MA46462B1 - Pyrazolo [1,5-a] pyridine substituted compounds as inhibitors of ret kinase - Google Patents

Pyrazolo [1,5-a] pyridine substituted compounds as inhibitors of ret kinase

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Publication number
MA46462B1
MA46462B1 MA46462A MA46462A MA46462B1 MA 46462 B1 MA46462 B1 MA 46462B1 MA 46462 A MA46462 A MA 46462A MA 46462 A MA46462 A MA 46462A MA 46462 B1 MA46462 B1 MA 46462B1
Authority
MA
Morocco
Prior art keywords
ret kinase
inhibitors
pyrazolo
substituted compounds
pyridine substituted
Prior art date
Application number
MA46462A
Other languages
French (fr)
Inventor
Li Ren
Steven W Andrews
Tony P Tang
Yutong Jiang
Julia Haas
Sean Aronow
James F Blake
Barbara J Brandhuber
Adam Cook
Gabrielle R Kolakowski
Elizabeth A Mcfaddin
Megan L Mckenney
Oren T Mcnulty
Andrew T Metcalf
David A Moreno
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Priority claimed from PCT/US2017/055983 external-priority patent/WO2018071447A1/en
Publication of MA46462B1 publication Critical patent/MA46462B1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des composés de formule i et des stéréoisomères et des sels ou des solvates pharmaceutiquement acceptables de ceux-ci, dans laquelle a, b, x1, x2, x3, x4, cycle d, et e présentent les significations données dans la description, qui sont des inhibiteurs de la kinase ret et qui sont utiles dans le traitement et la prévention de maladies qui peuvent être traitées avec un inhibiteur de la kinase ret, y compris des maladies ou des troubles associés à la kinase ret.The present invention relates to compounds of formula i and stereoisomers and pharmaceutically acceptable salts or solvates thereof, wherein a, b, x1, x2, x3, x4, ring d, and e have the meanings given in the present invention. description, which are ret kinase inhibitors and which are useful in the treatment and prevention of diseases which can be treated with a ret kinase inhibitor, including diseases or disorders associated with ret kinase.

MA46462A 2016-10-10 2017-10-10 Pyrazolo [1,5-a] pyridine substituted compounds as inhibitors of ret kinase MA46462B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662406252P 2016-10-10 2016-10-10
PCT/US2017/055983 WO2018071447A1 (en) 2016-10-10 2017-10-10 Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors

Publications (1)

Publication Number Publication Date
MA46462B1 true MA46462B1 (en) 2020-09-30

Family

ID=65728636

Family Applications (1)

Application Number Title Priority Date Filing Date
MA46462A MA46462B1 (en) 2016-10-10 2017-10-10 Pyrazolo [1,5-a] pyridine substituted compounds as inhibitors of ret kinase

Country Status (2)

Country Link
AR (1) AR109919A1 (en)
MA (1) MA46462B1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111808077B (en) * 2019-04-12 2023-05-02 浙江海正药业股份有限公司 Piperazine amide derivatives, process for their preparation and their use in medicine

Also Published As

Publication number Publication date
AR109919A1 (en) 2019-02-06

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