MA26494A1 - Inhibiteurs de proteases nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. - Google Patents
Inhibiteurs de proteases nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.Info
- Publication number
- MA26494A1 MA26494A1 MA25064A MA25064A MA26494A1 MA 26494 A1 MA26494 A1 MA 26494A1 MA 25064 A MA25064 A MA 25064A MA 25064 A MA25064 A MA 25064A MA 26494 A1 MA26494 A1 MA 26494A1
- Authority
- MA
- Morocco
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- protease inhibitors
- novel protease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4686597P | 1997-05-08 | 1997-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA26494A1 true MA26494A1 (fr) | 2004-12-20 |
Family
ID=21945814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA25064A MA26494A1 (fr) | 1997-05-08 | 1998-05-06 | Inhibiteurs de proteases nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6369077B1 (fr) |
| EP (1) | EP0991753A4 (fr) |
| JP (1) | JP2001525809A (fr) |
| KR (1) | KR20010012316A (fr) |
| CN (1) | CN1255162A (fr) |
| AU (1) | AU7288598A (fr) |
| BR (1) | BR9808502A (fr) |
| CA (1) | CA2289010A1 (fr) |
| CO (1) | CO4950617A1 (fr) |
| HU (1) | HUP0001285A3 (fr) |
| IL (1) | IL131661A0 (fr) |
| MA (1) | MA26494A1 (fr) |
| NO (1) | NO995433L (fr) |
| PE (1) | PE73799A1 (fr) |
| PL (1) | PL336625A1 (fr) |
| TR (1) | TR199902752T2 (fr) |
| WO (1) | WO1998050534A1 (fr) |
| ZA (1) | ZA983843B (fr) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3786578B2 (ja) * | 1997-11-18 | 2006-06-14 | 帝人ファーマ株式会社 | 環状アミン誘導体、およびその薬剤としての使用法 |
| CO5150165A1 (es) * | 1998-11-13 | 2002-04-29 | Smithkline Beecham Plc | Inhibidores de proteasa: tipo catepsina k |
| CO5180541A1 (es) * | 1998-12-23 | 2002-07-30 | Smithkline Beechman Corp | Inhibidores de proteasa del tipo de 1,3-diaminocetonas con anillo de 8-14 miembros |
| WO2000069815A1 (fr) * | 1999-05-13 | 2000-11-23 | Teijin Limited | Derives d'amines cycliques ureido-substituees et leur utilisation en tant que medicament |
| ATE277903T1 (de) * | 1999-05-14 | 2004-10-15 | Bristol Myers Squibb Pharma Re | Zyklische aminderivate und ihre verwendung |
| ATE308985T1 (de) | 1999-05-18 | 2005-11-15 | Teijin Ltd | Heilmittel und vorbeugung für mit chemokinen verbundenen erkrankungen |
| EP1201239A4 (fr) * | 1999-08-04 | 2004-12-08 | Teijin Ltd | Antagonistes d'amine cyclique ccr3 |
| US20070010509A1 (en) * | 1999-12-08 | 2007-01-11 | Tatsuki Shiota | Cycloamine ccr5 receptor antagonists |
| DE60015187T2 (de) * | 1999-12-21 | 2005-02-17 | Smithkline Beecham Corp. | Urotensin-ii rezeptorantagonisten |
| WO2001066521A1 (fr) | 2000-03-06 | 2001-09-13 | Acadia Pharmaceuticals, Inc. | Composes azacycliques utilises dans le traitement de maladies liees a la serotonine |
| SK13632002A3 (sk) * | 2000-03-21 | 2003-02-04 | Smithkline Beecham Corporation | C1-6-alkyl-4-amino-azepán-3-ónové zlúčeniny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty |
| US6362177B1 (en) | 2000-05-16 | 2002-03-26 | Teijin Limited | Cyclic amine derivatives and their use as drugs |
| US8211916B2 (en) | 2000-06-20 | 2012-07-03 | Wayne State University | N- and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith |
| US6995268B2 (en) | 2000-06-20 | 2006-02-07 | Wayne State University | N- and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1- (phenyl) methyl) piperidine analogs and methods of treating CNS disorders therewith |
| US6395753B1 (en) * | 2001-08-30 | 2002-05-28 | Kowa Co., Ltd. | Cyclic amine compounds and pharmaceutical composition containing the same |
| KR100974901B1 (ko) | 2001-12-28 | 2010-08-10 | 아카디아 파마슈티칼스 인코포레이티드 | 모노아민 수용체 조정자로서의 스피로아자사이클릭 화합물 |
