MA30778B1 - Derives de sulfonamides servant d'agonistes adrenergique et d'antagonistes muscariniques - Google Patents
Derives de sulfonamides servant d'agonistes adrenergique et d'antagonistes muscariniquesInfo
- Publication number
- MA30778B1 MA30778B1 MA31760A MA31760A MA30778B1 MA 30778 B1 MA30778 B1 MA 30778B1 MA 31760 A MA31760 A MA 31760A MA 31760 A MA31760 A MA 31760A MA 30778 B1 MA30778 B1 MA 30778B1
- Authority
- MA
- Morocco
- Prior art keywords
- adrenergic agonists
- sulfonamide derivatives
- muscarinic antagonists
- disorders
- present
- Prior art date
Links
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 title 1
- 239000000048 adrenergic agonist Substances 0.000 title 1
- 239000003149 muscarinic antagonist Substances 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82809906P | 2006-10-04 | 2006-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA30778B1 true MA30778B1 (fr) | 2009-10-01 |
Family
ID=38947725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA31760A MA30778B1 (fr) | 2006-10-04 | 2009-04-03 | Derives de sulfonamides servant d'agonistes adrenergique et d'antagonistes muscariniques |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20080090873A1 (sr) |
| EP (1) | EP2074094A1 (sr) |
| JP (1) | JP2010505810A (sr) |
| KR (1) | KR20090050104A (sr) |
| CN (1) | CN101522622A (sr) |
| AP (1) | AP2009004791A0 (sr) |
| AR (1) | AR063118A1 (sr) |
| AU (1) | AU2007303909A1 (sr) |
| BR (1) | BRPI0719270A2 (sr) |
| CA (1) | CA2665385A1 (sr) |
| CL (1) | CL2007002791A1 (sr) |
| CO (1) | CO6180437A2 (sr) |
| CR (1) | CR10700A (sr) |
| EA (1) | EA200900337A1 (sr) |
| IL (1) | IL197244A0 (sr) |
| MA (1) | MA30778B1 (sr) |
| MX (1) | MX2009002209A (sr) |
| NO (1) | NO20090910L (sr) |
| PE (1) | PE20080831A1 (sr) |
| RS (1) | RS20090137A (sr) |
| TN (1) | TN2009000112A1 (sr) |
| TW (1) | TW200823185A (sr) |
| UY (1) | UY30617A1 (sr) |
| WO (1) | WO2008041095A1 (sr) |
| ZA (1) | ZA200901320B (sr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| JP5801997B2 (ja) | 2009-07-07 | 2015-10-28 | ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ | 薬品の組合せを吸入するための投薬ユニット、投薬ユニットのパック、および吸入器 |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| ITRM20110083U1 (it) | 2010-05-13 | 2011-11-14 | De La Cruz Jose Antonio Freire | Piastra per la costruzione di carrelli per aeroplani |
| GB201016912D0 (en) | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| ES2750523T3 (es) | 2012-12-18 | 2020-03-26 | Almirall Sa | Derivados de ciclohexil y quinuclidinil carbamato que tienen actividades de agonista beta2 adrenérgicos y antagonistas muscarínicos M3 |
| TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
| TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽 |
| TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
| CN106336406B (zh) * | 2015-07-10 | 2020-01-03 | 四川海思科制药有限公司 | 具有β2受体激动及M受体拮抗活性的八氢并环戊二烯衍生物及其在医药上的用途 |
| CA3047023C (en) | 2016-12-14 | 2022-05-31 | Beijing Showby Pharmaceutical Co., Ltd. | Class of bifunctional compounds with quaternary ammonium salt structure |
| WO2019071147A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| US20200308168A1 (en) * | 2017-12-04 | 2020-10-01 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Fluorophenyl substituted muscarinic receptor ligands with selectivity for m3 over m2 |
| CN116033893A (zh) | 2020-06-26 | 2023-04-28 | 迈兰制药英国有限公司 | 包含5-[3-(3-羟基苯氧基)氮杂环丁烷-1-基]-5-甲基-2,2-二苯基己酰胺的制剂 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5776983A (en) * | 1993-12-21 | 1998-07-07 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
