2022-07-01 |
Family
ID=71521936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021001790A CL2021001790A1 (en) | 2019-01-08 | 2021-07-06 | Non-trace linkers, protein conjugates thereof and compositions thereof |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP3908323A2 (en) |
JP (1) | JP2022517767A (en) |
KR (1) | KR20210114008A (en) |
CN (1) | CN113905767A (en) |
AU (1) | AU2020205662A1 (en) |
BR (1) | BR112021013464A2 (en) |
CA (1) | CA3125998A1 (en) |
CL (1) | CL2021001790A1 (en) |
CO (1) | CO2021010315A2 (en) |
IL (1) | IL284673A (en) |
MA (2) | MA53772B1 (en) |
MX (1) | MX2021008114A (en) |
SG (1) | SG11202107212QA (en) |
WO (1) | WO2020146541A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20190074310A (en) | 2016-11-08 | 2019-06-27 | 리제너론 파마슈티칼스 인코포레이티드 | Steroids and their protein-conjugates |
AU2018270784B2 (en) | 2017-05-18 | 2024-05-16 | Regeneron Pharmaceuticals, Inc. | Cyclodextrin protein drug conjugates |
CA3098453A1 (en) | 2018-05-09 | 2019-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-msr1 antibodies and methods of use thereof |
US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
WO2023079362A1 (en) * | 2021-11-03 | 2023-05-11 | Ripple Therapeutics Corporation | Processable compositions and use for the same |
US20230287138A1 (en) | 2022-01-12 | 2023-09-14 | Regneron Pharmaceuticals, Inc. | Protein-drug conjugates comprising camptothecin analogs and methods of use thereof |
WO2023143351A1 (en) * | 2022-01-29 | 2023-08-03 | 上海盛迪医药有限公司 | Drug conjugate of glucocorticoid |
WO2024118785A2 (en) | 2022-11-30 | 2024-06-06 | Regeneron Pharmaceuticals, Inc. | Tlr7 agonists and antibody-drug-conjugates thereof |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
US20070258987A1 (en) | 2000-11-28 | 2007-11-08 | Seattle Genetics, Inc. | Recombinant Anti-Cd30 Antibodies and Uses Thereof |
AR048098A1 (en) | 2004-03-15 | 2006-03-29 | Wyeth Corp | CALIQUEAMYCIN CONJUGATES |
EP2286844A3 (en) | 2004-06-01 | 2012-08-22 | Genentech, Inc. | Antibody-drug conjugates and methods |
AU2005316844A1 (en) | 2004-11-29 | 2006-06-22 | Seattle Genetics, Inc. | Engineered antibodies and immunoconjugates |
US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
WO2008122039A2 (en) | 2007-04-02 | 2008-10-09 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Selenocysteine mediated hybrid antibody molecules |
DK2167963T3 (en) | 2007-05-23 | 2019-06-24 | Ventana Med Syst Inc | Polymer carriers for immunohistochemistry and in situ hybridization |
KR20100137585A (en) | 2008-04-30 | 2010-12-30 | 이뮤노젠 아이엔씨 | Potent conjugates and hydrophilic linkers |
KR101000067B1 (en) | 2008-12-30 | 2010-12-10 | 엘지전자 주식회사 | Laser Firing Apparatus For High Efficiency Sollar Cell And Fabrication Method For High Efficiency Sollar Cell |
PE20130342A1 (en) | 2010-04-15 | 2013-04-20 | Spirogen Sarl | PIRROLOBENZODIACEPINES AND CONJUGATES OF THE SAME |
WO2012005982A2 (en) | 2010-07-06 | 2012-01-12 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Reporter for rna polymerase ii termination |