| US7282512B2 (en) | 2002-01-17 | 2007-10-16 | Smithkline Beecham Corporation | Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors |
| US7253186B2 (en) | 2002-06-24 | 2007-08-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
| NZ537522A (en) | 2002-06-24 | 2006-07-28 | Acadia Pharm Inc | N-substituted piperidine derivatives as serotonin receptor agents |
| US7538222B2 (en) | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
| KR100962972B1 (ko) | 2002-07-26 | 2010-06-09 | 주식회사유한양행 | 1-페닐피페리딘-3-온 유도체 및 그의 제조방법 |
| NZ541146A (en) | 2003-01-16 | 2009-04-30 | Acadia Pharm Inc | N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide, also known as ACP-103, and its tartrate salt as therapeutics for neurodegenerative diseases |
| US20040192674A1 (en) * | 2003-02-14 | 2004-09-30 | Marquis Robert W. | Cathepsin L inhibitors |
| US7109243B2 (en) | 2003-03-24 | 2006-09-19 | Irm Llc | Inhibitors of cathepsin S |
| US7384970B2 (en) | 2003-03-24 | 2008-06-10 | Irm Llc | Inhibitors of cathepsin S |
| US8017791B2 (en) | 2003-03-28 | 2011-09-13 | Wayne State University | Tri-substituted 2-benzhydryl-5-benzylamino-tetrahydro-pyran-4-ol and 6-benzhydryl-4-benzylamino-tetrahydro-pyran-3-ol analogues, and novel, 3,6-disubstituted pyran derivatives |
| US7173051B2 (en) | 2003-06-13 | 2007-02-06 | Irm, Llc | Inhibitors of cathepsin S |
| US7256207B2 (en) | 2003-08-20 | 2007-08-14 | Irm Llc | Inhibitors of cathepsin S |
| EP1734948B1 (fr) | 2004-04-16 | 2014-06-11 | Wayne State University | À trois substitut 2-benzhydryl-5- benzylamino- tétrahydropyran-4-ol et 6-benzhydryl-4-benzylamino-analogues tétrahydropyran-3-ol et nouveaux dérivés pyranne disubstitué 3,6 |
| US7820695B2 (en) | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US20050261278A1 (en) | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
| WO2006029154A2 (fr) * | 2004-09-07 | 2006-03-16 | Smithkline Beecham Corporation | Nouveaux composes |
| US7790899B2 (en) | 2004-09-27 | 2010-09-07 | Acadia Pharmaceuticals, Inc. | Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
| EP1794126B1 (fr) | 2004-09-27 | 2013-03-20 | Acadia Pharmaceuticals Inc. | Forme cristalline du sel d'hémi-tartrate de n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide |
| CN102633730A (zh) | 2004-12-03 | 2012-08-15 | 先灵公司 | 作为cb1拮抗剂的取代哌嗪 |
| EP1931657B1 (fr) * | 2005-08-17 | 2013-12-25 | Merck Sharp & Dohme Corp. | Nouveaux ligands de kinases a base de quinoline a affinite elevee |
| WO2007053498A1 (fr) * | 2005-11-01 | 2007-05-10 | Millennium Pharmaceuticals, Inc. | Composés pouvant être employés en tant qu'antagonistes de ccr2 |
| US20100016289A1 (en) * | 2005-11-01 | 2010-01-21 | Kevin Sprott | Compounds Useful as Antagonists of CCR2 |
| US8067415B2 (en) | 2005-11-01 | 2011-11-29 | Millennium Pharmaceuticals, Inc. | Compounds useful as antagonists of CCR2 |
| AR058985A1 (es) * | 2006-01-13 | 2008-03-05 | Schering Corp | Diaril piperidinas como moduladores de cb1. |
| AU2007207706A1 (en) * | 2006-01-18 | 2007-07-26 | Merck Sharp & Dohme Corp. | Cannibinoid receptor modulators |
| EP2060563A4 (fr) * | 2006-09-08 | 2010-12-22 | Dainippon Sumitomo Pharma Co | Dérivé d'aminoalkylcarboxamide cyclique |
| CA2681506C (fr) | 2007-03-19 | 2016-05-24 | Perry Peters | Combinaisons d'agonistes ou antagonistes inverses de 5-ht2a avec antipsychotiques |
| WO2008130616A2 (fr) * | 2007-04-19 | 2008-10-30 | Schering Corporation | Diaryl morpholines comme modulateurs des récepteurs cb1 |
| KR20100051625A (ko) * | 2007-06-28 | 2010-05-17 | 인터벳 인터내셔널 비.브이. | Ｃｂ1 길항제로서의 치환된 피페라진 |
| CA2694264A1 (fr) * | 2007-06-28 | 2009-01-08 | Intervet International B.V. | Piperazines a substitution servant d'antagonistes des recepteurs cb1 |
