LV11667B - Remedy for renewal of disordered function of immunomodulation and cell tissue reproduction adjustors - Google Patents

Description

1 LV 11667 CPEflCTBO HMMyHOMOflyJIHPym{ErO flEHCTBHfl H BOCCTAHABJIHBAlOūIErO HAPJTHEHHOE 4>yHKIļHOHHPOBAHHE CHCTEMH PEryJIHIlHH ΡΑ3ΜΗ0ΧΕΗΗΗ KJIETOK TKAHH 06JiaCTb ΤΘΧΗΗΚΗ

HacToanee Η3θ6ρβτθΗΗβ othochtch k MejmmHHe, a TOHHee κ ηοβομυ cpencTBy HMMy η ομοαυ ji Hpyiome r ο ηβήστΒΗ a h

BoccTaHaBnHBaiomero HapymeHHoe $yHKiiHOHHpoBaHHe cHCTemi peryjiiiiiHH pa3MHO*eHHH κϋβτοκ τκβηη · npejņnecTBjromHft ypoeeHb τθχηηκη ΙΙΐΗροκο H3BecTHH pa3JiHHHHe JieKapcTB€HH£ie npenapaTH, MOfleJiHpyiomiie npoiļeccM HMMyHHTeTa · TaK, HanpHMep, cnOCo6HOCTbIO CTHMyJIHpOBaTb ΗΜΜγΗΗΗβ peaiuļHH opraHH3Ma (a TaK*e jiefīKono33) o6jia,qaiOT npoH3BOflHtie ΗγκιιβΜΗΟΒΟΗ KHciroTBi; οποοο6ηοοτβιο σπβΐίΗφΗΗβσκΗ βκτηβηροββτβ ΗΜΜγΗΟΚΟΜΠβΤβΗΤΗΗβ KJieTKH (T- Η Β-.ΠΗΜφθΙ1ΗΤΗ) o6jiaHaK)T npenapaTBi miporeHan, npoflHrH03aH h apyrHe. EtoBecTeH npenapaT jieBaMH30Ji [ (-) 2,3,5,6-TeTparimpo-6-^eHHJiHMHna30-( 2,1-b) -Tna30Jia rHEpoxjiopnn ] (M.fl.ManncoBCKHii, "JleKapcTBeHHLie cpe;qc:TBa", MocKBa, "MeflHiUiHa" , 1992, τ.2, cTp. 169-170) , oČJianaiomHH cnoco6HocTbio H36HpaTeJibHo CTHMyJTHpOBaTb perynHTOpHyiO φγΗΚΙΪΗΗ) Τ-πΗΜφοΐ1ΗτθΒ, cnocoČHOCTbio ycHJiHBaTb c Jia6ym peaiOļHio κλθτοηηογο 0MMyHHTeTa, ocjia6ji5iTL· CHJibHyio h He neftcTBOBaTb Ha HopMajibHyio peaiuļHio. 03BecTeH Tax*e npenapaT THMajiHH (npenapaT, npencTaBJiiiKimHH co6oft KOMnneKc ηοπΗΠβητΗΗΗΗΧ φρΒΚΐίΗϊί, BMfleneHHHx H3 βμιιο^χοβοη xejie3H KpynHoro poraToro CKOTa)/M.fl.MainKOBCKHH, "JIexapcTBeHHHe cpejļCTBa", MocKBa, "MejļHiļHHa", 1992, τ.2, CTp.171), o6jiaaaiomHii cnocoČHocTbio peryjiHpoBaTb KOJinnecTBo T- η Β-λημΦοιϊητοβ, CTHMyjiHpoBaTb peaKiļHio KJieTOHHoro HMMyHHTeTa, a Tax*e npoueccu pereHepauHH. ΠρΗΗβΗίποτ yKa3aHHHH npenapaT b Ka^ecTBe HMMyHocTHMynsTopa h 6HocTHMyjiiiTopa npn 3a6oneBaHHJix, COnpOBO*«aiomHXCH ΠΟΗΗΧβΗΗΘΜ Κ,ΠβΤΟΗΗΟΓΟ HMMyHHTeTa, B TOM MHCjie npn οοτρΗχ xpoHHHecxHX γηοηηηχ npoijeccax H BOcnajiHTejtbHwx 3a6ojieBaHHHx, npn omoroBoft 6οηβ3ΗΗ, npn 2

II γΓΗβΤΘΗΗΗ HMMyHHTeTa Η ΚρΟΒβΤΒΟρΗΟή φγΗΚΙ1ΗΗ nOCJie ϋγΗβΒΟΗ HJIH XHMHOTepanHH y ΟΗΚΟΠΟΓΗΗΘΟΚΗΧ δοΠΒΗΗΧ.

OnHaKO, Bce BHmeyKa3aHHHe npenapaTBi xapaKTepH3yioTCH H36HpaTeJIbHOCTBIO fleaCTBHH, TOKCHHHOCTb», ΗΜβΜΤ ρΗΙ* 5 ΠΟδΟΗΗΜΧ HBJieHHH Μ ΠρθΤΗΒΟΠΟΚ333ΗΗΗ K ΠρΗΜβΗΘΗΗΙΟ. H3B6CTHO, ΗΤΟ pemaiomHM 3TanOM Β03ΗΗΚΗ0ΒβΗΗΗ HOBoo6pa30BaHHft (onyxojiea) HBJtHeTCH HapynieHHe cHCTeioi peryjumHH HeJieHHa (pa3MHoxeHHe) κπβτοκ. H3BecTHH pa3JiHHHHe npoTHBoonyxojieBBie cpencTBa, 10 κοτορκβ npenCTaBJIiDOT Co6oā COeflHHeHHH pa3JIHHHOH ΧΗΜΗΗβοκοβ CTpyKTypM. TaKHe coeflHHeHHH MoryT 6htb noJiyneHH, xax χημημθοκημ πγτβΜ, Tax η πγτβΜ ΒΗΟβπβΗΗίΐ eHOJIOrHHeCKH aKTHBHMX BeņeCTB H3 CMpbH paCTHTenbHOrO H SHBOTHOrO npOHCXO*īīeHHH ( M . .ΜβΙΠΧΟΒΟΚΗβ , " Jl€KapCTB6HHHe 15 cpeflCTBa", MocKBa, "MenmļHHa", 1992, T.2, ατρ. 423-468) . H3BecTHH TaKHe προτΗΒΟοπγχοπβΒΜβ cpencTBa, xax miKJio(ļ)oc<ļ>aH, capKonH3HH, MycTapreH, KapHOJin3HH h cpyrne, b MexaHH3Me neacTBaa κοτορκχ cymecTBeHHyio pojib HrpaioT hx ajtKHJiHpjroimīe cBoacTBa. Ohh ciiocočhh pearnpoBaTb c 20 HyK.Jieo<ļ)HJibHMMH lieHTpaMH δβπχοΒΗΧ MOJiexyji, Hapyma.a cnHTe3 ΠΗΚ, b pe3yjibTaTe nero HapymaeTCii *H3HefleHTejibHocTb κπβτοκ h δποκΗργβτοπ hx MHTOTHHSCKHe nejīeHHe. H3BecTHH Taxate προτκΒοοπγχοπβΒΗβ cpeflCTBa, conep*amHe rpynrra sTHJieHHMHHa, Taoe xax ΤΗοφοοφβΜΗπ, 25 flHIlHH, 6βΗ30Τ3φ Η ΛργΓΗβ, ΚΟΤΟρΗβ ΟΚΒ3ΒΙΒΒΙΟΤ iļHTOcTaTHHecKoe jjeacTBHe η γΓΗβτβιοτ pa3BHTne ΠρΟίΙΗφβρΗργΜίςββ, B TOM HHCJie 3JIOKaKeCTBeHHOa TKaHH. B M6xaHH3Me AeacTBHM 3ΤΗΧ cpejļcTB Ba*Hyro pojib HrpaeT HapymeHHe o6MeHa ΗγχπβΗΗΟΒΒΐχ khcjīot h 6jioxaHa 30 MHTOTHHecKoro fleneHHa κπβτοκ. ninpoKoe pacnpocTpaHeHae b Ka^ecTBe cpencTB, npOHBJīammHX ΠρΟΤΗΒΟΟΠγΧΟπβΒΟβ fleaCTBHe, ΠΟπγ^ίΜΠΗ ΗβΚΟΤΟρΒΙβ aHTH6HOTHKH, B HaCTHOCTH, ΠΟΠγΟΗΗΤβΤΗΊβΟΚΜβ ΠρθΗ3ΒΟΠΗΗβ C HCII0Jīb30BaHH6M ίϊΗβρ MOJieKyjI H3B6CTHHX 35 npOTHBOOnyXOJteBUX aHTH6HOTHXOB. MexaHH3M ΠβΗΟΤΒΗΛ 3ΤΗΧ npenapaTOB cB.S3aH c H36HpaTenbHMM ποπβΒπβΗΗβΜ flHK saBHCHHoro CHHTe3a PHK, mto πρΗΒΟΠΗΤ κ HapymeHtno CHHTe3a, 3 LV 11667

HyKJieHHOB£IX ' KMCJIOT. OEHaKO, SoJlfelttHHCTBO yKa3aHHHX npoTHBOonyxoJieBHX npenapaTOB xapaKTepn3yioTCH bucokoS TOKCHsHOCTtīj, πο6οηηιικη neftcTBKflitH (yrHeTamT nponecc ΚρΟΒβΤΒΟρβΗΗίΐ) . B JIHTepaTJTpe Ηβ OnHcaHil npOTHBOOnyxoneB£ie cpencTBa, flefiCTBHe χοτορωχ HanpaBJieHo Ha BoccTaHOBJieHHe HapyineHHOrO φγΗΚηΗΟΗΗρΟΒΒΗΗΗ CHCTeMM peryJIBliMH pasMHojieHKii κπβτοκ τκ&ηη · ΠΙκροκο HSBecTHO πρκκβκβΗΗΘ b MeflKiļHHe npenapaTOB ρτγτΗ, b KacTHocTM nHXJiopHita pTyTH b KanecTBe aHTKcenTHHecKoro cpencTBa, a Tax*e npHMeHeHHe npenapaTOB Kann»nKa (apceHaTa ΗΒτρκκ κ apceHHTa KanHn aji« nenemia reKaTOJIOrHMeCKHX 60Jlt»HHX B CBfl3H C HX CBOftCTBOM BBiatlBaTb B036yxneHne apHTponoaTHHecKoft φγΗχηκκ κοοτηογο M03ra h yrHeTeHHe neBKonooaa.

OpHaKo, πρκκβΗβΗΗβ yxa3aHHHX npenapaTOB b KanecTBe cpeflCTB H30iyHOMonyJiHpyiomero neftcTBHH, h cpencTBa nnn BOCCTaHOBIieHHn HapjTUeHHOro (pyKXnHOHHpOBaHH5ī CHCTeMM peryJIKlĪHH ρβ3ΜΗΟΧΘΗΗ.8 ΚίΤβΤΟΚ TKaHH HeHSBeCTHO ·

PacKptiTHe H3o6peTeHH.H B OGHOBy H3o6peTeHM.H noJio*eHa aanana co3jņaHHji ηοβογο cpencTBa HMMyHOMonyJiHpyioniero «eācTBH^ h

BoccTaHaBJiKBaBmero HapymeHHoe φγΗκηΗ oHHp ο b aHH e cncTeMii perynjmH« pa3MH0*eHHH κπβτοκ TKaHH, o6jxajņajomee BticoKoft ΟφφβΚΤΗΒΗΟΟΤΒΚΙ HH3KOH TOKCHHHOCTBK), ΠΙΗροΚΗΚ ΟΠβΚΤρΟΜ neftCTBHH. 3aflana pemeHa TeM, hto 3aHBJīneMoe cpencTBO HMMyHOMonyjiHpyiomero neftcTBKii h BoccTaHaB-riviBajoniero HapynieHHoe Φυηκβ;ηοηηροβηηηθ οηοτθμη perynHHHH pasMHO^eHHn κπβτοκ TKaHH, BKJUOHaiomee neftcTBymmee BemecTBo h paaSaBHTejiB, cornacHo H3o6peTeHim, b KanecTse neūCTBjTornero BeņecTBa conepaiKT ΠΗχηορκη ρτγτΗ hjih apceHHT KaUHit, hjih apceHaT HaTpHH, npH cnenyīomeM cooTHonieHHH ΗΟΧΟηΗΒΙΧ ΚΟΜΠΟΗβΗΤΟΒ , B MaC.%:

ΑΗΧηΟρΗΠ ρτγτκ HJIH apceHHT

KanHii, hjih apceHaT HaTpHH 0,0 1-1,5 pa36aBHTexib no 100,0 3anBJTneMoe cpencTao b KanecTBe pa36aBHTejiii 4 npennoHTHTeJibHo conep*HT HaTypajibHoe BHHorpaflHoe 6e;ioe bhho c coflepacaHHeM caxapa 3-4 Mac.% hjih mojiohhjtk) cHBopoTKy c 3-4 Mac.% conep*aHHeM caxapa.

