MA36330B1 - Kit for the diagnosis of chronic myeloide leukemia in multiplex reaction and its applications in the monitoring of treatment and residual disease - Google Patents
Kit for the diagnosis of chronic myeloide leukemia in multiplex reaction and its applications in the monitoring of treatment and residual diseaseInfo
- Publication number
- MA36330B1 MA36330B1 MA36330A MA36330A MA36330B1 MA 36330 B1 MA36330 B1 MA 36330B1 MA 36330 A MA36330 A MA 36330A MA 36330 A MA36330 A MA 36330A MA 36330 B1 MA36330 B1 MA 36330B1
- Authority
- MA
- Morocco
- Prior art keywords
- kit
- diagnosis
- monitoring
- treatment
- residual disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La présente invention concerne un kit de diagnostic in vitro pour l'identification et la quantification de la translocation génétique bcr-abl présent dans le cas de leucémie myéloïde chronique (lmc) et la leucémie iymphoblastique aigue (lla). Le présent kit est composée d'une combinaison innovante de nouveaux sets d'amorces et de sondes et d'une série de dilution plasmidique calibrant permettant la détection spécifique et la quantification du gène bcr-abl et du gène de référence abll en utilisant la méthode de pcr en temps réel (qpcr) en format multiplex ou simplex. Le présent kit est destiné pour le diagnostic, le suivi du traitement et l'établissement de la maladie résiduelle dans le cas de la lmcet lla.The present invention relates to an in vitro diagnostic kit for the identification and quantification of the bcr-abl genetic translocation present in the case of chronic myeloid leukemia (lmc) and acute lymphoblastic leukemia (lla). This kit consists of an innovative combination of new primers and probes sets and a calibrated plasmid dilution series for the specific detection and quantification of the abll bcr-abl gene and reference gene using the method real-time pcr (qpcr) in multiplex or simplex format. This kit is intended for the diagnosis, monitoring of treatment and establishment of residual disease in the case of lmcet lla.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MA36330A MA36330B1 (en) | 2013-10-10 | 2013-10-10 | Kit for the diagnosis of chronic myeloide leukemia in multiplex reaction and its applications in the monitoring of treatment and residual disease |
PCT/MA2014/000031 WO2015060703A2 (en) | 2013-10-10 | 2014-11-11 | Kit for diagnosing chronic myeloid leukaemia in a multiplex reaction and applications of same to monitor the treatment and the residual disease |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MA36330A MA36330B1 (en) | 2013-10-10 | 2013-10-10 | Kit for the diagnosis of chronic myeloide leukemia in multiplex reaction and its applications in the monitoring of treatment and residual disease |
Publications (2)
Publication Number | Publication Date |
---|---|
MA20150144A1 MA20150144A1 (en) | 2015-05-29 |
MA36330B1 true MA36330B1 (en) | 2016-04-29 |
Family
ID=52444609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36330A MA36330B1 (en) | 2013-10-10 | 2013-10-10 | Kit for the diagnosis of chronic myeloide leukemia in multiplex reaction and its applications in the monitoring of treatment and residual disease |
Country Status (2)
Country | Link |
---|---|
MA (1) | MA36330B1 (en) |
WO (1) | WO2015060703A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106701957A (en) * | 2017-01-12 | 2017-05-24 | 广州蓝吉生物技术有限公司 | Kit for detecting fusion gene BCR-ABL (P210) mRNA expression |
CN109706147A (en) * | 2018-05-09 | 2019-05-03 | 深圳市第二人民医院 | Circular rna circBA9.3 and its preparing the purposes in CML diagnostic kit |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1454994A1 (en) * | 2003-03-07 | 2004-09-08 | Université de la Méditerranée | Standardized and optimized real-time quantitative reverse transcriptase polymerase chain reaction method for detection of MRD in leukemia |
KR100652247B1 (en) * | 2004-06-29 | 2006-12-08 | 가톨릭대학교 산학협력단 | - Kit for Quantitative Analysis of BCR-ABL |
CN101624621B (en) * | 2008-07-11 | 2012-01-18 | 北京大学人民医院 | Kit for quantitatively detecting BCR/ABL mRNA level |
CN101701253B (en) * | 2009-11-26 | 2012-05-30 | 南方医科大学 | Double fluorescent quantitative PCR kit used for detecting gene expression |
US9611330B2 (en) * | 2011-09-08 | 2017-04-04 | The Regents Of The University Of California | Compositions and methods for cancer and cancer stem cell detection and elimination |
CN102827937B (en) * | 2012-09-06 | 2014-03-19 | 上海源奇生物医药科技有限公司 | Primer and probe for detecting relative fusion genes of leukemia and kit of primer and probe |
MA35216B1 (en) * | 2012-09-13 | 2014-07-03 | Mascir | Probes and primers for detecting bcr-abl gene in duplex reaction |
-
2013
- 2013-10-10 MA MA36330A patent/MA36330B1/en unknown
-
2014
- 2014-11-11 WO PCT/MA2014/000031 patent/WO2015060703A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2015060703A3 (en) | 2015-08-13 |
WO2015060703A4 (en) | 2015-10-01 |
WO2015060703A2 (en) | 2015-04-30 |
MA20150144A1 (en) | 2015-05-29 |
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