LV13611B - Modified hernia patch - Google Patents
Modified hernia patch Download PDFInfo
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- LV13611B LV13611B LV060041A LV060041A LV13611B LV 13611 B LV13611 B LV 13611B LV 060041 A LV060041 A LV 060041A LV 060041 A LV060041 A LV 060041A LV 13611 B LV13611 B LV 13611B
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Abstract
Description
Modificēts trūču ielāpsModified hernia patch
Izgudrojums attiecas uz medicīnas tehniku, to var pielietot, lai slēgtu trūces atveres vārtus vēdera dobumā - cirkšņu apvidū, augšstilba un nabas apvidū, vai jebkurā citā vietā.BACKGROUND OF THE INVENTION The invention relates to a medical technique and can be used to close a hernia opening in the abdominal cavity - in the groin area, the thigh and umbilical region, or anywhere else.
Tradicionālie trūču ielāpi ir relatīvi cieti (PROLENE Hernia System), tos izgatavo no dažādiem sintētiskiem pavedieniem, pārsvarā no monopropilēna ar adīšanas tehnoloģiju.Traditional hernia patches are relatively hard (PROLENE Hernia System) and are made from a variety of synthetic filaments, mostly monopropylene with knitting technology.
Ir zināms sietveida implants, kuru piedāvā vēdera dobuma ķirurģijai, lai novērstu bruku (1). Tāpat ir zināms trūču ielāps (siets) un speciāls instruments - adata ar eļļainu klājumu, paredzēta berzes samazināšanai un dzīvo audu traumēšanai implantēšanas laikā (2). Tomēr lielas vēdera trūces vārtos bieži rada pēcoperācijas periodā ķirurģiskas problēmas (ielāps traumē dzīvo audu membrānas un pielīp pie zarnām).There is a known mesh implant that is offered for abdominal surgery to prevent puberty (1). Also known is a hernia patch (mesh) and a special tool, an oily needle, designed to reduce friction and to injure live tissue during implantation (2). However, large abdominal hernia at the gate often causes surgical problems in the postoperative period (patch injures living tissue membranes and sticks to the intestine).
Piedāvātā izgudrojuma mērķis ir modificēt trūču ielāpus, piesūcinot tos ar bioloģiski aktīviem preparātiem. Implantam izžūstot, tā virsmu un poras nosedz stipra un elastīga plēvīte - membrāna. Šī plēvīte izpilda matricas lomu, uzlabo implanta kvalitāti, rada iespējas modificētam ielāpam ātri inkorporēties organismā, izslēdzot iespēju traumēt dzīvo audu membrānas, vairoties baktērijām un pielipt pie zarnām, vienlaicīgi saglabājot materiāla biomehāniskos parametrus.The object of the present invention is to modify the patch patches by impregnating them with biologically active preparations. When the implant dries, its surface and pores are covered by a strong and elastic membrane. This film serves as a matrix, improves implant quality, enables modified patches to incorporate rapidly into the body, eliminating the possibility of trauma to living tissue membranes, bacterial growth and adhesion to the gut, while preserving the biomechanical properties of the material.
Mērķi sasniedz sekojoši - no biosaderīgiem, netoksiskiem, kompleksiem poliestera pavedieniem auž porainu ielāpu, kuru pēc apstrādes tvaika sterilizatorā piesūcina ar etilspirtā atšķaidītu karboksimetilcelulozi, zirgkastaņu augļu ekstraktu, dzērveņu ekstraktu un polisorbātu 80 (Tween 80) šādās proporcijās:The purpose is achieved by the following: from the biocompatible, non-toxic, complex polyester filaments to a porous patch impregnated with ethyl alcohol diluted carboxymethyl cellulose, horse chestnut fruit extract, cranberry extract and polysorbate 80 after treatment in a steam sterilizer:
Karboksimetilceluloze - 400 (METHYCELLULOSE - METOTOSE) - 10% Zirgkastaņu augļu ekstrakts - 43%Carboxymethyl Cellulose - 400 (METHYCELLULOSE - METOTOSE) - 10% Horse Chestnut Fruit Extract - 43%
Dzērveņu ekstrakts - 45%Cranberry Extract - 45%
Polisorbāts 80 (Tween 80) - 2%Polysorbate 80 (Tween 80) - 2%
Modificētu implantu žāvē 30 minūtes pie 50° C temperatūras un sterilizē gāzes sterilizatorā. Visi minētie preparāti organismā saglabājas vairākas dienas pēc trūču ielāpa implantēšanas.The modified implant is dried for 30 minutes at 50 ° C and sterilized in a gas sterilizer. All of these preparations remain in the body for several days after hernia patch implantation.