CoflepaantHecH B HaTypaJibHOM BMHorpaHHOM 6θιιομ βηηθ b He6oJibmoM κοιιηηθοτβθ očpaTHMO KoaryJiHpoBaHH£ie paCTHTeJIBHHe 6ejIKH C BHCB06oHHBIIIHMHCH cyJIb<ļ)rHnpHJIbHHMH rpynnaMH - SH, a TaKse o6paTHMO KoaryjiHpoBaHHLie 6eJiKH b COCTaBe ΜΟπΟΗΗΟή CHBOpOTKH O0paTHMO 6jIOKHpyiOTCH HOHaMH pTyTH hjih MHmbHKa, BCJiencTBHH nero ycTpaH5ieTCJi TOKCHHHOCTb 3aHBJIHeMOrO CpeflCTBa.

Caxapa, conepaiamHecH b KOJiHHecTBe 3-4 Mac.% b yxa3aHHHX βηηθ h mojiohhož cwBopoTxe cnoco6cTByioT noOTepaeaHHM khcjiož cpejņj nyTeM 6poxeHHH, yJiyHinajoT BKycoBHe KanecTBa JieKapcTBeHHoro cpencTBa. 3asBjiHeMoe cpencTBo, cornacHO η3ο6ρθτθηηιο, npajjnoHTHTejibHO HcnoJib3yeTCH b BHne CJienyiomHX BapnaHTOB. 3aHBjineMoe cpencTBo hjih BHyTpeHHero h Hapy*Horo ΠρΗΜΘΗΘΗΗΗ, COCTOHT H3 ΟΠΘΠΥΜΠίΗΧ ΚΟΜΠΟΗΘΗΤΟΒ, B MaC.%!

Hhxjiophh pTyTH 0,01-0,1

HaTypajibHoe BHHorpanHoe 6ejioe bhho c conep*aHHeM 3-4 Mac.% caxapa hjih MOJioHHan CHBopoTKa c conepacaHHeM caxapa 3-4 Mac.% no 100,0. 3 aHB JIH6MO e cpencTBO hjih BHyTpeHHero h Hapy*Horo πρημθηθηηη, conepxamee b KanecTBe pa36aBHTejiH cMecb cBHHoro *Hpa, Mesa HaTypajibHoro η βτηιιοβογο cnHpTa, coctoht ’H3 cJieny»iuHx κομποηθητοβ, b Mac.%:

HhxjiopHH pTyTH 0,03-0,13 CBHHOii *Hp 30,7-37,3 μθη HaTypajibHHfi 30,7-37,3 3THJIOBHŪ CnHpT HO 100,0. 3θηβπηθμοθ cpeHCTBo hjih BHyTpeHHero πρημθηθηηη, npennoHTHTejibHO HcnoJib3yeMoe hjih ιιθηθηηη οστρυχ η ΧρΟΗΗΗΘΟΚΗΧ ΗθήΚ030Β, COCTOHT H3 ΟΗΘΗΥΪΟΠΙΗΧ ΚΟΜΠΟΗΘΗΤΟΒ, Β Mac.%: apceHaT HaTpHH hjih apceHHT kbjihh 0,05-0,15

HaTypaJibHoe BHHorpaHHoe 6ejioe 5 LV 11667 bhho c cooep*aHHeM caxapa 3-4 Mac.%

HJIH MOJIOHHaH CHBOpOTKa C COHepjKaHHeM caxapa 3-4 Mac.% no 100,0.

ΠρΗΜβΗβΗΗΘ 3aSBJISeMOrO CpeHCTBa SBJIHeTCS

πρβηΠΟΗΤΗΤβϋΒΗΜΜ JĻ7IH ϋβΗβΗΗϋ OCTpMX H XpOHHHeCXHX jieHX030B, Tax xax ochobhhm neno HaxoruieHHH MHmbHxa SBJIHeTCS KpOBfa. 3asBJiseMoe cpencTBO hji s Hapy*Horo πρκμθηθηηη, coctoht H3 cJienyiomHX κομποηθητοβ, b Mac.%: ΗΗχπορΗΠ ρτγτΗ 0,3-1,5

HaTypaJitHoe BHHorpanHoe 6enoe bhho c cojjepxaHHeM caxapa 3-4 Mac.% hjih MOjiosHas CHBopoTKa c conepxaHHeM caxapa 3-4 Mac.% HO 100,0. 3asBJiseMoe cpencTBo He tokchhho, 6jiaro,ū[aps CBoftcTBy HOHOB ρτγτΗ H MHmbHXa o6paTHMO 6jIOXHpOBaTb σγΠΒφΓΗΗρΗΠΒΗΜβ ΓργΠΠΗ, K ΧΟΤΟρΜΜ ΟΗΗ ΗΜβϊΟΤ CaMOe BMCOKOe cponcTBo Η3 Bcex peaxiļHOHHEix rpynn. 06nfHM CBOHCTBOM JĻJIS ΒΟβΧ OpraHH 3MOB h Bcex onyxoji eft SBJiseTcs pa3HHoxeHHe (nenemie), npHxa3 o «ejieHHH nepenaioT cneiļnajīBHHe MOJiexyjnj - pocTOBtie φ3ΧτορΗ sepe3 npyrne 6ejixoBHe MOJiexynu - ρβμβπτορΜ. ΟπβΐίΗφΗΗβοχΗΜ cbohctbom στργκτγρκ Mojiexyn Bcex φΒΚΤΟρΟΒ pOCTa H HMMyHOrJIo6yjIHHOB, ΙίΗΤΟΧΗΗΟΒ, peiļeiITOpOB ΠΗΜφθΙ1ΗΤΟΒ Η 3pHTpOIļHTOB Η ΗβΧΟΤΟρΜΧ ΓΟρΜΟΗΟΒ (HHCyjIHH, Ba30npecCHH Η ηρ. ) SBJIHeTCS HaJIHHHe ηΗΟγΗΒφΗΠΗΗΧ CBS3eft, κοτορκβ o6jianaioT cnocoČHOCTbio rHnpojiH30BaTbcs (pa3pUBaTbCH) B npHCyTCTBHH HOHOB pTyTH, He3āBHCHMO OT HaJIHHHH npyrHX φγΗΚυ(ΗΟΗΒΗΒΗ£ΙΧ ΓργΠΠ. ΟπβΗΗφΗΗΘΟΧΗΜ CBOHCTBOM CTpoeHHH MOJiexyJI BCeX iļHTonjia3MOTHHecxHX ρβηβπτοροΒ h 6onee «Byx necsTXOB φβρΜβΗτοΒ (BxraoHas npoTeoJiHTHsecxHe) HBJiseTcs HaJiHHHe cBH3biBaK)iiļHx ysacTXOB cbo6ohhhx ογπΒφΓΗΗρκίίΒΗΒΐχ rpynn. 06paTHMHM 6jIOXHpOBaHHeM σγΛΒφΓΗβρΗΛΒΗΜΧ ΓργΠΠ ρβιχβπτοροΒ φΒΧΤοροΒ pocTa, peijenTopoB στβροΗ^ΗΗΧ rapMOHOB h aflpeHeprHsecxHX peijenTopoB hohcImh ρτγτΗ hjih Mfinnbsxa npHOCTaHaBjiHBaeTcs pocT onyxojiH. 6

Hy6jiHpyioniaH npoTHBoonyxojieBa.a 3arņnTa o6ecneHHBaeTC5i 3a cneT pa3pMBa HHcyji£»<ļ>HHHHX CBH3eft φaκτopoB pocTa, HMMyHOrJIo6yjIHHOB, ρβΙίβΠΤΟρΟΒ JIHMtJjOIļHTOB H apHTpoiļHTOB B npHCyTCTBHH HOHOB pTyTH HJIH MUBbHKa. HBJieHHe pa3ptIBa HHCyJII>$HHHHX CBH3eŽ HMMyHOrJīo6yjIHHOB, ΗΘΚΟΤΟρΒΙΧ ΓΟρΜΟΗΟΒ (HHCyJIHH,

Ba30npeCCHH) , IļHTOKHHOB, peiļenTOpOB ΠΗΗφΟΙίΗΤΟΒ H BpHTpoiļHTOB očecneHHBaeT cbohctbo npenapaTa xax HMMyHOMOJiyJIHTOpa . 06paTHMoe 6jioKHpoBaHHe npenapaTOM cyJIbφΓHί^pHJI£>HBIX rpynn φθρΜθΗτοΒ η ρβιιβπτοροΒ o6ecneHHBaeT opraHH3My 3amHTy ot paHHaijHOHHoro B03fleūCTBKH.

HCXOfliI H3 ΤΟΓΟ, HTO Ha ITOBepXHOCTH onyXOneBHX KJieTOK peiļenTopoB φ3κτοροΒ pocTa b 20-100 pa3 6oJibme, ηθμ Ha noBepxHocTH «pyrHX κπβτοκ, a φyHx^noHa.πbHaί^ rpynnHpoBKa ρβιχβπτοροΒ φΒκτοροΒ pocTa - ογιΐΗφΓΉ,ιηρΗΐΐΗΗΒίϊ rpynna, κ κοτοροή HOHBI pTyTH ΗΜβΙΟΤ CaMOe BHCOKOe CpOflCTBO, TO Βθ3ββήοτΒΗβ Ha onyxojieB£ie κπθτκη b 20-100 pa3 cHJībHee.

