MA28656B1 - Vaccin pour lutter contre la theileriose - Google Patents
Vaccin pour lutter contre la theilerioseInfo
- Publication number
- MA28656B1 MA28656B1 MA29521A MA29521A MA28656B1 MA 28656 B1 MA28656 B1 MA 28656B1 MA 29521 A MA29521 A MA 29521A MA 29521 A MA29521 A MA 29521A MA 28656 B1 MA28656 B1 MA 28656B1
- Authority
- MA
- Morocco
- Prior art keywords
- cells
- infected
- vaccine
- viable cells
- calves
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 208000001117 Theileriasis Diseases 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 7
- 238000000034 method Methods 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 244000309466 calf Species 0.000 abstract 2
- 239000001963 growth medium Substances 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 241000223778 Theileria annulata Species 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000005138 cryopreservation Methods 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002489 hematologic effect Effects 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000007918 pathogenicity Effects 0.000 abstract 1
- 210000001563 schizont Anatomy 0.000 abstract 1
- 230000000405 serological effect Effects 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
- A61K39/018—Babesia antigens, e.g. Theileria antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La présente invention concerne un procédé pour préparer un vaccin pour lutter contre la theilériose. Ce procédé consiste à isoler des cellules lymphoïdes infectées avec des schizontes de Theileria annulata présentes chez un animal infecté, à mettre en culture les cellules infectées dans un milieu de croissance, à soumettre ces cellules en culture à l'étape de propagation in vitro par un repiquage en série, à développer ces cultures clonées à partir d'une seule cellule en limitant la technique de dilution et en repiquant à nouveau celles-ci, à établir un caryotype des cellules dans le milieu, afin de déterminer le caractère diploïde, à obtenir des cellules viables avec des taux d'infectiosité maximum, à déterminer le nombre de masse des macroschizontes, à soumettre un certain nombre de cellules viables avec le caractère diploïde à l'étape de cryoconservation dans de l'azote liquide, en présence d'un agent de cryoprotection dans le milieu de croissance, afin d'obtenir une suspension de cellules viables, à tester ces cultures aux différents repiquages et à divers niveaux de dosage dans des groupes de veaux, afin de déterminer leur pouvoir pathogène/pouvoir antigénique, à déterminer le niveau de repiquage et la dose pour la sécurité et l'efficacité d'un vaccin candidat, son utilisation sûre chez des veaux nouveau-nés et chez des vaches pleines, le temps mis pour induire l'immunité, les réponses sérologiques et l'effet sur des paramètres hématologiques, puis enfin à tester son efficacité dans des conditions à champ large sur la population susceptible d'être touchée.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN880DE2004 | 2004-05-14 | ||
| IN2103DE2004 | 2004-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA28656B1 true MA28656B1 (fr) | 2007-06-01 |
Family
ID=35394566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA29521A MA28656B1 (fr) | 2004-05-14 | 2006-12-08 | Vaccin pour lutter contre la theileriose |
Country Status (5)
| Country | Link |
|---|---|
| AP (1) | AP2709A (fr) |
| IL (1) | IL179254A (fr) |
| MA (1) | MA28656B1 (fr) |
| RU (1) | RU2404800C2 (fr) |
| WO (1) | WO2005109991A2 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118489005A (zh) * | 2021-10-27 | 2024-08-13 | 苏州博腾生物制药有限公司 | 用于开发用于在悬浮细胞培养中产生病毒的细胞系的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2914813C2 (de) * | 1979-04-11 | 1984-04-19 | Vsesojuznyj institut eksperimental'noj veterinarii, Moskva | Lebend-Impfstoff gegen Theieriosis beim Rindvieh und Verfahren zu dessen Herstellung |
-
2005
- 2005-05-12 WO PCT/IN2005/000154 patent/WO2005109991A2/fr active Application Filing
- 2005-05-12 AP AP2006003856A patent/AP2709A/xx active
- 2005-05-12 RU RU2006144451/15A patent/RU2404800C2/ru not_active IP Right Cessation
-
2006
- 2006-11-14 IL IL179254A patent/IL179254A/en active IP Right Grant
- 2006-12-08 MA MA29521A patent/MA28656B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2006144451A (ru) | 2008-06-20 |
| WO2005109991A3 (fr) | 2006-03-30 |
| AP2006003856A0 (en) | 2006-12-31 |
| AP2709A (en) | 2013-07-30 |
| IL179254A (en) | 2011-12-29 |
| WO2005109991A2 (fr) | 2005-11-24 |
| WO2005109991A8 (fr) | 2006-08-24 |
| IL179254A0 (en) | 2007-03-08 |
| RU2404800C2 (ru) | 2010-11-27 |
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