| PE20040950A1 (es) * | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| JP4767842B2 (ja) * | 2003-04-01 | 2011-09-07 | セラヴァンス， インコーポレーテッド | β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物 |
| DE602004021921D1 (de) * | 2003-05-28 | 2009-08-20 | Theravance Inc | Azabicycloalkanverbindungen als muscarinrezeptor antagonisten |
| PT1708992E (pt) * | 2004-01-22 | 2007-11-16 | Pfizer | Derivados de sulfonamida para o tratamento de doenças |
| US7320990B2 (en) * | 2004-02-13 | 2008-01-22 | Theravance, Inc. | Crystalline form of a biphenyl compound |
| TWI374883B (en) * | 2004-08-16 | 2012-10-21 | Theravance Inc | Crystalline form of a biphenyl compound |
-
2007
- 2007-09-21 AP AP2009004791A patent/AP2009004791A0/xx unknown
- 2007-09-21 WO PCT/IB2007/002896 patent/WO2008041095A1/en not_active Ceased
- 2007-09-21 CN CNA2007800373310A patent/CN101522622A/zh active Pending
- 2007-09-21 MX MX2009002209A patent/MX2009002209A/es not_active Application Discontinuation
- 2007-09-21 BR BRPI0719270-3A patent/BRPI0719270A2/pt not_active IP Right Cessation
- 2007-09-21 KR KR1020097006899A patent/KR20090050104A/ko not_active Ceased
- 2007-09-21 EA EA200900337A patent/EA200900337A1/ru unknown
- 2007-09-21 RS RSP-2009/0137A patent/RS20090137A/sr unknown
- 2007-09-21 JP JP2009530960A patent/JP2010505810A/ja not_active Withdrawn
- 2007-09-21 CA CA002665385A patent/CA2665385A1/en not_active Abandoned
- 2007-09-21 EP EP07805009A patent/EP2074094A1/en not_active Withdrawn
- 2007-09-21 AU AU2007303909A patent/AU2007303909A1/en not_active Abandoned
- 2007-09-27 PE PE2007001318A patent/PE20080831A1/es not_active Application Discontinuation
- 2007-09-27 CL CL200702791A patent/CL2007002791A1/es unknown
- 2007-10-02 US US11/906,796 patent/US20080090873A1/en not_active Abandoned
- 2007-10-02 UY UY30617A patent/UY30617A1/es not_active Application Discontinuation
- 2007-10-03 AR ARP070104386A patent/AR063118A1/es not_active Application Discontinuation
- 2007-10-03 TW TW096137048A patent/TW200823185A/zh unknown
-
2009
- 2009-02-24 ZA ZA200901320A patent/ZA200901320B/xx unknown
- 2009-02-25 IL IL197244A patent/IL197244A0/en unknown
- 2009-02-26 NO NO20090910A patent/NO20090910L/no not_active Application Discontinuation
- 2009-03-31 TN TN2009000112A patent/TN2009000112A1/fr unknown
- 2009-03-31 CR CR10700A patent/CR10700A/es not_active Application Discontinuation
- 2009-04-02 CO CO09034044A patent/CO6180437A2/es not_active Application Discontinuation
- 2009-04-03 MA MA31760A patent/MA30778B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007303909A1 (en) | 2008-04-10 |
| EP2074094A1 (en) | 2009-07-01 |
| CN101522622A (zh) | 2009-09-02 |
| CR10700A (es) | 2009-04-24 |
| NO20090910L (no) | 2009-03-24 |
| JP2010505810A (ja) | 2010-02-25 |
| KR20090050104A (ko) | 2009-05-19 |
| US20080090873A1 (en) | 2008-04-17 |
| AP2009004791A0 (en) | 2009-04-30 |
| EA200900337A1 (ru) | 2009-10-30 |
| TN2009000112A1 (fr) | 2010-08-19 |
| IL197244A0 (en) | 2009-12-24 |
| WO2008041095A1 (en) | 2008-04-10 |
| CL2007002791A1 (es) | 2008-04-11 |
| UY30617A1 (es) | 2008-05-31 |
| MX2009002209A (es) | 2009-03-16 |
| PE20080831A1 (es) | 2008-06-20 |
| CO6180437A2 (es) | 2010-07-19 |
| TW200823185A (en) | 2008-06-01 |
| RS20090137A (sr) | 2010-06-30 |
| ZA200901320B (en) | 2010-04-28 |
| CA2665385A1 (en) | 2008-04-10 |
| BRPI0719270A2 (pt) | 2014-03-11 |
| AR063118A1 (es) | 2008-12-30 |
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