HeficTBjnomee BemecTBO 3aHBJineMoro cpeflCTBa - HHxnopHH pTyTH πρκ pacTBopeHHH He npoBOflHT BJieKTpHHecKoro TOKa (HeHOHH3HpOBāHO ) , a ΗβΗΟΗΗ3ΗρθΒ3ΗΗΒΙβ ΜΟΠβΚγΠΜ ΠβΓΚΟ npOHHKaiOT Hepe3 MeM6paHH, B TOM HHCJie Η B Μ03Γ, a npoHHKHyB, nonaflaioT b iļHTonna3My c 6ojiee ΗΗ3κοή pH, B to *e BpeMH Bce naToreHHHe κπθτκη , βκπιοηθη onyxoneBMe, ημθιοτ aHOMaJIbHO HH3KHe ΒΘΠΗΗΗΗΗ pH, H BCJieflCTBHe ΠΟΒ&ΠΠΘΗΗ.Η khcjiothocth HM6HHO naToreHHHe KJieTKH nomamaiDT ρτγτι», to ecTb o6ecneHHBaeTCH H36HpaTenbHoe B03fleūcTBHe He naToreHHHe κπθτκη. 3aHBJiHeMoe cpencTBO, 6jiarojnapH onHcaHHOMy MexaHH3My Πθηοτβηη o6na,n;aeT οποοο6ηοοτβμ BoccTaHaBJiHBaTb HapymeHHoe φγΗΚΗΗΟΗΗροΒθΗΗθ οηοτθμη perynHiļHH pa3MHO*eHHH κπβτοκ TKaHH. 3aHBJiHeMoe cpencTBo o5jiaflaeT HMMyHOMOnynHpywmHM nežcTBHeM. Ποπ βπηηηηθμ 3aHBJiHeMoro cpencTBa προκοχοΛΗτ nepecTpoHKa BHyTpeHHHX perynHTopHHX MexaHH3MOB, o6beHHHHI0in;HX HMMyHHHe ΚΠΘΤΚΗ B ΘΗΗΗγίΟ CHCTeMy H HopMajiH3aiļHJi HMMyHOJiorHHecKHX riapaMeTpoB. 7 Īli LV 11667 JIyHfflHH Ba.pna.HT ocymecTBneHHH ΗΒοδρβτβΗΗΗ SaHBJiHeMoe cpejīCTBo, cornacHO Η3ο6ρβτθΗκπο, cojiepaiHT B KanecTBe neftCTBjromero BemecTBa hhxjiophh ρτγτκ hjih apcsHHT KaJTHH/ hjih apceHaT HaTpHH b KOJiHHecTBe 0,01-1,5 uac. % B COSeTaHHH C $apMaijeBTHHeCKH ΠρΗΓΟΙΙΗΗΜ

paa6aBHTejieM. Πρκ stom ajiji BHyTpeHHero h Hapy*Horo ΠρΗΜΘΗΘΗΗΗ SaJĪBJIJieMOe CpenCTBO npejļnOHTHTe/IbHO ΟΟΑβρχΗΤ J3HXJIOp HJJ pTJTTH B KO JIHHeCTB e 0,01-0,1 Mac.% npH

HcnojiBGOBaHHH b KanecTBe pa36aBHTeJiH HaTypanbHoro BHHorpanHoro 6ejioro βηη3 c coaepxaHHeM caxapa 3-4 Mac.% hjih μοβοηηοΗ cMBopoTKH c conepaeaHHeM caxapa 3-4 Mac.%;

HJIH COAepffHT HHXJIOpHH pTyTH B KOJIHHeCTBe 0,03-0,13 Mac.% npH HCnOJIB30BaHHH B KaHeCTBe pa36aBHTeJIH CMeCH CBHHOrO *Hpa, Mena HaTypaJibHoro η βτηιιοβογο cnnpTa. yxa3aHHtie KojiHHecTBa AKXJiopHna pTyTH b 3 asB JiiieHOM cpencTBe no,ao6paHti BKcnepHMeHTaJībHo h o6ecneKHBaiOT οφφβκτκΒΗοοτΒ neftcTBKJi 3aHBJiHeMoro npenapaTa. CHioaeKHe conepsaHHH HHXJiopHna pTyTH ηηλθ yxaaaHHoro npecena hjih noBHmeHHe Bume 3aaB JieHHoro npenejia Heuejiecoo6pa3Ho, Tax KaK He očecneHHBaeT αοοτηχθηηη acejraeMoro pe3yjiE.Tara. IJeJiecoo6pa3HO, hjih πεπβΗΗίΐ οοτρΜΧ η χροΗΚΊβοκκχ jieftK030B HcnoJibaoBaTb aaHBJiHeiioe cpencTBo hjih BHyTpeHHero πρΗΜβΗβΗΗΗ, conepxamee b KasecTBe HeiicTByKimero BemecTBa apceHaT HaTpHH hjih apceHHT KaJiHH b KoJiHHecTBe 0,05-0,15 Mac.% b coHeTaHHH c pa36aBHTejieM-HaTypaJibHiiM BHHorpanHLiM 6ejE&rM bhhom c cojjepjaaHHeM caxapa 3-4 Mac.% hjih mojiohhoH ctiBopoTKoft c coflepMaHHeM 3-4 Mac.%. yxa3aHHBie KojiHHecTBa neHCTByiomHx BemecTB Tajcce naAo6paHti OKcnepHMeHTaJībHO h o6ecneHHBajDT ΒφφεκτκΒΗΟοτΒ neĀCTBHH 3aHBJiHeMoro cpeflCTBa. 3aHBHjieMoe cpencTBo CTHMyjiHpyeT μηογηθ φyHκ^HH opraHH3Ma, ocjia6juieT OKHCJtHTejibHHe npoueccH h noBtunaeT ycBoeHHe aaoTa κ φοοφορ3, orpaHHHHBaH pacmeruieHHe δειτκοΒ, yjiyHmaeT o6MeH s KJieTKax η τκζηκχ, oKa3MBaa tskhm o6paaoM o6meTOHH3HpyBmee neftCTBHe, yJiyninaeT o6mee cocTOHHHe, yBejiHHHBaer npoueHT ΓβΜΟΓΤΙΟδΗΗβ H KOJIHHeCTBO ΟρΗΤρΟΙΙΗΤΟΒ B KpOBH. 3aHBJixeMoe cpencTBo hjih Hapy*Horo πρημθηθηηη 8 conepatHT neiicTBjnomee BemecTBo-nHXJiopHn ρτγτΗ b KOJiHHecTBe 0,3-1,5 Mac.% b coHeTaHHH c pa36aBHTejieM - HaTypajibHHM BHHorpaflHHM 6eJīHM bhhom c conep*aHHeM caxapa 3-4 Mac.% hjih mojiohhoh cuBopoTKoft c conepacaHHeM caxapa 3-4 Mac.%. B KanecTBe HaTypaJibHoro BHHorpanHoro 6ejioro BHHa MOJKHO HCn0JIb30BaTb, HanpHMep OflHO H3 CJieHyiOIIlHX MapoK BHH "MjriiBaHH” , "COBHHbOH” H HpyrHe. B ΤβΧΗΟΙΙΟΓΗΙΟ Η3ΓΟΤΟΒ11βΗΗΗ TaXHX BHH BXOflHT npOIļeCC HarpeBaHHH ΠΟ 60 °C ΗβοβΧΟΗΗΜΒΙΗ, hjih npeKpameHHH c6pa*HBaHHH HacTH caxapoB. Πρκ yica3aHHOH TeMnepaType npoHcxonHT o6paTHMan Koaryji.smH.si pacTHTejibrooc 6eJIKOB, B ΗβδΟΧΙΒΙΠΟΜ KOJIHHeCTBe ΒΧΟΗΗΠξΗΧ B COCTaB BHHa, B pe3yjit>TaTe nero ocBo6oxnaiOTCH σγπΒφΓΗηρΗΐίΒΗΗβ rpynnti 6eJiKOB - SH, KOToptie o6paTHMo 6jioKHpyioTCiī ηοηβμη ρτγτκ hjih MumbHKa, BCJiencTBHe οτογο ycTpaHaeTca tokchhhoctb pacTBopa. B COCTaB MOJIOHHOft CHBOpOTKH TČLKJK6 ΒΧΟΛΗΤ o6paTHMO KOaryjIHpOfiaHHHe 6eJIKH C BHCBo6oflHBIIIHMHCH CyJIb$rHHpHJIi»HBIMH rpynnaMH - SH, KOTOpHe OČpaTHMO 6jīOKHpyHJTCiI HOHaMH ρτγτκ HJIH HOHaMH MHmbHKa, BCJieflCTBHe ΗβΓΟ TOKCHHHOCTb paCTBOpa CHHiiaeTca no HyjiH. 3aHBJIHeMOe CpeHCTBO ΜΟ*βΤ ČHTb ρΚΟΜβΗ£ΟΒΒΗΟ nJIH JieneHHH cjienyioniHx 3a6ojieBaHHft: Bce bhjīm no6poKaHecTBeHHHx onyxoJieft; Bce bhhh 3JioxaHecTBeHHHX οπγχοιιβκ; ΗΜΜγΗΟΗθφΗΗΗΤΗ pa3JIHHHOrO ΠρΟΗΟΧΟΧΗΘΗΗΗ; ρβΒΜΒΤΗ3Μ; peBMaTOHHHHe apTpuTH; nonHapTpHTH; 6poHXHaJibHaH acTMa; BOJinaHKa cHCTeMHaa KpacHaji; h3BH xenynKa; τροφΗΗβοκπβ h3bh; repnec; ncopnas; KHisHHaa ηηΦθκηηη; HeftponepMHTH h npyrHe 3a6oJieBaHHH. B 3aBHCHMOCTH OT φορΜΜ, CTaflHH 3a6oJieBaHHH, nepeHocHMocTH npenapaTOB h npyrnx HHHHBHHyajibHBix OCo6eHHOCTeft OpraHH3Ma, BH6op H HJIHTeJIbHOCTb ΠρΗΜβΗβΗΗΗ 3aHBJiHeMoro cpencTBa μοχθτ MeHHTbca, b to *e BpeMH cjienyeT npHnep*HBaTbCH onpenejieHHHx npHHiļHnoB jieHeHHH. Tax HanpHMep, cJienyeT npHnepxHBaTbCH ηηθτηηθοχηχ OrpaHHHeHHH C HCKJIIOHeHHeM Τ3ΚΗΧ nponyKTOB ΠΗΤΒΗΗΗ, KaK mhco, pw6a, HHua, nocxojibKy npH JieneHHH 3aHBJiHeMHM epeneTBOM 6jIOKHpyiOTCJI ΟγΐΙΒφΓΗηρΗΙΙΒΗΗΘ ΓργΠΠΜ B CHCT6M6 9 LV 11667 npOTeOJĪHTHHeCKHX φθρΜβΗΤΟΒ, TO eeTfa CHHXaeTCH B03M0XH0CTb opraHH3Ma ycBaHBaTb 6ejiKOByw nHmy. *Iame jieneHHe HaHHHaioT c npneMa 3aHBJiHeMoro cpencTBa BHyTps - nepBBie τρΗ ηηη no 5 mji (hjih 5 r) 3 pa3a β ηθηβ, Hajiee no 10 mji (hjih 10 r) x 3 pa3a b neHb β τθηθηηθ Mecaiļa. napajiejiBHO npneMy npenapaTa BHyTpb hjih ηθ3Ββηοημο OT ΗβΓΟ OCymeCTBJIHWT M6CTHO6 B03fleĀCTBHe 3ajIBJIiīMBrM CpeHCTBOM B ΒΗΠβ ΠρΗΜΟΗβΚ, ΤόΙΜΠΟΗΟΒ, CnpHHIļeBaHHĀ Η KJĪH3M. Β 3aBHCHMOCTH OT JIOKaJIH3aiļHH npOIļeCCa ΒΒΐ6θρ 30HLI ΗβοδχΟΗΗΜΟΓΟ B03HeftCTBHH pa3JIHHeH - Ha κοπηηκ, naxoBHe JiHM$oy3JiH, nonMHineHHjno o6jiacTb, πο3Βοηοηηηκ, cycTaBH, JI0KaJIH30BaHHE>ie 06pa30BaHHH. ΠΟΚρΟΒΗΗβ HJIH KOCTHO-cycTaBHue tkbhh . Tax Hanpratep, πρκ JieneHHH 3a6oJieBaHHiī MOJIOHHOft JReJie3BI HJIH ΧβΗΟΚΟΗ ΠΟΟΙΟΒΟΗ ΟφβρΗ Ha φΟΗΘ ΠρΗβΜβ 3aHBJiHeMoro cpeflCTBa BHyTpi> μοχηο HcnojiB30BaTb MecTmie npHMOHKH, a Taicse BJiarajiHuiHHe TaMnoHU h kjih3MH. Πρκ jieHeHHH nopaxeHHH xejiynxa Ha φοΗβ npneMa 3aHBJiHeMoro Cpe^CTBa BHyTpb, ΠρΗΜΟΗΚΗ Ha ΠΟΗΜΒΠΠβΗΗΗβ OČJiaCTH Η ΚΟΠΗΗΚ hjih KJIH3MM. Πρκ nopaxeHHH npencTaTeJibHod xejie3H- 3aHBJIHeMOe CpeflCTBO BHyTpb Η B BHfle ΠρΗΜΟΗβΚ Ha ΚΟΠΗΗΚ, naxoBHe h nojiMHnieHHbie JIHMφoy3JIH. Πρκ ΜΗβποπβΗκθ3β 3aHBJIHeMOe CpeflCTBO BHyTpb Η B BHJje ΠρΗΜΟΗβΚ Ha ΚΟΠΗΗΚ, rpynHyio nojiocTb naxoBHe h noflMHmeHHHe JIHMφoy3JIH/ Π03Β0Η0ΗΗΗΚ, CyCTaBH. ΠρΗ ΠΟρβΧβΗΗΗ ΜΗΓΚΗΧ TKaHeŽ Η ΟΟΤβΟΓβΗΗΗΧ CapKOMaX -3aHBJIHeMOe CpeflCTBO BHyTpb Η B BHfle ΠρΗΜΟΗβΚ Ha ΚΟΠΗΗΚ, naxoBBie h πο,ΠΜΜίπβΗΗΗβ o6jiacTH, πο3βοηοηηηκ, o6jiacTb nopajKeHHH. 3aHBJiHeMoe cpencTBO c ποββππθηηοη KOHueHTpaiļHeH pTyTH ΠρΗΜβΗΗβΤΟΗ ΠρΗ ΗβΗβΗΗΗ 3JIOKaHeCTBeHHMX 3a6oJieBaHHft JierKHX, npH HaJIHHHH ΓΗΟΗ Η ΚρΟΒΗ Β ΜΟΚρΟΤβ, ΠρΗ ΙΙβΗβΗΗΗ nopajReHHH b 3anymeHHLix cjiyHaax.

