MA26755A1 - NEW OXAMIDE DERIVATIVES, THEIR MANUFACTURE AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM. - Google Patents
NEW OXAMIDE DERIVATIVES, THEIR MANUFACTURE AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM.Info
- Publication number
- MA26755A1 MA26755A1 MA26144A MA26144A MA26755A1 MA 26755 A1 MA26755 A1 MA 26755A1 MA 26144 A MA26144 A MA 26144A MA 26144 A MA26144 A MA 26144A MA 26755 A1 MA26755 A1 MA 26755A1
- Authority
- MA
- Morocco
- Prior art keywords
- hydrogen atom
- lower alkyl
- alkyl group
- diseases
- agent
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
NOUVEAUX DERIVES OXAMIDE, LEUR FABRICATION ET LES PREPARATIONS PHARMACEUTIQUES LES CONTENANT F. Hoffmann-La Roche AG Sont décrits des composés de formule générale dans laquelle R1 représente un groupe hetérocyclyle ; R2 représente un atome d'hydrogène, un groupe alkyle inférieur non substitué, alcoxy inférieur, un atome d'halogène, un groupe hydroxy ou cyano ; R3 représente un atome d'hydrogène, un groupe alkyle inférieur non substitué, alcoxy inférieur, un atome d'halogène, ou un groupe cyano ; R4 représente un atome d'hydrogène, un groupe alkyle inférieur, cycloalkyle inférieur, aryle ou hetérocyclyle ; R5 représente un atome d'hydrogène, un groupe alkyle inférieur non substitué, alcoxy inférieur, un atome d'halogène, ou un groupe cyano ; R6 représente un atome d'hydrogène, un groupe alkyle inférieur non substitué, alcoxy inférieur, un atome d'halogène, ou un groupe cyano ; R7 représente un atome d'hydrogène, ou un groupe alkyle inférieur non substitué ; R8 représente un atome d'hydrogène ou un groupe alkyle inférieur non substitué ; ou R4 et R8 pris ensemble avec l'atome d'azote auquel ils sont attachés représentent un groupe hétérocyclyle ; et leurs sels pharmaceutiquement acceptables. Les dérivés oxamide décrits sont des inhibiteurs de l'enzyme inosine monophosphate déshydrogénase (IMPDH). Ils peuvent être utilisés comme médicaments en particulier pour le traitement d'états ou de maladies à médiation immunitaire, de maladies virales, de maladies bactériennes, de maladies parasitaires, d'inflammation, de maladies inflammatoires, de maladies vasculaires hyperprolifératives, de tumeurs et du cancer. On peut les utiliser seuls, ou en combinaison avec d'autres agents thérapeutiquement efficaces, par exemple un immunosuppresseur, un agent chimiothérapeutique, agent antiviral, un antibiotique, un agent antiparasitaire, un agent anti-inflammatoire, un agent antifongique et/ou un agent anti-hyperprolifération vasculaire.NOVEL OXAMIDE DERIVATIVES, THEIR MANUFACTURE AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM F. Hoffmann-La Roche AG Compounds of general formula are described in which R1 represents a heterocyclyl group; R2 represents a hydrogen atom, an unsubstituted lower alkyl group, lower alkoxy, a halogen atom, a hydroxy or cyano group; R3 represents a hydrogen atom, an unsubstituted lower alkyl group, lower alkoxy, a halogen atom, or a cyano group; R4 represents a hydrogen atom, a lower alkyl, lower cycloalkyl, aryl or heterocyclyl group; R5 represents a hydrogen atom, an unsubstituted lower alkyl group, lower alkoxy, a halogen atom, or a cyano group; R6 represents a hydrogen atom, an unsubstituted lower alkyl group, lower alkoxy, a halogen atom, or a cyano group; R7 represents a hydrogen atom, or an unsubstituted lower alkyl group; R8 represents a hydrogen atom or an unsubstituted lower alkyl group; or R4 and R8 taken together with the nitrogen atom to which they are attached represent a heterocyclyl group; and their pharmaceutically acceptable salts. The oxamide derivatives described are inhibitors of the enzyme inosine monophosphate dehydrogenase (IMPDH). They can be used as medicaments in particular for the treatment of immune-mediated conditions or diseases, viral diseases, bacterial diseases, parasitic diseases, inflammation, inflammatory diseases, hyperproliferative vascular diseases, tumors and Cancer. They can be used alone, or in combination with other therapeutically effective agents, for example an immunosuppressant, a chemotherapeutic agent, antiviral agent, an antibiotic, an antiparasitic agent, an anti-inflammatory agent, an antifungal agent and / or an agent. vascular anti-hyperproliferation.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0004392A GB0004392D0 (en) | 2000-02-24 | 2000-02-24 | Oxamide derivatives |
| GB0020322A GB0020322D0 (en) | 2000-08-17 | 2000-08-17 | Oxamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA26755A1 true MA26755A1 (en) | 2004-12-20 |
Family
ID=26243721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA26144A MA26755A1 (en) | 2000-02-24 | 2001-02-22 | NEW OXAMIDE DERIVATIVES, THEIR MANUFACTURE AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM. |
Country Status (9)
| Country | Link |
|---|---|
| CO (1) | CO5300390A1 (en) |
| CZ (1) | CZ2001667A3 (en) |
| HR (1) | HRP20010127A2 (en) |
| HU (1) | HUP0100836A2 (en) |
| ID (1) | ID29372A (en) |
| IL (1) | IL141543A0 (en) |
| MA (1) | MA26755A1 (en) |
| NO (1) | NO20010900L (en) |
| PL (1) | PL346098A1 (en) |
-
2001
- 2001-02-21 HU HU0100836A patent/HUP0100836A2/en unknown
- 2001-02-21 IL IL14154301A patent/IL141543A0/en unknown
- 2001-02-21 CZ CZ2001667A patent/CZ2001667A3/en unknown
- 2001-02-21 HR HRP20010127 patent/HRP20010127A2/en not_active Application Discontinuation
- 2001-02-22 CO CO01014294A patent/CO5300390A1/en not_active Application Discontinuation
- 2001-02-22 MA MA26144A patent/MA26755A1/en unknown
- 2001-02-22 NO NO20010900A patent/NO20010900L/en not_active Application Discontinuation
- 2001-02-22 ID IDP20010157D patent/ID29372A/en unknown
- 2001-02-23 PL PL34609801A patent/PL346098A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20010900D0 (en) | 2001-02-22 |
| IL141543A0 (en) | 2002-03-10 |
| HU0100836D0 (en) | 2001-04-28 |
| CZ2001667A3 (en) | 2001-10-17 |
| CO5300390A1 (en) | 2003-07-31 |
| HUP0100836A2 (en) | 2001-10-28 |
| PL346098A1 (en) | 2001-08-27 |
| NO20010900L (en) | 2001-08-27 |
| ID29372A (en) | 2001-08-30 |
| HRP20010127A2 (en) | 2001-12-31 |
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