CN103702996A (en) | 2011-05-27 | 2014-04-02 | Ambrx公司 | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
EP3388435B1 (en) | 2011-10-14 | 2023-05-03 | Seagen Inc. | Pyrrolobenzodiazepines and targeted conjugates |
EA029046B1 (en) | 2011-10-14 | 2018-02-28 | Медимьюн Лимитед | Pyrrolobenzodiazepines and intermediates for the preparation thereof, synthesis methods thereof |
EA036202B1 (en) | 2011-10-14 | 2020-10-14 | Сиэтл Дженетикс, Инк. | Pyrrolobenzodiazepines and targeted conjugates |
BR112014008888A2 (en) | 2011-10-14 | 2017-04-18 | Seattle Genetics Inc | pyrrolobenzodiazepines |
WO2013068874A1 (en) | 2011-11-11 | 2013-05-16 | Pfizer Inc. | Antibody-drug conjugates |
SI2911699T1 (en) | 2012-10-23 | 2018-04-30 | Synaffix B.V. | Modified antibody, antibody-conjugate and process for the preparation thereof |
JP6744212B2 (en) * | 2013-06-21 | 2020-08-19 | イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. | Enzymatic binding of polypeptides |
TWI641620B (en) | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | Anti-prlr antibodies and uses thereof |
CN111228511B (en) * | 2014-04-10 | 2024-06-18 | 第一三共株式会社 | Anti-HER 3 antibody-drug conjugates |
KR20220119529A (en) * | 2016-06-02 | 2022-08-29 | 애브비 인코포레이티드 | Glucocorticoid receptor agonist and immunoconjugates thereof |
US10772972B2 (en) | 2016-09-23 | 2020-09-15 | Regeneron Pharmaceuticals, Inc. | Anti-STEAP2 antibody drug conjugates, and compositions and uses thereof |
US20180334426A1 (en) * | 2017-05-18 | 2018-11-22 | Regeneron Pharmaceutical, Inc. | Bis-octahydrophenanthrene carboxamides and protein conjugates thereof |
AU2018270784B2 (en) * | 2017-05-18 | 2024-05-16 | Regeneron Pharmaceuticals, Inc. | Cyclodextrin protein drug conjugates |
CN109106951A (en) * | 2017-08-18 | 2019-01-01 | 四川百利药业有限责任公司 | A kind of camptothecine-antibody coupling matter |
WO2019034177A1 (en) * | 2017-08-18 | 2019-02-21 | 四川百利药业有限责任公司 | Antibody drug conjugate having two different drugs |
BR112020013492A2 (en) * | 2018-01-08 | 2020-12-08 | Regeneron Pharmaceuticals, Inc. | STEROIDS AND ANTIBODY CONJUGATES THEREOF |
EP3764830B1 (en) | 2018-05-08 | 2021-07-21 | Nike Innovate C.V. | Bonding to polyolefin plates and articles of footwear formed therefrom |
CA3098453A1 (en) | 2018-05-09 | 2019-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-msr1 antibodies and methods of use thereof |
-
2020
- 2020-01-08 MX MX2021008114A patent/MX2021008114A/en unknown
- 2020-01-08 MA MA53772A patent/MA53772B1/en unknown
- 2020-01-08 JP JP2021539640A patent/JP2022517767A/en active Pending
- 2020-01-08 MA MA59295A patent/MA59295A1/en unknown
- 2020-01-08 KR KR1020217024347A patent/KR20210114008A/en unknown
- 2020-01-08 CN CN202080019317.3A patent/CN113905767A/en active Pending
- 2020-01-08 WO PCT/US2020/012798 patent/WO2020146541A2/en unknown
- 2020-01-08 EP EP20702563.6A patent/EP3908323A2/en active Pending
- 2020-01-08 AU AU2020205662A patent/AU2020205662A1/en active Pending
- 2020-01-08 BR BR112021013464-6A patent/BR112021013464A2/en unknown
- 2020-01-08 CA CA3125998A patent/CA3125998A1/en active Pending