3aHBJiHeMoe cpencTBO c neHCTBjnomHM BenļecTBOM HHXJiopHn pTyTH χοροιπο 3apeKOMeHHOBajio ce6n πρκ JieneHHH κοχηηχ 3a6ojieBaHHft, τβκηχ , KaK ncopHa3 h ΗβΗροπβρΜΗΤ. 3to CBH3aHO B OCHOBHOM, ΠΟ—BHflHMOMy, C HSOtyHOMOJŪtyjI HpjnonļHMH CBoiicTBaMH 3aHBJiHeMoro cpeflCTBa, κοτοροθ npH Hapy*HOM 10 πρΗΜβΗβΗΗΗ npoHBJiaeT Tax*e npoTHBOBOcnaJiHTejiBHoe H penapaTHBHoe cboūctbo. ΠρΗΜβΗβΗΗβ 3aHBJiaeMOro CpeflCTBa C HeftCTByiOmHM BemeCTBOM - ΑΗΧπορκη ρτγτκ ΠρΗ ΠΘΗβΗΗΗ ΤρΟφΗΗΘΟΚΗΧ H3B ηηχηηχ κοΗθΗΗοοτβϋ noKa3ajio ποποχΗτβπΒΗΕΐθ pe3yjibTaTH πρκ Ha3HaH6HHH cpencTBa BHyTpb no očņeft cxeMe h Hapy*HO b BHfle πρΗΜΟΗβκ. Kypc JieneHHB: cocTaBJLHeT 1 Mecnn. ΠρΗ Heo6xoflHMOCTH nocjie μθοηηηογο nepepuBa xypc πθηθηηβ: Μοχετ 6hTB ΠΟΒΤσρβΗ. 3aHBJiseMoe cpencTBo npHroTaBJīHBaiOT no Η3ΒβοτΗθή ΜβτοΗΗΚβ nyTeM cMemeHHH hcxo«hhx κομποηθητοβ. 3aHBJi.seMoe cpencTBo 6mjxo H3yneHo b sKcnepnHēHTe Ha ΧΗΒΟΤΗΗΧ H HCnHTaHO B KJIHHHXaX Ha ,ΙΠΟΗίϊΧ . H3yHeHHe οοτροή tokchhhocth 3aHBJiaeMoro cpencTBa 6hjxo προΒβηβΗΟ Ha 192 3AopoB£ix 6ecnopoAHHX Kp£icax-caMiļax Maccož 180-220 r., HaxoHHBmHxcH b cTaHQapTHHx ycnoBHHx nHTamis h co;qep*aHHH. 3a 24 naca no HcmrraHHH h bo BpeMH hx npoBeneHHH χηβοτηηθ HaxonHJiHCB b noMenjehhh BHBapHH c nocToHHHOH TeMnepaTypoft η ΒβΗΤΗπηηΗβή. 3a 2 naca no Hanana HcraiTaHHž jkhbothhm npeKpamaJiH nany bosu h KopMa.

OnpenejieHHe napaMeTpa οοτροή tokchhhocth (Jlfl^) Ka*noft H3 JieXapCTBeHHHX φορΜ npOBOnHJIH ΜβΤΟηΟΜ JĪHT^HJina h ynjiKOKcoHa πρκ nepopaJīBHOH nyTH BBeneHHa, cooTBeTCTBjnomeM HaaHaHeHmo, h BHyTpn6pioniHHHOM, oSecneHHBaromeM ηοοτΗχβΗΗβ βηοοκογο τοκοηηθοκογο 3φφβκτ3.

nyTeM oT6opa η B3BemHBaHHH 6hjih BtinejieHH 10 rpynn κρΗΟ nJtH BBeneHHa 3aaBnneMOro npenapaTa (b BHne BapnaHTOB - *HnKaH φΟρΜΒ Ha ΒΗΗβ H Ha ΜΟΟΧΟΗΗΟή CHBOpOTKe) . ^Ihcjio χηβοτηηχ b KaxnoH rpynne paBHHJioct. 6. ΠρΗ BHyTpH6piomHHHOM nyTH ΒΒβΠβΗΗΗ COOTBeTCTByKmHM rpynnaM κρκο ββοαηπη 5; 4; 3; 2 η 1 κπ 3aHBJiaeMoro cpencTBa, hto cooTBeTCTBOBajio no3aH nefiCTByiomero BemecTBa - 1/65; 1/32; 0/99; 0,66 h 0,33 μγ/κγ. nepopaJīBHo *e

BBOnHJIH 2; 1/5; 1 H 0/5 ΜΠ, ΗΤΟ COOTBeTCTBOBaJIO n03aM neHCTByiomero BemecTBa - 0,66; 0,495; 0,33 h 0,165 μγ/κγ.

B KOHTpOJie ΧΗΒΟΤΗΜΜ BB onHJIH COOTBeTCTBJTOmHe paCTBOpHTeJIH - HaTypajii»Hoe BHHorpaflHoe 6enoe βηηο h mojiohhjtio 11 II! LV 11667 CHBOpOTKy.

Ha6jIK3fleHHH 3a ΧΗΒΟΤΗΜΜΗ npOBOflHJIH B ΤβΗβΗΗβ 14 HHea nocjie ΒΒβΗβΗΗΗ 3aHBJiHeMoro cpeflCTBa. ΠρΗ otom oiļeHHBaJiH o6ņee coctoshhs χηβοτημχ, ηχ ποΒβπβΗΗβ h Maccy Tena. nocjie ΒΒβΗβΗΗΗ yKa3aHH£ix no3 3ajiBJi5ieMoro npenapaTa y Kpnc Ha6jiK)HaJiH cHHseHHe HBHraTejibHOH aKTHBHOCTH, COHJIHBOCTb . 3TH 5IBJleHH.il ČNJIH ČOJiee ΒΜρβΧβΗΜ npH BHyTpH6pfflfflHHHOM ΒΒβΗβΗΗΗ. ΟΠΗβΚΟ CJiyHaeB CMepTHOCTH ΧΗΒΟΤΗΜΧ B ΠβρΒΝβ HeCKOJTBKO ΠΗβ0 ĪIOCJTe ΒΒβΗβΗΗΗ Ηβ OTMeHaJIH. ΚρΟΜβ ΤΟΓΟ, npH nepopaJIBHOM ΒΒβΗβΗΗΗ 3aHBJi5ieMoro cpencTBa (b βηηθ BapnaHTOB Ha ΒΗΗβ η ΜοατοπΗοή CHBopoTKe) cjiynaeB βΜβρτΗοβτκ Ηβ Ha5JiionaJiH h b naJībHeftnieM B ΤβΗβΗΗβ Bcero cpOKa Ha6jIK)neHHH. ΠρΗ 3TOM pa3JIHHHH B Macce Tejia, οθιςβΜ coctohhhh η ποΒβπβΗΗΗ χηβοτηηχ β CpaBHeHHH C KOHTpOJieM ΒΗΗΒΠβΗΟ Ηβ 6mjio. AHajiorHHHHe pe3yni»TaTH 6hjih noJiyHeHH η πρκ BHyTpH6piOfflHHHOM ΒΒβΗβΗΗΗ 3aHBJIHeMOrO cpencTBa {BapnaHT Ha ΒΗΗβ) CJiyHaeB CMepTHOCTH Ηβ Ha6jTI0naJIH H pa3JTHHHH c KOHTpOJieM β ποΒβπβΗΗΗ h BejiHHHHax MaccM TeJia o6Hapy*eHo Ηβ 6hjio. OTcyTCTBHe cJiynaeB CMepTHOCTH πρκ nepopajībHOM ΒΒβΗβΗΗΗ Η ΠρΗ BHyTpH6piOfflHHHOM ΒΒβΗβΗΗΗ 3 aHBΗΗβΜΟ Γ O npenapaTa (sHHKaa φορΜβ Ha ΒΗΗβ), HecMOTpn Ha ΒΒβπβΗΗβ MaKCHMaJIbHO HOnyCTHMMX ΗΧ οβίβΜΟΒ, Ηβ n03B0JIHJI0

paccHHTaTb ochobho0 napaKeTp οστροή tokchhhocth · HTO jnca3HBaeT Ha HH3Kym tokchhhoctb οτηχ φορΜ npn yxa3aHHHX nyTax ΒΒβπβΗΗΗ h Hcnojib3yeMux no3ax. ΠρΗ BHyTpH6p»fflHHHOM ΒΒβΗβΗΗΗ 3βΗΒΠΗβΜΟΓΟ CpeflCTBa (JKHHKaΗ φορΜΒ Ha MOJIOHHO0 CHBOpOTKe) 6HJIH BMHBJieHM CJiyHaH CMepTHOCTH Kpuc Ha 5, 6, Ί, 8h9 cyTKH nocjie ΒΒβΗβΗΗΗ. ΠρΗ 3TOM y ΧΗΒΟΤΗΜΧ ΠβρβΗ rH6eJIbH) OTMeHaJIH BHJIOCTb, napaJiHH 3aHHHX κοΗβΜΗοστβζ, a Taxxe o6HapyxHJiH HapyraeHHH mepCTHOro ΠΟΚρΟΒβ. Υ ΒΜΧΗΒΠΙΗΧ KpMC 3TH HBJT6HHH 6hjih MaJIO BMpaxeHH η κ 14 cyTxaM no ποΒβπβΗΗΐο h noxa3aTejno Maccu Tejia OHH Ηβ OTJlHHaJIHCb ΟΤ KOHTpOJIH. AHaJIH3 HaCTOTH CMepTHOCTH ΧΗΒΟΤΗΜΧ, ΠρΟΒβΗβΗΗΜή ΜβΤΟΗΟΜ ΙίΗΤΗφΗηΠβ H yHJIXOKCOHa, n03BOJIHJI paCHHTaTb -^50 12 jijijī 3a5iBJīiīeMoro cpeflCTBa (BapnaHT Ha mojiohhoū οωΒοροτκβ) ΠρΗ HX BHyTpH6pwmHHHOM ΒΒΘ«βΗΗΗ.

BeJIHHHHa Jlflgg y KpbIC npH BHyTpH6pwniHHHOM BBefleHHH 3aaBJiaceMoro cpencTBa (MHUKaii <$opMa Ha mohohhoū ctiBopoTKa) cocTaBJisceT 5,8 (1,98-8,8) μγ/κγ Beca χηβοτηογο.

