BRPI0905687A2 - "compound of formula i or i ', pharmaceutical composition, method of treating a patient with a disease, use of the compound" - Google Patents
"compound of formula i or i ', pharmaceutical composition, method of treating a patient with a disease, use of the compound"Info
- Publication number
- BRPI0905687A2 BRPI0905687A2 BRPI0905687-4A BRPI0905687A BRPI0905687A2 BR PI0905687 A2 BRPI0905687 A2 BR PI0905687A2 BR PI0905687 A BRPI0905687 A BR PI0905687A BR PI0905687 A2 BRPI0905687 A2 BR PI0905687A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- disease
- patient
- treating
- formula
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/16—Eight-membered rings
- C07D313/20—Eight-membered rings condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1116308P | 2008-01-15 | 2008-01-15 | |
PCT/US2009/031149 WO2009091921A1 (en) | 2008-01-15 | 2009-01-15 | Synthesis of resorcylic acid lactones useful as therapeutic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0905687A2 true BRPI0905687A2 (en) | 2015-07-07 |
BRPI0905687A8 BRPI0905687A8 (en) | 2019-05-21 |
Family
ID=40885647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0905687A BRPI0905687A8 (en) | 2008-01-15 | 2009-01-15 | compound of formula i or i ', pharmaceutical composition, method of treating a patient with a disease, use of the compound |
Country Status (13)
Country | Link |
---|---|
US (3) | US9051302B2 (en) |
EP (1) | EP2242359B1 (en) |
JP (2) | JP2011510017A (en) |
KR (4) | KR20160017105A (en) |
CN (1) | CN101990399B (en) |
AU (1) | AU2009206097B2 (en) |
BR (1) | BRPI0905687A8 (en) |
CA (1) | CA2755876C (en) |
ES (1) | ES2587390T3 (en) |
IL (1) | IL207049A (en) |
MX (1) | MX2010007755A (en) |
RU (1) | RU2534527C2 (en) |
WO (1) | WO2009091921A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2242359B1 (en) | 2008-01-15 | 2016-06-01 | Universite De Strasbourg | Synthesis of resorcylic acid lactones useful as therapeutic agents |
FR2949467B1 (en) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | NOVEL 5,6,7,8-TETRAHYDROINDOLIZINE DERIVATIVES INHIBITORS OF HSP90, COMPOSITIONS CONTAINING SAME AND USE THEREOF |
RU2013122898A (en) * | 2010-10-22 | 2014-11-27 | Университы До Страсбур | Pohoxime conjugates applicable for the treatment of pathologies associated with the HSP90, composition and method of treatment using them |
US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
US10149823B2 (en) | 2013-04-30 | 2018-12-11 | Otitopic Inc. | Dry powder formulations and methods of use |
US10434085B2 (en) | 2015-06-04 | 2019-10-08 | University Of North Carolina At Greensboro | Non-aromatic difluoro analogues of resorcylic acid lactones |
US10195147B1 (en) | 2017-09-22 | 2019-02-05 | Otitopic Inc. | Dry powder compositions with magnesium stearate |
US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
KR102059808B1 (en) | 2018-06-11 | 2019-12-27 | 주식회사 티맥스오에스 | Container-based integrated management system |
JP6849729B2 (en) * | 2019-04-15 | 2021-03-24 | キヤノン株式会社 | Motor control device, sheet transfer device and image forming device |
CN110464717B (en) * | 2019-09-23 | 2022-02-18 | 张建国 | Application of 2, 4-dihydroxybenzoic acid in preparation of blood sugar reducing medicine |
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CA2218981C (en) * | 1995-04-26 | 2007-01-16 | Kyowa Hakko Kogyo Co., Ltd. | Radicicol derivatives |