- 2020-01-08 SG SG11202107212QA patent/SG11202107212QA/en unknown
-
2021
- 2021-07-06 CL CL2021001790A patent/CL2021001790A1/en unknown
- 2021-07-07 IL IL284673A patent/IL284673A/en unknown
- 2021-08-04 CO CONC2021/0010315A patent/CO2021010315A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2020205662A1 (en) | 2021-07-22 |
IL284673A (en) | 2021-08-31 |
MX2021008114A (en) | 2021-08-05 |
CA3125998A1 (en) | 2020-07-16 |
WO2020146541A3 (en) | 2020-08-13 |
CN113905767A (en) | 2022-01-07 |
MA53772B1 (en) | 2023-08-31 |
WO2020146541A2 (en) | 2020-07-16 |
CO2021010315A2 (en) | 2021-08-19 |
MA59295A1 (en) | 2023-07-31 |
SG11202107212QA (en) | 2021-07-29 |
JP2022517767A (en) | 2022-03-10 |
BR112021013464A2 (en) | 2021-09-21 |
KR20210114008A (en) | 2021-09-17 |
MA53772A1 (en) | 2022-10-31 |
EP3908323A2 (en) | 2021-11-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2021001790A1 (en) | Non-trace linkers, protein conjugates thereof and compositions thereof | |
CY1123783T1 (en) | ENANTI-B7-H3 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES | |
CL2020003461A1 (en) | A derivative of the cross-linked pyrrolobenzodiazepine dimer (pbd) and its conjugates | |
CL2020002024A1 (en) | Calpain modulators and therapeutic uses thereof. (divisional request 201900793) | |
CL2017003351A1 (en) | Anti-human transferrin receptor antibody that passes through the blood-brain barrier. | |
CO2018004152A2 (en) | Antibody-pyrrolobenzodiazepine drug conjugates and methods of use | |
CO2021000043A2 (en) | Selective estrogen receptor degraders | |
CL2019001129A1 (en) | Compounds of cyclic tyrosine tyrosine peptide with coupled antibody as neuropeptide receptor modulators and. | |
ECSP19000157A (en) | CONJUGATES OF ANTIBODY AND ANTI-EGFR DRUG | |
BR112018075653A2 (en) | anti-b7-h3 antibodies and drug antibody conjugates | |
BR112018075649A2 (en) | anti-b7-h3 antibodies and antibody drug conjugates | |
EA201900562A1 (en) | BIS-OCTAGHYDROPHENANTHRENE CARBOXAMIDES AND THEIR PROTEIN CONJUGATES | |
AR101742A1 (en) | CALCITONINE AND AMILINE RECEIVER AGONIST | |
PH12020551716A1 (en) | Anti-ror antibody constructs | |
CO2018000414A2 (en) | Il22's immunoconjugates | |
CL2021001308A1 (en) | Bis-octahydrophenanthrene carboxamide derivatives and protein conjugates thereof for use as lxr agonists. | |
CL2018002050A1 (en) | Antibody-drug conjugates directed to gcc. | |
ECSP18060820A (en) | DERIVATIVES OF 3- (CARBOXYETHYL) -8-AMINO-2-OXO-1,3-DIAZA-SPIRO- [4.5] - DECANE | |
CL2018001911A1 (en) | 3- (Carboxyethyl) -8-amino-2-oxo-1,3-diaza-spiro- [4.5] -decane derivatives | |
CO2022004743A2 (en) | Antibodies directed to flt3 and use thereof | |
PE20151603A1 (en) | ANTI-LAMP1 ANTIBODIES AND DRUG ANTIBODY CONJUGATES, AND USES OF THEM | |
WO2018175740A8 (en) | Anti-tmeff1 antibodies and antibody drug conjugates | |
ECSP20082970A (en) | ANTI-SEZ6 DRUG AND ANTIBODY CONJUGATES AND METHODS OF USE | |
BR112018016715A2 (en) | oritavancin formulations? | |
CL2022000752A1 (en) | Specific binding molecule for lif and use thereof |