Ehjih npoBefleHH HccjienoBaHHH npoTHBOonyxoJieBoS aKTHBHocTH 3aHBJiHeMoro cpencTBa Ha onyxojieBtix nepeBHBaeMHX xyji&Typax.

HccjieflOBaHHe npoBOflHJiH Ha nepeBHBaeMHX JieĀxoiļHTapH£ix onyxoneBHX xyjiBTypax jihhhh L-41.

KyjiE>THBHpoBaHHe Kyni»Typ npoBOHHJiH no o6menpHHHTOMy MeTony. IlJtoTHocTb noceBa κηβτοκ cocTaBJtHJia -1.10^ κπβτοκ b 1 mji cpenM. B KanecTBe nHTaTeJibHOž cpenti Hcnojib30BaJiH b paBH£ix cooTHomeHHfflt cpefly 199 h cpeny Urna c no6aBJieHHeM 10% 6MHE>eH CbIBOpOTKH H aHTH6HOTHKOB J 100 efl. neHHIļHJIJIHHa H 50 ejļ. cTpenTOMHiļHHa Ha 1 mji cpenBī. 3aHBJiHeMoe cpencTBO h OTflejibHO pa36aBHTeJib - bhho "SpeTH" h neūcTBjromee BemecTBo - ΗΗχηορΗΠ pTyTH pa3BOAHJin Ha 6e36ejixoBOH nHTaTeJIBHOH Cpene H BHOCHJIH HX B pa3JIHHH£IX KOHIieHTpaiļHHX b 3-4 KyjibTypM hjih KOHTaKTa c κπβτοπΗΗΜ MOHoejioeM. Tax xax aeūcTBjrcomHM BenjecTBOM b 3aflBοιηθμομ cpencTBe ηβιγηθτοη BHXJIOpHn pTyTH, TO MH B npeflBapHTejibHOM onHTe HJIH CpaBHeHHH yCTaHOBHJIH, HTO Eflso HHXJIOpHIia pTyTH, TopM03smaH pocT onyxojieBHX Kyjii»Typ L-41 cocTaBJiHeT MeHee 10 ηκγ / mji . Ha BTopae cyTKH nocjie nocTaHOBKH omrra npoH3BonHJiH MHKpocKonHHecKjno oijeHKy fleHCTBHH npenapaTa no 4-x 6ajitHOH οΗοτβΜθ h KOJiHHecTBSHHoe onpenejieHHe conepataHHH 6ejixa KyjitTyp no MeTony JIoypH b MOHH<ļ>HKaiļHH OHMa h Hrjia.

KpHTepHii iļHTocTaTHHecKOH aKTHBHocTH npenapaTa -nponeHT τορμολθηηη pocTa Kyji£»Typ no yrHeTeHHK> CHHTe3a 6ejixa. flaHHMe onuTa npeacTaBJieHM b Ta6jiHiļe 1.

CorJiacHO cymecTByiomHM CTanapTHHM MeTOflaM OT6opa npoTHBOonyxoJieBHX npenapaTOB - npenapaT HBJiaeTca βκτηβημμ ecjm ero EfķQ MeHbme hjih paBHbi 100 μκγ/mji.

HccjieHOBaHHH noxa3ajiH, hto Eflgg 3aHB JineMoro cpencTBa cocTaBJineT _10 μκγ/mji, hto b 10 pa3 npeBsnnaeT CTaHnapT h 13 LV 11667

cBHfleTeJii>cTByeT o ero Btip axe hh om iļHTocTaTHHecicoM neftcTBHH Ha οπγχοπβΒΗΧ KyjiBTypax.

Ta6jiHiļa 1

CpaBHHTeJiBHoe H3yneHHe 6HOJiorHHecK.oft εκτηβηοοτη 3aaBJiiieMoro cpefccTBa, pa36aBHTejia (HaTypajii>Hoe BHHorpaflHoe čejioe bhho c coHepacaHueM caxapa 4 Mac.%) h neacTBjnomero BemecTBa-i*HXJiopHna pTyTH Ha nepeBHBaeMOH onyxojieBoa KyJibType jihhhh L-41 IIpenapaT ΚΟΗΙίβΗ- % co- co^ep*aHHe ΠρθΙ1βΗΤ flocTOBep- TpaiļHH nep*a- 6ejixa b TopMose- HOCTB flHXJIO- pHflļa pTyTH B ΜΧΓ / MJI HH SL cnap- Ta μκγ/mji HHH HJIH CTHMyjIH-IiHH poc-Ta xyni>- Typ,% P 1 2 3 4 5 6 294,0±10,4 - 1 .KOHTpOJIb-2.3 aHB jiaeMo e cpencTBO 1,1 3.3aHBJTiīeMoe cpencTBO 3,3 4.3aHBJi5ieMoe cpeflCTBO 4,8 5.3aHBJiHeMoe cpeflCTBO 6,6 6.3aHBJiHeMoe cpencTBO 9,9 0,03 318,0±0 7,5 cth- MyJIHIļHH 0,1 238,3±9,1 18,9 τορ- MoaeHHH 0,15 224,0±0 23,8 τορ- ΜΟΧΘΗΗΗ >0,05 >0,05 0,2 214,0±0 27,2 τορ- ΜΟΛβΗΗΗ >0,05 0,3 144,0±0 51,0 τορ- >0,05 ΜΟΧβΗΗΗ 14 1 2 3 4 5 6 7.Bhho 6eJioe HaTypaJii>Hoe BHHorpanHoe - 0,03 316,0±25,1 6,9 cth- 8.Bhho 6ejioe HaTypaJiī»Hoe BHHorpajļHoe - 0,1 MyJIJmHH 318,0±0 7,5 cth- 9.Bhho 6ejioe HaTypaJiBHoe BHHorpaflHoe - 0,15 MynSIJHH 318,0±0 7,5 cth- 10.Bhho 6ejioe HaTypaJiE>Hoe BHHorpajļHoe - 0,2 MyjIHIļHH 322,5±5,6 8,8 cth- 11.Bhho 6ejioe HaTypaji&Hoe BHHorpanHoe - 0,3 MyjIHB[HH 307,0±13,8 4,2 cth- 12.ΗΗΧπορΗΗ pTyTH 1,0 MyjIHIļHH 390,3±2,6 1,2 τορΜΟ- <0,05 13.flHXnopHH pTyTH 3,3 ΧΘΗΗΗ 279,0±27,3 5,1 τορ- >0,05 14 . flHXJIOpHH pTyTH 5,0 ΜΟΧβΗΗΗ 256,0±5,2 12,9 τορ- >0,05 15.Ηηχπορηη pXyXH 8,0 ΜΟΧβΗΗΗ 154,0+5,0 47,6 τορ- >0,05 ΜΟΛΘΗΗΗ ιι: LV 11667 15 03 ΠρΗΒβΟβΗΗΗΧ flaHHHX BHflHO, HTO 3aHBJIJīeMOe cpeHCTBO OKasMBaeT eupaseHHoe TopM03anee neftCTBHe Ha onyxojieB&ie xyjii»Typu b KOHijeHTpaiļHH 9,9 μχγ/mji, hto h cociaBMeT ero Eflso/ HHXJiopHna pTyTH cocTaBJineT πρΗΜβρΗο 8 μκγ/mji. Bhho 5 b nccjienoBaHHBix KOHiieHTpaiļHB[X oKa3HBaeT Ha KyjibTypw He3HaHHTejibHoe cTHMyjiHpyiomee B03neācTBHe b npenejiax 4,2-8,8%.

Bmjio npoBejieHo H3yHeHne HMMyHo<ļ)apMaKOJiorHHecKHx CBOHCTB 3aHBJIHeMOrO CpejļCTBa. 10 ΠροΒβηβΗο HccneAOBaHHe bjihhhhh sajīBJUieMoro cpencTBa

Ha Maccy οοηοβηβιχ opraHOB HMMyHod CHCTeMH. ΟΠΗΤΗ npOBOflHJTH Ha iannax JIHHHH CBA, C57B1 H rn6pHHax ΠβρΒΟΓΟ nOKOJieHHH 3ΤΗΧ jihhhū. 3aHBJīHeMoe cpencTBo ( b BHne HByx BapHaHTOB: 15 pa36aBHTenb - bhho h pa36aBHTejib - mojiohhčih cHBopoTKa) BBOflHJIH MLimaM JIHHHH C57B1 Η ΓΗ6ρΗΠ3Μ ΠβρΒΟΓΟ Π ΟΚΟ JI ΘΗΚΗ jihhhh CBAxC57Bl b τβΗθΗΗβ 10 jiHež. ^epe3 cyTKH nocjie nocjienHero ββθπθηηη 3aHBJiHeMoro cpencTBa χηβοτηηχ B3BeūIHBaJIH, 3a6HBaJIH, H3BJieKajIH C6JI636HKH Η ΟΠρβΠβΙΙίΙΙΙΗ HX 20 Maccy.

Pe3yjibTaTH Β3Β6πιηββηηη h noncHeTa MaccoBLix κο3φφΗΐ1ΗθΗΤθΒ npeflCTaBJieHH b Ta6jiHi;e 2. 16

It

Ta6jiHiļa 2

Maccu cejie3eHOK npH ηθηοτβηη 3aHBJiHeMoro cpeflCTBa

N/π DpenapaT Kojih— Macca cejie3eHKn 5 ΜβΟΤΒΟ SHBOT- ΜΓ flOCTO- Macco- flocTOBep- ΗΗΧ B Bep- BHH HOCTb (P) rpynne HOCTt Κ03φ- OTJTHHHā (P) OT- φΗΙ1ΗβΗΤ OT KOHT- 10 JIHKH ή pOJIH OT KOHT— POJIH 15 1 2 3 4 5 6 7 JlHHHH C57B1 1 KOHTpOJIb 23 86 0,55 2 3aHBJiHeMoe 20 cpeflCTBO (pa3- 6aBHTejib-MO- JIOHHaH CBIBO — poTKa) 9 90 >0,05 0,56 >0,05 3 3aHBJiHeMoe 25 cpeflCTBO (pa36aBHTejib-BHHO ) 10 87 >0,05 0,51 >0,05 Γη6ρη« nepBoro 30 nOKOJieHHH JlHHHH CBAxC57Bl 1 KOHTpOJIb 25 114 0,46 2 3aHBJiHeMoe cpeflCTBO 11 112 >0,05 0,48 >0,05 3 5 (pa36aBHTejib- MOJIOHHaH CH-BopoTKa) 17

JE LV 11667 1 2 3 4 5 6 7 3 3aiiBJiaeMoe cpencTBo (pa36aBHTeJib- bhho) 12 114 >0,05 0,46 >0,05

HaHHbie 3thx οπβιτοβ noKastiBaioT, hto 3aūBJiHeMoe cpeflCTBO Ηβ BJiHHeT Ha Maccy ceJie3eHKH h MaccoBMū κο3φφΗΐ1ΗθΗτ 3Toro opraHa πρΗ ββθηθηηη npenapaTOB b ΤβΗβΗΗβ 10 ΠΗθή. B cJienyiomHX 3KcnepHMeHTax 3aaBJiaeMoe cpeflCTBo BBOJļHJIH B ΤβΗΘΗΗβ 30 ΠΗβή H 3aTeM npOBOJļHJIH Β3Β6ΠΙΗΒΒΗΗβ THMycoB; b om,iTax Hcnonb30BajiH μβππθη jihhhh CBA. ΡΪ3 pe3yjibTaTOB, npencTaBJieHHHX b Ta6jmiļe 3, cJieHyeT, hto Ha Bec THMyca npenapaT b HaHHHX 3KcnepnMeHTajibHHx yCJIOBHHX ΗΘ BJIHHJI ·

Ta6nHiļa 3

Macca THMyca h cejie3eHKH npH jļeiicTBHH 3ajīBJiHeMoro cpejļCTBa (pa36aBHTeJib-BHHO)

IlpenapaT KonHHecTBo Macca THMyca JKHBOTHBIX _ b rpynne ηγ P otjihhhž ot KOHTpojia

KoHTponb 8 174 3aHBJiHeMoe cpe£CTBO 7 170 >0,05

Ehjio HccjieaoBaHO BJiHHHHe 3aHBJi5ieMoro cpencTBa Ha peaKiļHM "TpaHcnJiaHTaT προτΗΒ xo3SHHa" . 3TH HCCJieHOBaHHH npOBOflHJIH ΠΟ CJieHyiomeH ΜβΤΟΠΗΚβ.