| US8686152B2 (en) | 2010-03-10 | 2014-04-01 | Janssen Pharmaceutica Nv | 4,4-disubstituted piperidine derivatives useful as inhibitors of dipeptidyl peptidase-1 (DPP-1) |
| AU2011224417B2 (en) * | 2010-03-10 | 2015-02-19 | Janssen Pharmaceutica Nv | 4,4-disubstituted piperidine derivatives useful as inhibitors of dipeptidyl peptidase-1 (DPP-1) |
| WO2015154023A1 (fr) | 2014-04-04 | 2015-10-08 | X-Rx Discovery, Inc. | Inhibiteurs spirocycliques substitués de l'autotaxine |
| PL3325444T3 (pl) | 2015-07-20 | 2021-12-06 | Acadia Pharmaceuticals Inc. | Sposoby wytwarzania N-(4-fluorobenzylo)-N-(1-metylopiperydyn-4-ylo)-N'-(4-(2-metylopropyloksy)fenylometylo)karbamidu oraz jego soli winianowej i postaci polimorficznej C |
| WO2017165635A1 (fr) | 2016-03-25 | 2017-09-28 | Acadia Pharmaceuticals Inc. | Association de pimavansérine et de modulateurs du cytochrome p450 |
| US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
| WO2018118626A1 (fr) | 2016-12-20 | 2018-06-28 | Acadia Pharmaceuticals Inc. | Pimavansérine seule ou en association pour une utilisation dans le traitement de la psychose liée à la maladie d'alzheimer |
| WO2018200977A1 (fr) | 2017-04-28 | 2018-11-01 | Acadia Pharmaceuticals Inc. | Pimavansérine pour le traitement d'un trouble de contrôle des impulsions |
| US20210077479A1 (en) | 2017-08-30 | 2021-03-18 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2804416A1 (de) * | 1978-02-02 | 1979-08-09 | Boehringer Mannheim Gmbh | Neue purin-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| ES8100016A1 (es) * | 1978-07-18 | 1980-04-01 | Hoechst Ag | Procedimiento para la preparacion de nuevos derivados de 1-(4-aminopiperidino)-3,4-dihidroisoquinoleina. |
| US4301151A (en) * | 1979-11-27 | 1981-11-17 | Merck & Co., Inc. | Long-lasting agonists of enkephalin |
| US4443461A (en) * | 1981-09-10 | 1984-04-17 | John Wyeth & Brother Limited | N-[2-[[1-[1H-Indolylalkyl- or oxoalkyl]-4-piperidinyl]-amino]-2-oxoethyl]-arylcarboxamide derivatives |
| US4680283A (en) | 1984-09-26 | 1987-07-14 | Merck & Co., Inc. | Analogs of substance P and eledoisin |
| DK386089A (da) * | 1988-08-12 | 1990-02-13 | Japan Tobacco Inc | Katekolderivater |
| IE903196A1 (en) * | 1989-09-05 | 1991-03-13 | Searle & Co | Substituted n-benzylpiperidine amides |
| EP0480044A4 (en) * | 1990-03-30 | 1993-06-09 | Japan Tobacco Inc. | Novel 4h-3,1-benzoxazin-4-one derivative |
| US5514694A (en) | 1992-09-21 | 1996-05-07 | Georgia Tech Research Corp | Peptidyl ketoamides |
| EP0700385A1 (fr) * | 1993-05-26 | 1996-03-13 | Smithkline Beecham Laboratoires Pharmaceutiques | Nouveaux composes |
| US5827866A (en) * | 1995-06-07 | 1998-10-27 | Ortho Pharmaceutical Corporation | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
| DZ2285A1 (fr) | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
-
1998
- 1998-05-06 WO PCT/US1998/009192 patent/WO1998050534A1/fr not_active Application Discontinuation
- 1998-05-06 JP JP54841898A patent/JP2001525809A/ja not_active Ceased
- 1998-05-06 PL PL98336625A patent/PL336625A1/xx not_active Application Discontinuation
- 1998-05-06 KR KR1019997010268A patent/KR20010012316A/ko not_active Application Discontinuation
- 1998-05-06 EP EP98920274A patent/EP0991753A4/fr not_active Withdrawn
- 1998-05-06 TR TR1999/02752T patent/TR199902752T2/xx unknown
- 1998-05-06 HU HU0001285A patent/HUP0001285A3/hu unknown
- 1998-05-06 US US09/423,325 patent/US6369077B1/en not_active Expired - Fee Related
- 1998-05-06 IL IL13166198A patent/IL131661A0/xx unknown
- 1998-05-06 MA MA25064A patent/MA26494A1/fr unknown
- 1998-05-06 CA CA002289010A patent/CA2289010A1/fr not_active Abandoned
