MA33102B1 - Derivatives of 6- (6-o-cycloalkyl or 6-nh-cycloalkyl-triiazolopridzine-sulfanil) (benzothiazole and benzimidazole: preparation and use as a drug and use as inhibitors met - Google Patents
Derivatives of 6- (6-o-cycloalkyl or 6-nh-cycloalkyl-triiazolopridzine-sulfanil) (benzothiazole and benzimidazole: preparation and use as a drug and use as inhibitors metInfo
- Publication number
- MA33102B1 MA33102B1 MA34147A MA34147A MA33102B1 MA 33102 B1 MA33102 B1 MA 33102B1 MA 34147 A MA34147 A MA 34147A MA 34147 A MA34147 A MA 34147A MA 33102 B1 MA33102 B1 MA 33102B1
- Authority
- MA
- Morocco
- Prior art keywords
- cycloalkyl
- inhibitors
- met
- triiazolopridzine
- sulfanil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
L'INVENTION CONCERNE LES NOUVEAUX PRODUITS DE FORMULE (I) DANS LAQUELLE - - - - REPRÉSENTE UNE LIAISON SIMPLE OU DOUBLE; RA REPRÉSENTE -O-CYCLOALKYLE OU -NH-CYCLOALKYLE; X REPRÉSENTE S, SO OU SO2, A REPRÉSENTE NH OU S; W REPRÉSENTE H, ALKYLE OU COR AVEC R REPRÉSENTE CYCLOALKYLE; ALKYLE; ALCOXY; O-PHÉNYLE; -O-(CH2)N-PHÉNYLE AVEC N= 1 À 4; OU NR1 R2 AVEC R1 REPRÉSENTE H OU ALK ET R2 REPRÉSENTE H, CYCLOALKYLE, HÉTÉROCYCLOALKYLE, OU ALKYLE; OU BIEN R1, R2 FORMENT AVEC N UN CYCLE RENFERMANT ÉVENTUELLEMENT O, S, N ET/OU NH; TOUS CES RADICAUX ÉTANT ÉVENTUELLEMENT SUBSTITUÉS; CES PRODUITS ÉTANT SOUS TOUTES LES FORMES ISOMÈRES ET LES SELS, À TITRE DE MÉDICAMENTS NOTAMMENT COMME INHIBITEURS DE MET.The invention relates to the novel products of formula (I) in which - - - - represents a simple or double bond; RA REPRESENTS -O-CYCLOALKYL OR -NH-CYCLOALKYL; X REPRESENTS S, SO OR SO2, REPRESENTS NH OR S; W REPRESENTS H, ALKYL OR COR WITH R REPRESENT CYCLOALKYL; Alkyl; ALCOXY; O-phenyl; -O- (CH 2) N-phenyl with N = 1 to 4; OR NR1 R2 WITH R1 REPRESENTS H OR ALK AND R2 REPRESENTS H, CYCLOALKYL, HETEROCYCLOALKYL, OR ALKYL; OR R1, R2 FORMULA WITH N A CYCLE INCLUDING O, S, N AND / OR NH; ALL THESE RADICALS ARE POSSIBLY SUBSTITUTED; THESE PRODUCTS ARE IN ALL ISOMERIC FORMS AND SALTS, AS MEDICINES IN PARTICULAR AS MET INHIBITORS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0900510A FR2941949B1 (en) | 2009-02-06 | 2009-02-06 | DERIVATIVES OF 6- (6-O-CYCLOALKYL OR 6-NH-CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS INHIBITORS OF MET. |
PCT/FR2010/050177 WO2010089506A1 (en) | 2009-02-06 | 2010-02-04 | Derivatives of 6-(6-o-cycloalkyl or 6-nh-cycloalkyl-triazolopyridazine-sulfanyl) benzothiazoles and benzimidazoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33102B1 true MA33102B1 (en) | 2012-03-01 |
Family
ID=40863635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34147A MA33102B1 (en) | 2009-02-06 | 2010-02-04 | Derivatives of 6- (6-o-cycloalkyl or 6-nh-cycloalkyl-triiazolopridzine-sulfanil) (benzothiazole and benzimidazole: preparation and use as a drug and use as inhibitors met |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP2393790A1 (en) |
JP (1) | JP2012517407A (en) |
KR (1) | KR20110126660A (en) |
CN (1) | CN102388029A (en) |
AR (1) | AR075248A1 (en) |
AU (1) | AU2010212231A1 (en) |
BR (1) | BRPI1011354A2 (en) |
CA (1) | CA2751525A1 (en) |
CO (1) | CO6400222A2 (en) |
EA (1) | EA201171010A1 (en) |
FR (1) | FR2941949B1 (en) |
IL (1) | IL214407A0 (en) |
MA (1) | MA33102B1 (en) |
MX (1) | MX2011008312A (en) |
SG (1) | SG173558A1 (en) |
TW (1) | TW201040187A (en) |
