MA35215B1 - Inhibitors of activity akt - Google Patents

Inhibitors of activity akt

Info

Publication number
MA35215B1
MA35215B1 MA30546A MA30546A MA35215B1 MA 35215 B1 MA35215 B1 MA 35215B1 MA 30546 A MA30546 A MA 30546A MA 30546 A MA30546 A MA 30546A MA 35215 B1 MA35215 B1 MA 35215B1
Authority
MA
Morocco
Prior art keywords
akt
inhibitors
compounds
activity
activity akt
Prior art date
Application number
MA30546A
Other languages
French (fr)
Inventor
Philip E Sanderson
Essa H Hu
Kevin J Rodzinak
Jun Liang
Mark E Layton
Michael J Kelly Iii
Yiwei Li
Donna J Armstrong
Michael A Rossi
Jiabing Wang
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2006/022079 external-priority patent/WO2006135627A2/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA35215B1 publication Critical patent/MA35215B1/en

Links

Abstract

L'invention concerne des composés de naphthyridine substitués qui inhibent l'activité akt. Notamment, les composés de cette invention permettent d'inhiber sélectivement au moins deux des isoformes akt. Ladite invention a aussi pour objet des compositions renfermant de tels composés inhibiteurs et des méthodes d'inhibition de l'activité akt par administration du composé à un patient nécessitant un traitement contre le cancer.The invention provides substituted naphthyridine compounds that inhibit akt activity. In particular, the compounds of this invention can selectively inhibit at least two of the akt isoforms. The invention also relates to compositions comprising such inhibitory compounds and methods of inhibiting akt activity by administering the compound to a patient in need of cancer treatment.

MA30546A 2005-06-10 2008-01-07 Inhibitors of activity akt MA35215B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68972605P 2005-06-10 2005-06-10
PCT/US2006/022079 WO2006135627A2 (en) 2005-06-10 2006-06-07 Inhibitors of akt activity

Publications (1)

Publication Number Publication Date
MA35215B1 true MA35215B1 (en) 2014-07-03

Family

ID=40448246

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30546A MA35215B1 (en) 2005-06-10 2008-01-07 Inhibitors of activity akt

Country Status (5)

Country Link
CN (1) CN101374515B (en)
MA (1) MA35215B1 (en)
SI (1) SI1898903T1 (en)
UA (1) UA87929C2 (en)
ZA (1) ZA200709762B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187026A1 (en) * 2001-12-13 2003-10-02 Qun Li Kinase inhibitors

Also Published As

Publication number Publication date
ZA200709762B (en) 2009-08-26
SI1898903T1 (en) 2013-07-31
CN101374515A (en) 2009-02-25
UA87929C2 (en) 2009-08-25
CN101374515B (en) 2013-01-09

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