MA39190B1 - Dérivés d'imidazolyle fusionnés, leur préparation et leur utilisation en tant que médicaments - Google Patents
Dérivés d'imidazolyle fusionnés, leur préparation et leur utilisation en tant que médicamentsInfo
- Publication number
- MA39190B1 MA39190B1 MA39190A MA39190A MA39190B1 MA 39190 B1 MA39190 B1 MA 39190B1 MA 39190 A MA39190 A MA 39190A MA 39190 A MA39190 A MA 39190A MA 39190 B1 MA39190 B1 MA 39190B1
- Authority
- MA
- Morocco
- Prior art keywords
- medicaments
- preparation
- imidazolyl derivatives
- fused imidazolyl
- fused
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La présente invention concerne des nouveaux dérivés d'imidazolyle fusionnés ayant une grande affinité avec des récepteurs sigma, en particulier les récepteurs sigma 1, ainsi que leur procédé de préparation, des compositions les comprenant et leur utilisation en tant que médicaments.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13384003 | 2013-12-20 | ||
PCT/EP2014/078457 WO2015091795A1 (fr) | 2013-12-20 | 2014-12-18 | Dérivés d'imidazolyle fusionnés, leur préparation et leur utilisation en tant que médicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
MA39190A1 MA39190A1 (fr) | 2017-10-31 |
MA39190B1 true MA39190B1 (fr) | 2018-12-31 |
Family
ID=49998039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA39190A MA39190B1 (fr) | 2013-12-20 | 2014-12-18 | Dérivés d'imidazolyle fusionnés, leur préparation et leur utilisation en tant que médicaments |
Country Status (18)
Country | Link |
---|---|
US (1) | US9676784B2 (fr) |
EP (1) | EP3083628B1 (fr) |
JP (1) | JP6464171B2 (fr) |
KR (1) | KR20160095157A (fr) |
CN (1) | CN105916858B (fr) |
AU (1) | AU2014368591A1 (fr) |
BR (1) | BR112016014295A2 (fr) |
CA (1) | CA2934144A1 (fr) |
ES (1) | ES2754430T3 (fr) |
IL (1) | IL246272A0 (fr) |
MA (1) | MA39190B1 (fr) |
MX (1) | MX2016008062A (fr) |
PH (1) | PH12016501169A1 (fr) |
RU (1) | RU2016126431A (fr) |
SG (1) | SG11201604878XA (fr) |
TN (1) | TN2016000254A1 (fr) |
UA (1) | UA119547C2 (fr) |
WO (1) | WO2015091795A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3328857B1 (fr) | 2015-07-31 | 2019-08-14 | Merck Patent GmbH | Dérivés hétérocycliques bicycliques |
DK3464336T3 (da) | 2016-06-01 | 2022-05-09 | Athira Pharma Inc | Forbindelser |
KR101887993B1 (ko) * | 2016-07-27 | 2018-08-13 | 주식회사 엘지화학 | 광경화 수지 조성물 및 이의 용도 |
CN112010927B (zh) * | 2019-05-28 | 2021-10-26 | 首都医科大学 | Egh及羟甲基修饰的苯并咪唑喹唑啉,其合成,活性和应用 |
WO2024105225A1 (fr) | 2022-11-18 | 2024-05-23 | Universitat De Barcelona | Combinaisons synergiques d'un antagoniste du récepteur sigma 1 (s1r) et d'un inhibiteur d'époxyde hydrolase soluble (sehi) et leur utilisation dans le traitement de la douleur |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07101959A (ja) * | 1993-09-30 | 1995-04-18 | Sankyo Co Ltd | 1−メチルカルバペネム誘導体 |
EP1363899B1 (fr) * | 2001-01-02 | 2005-05-11 | F.Hoffmann-La Roche Ag | Derives quinazolone antagonistes de recepteur alpha 1a/b adrenergique |
GB0206033D0 (en) * | 2002-03-14 | 2002-04-24 | Pfizer Ltd | Compounds useful in therapy |
MX2007002340A (es) * | 2004-08-27 | 2007-10-10 | Esteve Labor Dr | Inhibidores del receptor sigma. |