Minnai* - rn6pnHaM nepBoro noKOJieHHH jihhhū CBA n C57B1 18 B nonynieMKy OffHOii 3βΑΗβή JianKH ΠΟίΙΧΟΧΗΟ BBOflHJIH KJieTKH JiHM(ļ)aTHHecKHX y3JTOB Munreii jihhhh C57B1, b xoHTpjiaTepajii>Hyīo jiany bboahjih to xe κοπηηθοτβο οηηγθηηηχ κπβτοχ jihm$oy3jiob rn6pHHOB. Ha BoefaMLie ογτκκ nocjie nepeBHBKH κίΐβτοχ JīHM$aTHHecKHX y3JioB noHopoB onpeneJiHJiH Maccy ποηκολθηηηχ JĪHM$aTHHeCKHX y3JIOB οδβΗΧ Jian ρβΙζΗΠΗβΗΤΟΒ . PeaKIiHIO oueHHBajiH no ΗΗββκογ peaioiHH /HP/, pacHHTaHHOMy no φορΜγπβ:

Bec JiHM(ļ>oy3Jia πρη ΒΒβηβΗΗΗ κπβτοκ C57B1 HP ------------------------------------------------

Bec JiHM(ļ>oy3Jia πρη BBeneHHH κπβτοκ ΓηδρηποΒ 3aHBJiHeMoe cpencTBO (b AByx BapnaHTax: pa36aBHTeni>-MOJTOMHaH CHBOpOTKa H pa36aBHTeJII> - BHHO) BBOHHJIOCI» b τβΗβΗΗβ 10 ηΗβή η 20 nHevi noHopaM h penHnneHTaM.

Pe3yjibTaTH θτηχ HccjieflOBaHHfi npencTaBJieHH b Ta6jtniļax 4-5.

TaČJiHiļa 4 Βπηηηηθ 3anBJineMoro cpencTBa (pa36aBHTejiB-MOJioHHasi cHBopoTKa) Ha Maccy ποπκολθηηηχ JiHM$oy3JioB b peaKijHH " TpaHcnJiaHTaT προτΗΒ xo3SHHa"

CxeMa BseneHHn *lHCJIO MaCCH JĪHM$Oy3JĪOB HHfleKC 3anBJiJieMoro SHBOT- peaKiļHH cpencTBa ΗΗΧ B KOHTpOJIB- ΟΠΕΙΤΗΟϋ rpynne HOft JianKH peiļHnH- noHopan JianKH θητβμ /μγ/ /«hh/ 1 2 3 4 5 6 KOHTPOJĪB 8 2,8 9,2 3,35 14 10 9 7,2 7,7 1,10 14 20 10 11,5 13,3 1,24 KOHTpOJIB 11 3,3 7,1 2,4 14 9 5,2 6,6 1,3 19 LV 11667 1 2 3 4 5 6 - 10 10 6,0 7/0 1/3 14 10 10 5/2 6,6 1/4

Ta6jnma 5 BJiHHHHe 3aaBJiHeMoro cpeacTBa (pa36aBHTeJtb - bhho) Ha Maccy ποπκοπβΗΗΗΧ πΗΜφογ3ποΒ b peaioiHH TpaHciuiaHTaT npOTHB X03HHHa

CxeMa BBeneHHH ^HCJIO MaCCH ϋΗΜφθγ3ίΙΟΒ HHHeKC 3aHBJijieMoro cpejļCTBa *HBOT-ΗΗΧ B KOHTpOJIb- ΟΠΒΙΤΗΟΗ peaKiļHH ρβΙίΗΠΗ- JļOHOpaM eHTaM /hhh/ rpynne HOft jianKH /μγ/ JianKH 1 2 3 4 5 6 KOHTpOJIb 11 3/3 7,1 2,4 14 - 9 6,7 8,2 1,3 - 10 10 4,6 6,2 1,4 14 10 9 5/1 6,3 1,2 Kax cnenyeT H3 flaHHBIX, npeHCTaBJieHHiix b Ta6jiHuax 4 h

5 3aHBJiHeMoe cpencTBo OKa3HBaeT MonjHoe βιϊηηηηθ Ha KJieTOHHHft ΗΜΜγΗΗΤΘΤ B peaKIiHH " TpaHCIIJiaHTaT npOTHB X03HHHa". CBoeo6pa3He neftcTBHH 3a.HBJi5ieMoro cpejjCTBa

3aKHHDHaeTCiī b τομ,ητο 3φφθκτ jjocTHraeTCH xax πρκ ββθπθηηη npenapaTa peiļHnHeHTaM, TaK h HOHopaM. Bo Bcex cJiyHaHx npoHcxojiHT yBenHHeHHe Macca JiHM$aTHHecKHX y3JiOB npn nepecanxe κπβτοκ toh *e jihhhh MtmieĀ. 3th "KOHTpojibHHe" jiHM$oy3jai flocTHraioT pa3MepoB "οπητηηχ", to ecTb τβχ, peaKIļHIO B ΚΟΤΟρΜΧ OCymeCTBJIiDOT ΠΗΜφΟΗΗΗΗβ KJieTKH 20 pOflHTeJIbCKOft JIHHHH ΠρΟΤΗΒ KJISTOK ΓβΗΟΤΗΠΒ ΓΗΑρΗΑΟΒ . MaCCa 3ΤΗΧ "οπητηηχ" ΛΗΜφογ3ΛθΒ npaxTHHecxn OflHHaxOBa BO Bcex rpynnax ληβοτηβιχ, BXJiioHaH ΜΗΐπβή, He nonyHaBūiHX 3aHBAiieMoe cpencTBO. CjieAOBaTejibHO, 3aūBJixeMoe cpencTBO πρκ ββθα€ηηη 5 B τβκβΗΗβ 10 jļHeH xax AOHopaM, Tax h peAHnHeHTaM He BJmsieT Ha Maccy τβχ πκΜφβτΗΗβοχΗΧ y3JioB/ b χοτορκχ h npoTexaeT peaxiļHH πΗΜφοΑΗΤΟΒ noHopoB προτΗΒ χπβτοχ ny*epoAHoro reHOTHna, ho ycHJiHBaeT peaxijnīo πΗΜφοΑΗΤΟΒ προτΗΒ χπβτοχ co6cTBeHHoro reHOTHna. Πρκ TaKOM xapaxTepe 10 πθηοτβηη npenapaTa HHnexc peaxuHH jiHini» He3HaHHTeni»Ho npeBtnnaeT 1 b οπητηηχ rpynnax.

Πρκ yBeJiHHeHHH xypca ββθαθηηη 3aHBJineMoro cpencTBa HOHOpaM AO 20 ΑΗβΗ B03paCTaeT Maeca o6oHX πHMφoy3πOB /"ΟΠΗΤΗΗΧ" H "KOHTpOJIbHHX" H CTaHOBHTCfl ΒΒΠΠΘ , ΗβΜ B 15 rpynne χηβοτηηχ, He nonyHaBineft aasBJiaeMoro cpeACTBa /Ta6jiHAa 4/. 0AHaxo, Me*Ay co6oft 3TH πHMφoy3πH otjihhcUotch He3HaHHTenbHO η ηηαθχο peaxAHH paeeH 1,24.

KccJieAOBaHO βηηηηηθ 3aaBJiaeMoro cpeACTBa Ha KojiHHecTBo po3eTXOo6pa3yiomHX χπβτοχ b cene3eHxax μηοπθη.

20 IIonyjTHAHH po3eTxoo6pa3yK>mHX χπβτοχ ΗΒππβτοπ CMemaHHoft, ho npaxTHxa noxa3HBaeT, ητο ηχ οηρβΑβπβΗΗβ πΒππβτοπ oahhm H3 ηάκ6ο Jiee vyBCTBHTenbHHX τθοτοβ npH HccneAOBaHHH HMMyHHOTponHOrO AeiiCTBHH CcLMHX p03H006pa3HHX ΧΗΜΗΜβΟΧΗΧ ΟΟβΑΗΗβΗΗή. 25 ΒπκπΗΗβ 3βπΒπΗβΜθΓο cpeACTBa Ha hhcjio po3eTxoo6pa3yiomHX χπβτοχ b cene3eHxax οπρβΑβπππΗ y Mtnneii 0ΠΠ03ΗΤΗΗΧ JIHHHH, HMKyHH3HpOBaHHUX SpHTpOAHTcLMH 6apaHa. KypcH ΒΒβΑβΗΗΗ 3aūBJiHeMoro cpeACTBa paanHHHOii AJIHTeJIliHOCTH HaHHHanH npOBOAHTb AO HMMyHH3aiļHH Χ5ΗΒΟΤΗΗΧ 30 TecT-aHTHreHOM η ηροΑοπχβπΗ enie πητβ αηθη nocjie HMMyHH3aiļHH · Ha ceAfaMae cyTXH nocne βητηγθηηογο cTHMyna MLimeH 3a6HBanH h b cene3eHxax οπρβηβπππΗ KonnnecTBO χπβτοχ, CBH3HBaiomHX ορκτροΑΗΤΗ 6apaHa. IIonyHeHH£ie AaHHMe cBHAeTenbCTByioT, hto 3aHBHiieMoe cpeACTBO b TepaneBTHHecxoft A°3e nocne 10 h 20 αηθη nepopanbHoro ββθαθηηη MHmaM yMeHbmaeT KOJiHHecTBO aHTHreHCBH3HBaiomHX χπβτοχ b cene3eHxax MtnneH xax bbicoko, 35 21 ΙΕ LV 11667

TaK η HHaKOOTBeHajoņeii jihhhh . Πρπ stom b cjiyHae HH3KOOTBeHaiOmeii JIHHHH ΧΗΒΟΤΗΗΧ ΟΗΗΒΙβΗΗβ HHTeHCHBHOCTH HMMyhhoro oTBeīa 6ojiee 3aMeTHo.

BjiHHHHe 3aHBJiHeMoro cpencTBa Ha hhcjio aHTHTejioo6pa3yiomHX κπβτοκ b cejie3eHxax μεππθη npoBOflHJiH, HCCJienyH ηβήοτΒΗβ cpeflCTBa Ha hhcjio

reMOJIH3HHnpOJiyiļHpyiOmHX KJieTOK B 3TOM opraHe «ΗΒΟΤΗΒΙΧ, HMMyHH3HpOBaHHUX BpHTpOUHTaMH 6apaHa. KypCM ΒΒββΘΗΗΗ 3aHBJI«eMOrO CpenCTBa pa3JIHHHOH HJIHTeJIbHOCTH HaHHHāJIH npOBOJļHTb HO HHMyHH3aiIHH ΧΗΒΟΤΏΙΧ ΤβΟΤ - ΒΗΤΗΓΘΗΟΜ H npoflOJiacajiH eiņe τρκ ahh nocJie HMMyHH3aijHH. IIpenapaT BBOflHJIH SHBOTHBEM nepopaJIbHO B Π03θ, SKBHBaJieHTHOH TepaneBTHHecKoft, eacenHeBHo. Ha 5 cyTKH nocjie HMMyHH3aiļHH MLirneā 3pHTpoiļHTaMH 6apaHa jkhbothbix 3a6HBaJiH h b cene3eHKax onpeneJiHJiH KOJinnecTBo KJieTOK, nponynnpyMiHHX aHTHTejia. IIojiyHeHHHe naHHHe, noKa3ajiH, hto 3aBJiaeMoe cpencTBO yMeHi>niaeT KOJinnecTBo aHTHTejioo6pa3yiomHx KJieTOK b cejie3eHKax MHinefi KaK hh3ko, TaK h BHCOKooTBeHaiomHX jihhhh ΠρΗ HMMyHH3aiIHH ΗΗΒΟΤΗΗΧ 3pHTpOIļHT aMH 6apaHa B KaneCTBe TecT—aHTHreHa. Πρπ stom CTeneHt οηηχθηηη HHCJia reMOJIH3HHnponyiEHpyiOmHX KJieTOK 3aBHCHT OT HJlHTeJIbHOCTH Kypca BBefleHHH npenapaTa. Πρκ ββθαθηηη 3aHBJiHeMoro cpencTBa β τβπβΗΗβ 20 η«βή sto cHHseHHe οτβηοβητβοη CTaTHCTHHeCKH 3HaHHMHM y «ΗΒΟΤΗΗΧ θ6βΗΧ JIHHHH.

