LV15544A - Novel peptidomimetic agents containing boric acid as malaria serine protease inhibitors - Google Patents

Novel peptidomimetic agents containing boric acid as malaria serine protease inhibitors

Info

Publication number
LV15544A
LV15544A LVP-19-32A LV190032A LV15544A LV 15544 A LV15544 A LV 15544A LV 190032 A LV190032 A LV 190032A LV 15544 A LV15544 A LV 15544A
Authority
LV
Latvia
Prior art keywords
malaria
boric acid
serine protease
protease inhibitors
agents containing
Prior art date
Application number
LVP-19-32A
Other languages
Latvian (lv)
Inventor
Aigars Jirgensons
Elīna LĪDUMNIECE
Chrislaine Withers-Martinez
Michael BLACKMAN
Paul William Finn
Original Assignee
Latvijas Organiskās Sintēzes Institūts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Latvijas Organiskās Sintēzes Institūts filed Critical Latvijas Organiskās Sintēzes Institūts
Priority to LVP-19-32A priority Critical patent/LV15544A/en
Priority to CA3144846A priority patent/CA3144846A1/en
Priority to PCT/IB2020/053392 priority patent/WO2021001697A1/en
Priority to DE112020003182.9T priority patent/DE112020003182T5/en
Publication of LV15544A publication Critical patent/LV15544A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention relates to novel boric acid-containing peptidomimetics I:acting as inhibitors of the malaria subtilisin-related serine protease (SUB). They are useful as medicinal preparations or as ingredients for the treatment of malaria.
LVP-19-32A 2019-07-01 2019-07-01 Novel peptidomimetic agents containing boric acid as malaria serine protease inhibitors LV15544A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
LVP-19-32A LV15544A (en) 2019-07-01 2019-07-01 Novel peptidomimetic agents containing boric acid as malaria serine protease inhibitors
CA3144846A CA3144846A1 (en) 2019-07-01 2020-04-09 Novel boronic acid containing peptidomimetics as malarial serine protease inhibitors
PCT/IB2020/053392 WO2021001697A1 (en) 2019-07-01 2020-04-09 Novel boronic acid containing peptidomimetics as malarial serine protease inhibitors
DE112020003182.9T DE112020003182T5 (en) 2019-07-01 2020-04-09 Novel boric acid-containing peptidomimetics as malaria serine protease inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LVP-19-32A LV15544A (en) 2019-07-01 2019-07-01 Novel peptidomimetic agents containing boric acid as malaria serine protease inhibitors

Publications (1)

Publication Number Publication Date
LV15544A true LV15544A (en) 2021-01-20

Family

ID=67551401

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-19-32A LV15544A (en) 2019-07-01 2019-07-01 Novel peptidomimetic agents containing boric acid as malaria serine protease inhibitors

Country Status (4)

Country Link
CA (1) CA3144846A1 (en)
DE (1) DE112020003182T5 (en)
LV (1) LV15544A (en)
WO (1) WO2021001697A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012022060A2 (en) * 2010-03-01 2018-05-08 Onyx Therapeutics Inc compound for inhibition of immunoproteasome
KR20150132362A (en) * 2013-03-15 2015-11-25 에이다에레이타, 리미티드 파트너쉽 Small molecule modulators of pcsk9 and methods of use thereof

Also Published As

Publication number Publication date
CA3144846A1 (en) 2021-01-07
WO2021001697A1 (en) 2021-01-07
DE112020003182T5 (en) 2022-04-14

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