- 1998-05-06 PE PE1998000344A patent/PE73799A1/es not_active Application Discontinuation
- 1998-05-06 BR BR9808502-6A patent/BR9808502A/pt not_active Application Discontinuation
- 1998-05-06 AU AU72885/98A patent/AU7288598A/en not_active Abandoned
- 1998-05-06 CN CN98804794A patent/CN1255162A/zh active Pending
- 1998-05-07 ZA ZA983843A patent/ZA983843B/xx unknown
- 1998-05-08 CO CO98025629A patent/CO4950617A1/es unknown
-
1999
- 1999-11-05 NO NO995433A patent/NO995433L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE73799A1 (es) | 1999-10-22 |
| EP0991753A4 (fr) | 2001-07-11 |
| IL131661A0 (en) | 2001-01-28 |
| NO995433D0 (no) | 1999-11-05 |
| ZA983843B (en) | 1998-11-09 |
| HUP0001285A2 (hu) | 2000-09-28 |
| EP0991753A1 (fr) | 2000-04-12 |
| KR20010012316A (ko) | 2001-02-15 |
| CN1255162A (zh) | 2000-05-31 |
| CA2289010A1 (fr) | 1998-11-12 |
| TR199902752T2 (xx) | 2000-06-21 |
| US6369077B1 (en) | 2002-04-09 |
| AU7288598A (en) | 1998-11-27 |
| CO4950617A1 (es) | 2000-09-01 |
| HUP0001285A3 (en) | 2000-10-30 |
| NO995433L (no) | 1999-11-05 |
| PL336625A1 (en) | 2000-07-03 |
| JP2001525809A (ja) | 2001-12-11 |
| WO1998050534A1 (fr) | 1998-11-12 |
| BR9808502A (pt) | 2000-05-23 |
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| MA26630A1 (fr) | 4-phenylpyperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| MA26743A1 (fr) | Composes nouveaux inhibiteurs de metalloproteases, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| MA26551A1 (fr) | Agonistes de prostaglandines nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
| MA26487A1 (fr) | Heterocyclecetohydrazides inhibiteurs de proteases, procede pour leur preparation et compositions pharmaceutiques les contenant . | |
| MA26622A1 (fr) | Pyrazolopyrimidinones nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| MA26687A1 (fr) | 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinoleines, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| MA26508A1 (fr) | Formulations pharmaceutiques contenant du variconazole, et procede pour leur preparation. | |
| MA26558A1 (fr) | Derives nouveaux de 6-0-methylerythromycine a, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
| MA26424A1 (fr) | Derives de 6-phenylpyridyl-2-amine, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
| MA26499A1 (fr) | Derives de tetrazole, procede pour leur preparation et compositions pharmaceutiques les contenant . | |
| MA26614A1 (fr) | Bicyclo [2.2.1] heptanes nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
| MA26468A1 (fr) | Derives de sulfonyluree, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| MA26654A1 (fr) | Pyrrolopyrimidines nouvelles procede pour leur preparation et compositions pharmaceutiques les contenant | |
| MA26432A1 (fr) | Derives de 2-(2-oxo-ethylidene)-imidazolidine-4-one, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
| DZ2890A1 (fr) | 4-Carboxamino-2-substitué-1,2,3,4-tétrahydroquinoléines, procédé pour leur préparation et compositions pharmaceutiques les contenant. | |
| MA26490A1 (fr) | Derives de tetrahydroisoquinoleine nouveaux, procedes pour leur preparation et compositions pharmaceutiques les contenant. | |
| MA26559A1 (fr) | Derives de d-proline, procede pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation | |
| MA26465A1 (fr) | Derives de quinoleine et derives de quinazoline nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| DZ2866A1 (fr) | 1-Aryl-3-arylméthyl-1,8-naphtyridine-4-(1H)-ones nouvelles, procédé pour leur préparation et compositions pharmaceutiques les contenant. | |
| MA26707A1 (fr) | Azalides nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. |