BjiHHHHe 3aHBJiaeMoro cpencTBa Ha KOJinnecTBo IļHpKyJIHpyiOIIIHX B KpOBH aHTHTejI npOBOHHJIH Hepe3 10 H 20 ΠΗβή nocjie BBejteHHH npenapaTa h nepe3 7 ηκβή nocjie HMMyHH3aiļHH ΜΗΙΠβή 3pHTpOIļHTaMH 6apaHa. KypCH BBeneHHH 3aHBJI5ieMOro cpencTBa pa3JIHHHOH HJIHTejIbHOCTH HaHHHaJIH npOBOnHTb no HMMyHH3aiļHH ΛΗΒΟΤΗΗΧ ΤβΟΤ-3ΗΤΗΓβΗΟΜ H nponoji*aJiH eme πητβ ηΗβή nocjie HMMyHH3anHH. IIojīyHeHHKe pe3yjibTaTH noKa3aJiH, hto hh y bhcoko, hh y HH3KOOTBeHaiOmHX ΧΗΒΟΤΗΒΙΧ 3aHBJIHeMOe CpenCTBO He BJIHHJIO Ha 3Ty peaKiļHH) ryMopaJibHoro KMMyHHTeTa npH HccJienoBaHHH noKa3aTejieii hhtshchbhocth HMMyHHoro oTBeTa nocjie 10 h 20 ηΗβή nepopaoibHoro BBeneHHH npenapaTa b TepaneBTHHecKoū 22 Ηθ3β. TāKHM o6pa30M, KOJiHHecTBO aHTHTeji, HaH6oiiee HHTerpajīfaHHH noKa3aTeJib hhtshchbhocth ημμυηηογο οτβθτβ , πρκ BBejļeHHH 3ajiBJīHeMoro cpencTBa coxpaHaeTCH b npenejiax HOpManbHOrO / KOHTpOJIBHOro/ ypOBH5X.

HccjienoBajioci» TaKxe βληηηηθ 3aHBληθμοro cpejļCTBa Ha jļJiHTejiBHocTb reKceHajioBoro CHa KaK noKa3aTena $yHKIļHOHaJlbHOrO COCTŪ5IHHS MOHOOKCHreHa3HOft CHCT6MBI OpraHH3Ma. Οπβιτβι npoBOHHJiH Ha 6ecnopoflHHX MHmax-ca*max, Maccoii 20-22. Χηβοτηβιμ bbohhjih cpencTBo esejļHeBHo nepopaJībHO b ΤβΗβΗΗβ OHHOH Η Tpex HeneJIb ; KOHTpOJIbHHM ΓργΠΠβΜ ΒΒΟΠΗΠΗ τοτ *e ο6βθμ $H3HOJiorHHecxoro pacTBopa. TecT-MeTa6ojiHT (reKceHan) boahjīh ΒΗγτρκδριοιιΐΗΗΗΟ b H03e 70 μγ/κγ h OlļeHHBaJIH JļJTHTeJIbHOCTb HapKOTHHeCKOrO COCTOHHHa ΜΒΠΠβΗ. ΠοτιγΗθΗΗΒΐβ pe3yjibTaTBi noKa3ajiH, ητο ββθχχθηηθ 3aHBJiH6Moro cpejjCTBa b TepaneBTHHecicož fl03e b τθηθηηθ οηΗΟή hjih τρβχ Henejib He Βπκκβτ Ha flJiHTeJibHOCTb MeTa6ojiH3Ma reKceHajia, hto CBHjnsTejibCTByeT 06 otcytctbhh

CymeCTBeHHBIX peaiCIļHHt CO CTOpOHBI MHKpOCOMaJlbHOĪĪ chctshu φβρΜβΗΤΟΒ opraHH3Ma πρκ fleūcTBHH θτογο npenapaTa.

TaKKM o6pa30M, Ha ocHOBaHHH npoBeneHHoro HCCJieHOBaHHH ΗβΚΟΤΟρΒΙΧ HMMy Ηθφ3ρΜ3ΚΟ JIΟΓΗΗΘ CKHX CBOHCTB 3aHBJĪiieMOrO cpeHCTBa BBIHBJīeHO 3Η3ΊΗΤ6ΠΒΗ06 ΗΜΜγΗΟΤρΟΠΗΟβ ΗβήοτΒΗβ ero b οτηοπιθηηη peaiciiHH κπβτοΗΗΟΓο ημμυηητθτβ -peaKijHH " TpaHcnjiaHTaT προτΗΒ χο3ηηη3" . Πθ£ βχτηηηηθμ 3aHBJIHeMOTO CpeHCTBa npOHCXOJXHIta CTHMyJIimHH ΟΪΗΜφΟΙίΗΤΟΒ xax b oTHomeHHH peaKiļHž προτΗΒ ΗγκβροπΗΗχ κίΐβτοκ (πρκ BBefleHHH npenapaTa b τθηθηηθ 3 HeneJIb) , TaK η b οτηοπιθημη κχιβτοκ τογο xe reHOTHna, ho HaxoftSBHHXCH b npyroā ocočh ( πρκ BBensHHH npenapaTa 10 h 20 ΠΗβή) . 3τκ pe3yjibTaTBi 6bijth nonyHeHBi KaK πρκ ββθηθηηη 3aHBJiaeMoro cpencTBa peiļHnHeHTSLM, TaK h npH BBejļeHHH hx jjoHopaM. B ycjtoBHHX 3KcnepHMeHTOB npenapaT HHrH6HpoBaji ημμυηηοθ po3eTKoo6pa30BaHHe h cHHxaji KOJiHHecTBO aHTHTejioo6pa3y*)^x κπβτοκ b cejie3eHKax ΜΒππβή. O^HaKO, HHTerpaJībHBie πoκa3aτeIIκ ryMopajibHoro ΗΜΜγΗκτβτβ - τκτρπ 23 LV 11667 IļHpKyJIHpyiOmHX. B KpOBH aHTHTeJI, — OCTaBaJIHCb B ΟΠΒΙΤΗΗΧ rpynnax Ha ypoBHe bthx xapaxTepHCTHx y KOHTpoJibHbix ΧΗΒΟΤΗΒΙΧ . B TepaneBTHHecKHX no3ax 3aHBJi5ieMoe cpeflCTBo He oxa3HBajio BJiHHHHe Ha φyHK^HOHaπfaHyn aKTHBHOCTb MOHOOKCHreHa3HOH φβρΜβΗΤΗΟή CHCTeMH, ΒΜβΟΤβ C HMMyHHOft HBJiHMņeiicjī nacTbio eflHHož CHCTeMH opraHH3Ma, o6ecneHHBaīomeft ero οτβθτ Ha BHemHHe B03neftCTBHH. 3to TaKJKe CBHneTenbCTByeT ο μηγκομ HMMyHOTponHOM neācTBHH 3aHBJiHeMoro cpeflCTBa.

Pl3yHeHHe cnoco6HocTH 3asBMeMoro cpencTBa HHnyiļHpoBaTB reHHbie MyTanHH Ha CTaHHapTHHX TecT—niTaMMax S. typhimurium TA 100/ TA 98, TA 1537 MeTOflOM 3ftMca, noKa3aiio, hto 3aHBJiHeMoe cpencTBO ηθ o6jianaeT MyTareHHoft aKTHBHOCTbH) ·

EbIJIO ΠρΟΒβΗΘΗΟ KJIHHHHeCKOe H3yHeHHe HMMyHOTpOIIHbIX cbohctb 3aHBJiHeMoro cpencTBa. Et3yHeHHe npoBOflHJioct Ha Ho6poBOJibu;ax (78 naiļHeHTOB): c pa3JiHHHHMH onyxoJteBHMH 3a6oJXeBaHHHMH - 56 ΗβΠΟΒβΚ; peBMaTOHHHHM apTpHTOM (Π-1Π peHTreHOJiorHHecxHe CTajļHH η Π-ΠΙ cTeneHb aKTHBHocTH) 22

HejTOBexa.

BbiJiH HccjieHOBaHbicJienyiomHe noKa3aJiH: o6qee KOJiHHecTBO ΠΗΜφΟΗΗΤΟΒ, HHCJIO B-ΠΗΜφθΗΗΤΟΒ Η Τ-ΠΗΜφθΙ1ΗΤΟΒ, cooTHomeHHe Τ-χβππβροΒ h T-cynpeccopoB, conepataHHe HMMyHOrJIo6yjIHHOB C/M/A Η E H IļHpKyJlHpytOmHX HMMyHHbIX KOMnJieKCOB , φyHX^HOHaJIbHa5^ aKTHBHOCTb Τ-ΠΗΜφΟΗΗΤΟΒ {T- χβππβροΒ h T-cynpeccopoB) η Β-πΗΜφοακτοΒ b peaimHHx 6ϋ3αΤΤρ3ΗαφσρΜ3ΙίΗΗ C pa3JĪHHHE!MH ΜΗΤΟΓΘΗβΜΗ, φ3ΓΟΙ1ΗΤ3ρΗόΙΗ aKTHBHOCTb H HHTOXHMHHeCK3LH XapaKTepHCTHKa φβρΜβΗΤΒΤΗΒΗΟϋ aKTHBHOCTH HMMyHOKOMneTeHTHHX KJieTOK. JTeHeHHe 3 aHB ji ηθμβιμ cpencTBOM npoBORHJiocb b COOTB6TCTBMH C ΠρΗΜΘΗΗβΜΟΗ CXeMOH. 0MMyHOJIorHHeCKHe o6cJie«oBaHHH ocymecTBJiHJiH nepefl HanajioM ηθηθηκη, b npoiļecce πθηθηηη: nocjie nepBux HByx HeneJib πρΗΜβΗβΗΗΗ npenapaTa h nocjie οαηογο Kypca (HeTHpe HeneJiH c HanaJia JieneHHH) /— h cnycTH 2-3 Mecmja nocjie οκοηηηηηη npHeMa npenapaTa. B ΗβκοτορΗΧ cnyHanx onpenejreHHe 24 HMMyHOJiorHHecKHX noKa3aTejieā npoBonnjin πρη ποβτορηηχ Kypcax ββθηθηηη cpencTBa n cnycTH 6 MecsmeB nocjie Hanajia npneMa 3aūBjiHeMoro cpeflCTBa. iiHHaMHKa ΤβηβΗΗΗ OCHOBHOrO 3a6oJieBaHHi[ npH ΠΘΗΘΗΗΗ 5 3aHBJIH€MbIM CpeHCTBOM B flaHHHX HCCJieflOBaHHHX CTaHOBHJiaCb nojio*HTenbHoii nocjie npneMa npenapaTa 6ojiee nByx HeneJib.