UY (1) | UY32419A (en) |
WO (1) | WO2010089506A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112014006223A8 (en) | 2011-09-15 | 2018-01-09 | Novartis Ag | 6-substituted 3- (quinolin-6-ylthio) - [1,2,4-triazol [4,3-a] pyradines, their uses, pharmaceutical compositions, and combination |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1298125A1 (en) | 2001-09-26 | 2003-04-02 | Aventis Pharma S.A. | Substituted benzimidazole compounds and their use for the treatment of cancer |
ZA200804681B (en) * | 2005-11-30 | 2009-11-25 | Vertex Pharma Inc | Inhibitors of C-Met and uses thereof |
CA2630884A1 (en) * | 2005-11-30 | 2007-06-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-met and uses thereof |
RS55630B1 (en) * | 2005-12-21 | 2017-06-30 | Janssen Pharmaceutica Nv | Triazolopyridazines as tyrosine kinase modulators |
EP2032578A2 (en) * | 2006-05-30 | 2009-03-11 | Pfizer Products Incorporated | Triazolopyridazine derivatives |
PE20080403A1 (en) * | 2006-07-14 | 2008-04-25 | Amgen Inc | FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE |
BRPI0717320A2 (en) * | 2006-10-23 | 2013-10-22 | Sgx Pharmaceuticals Inc | Bicyclic triazols as protein kinase modulators |
PA8792501A1 (en) * | 2007-08-09 | 2009-04-23 | Sanofi Aventis | NEW DERIVATIVES OF 6-TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS. |
-
2009
- 2009-02-06 FR FR0900510A patent/FR2941949B1/en not_active Expired - Fee Related
-
2010
- 2010-02-04 SG SG2011056470A patent/SG173558A1/en unknown
- 2010-02-04 WO PCT/FR2010/050177 patent/WO2010089506A1/en active Application Filing
- 2010-02-04 CA CA2751525A patent/CA2751525A1/en not_active Abandoned
- 2010-02-04 BR BRPI1011354A patent/BRPI1011354A2/en not_active IP Right Cessation
- 2010-02-04 EA EA201171010A patent/EA201171010A1/en unknown
- 2010-02-04 KR KR1020117020676A patent/KR20110126660A/en not_active Application Discontinuation
- 2010-02-04 MA MA34147A patent/MA33102B1/en unknown
- 2010-02-04 EP EP10708277A patent/EP2393790A1/en not_active Withdrawn
- 2010-02-04 CN CN2010800150530A patent/CN102388029A/en active Pending
- 2010-02-04 AU AU2010212231A patent/AU2010212231A1/en not_active Abandoned
- 2010-02-04 MX MX2011008312A patent/MX2011008312A/en not_active Application Discontinuation
- 2010-02-04 JP JP2011548750A patent/JP2012517407A/en not_active Withdrawn
- 2010-02-05 UY UY0001032419A patent/UY32419A/en not_active Application Discontinuation
- 2010-02-05 TW TW099103558A patent/TW201040187A/en unknown
- 2010-02-05 AR ARP100100316A patent/AR075248A1/en unknown
-
2011
- 2011-08-02 IL IL214407A patent/IL214407A0/en unknown
- 2011-08-05 CO CO11099121A patent/CO6400222A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2010089506A1 (en) | 2010-08-12 |
IL214407A0 (en) | 2011-09-27 |
BRPI1011354A2 (en) | 2019-09-24 |
UY32419A (en) | 2010-09-30 |
EP2393790A1 (en) | 2011-12-14 |
KR20110126660A (en) | 2011-11-23 |
SG173558A1 (en) | 2011-09-29 |
JP2012517407A (en) | 2012-08-02 |
CO6400222A2 (en) | 2012-03-15 |
FR2941949B1 (en) | 2011-04-01 |
EA201171010A1 (en) | 2012-03-30 |
TW201040187A (en) | 2010-11-16 |
CA2751525A1 (en) | 2010-08-12 |
MX2011008312A (en) | 2011-11-02 |
AR075248A1 (en) | 2011-03-16 |
AU2010212231A1 (en) | 2011-08-25 |
CN102388029A (en) | 2012-03-21 |
FR2941949A1 (en) | 2010-08-13 |
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