EP1634873A1 (fr) * | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Inhibiteurs des récepteurs sigma |
EP1847542A1 (fr) * | 2006-04-21 | 2007-10-24 | Laboratorios del Dr. Esteve S.A. | Dérivés de spiro[benzopyran] ou de spiro[benzofuran] comme antagonistes du récepteur sigma |
EP1982714A1 (fr) * | 2007-04-16 | 2008-10-22 | Laboratorios del Dr. Esteve S.A. | Pyrano-pyrazole-aminés |
EP1982987A1 (fr) * | 2007-04-16 | 2008-10-22 | Laboratorios del Dr. Esteve S.A. | Dérivés de spiro-pyrano-pyrazole |
AU2008265655B2 (en) * | 2007-06-21 | 2014-02-06 | Cara Therapeutics, Inc. | Substituted imidazoheterocycles |
US8173672B2 (en) * | 2008-03-21 | 2012-05-08 | Merck Sharp & Dohme Corp. | Quinolizidinone M1 receptor positive allosteric modulators |
EP2468728A1 (fr) * | 2010-12-03 | 2012-06-27 | Laboratorios Del. Dr. Esteve, S.A. | Dérivés de 2-(1-phényl-4,5,6,7-tétrahydro-1h-indazol-4-yl)éthylamine utiles en tant qu'inhibiteurs de récepteur sigma |
EP2548878A1 (fr) * | 2011-07-21 | 2013-01-23 | Laboratorios Del. Dr. Esteve, S.A. | Composés de pyrazolo[3,4-d]pyrimidine, leur préparation et utilisation en tant que ligands sigma |
-
2014
- 2014-12-18 US US15/105,105 patent/US9676784B2/en active Active
- 2014-12-18 KR KR1020167019011A patent/KR20160095157A/ko not_active Application Discontinuation
- 2014-12-18 BR BR112016014295A patent/BR112016014295A2/pt not_active Application Discontinuation
- 2014-12-18 JP JP2016541066A patent/JP6464171B2/ja not_active Expired - Fee Related
- 2014-12-18 ES ES14825134T patent/ES2754430T3/es active Active
- 2014-12-18 WO PCT/EP2014/078457 patent/WO2015091795A1/fr active Application Filing
- 2014-12-18 SG SG11201604878XA patent/SG11201604878XA/en unknown
- 2014-12-18 UA UAA201606725A patent/UA119547C2/uk unknown
- 2014-12-18 MX MX2016008062A patent/MX2016008062A/es unknown
- 2014-12-18 MA MA39190A patent/MA39190B1/fr unknown
- 2014-12-18 TN TN2016000254A patent/TN2016000254A1/en unknown
- 2014-12-18 CN CN201480073636.7A patent/CN105916858B/zh not_active Expired - Fee Related
- 2014-12-18 AU AU2014368591A patent/AU2014368591A1/en not_active Abandoned
- 2014-12-18 RU RU2016126431A patent/RU2016126431A/ru unknown
- 2014-12-18 EP EP14825134.1A patent/EP3083628B1/fr active Active
- 2014-12-18 CA CA2934144A patent/CA2934144A1/fr not_active Abandoned
-
2016
- 2016-06-16 IL IL246272A patent/IL246272A0/en unknown
- 2016-06-16 PH PH12016501169A patent/PH12016501169A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112016014295A2 (pt) | 2017-08-08 |
WO2015091795A1 (fr) | 2015-06-25 |
ES2754430T3 (es) | 2020-04-17 |
KR20160095157A (ko) | 2016-08-10 |
EP3083628B1 (fr) | 2019-08-07 |
PH12016501169A1 (en) | 2016-07-18 |
RU2016126431A (ru) | 2018-01-25 |
CA2934144A1 (fr) | 2015-06-25 |
US9676784B2 (en) | 2017-06-13 |
MA39190A1 (fr) | 2017-10-31 |
JP6464171B2 (ja) | 2019-02-06 |
US20160311828A1 (en) | 2016-10-27 |
JP2016540817A (ja) | 2016-12-28 |
CN105916858B (zh) | 2018-09-14 |
EP3083628A1 (fr) | 2016-10-26 |
UA119547C2 (uk) | 2019-07-10 |
TN2016000254A1 (en) | 2017-10-06 |
SG11201604878XA (en) | 2016-07-28 |
AU2014368591A1 (en) | 2016-07-07 |
IL246272A0 (en) | 2016-08-02 |
CN105916858A (zh) | 2016-08-31 |
MX2016008062A (es) | 2017-03-09 |
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