MA56608B1 - Composition et utilisation d'une solution ophtalmique à base d'acide hyaluronique et d'arabinogalactane - Google Patents
Composition et utilisation d'une solution ophtalmique à base d'acide hyaluronique et d'arabinogalactaneInfo
- Publication number
- MA56608B1 MA56608B1 MA56608A MA56608A MA56608B1 MA 56608 B1 MA56608 B1 MA 56608B1 MA 56608 A MA56608 A MA 56608A MA 56608 A MA56608 A MA 56608A MA 56608 B1 MA56608 B1 MA 56608B1
- Authority
- MA
- Morocco
- Prior art keywords
- arabinogalactan
- hyaluronic acid
- solution based
- ophthalmic solution
- composition
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 2
- SATHPVQTSSUFFW-UHFFFAOYSA-N 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol Chemical compound OC1C(OC)C(O)COC1OCC1C(O)C(OC)C(O)C(OC2C(C(CO)OC(C)C2O)O)O1 SATHPVQTSSUFFW-UHFFFAOYSA-N 0.000 title abstract 2
- 229920000189 Arabinogalactan Polymers 0.000 title abstract 2
- 239000001904 Arabinogalactan Substances 0.000 title abstract 2
- 235000019312 arabinogalactan Nutrition 0.000 title abstract 2
- 229920002674 hyaluronan Polymers 0.000 title abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 2
- 229940054534 ophthalmic solution Drugs 0.000 title abstract 2
- 239000002997 ophthalmic solution Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 108010093894 Xanthine oxidase Proteins 0.000 abstract 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 abstract 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 1
- 206010013774 Dry eye Diseases 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 abstract 1
- 102000005773 Xanthine dehydrogenase Human genes 0.000 abstract 1
- 108010091383 Xanthine dehydrogenase Proteins 0.000 abstract 1
- 102100033220 Xanthine oxidase Human genes 0.000 abstract 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 229940101267 panthenol Drugs 0.000 abstract 1
- 235000020957 pantothenol Nutrition 0.000 abstract 1
- 239000011619 pantothenol Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne une solution ophtalmique à base d'acide hyaluronique et d'arabinogalactane en quantités synergiques qui est utilisée, seule ou en association avec du panthénol, de la vitamine e-d-a-polyéthylène-glycol (tgps) et du tréhalose, dans le traitement du syndrome de l'œil sec, accompagné des phénomènes inflammatoires liés à l'action du système enzymatique xanthine déshydrogénase/xanthine oxydase.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102019000018929A IT201900018929A1 (it) | 2019-10-15 | 2019-10-15 | “composizione ed uso di una soluzione oftalmica a base di acido ialuronico ed arabinogalattano” |
| PCT/IB2020/059599 WO2021074782A1 (fr) | 2019-10-15 | 2020-10-13 | Composition et utilisation d'une solution ophtalmique à base d'acide hyaluronique et d'arabinogalactane |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA56608A1 MA56608A1 (fr) | 2022-12-30 |
| MA56608B1 true MA56608B1 (fr) | 2023-03-31 |
Family
ID=69743731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA56608A MA56608B1 (fr) | 2019-10-15 | 2020-10-13 | Composition et utilisation d'une solution ophtalmique à base d'acide hyaluronique et d'arabinogalactane |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20240148780A1 (fr) |
| EP (1) | EP3808353B1 (fr) |
| KR (1) | KR20220084116A (fr) |
| AU (1) | AU2020368693A1 (fr) |
| CA (1) | CA3153905A1 (fr) |
| CL (1) | CL2022000951A1 (fr) |
| ES (1) | ES2960944T3 (fr) |
| IT (1) | IT201900018929A1 (fr) |
| MA (1) | MA56608B1 (fr) |
| MX (1) | MX2022004578A (fr) |
| PL (1) | PL3808353T3 (fr) |
| WO (1) | WO2021074782A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024059626A2 (fr) * | 2022-09-14 | 2024-03-21 | Exopolymer, Inc. | Biopolymères à usage ophtalmique |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20050443A1 (it) * | 2005-08-12 | 2007-02-13 | Opocrin Spa | Preparati oftalmici a base di polisaccaridi mucoadesivi con capacita' riepitelizzante della cornea. |
| US20090036554A1 (en) | 2007-08-01 | 2009-02-05 | Burke Susan E | Ophthalmic compositions comprising a terpene compound |
-
2019
- 2019-10-15 IT IT102019000018929A patent/IT201900018929A1/it unknown
-
2020
- 2020-09-30 EP EP20199450.6A patent/EP3808353B1/fr active Active
- 2020-09-30 ES ES20199450T patent/ES2960944T3/es active Active
- 2020-09-30 PL PL20199450.6T patent/PL3808353T3/pl unknown
- 2020-10-13 US US17/769,261 patent/US20240148780A1/en active Pending
- 2020-10-13 MA MA56608A patent/MA56608B1/fr unknown
- 2020-10-13 AU AU2020368693A patent/AU2020368693A1/en active Pending
- 2020-10-13 CA CA3153905A patent/CA3153905A1/fr active Pending
- 2020-10-13 WO PCT/IB2020/059599 patent/WO2021074782A1/fr active Application Filing
- 2020-10-13 KR KR1020227016246A patent/KR20220084116A/ko unknown
- 2020-10-13 MX MX2022004578A patent/MX2022004578A/es unknown
-
2022
- 2022-04-13 CL CL2022000951A patent/CL2022000951A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA56608A1 (fr) | 2022-12-30 |
| EP3808353A1 (fr) | 2021-04-21 |
| MX2022004578A (es) | 2022-05-10 |
| WO2021074782A1 (fr) | 2021-04-22 |
| US20240148780A1 (en) | 2024-05-09 |
| IT201900018929A1 (it) | 2021-04-15 |
| PL3808353T3 (pl) | 2024-01-03 |
| ES2960944T3 (es) | 2024-03-07 |
| EP3808353C0 (fr) | 2023-08-16 |
| CA3153905A1 (fr) | 2021-04-22 |
| KR20220084116A (ko) | 2022-06-21 |
| CL2022000951A1 (es) | 2023-01-13 |
| EP3808353B1 (fr) | 2023-08-16 |
| AU2020368693A1 (en) | 2022-05-26 |
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