Modificētais trūču ielāps ir mīksts, lokans, viegli griežas, neveido spuras griezuma vietās, ķirurgam ar to ir viegli manipulēt.The modified hernia patch is soft, pliable, easy to rotate, does not form fins at the incisions, and is easy to manipulate by the surgeon.
Zirgkastaņa augļu ekstrakts palielina kapilāru izturību, mazina asinsvadu sieniņu caurlaidību un trauslumu. Dzērveņu ekstrakts nepieļauj trūču ielāpā dzīvo audu traumēšanu un baktēriju vairošanos, kā arī novērš implanta pielipšanu pie zarnu gļotādas membrānām. Karboksimetilceluloze -400 un polisorbāts -80 kopā ar bioloģiski aktīviem preparātiem veido hidrofilu mīkstu plēvīti.Horse chestnut fruit extract increases capillary strength, reduces vascular wall permeability and brittleness. Cranberry extract prevents trauma and bacterial growth in the hernia patch and prevents the implant from sticking to the intestinal mucosa. Carboxymethylcellulose-400 and polysorbate -80 together with biologically active preparations form a hydrophilic soft film.
Zīmējumā 1 parādīta modificēto trūču ielāpu spēka - relatīvās deformācijas saistība. Vidējais saraušanas spēks modificētam trūču ielāpa paraugam ir 290 ± 7,0 N, bet maksimālā relatīvā deformācija - 27,45 ± 0,64%. Vēderplēve vidēji iztur 16 N, bet spēj deformēties 25 ± 7%.Figure 1 shows the force-relative deformation relationship of the modified hernia patches. The average breaking force for the modified hernia patch sample is 290 ± 7.0 N and the maximum relative deformation is 27.45 ± 0.64%. The peritoneum withstands an average of 16 N but has a deformation of 25 ± 7%.
Modificēta trūču ielāpa aprēķinātā elastības moduļa vidējā vērtība (līknes lineāram posmam 1-2) līdzinās: E = 927,3 ± 10,2 MPa.The mean value of the elastic modulus of the modified hernia patch (linear curve 1-2) is: E = 927.3 ± 10.2 MPa.
Modificētos trūču ielāpus implantēja suņiem, pēc 90 dienu funkcionēšanas dzīvā organismā tos eksplantēja un morfoloģiski izpētīja. Iegūtie rezultāti pierādīja, ka lielos vedera truces vārtos modificētie trūču ielāpi optimāli inkorporejas un nepielīp pie zarnām.Modified hernia patches were implanted in dogs, exploded and morphologically examined for 90 days in living organisms. The results obtained showed that the modified hernia patches in the large gutter gland gate were optimally incorporated and did not adhere to the intestine.
Izmantotā literatūra:References:
1. Patents Nr WO 0219944,int.cl.A61F2/001. Patent No. WO 0219944, int.cl.A61F2 / 00
2. Patents NrWO 1005007019,int.cl.A61F (prototips)2. Patent No.WO 1005007019, int.cl.A61F (Prototype)
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LV060041A LV13611B (en) | 2006-03-10 | 2006-03-10 | Modified hernia patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LV060041A LV13611B (en) | 2006-03-10 | 2006-03-10 | Modified hernia patch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LV13611B true LV13611B (en) | 2008-02-20 |
Family
ID=39638460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LV060041A LV13611B (en) | 2006-03-10 | 2006-03-10 | Modified hernia patch |
Country Status (1)
| Country | Link |
|---|---|
| LV (1) | LV13611B (en) |
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2006
- 2006-03-10 LV LV060041A patent/LV13611B/en unknown
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