US6316491B1 (en) * | 1996-10-25 | 2001-11-13 | Kyowa Hakko Kogyo Co., Ltd. | Radicicol derivatives |
AU2001271567A1 (en) | 2000-06-29 | 2002-01-14 | Trustees Of Boston University | Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders |
EP1315732B1 (en) * | 2000-08-25 | 2006-06-07 | Sloan-Kettering Institute For Cancer Research | Radicicol and monocillin and their analogues and uses thereof |
US20060177416A1 (en) * | 2003-10-14 | 2006-08-10 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
RU2312863C2 (en) * | 2002-04-17 | 2007-12-20 | Тайсо Фармасьютикал Ко., Лтд. | Tonic for hair growth |
US20050002996A1 (en) * | 2003-07-02 | 2005-01-06 | Milan Sojka | Sustained release compositions and controlled delivery method |
WO2006051808A1 (en) | 2004-11-09 | 2006-05-18 | Kyowa Hakko Kogyo Co., Ltd. | Hsp90 FAMILY PROTEIN INHIBITORS |
WO2007143630A2 (en) * | 2006-06-02 | 2007-12-13 | Nexgenix Pharmaceuticals | Treatment of neurofibromatosis with hsp90 inhibitors |
WO2008150302A1 (en) * | 2007-06-04 | 2008-12-11 | Nexgenix Pharmaceuticals | Treatment of neurofibromatosis with radicicol and its derivatives |
US8067412B2 (en) * | 2006-08-11 | 2011-11-29 | Universite De Strasbourg | Macrocyclic compounds useful as inhibitors of kinases and HSP90 |
EP2242359B1 (en) | 2008-01-15 | 2016-06-01 | Universite De Strasbourg | Synthesis of resorcylic acid lactones useful as therapeutic agents |
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- 2009-01-15 KR KR1020167001931A patent/KR20160017105A/en not_active Application Discontinuation
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- 2009-01-15 RU RU2010133979/04A patent/RU2534527C2/en active
- 2009-01-15 US US12/863,123 patent/US9051302B2/en active Active
- 2009-01-15 KR KR1020107018150A patent/KR20110003468A/en not_active Application Discontinuation
- 2009-01-15 JP JP2010543254A patent/JP2011510017A/en active Pending
- 2009-01-15 CN CN200980109146.7A patent/CN101990399B/en active Active
- 2009-01-15 CA CA2755876A patent/CA2755876C/en active Active
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- 2009-01-15 KR KR1020167025373A patent/KR101835252B1/en active IP Right Grant
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CA2755876A1 (en) | 2009-07-23 |
KR20160017105A (en) | 2016-02-15 |
JP2011510017A (en) | 2011-03-31 |
EP2242359A1 (en) | 2010-10-27 |
AU2009206097A1 (en) | 2009-07-23 |
IL207049A0 (en) | 2010-12-30 |
MX2010007755A (en) | 2010-12-21 |
US10239856B2 (en) | 2019-03-26 |
CN101990399A (en) | 2011-03-23 |
JP6159350B2 (en) | 2017-07-05 |
RU2534527C2 (en) | 2014-11-27 |
US20110217335A1 (en) | 2011-09-08 |
EP2242359B1 (en) | 2016-06-01 |
KR101835252B1 (en) | 2018-03-06 |
KR20160112015A (en) | 2016-09-27 |
BRPI0905687A8 (en) | 2019-05-21 |
CN101990399B (en) | 2016-05-04 |
US20190359585A1 (en) | 2019-11-28 |
US9051302B2 (en) | 2015-06-09 |
IL207049A (en) | 2015-01-29 |
US20160075677A1 (en) | 2016-03-17 |
EP2242359A4 (en) | 2011-11-09 |
CA2755876C (en) | 2017-04-18 |
WO2009091921A1 (en) | 2009-07-23 |
KR20160112016A (en) | 2016-09-27 |
JP2015110624A (en) | 2015-06-18 |
AU2009206097B2 (en) | 2014-08-14 |
KR20110003468A (en) | 2011-01-12 |
ES2587390T3 (en) | 2016-10-24 |
RU2010133979A (en) | 2012-02-27 |
KR101835253B1 (en) | 2018-03-06 |
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