Cy6teKTHBHO oHKOJiornHecKne SojibHHe nocjie xypcoBoro npneMa 3anBJineMoro cpencTBa OTMeHaJin 3HaHHTejibHoe yjiyHineHHe o6mero caMOHyBCTBna. 06ϊ>βκτΗΒΗθ - 6bijih οτμθηθηβι 10 cjiyHan yMeHbmeHnn pa3Mepoe onyxoJin n nnM$oy3JioB,

BoccTaHOBJieHne προχοηηΜΟοτη KnmenHHKa. Eocjie npoBeneHnn HByx-Tpex xypcoB JieHeHHH 3aHBJiHeMHM npenapaTOM 6ojibHue nojio*nTejibHo oneHHBaJin caMonyBCTBne, coxpaHnnn

Tpynocnoco6HocTb; HeKOTopyw cna6ocTb CBH3iiBajin c 15 Heo6xojn;HMocTbio co6juoneHHn πηθτη. y 6oJIbmHHCTBa 6oJībHHX peBMaTOHHHHM apTpHTOM BpaHH οτμθτηπη nojiOMHTeJibHyio HHHaMHKy cycTaBHoro CHHnpoMa b Bnne yueHbmeHHH cKOBaHHOCTH nocjie οηηογο xypca Tepannn npenapaTOM. B θτηχ ycjioBnnx 6hjio o6Hapy®eHO ncne3HOBeHne 20 φηδροΜΗ Hapy*Hbix ποποββιχ opraHOB y ohhoū H3 6οπβηηχ. Πρη očcjieflOBaHHH 6ojibHHX no nenemiM 3aHBjmeMBiM cpeflCTBOM oTMenaeTcn M03annHHft xapaxTep Η3ΜβΗβΗηή nMMyHOJiornHecKoro CTaTyca KaK y 6ολβηηχ pa3JiHHHHMH 3a6oneBaHHflMn, Taic n y 6ojie»hhx onHoft rpynnH. Πρη otom 25 BejrnnnHH nccjienoBaHHHx napaMeTpoB nMMyHHTeTa He bbkobhjih 3a paMxn cpenHe-(ļ>H3noJiornHecKnx noxa3aTejīeft y npaKTnnecKH 3JHopoBbix juoneft. OnHaxo,y 3HaHHTejibHoro nncjia ΟΗΚοποΓΗΗβοκηχ 6ojibhhx 6hjio HapymeHO οοοτΗοπιβΗΗβ cy6nonyjiHnnū T-xejinepoB:T- cynpeccopoB. 30 EnnHCTBeHHHM noxa3aTejieM, onHOHanpaBJieHHO Η3Μθηθηηβιμ y Bcex nanneHTOB, HBJiHeTcn κοατηΜβοτΒο nnpKyjinpyiomHx nMMyHHHX KOMnneKCOB, κοτορυβ yBejiHHeHH n y οηκοπογηηθοκηχ 6οίιβηηχ , n y nanneHTOB cTpanaK>mnx peBMaTonnHHM apTpnTOM.

Hepe3 nBe Henenn nocjie HanaJia npneMa 3anBJi5ieMoro 35 cpencTBa npn nccjienoBaHnn noKa3aTejien HMMyHHTeTa y nanneHTOB 6bnia o6Hapy*eHa 3HaHHTejibHan peaKiļnn HMMyHHon CHCTeMU. 25 LV 11667 y 6oJii»mHHCTBa 6ojti»hbix o6enx rpynn Ha6jixmaitoc:b cHHaeHHe o6ņero HHCJia ΠΗΜφοιίΗτοΒ, οηηχθηηθ T- η B- ΠΗΜφομΗΤΟΒ, CHHXeHHS Τ-ΧβϋΠβρΟΒ H 3aMeTHOe CHHX6HH6 T-cy npeccopoB, η3μθηθηηθ KOJinnecTBa HMMyHorJio6yjiHHOB pa3JiHHHBix KJiaccoB hochjio pa3HOHanpaBJieHHHtf xapaxTep y pa3HHx naiļneHToB, y oHKOJiornHecicnx 6ojibhhx οτμθηθηο yBeJiHHeHHe φaΓo^nτapHoή axTHBHocTH mohoiihtob h jieftKoiļHTOB. KojiH^ecTBO *e iļnpKymipynmnx HMMyHHHx KOMiiJieKCOB yMeHtmanoci» h y οηκοπογηηθοκηχ 6ojibmix h y 6oJIbHBIX peBMaTOHHHHM apTpHTOM.

Ba*HO ΟΤΜΘΤΗΤΒ, HTO y OHKOJĪOrH'tieCKHX 60JIbHBIX ripu

HapymeHHK cooTHomeHHJi T-xeJinepoB:T-cynpeccopoB πρκ CHHSeHHH HHCJia Τ-ΙΙΗΜφΟΙίΗΤΟΒ, JTMeHblIieHHe HHCJieHHOCTH HX cy6nonyjiHiiHž npoHcxonHjio b pa3Hož CTeneHH. 3a σπβτ θτογο nocTHrajīoci» BoccTaHOBJieHHe cootkoh6Hhx T-xennepoB:T-cynpeccopoB, χοτη h Ha hh3kom φyHK^HOHa.πbHOM ypoBHe. Ρΐ3ΜΘΗβΗΗβ COHep*aHHH Β-ΠΗΜφΟΙΙΗΤΟΒ H 0C06eHH0 ypOBHa HMMyHOr\JIo6yJIHHOB pa3JIHHH£>IX KJiaccoB HOCHJIH HeperynHpHHH xapaKTep.

HaHHMe H3yHeHHJĪ ΠρΟΙΙΗφβρΒΤΗΒΗΟίί āKTHBHOCTH ϋΗΜφοΐ1ΗτοΒ b peaxiiH.sx 6>π3θττρΒΗαφορΜΒΐΐΗΗ nonTBep*flaiOT ΒΗΒΟΠ O 3HaHHTeJIbHOft peaKIļHH HMMyHHOft CHCTeMH npH BBefleHHH 3aHBJiHeMoro cpeflCTBa η o cymecTBeHHLix HHnHBHnyaJIbHHX 0C06eHH0CT5IX 3TOŽ peaKITHH noCJie nByx nepBtix HeneJib npHeMa npenapaTa. Πο OKOHHaHHH ΠβρΒΟΓΟ Kypca JieneHHH CpenH Η3ΜβΗβΗΗΗ noxa3aTeJieiī HMMyHHTeTa o6pamaeT Ha ce6K BHHMaHHe 3ausTHoe yMeHbmeHHe u;npKyjiHpyiomHx ημμυηηηχ KOMniieKCOB. Πρκ BceM pa3HOHanpaBJieHHOM xapaKTepe KOJie6aHHft ocTaJibHHx HMMyHojiorHHecxHx napaMeTpoB Heo6xonnMo οτμθτητβ τοτ φ3κτ, HTO OHH He BUXOHHT 3a rpaHHLTM φΗ3ΗθπθΓΗΗθαΚΟΗ HOpMH. AHaJiorHHHaii KapTHHa coxpaHaeTCii πρκ HccneflOBaHHH HMMyHOJiorHHecKHX noxa3aTeJiea y naiļHeHTOB Hepe3 2-3 Mecima nocite oKOHHaHHii nepBoro xypca Teparinn nepejr Βτοροή cepaeii npneMa npenapaTa. B τθηθηηθ noBTopHoro xypca HHHHBHjiyajibHHe Η3ΜβΗβΗΗΗ HMMyHojiorHHecKHx napaMeTpoB y 6ojibHHX hocht τοτ xe xapaxTep, hto h npn nepBOM xypce 26

TepanHH, HO Ηβ HMeioT eflHHoro BeKTopa HanpaBJieHHocTH y Bcex 6ojibhhx. B npoiļecce HccjienoBaHHft ntiTaJTHCb ο6ί»θπηηητβ 6oJIBHBIX B rpynnBĪ ΠΟ THnaM Η3ΗβΗβΗΗΗ, CBH3aTb 3TH Η3ΜΘΗΘΗΗΗ C rpynnēLMH KpOBH ļ OJļHaKO f ΗβΤΚΗΧ 3aKOHOMepHOCTefit ββμβητβ He ynajiocb. tJepea 6 MecaneB nocne npneita 2-3 xypcoB JieneHHSī 3ΒϋΒΠΗβΜ£ΙΗ CpejļCTBOM ΟΤΜΘΗβΗ3 nOJIOJKHTeJIbHaH JJHHaMHKa H3yMaeMHX noxa3aTejieft.

ΠρΗ aHajiH3e Bcex, npencTaBJieHHHX κ paccMOTpeHHio pe3yJIBTaTOB KJIHHHHeCKHX HCCJieJiOBaHHft HMMyHOTpOnH£IX cbožctb 3aHBJiaeMoro cpeacTBa, o6pamaeT Ha ce6s BHHMaHHe b BBicmeft οτβπβΗΗ ηηπηβHnyajit>heih xapaxTep peaKiļHH HMMyHHOH CHCTeMU Kasnoro 6ojibHoro. B iļejioM peaKiļHa: προτβκββτ b λβθ φ33Η. IlepBaH - xapaxTepH3yeTCH HeHanpaBJieHHHMH K3MeHeHHHHH HMMyHOJTOrHxieCKHX nOKa3aTeJieŽ. OHeBHflHO, non BJTHSīHHeM 3asiBJisīeMoro cpencTBa npoHcxonnT nepecTpožka BHyTpeHHHX peryjIS[TOpHHX HexaHH3HOB, o6be,nHHHIomHX HMMyHHBie KJieTKH b eHHHyw cHCTeMy. BTopan $a3a - <ļ>a3a HopMaxin3aiļHH HMMyHOJiornHecKHx napaMeTpoB. 06π1ημη 3jiecb hbjiūiotch nea θφφβκτβ: yMeHbineHHe conepjKaHHii nnpicyiiHpyīoiaHx hmmjthhbdc

KOMīineKCOB; HopMaiiH3anHH cooTHomeHHH cy6nonyjiHXiHū T-xeJinepoB:T-cynpeccopoB. 06a Ha6jiBHaeMHX stBJieHHii μμθϊοτ nojTo*HTejibHoe nporHocTHHecxoe 3HaHeHHe, Tax xax CBHHeTeJIbCTByiOT O HOpMaJIH3aiļHH COCTOiīHHJI HMMyHHOH CHCTeMH. Υμθηβπιθηηθ nHpKyjiHpyiomHX nwMyHHHx κομππθκοοβ Ha6jiMHaeTCH y ecex 6ojibHi>ix (οΗχοιιοΓΗΗβοκΗΧ h cTpanaiomnx peBMaTOHHHLIM apTpHTOM) , HOpMaJIM3aiļHJI COOTHOmeHHiī cy6nonyjisiļHft πΗΜφοηΗΤΟΒ xapaKTepHa nnn 6ojibmHHCTBa naiļHeHTOB ηβηηβιχ rpynn. 3aHBJiiieMoe cpeflCTBO 6bijio HcnHTaHo b KJiHHHKax 6ojiee ηθμ Ha 250 6ojibHMX. IIpenapaT npomeji HcraiTaHHH πρκ πθηθηηη cjienyH)mHX 3a6ojieBaHHū: 3JiooxaHecTBeHHBie h floepoKaHecTBeHHHe onyxonH, peBMaTH3M, peBMaTOHflHtiii apTpHT f 6poHXHaJibHaH acTMa, HeftpoflepMHTH h npyrHe 3a6oJieBaHHH. IIpeHMymeCTBeHHMMH OHKOJIOrHHeCKHMH 3a6oJieBaHHHMH HBJiHJiHCb: 3a6ojieBaHHH *eHCKHX opraHOB (pax mojiohhož 27 LV 11667 xejie3u, paK rēna h ιπθηκη μ3τκη , paK hhmhhkob) , 3a6oJieBaHHH ΚρΟΒβΤΒΟρΗΟή ΟΗΟΤβΜΜ (ΛΗΜφ0Γρ3ΗγπβΜ3Τ03, ΙΙΗΜφ0ΧΙΘΗΚ03, OCTpMft ΠΗΜφοβ^ΟΤΗΗΪΪ ΠΘΗΚ03, MHeJĪOMHaH 6ojie3Hb), 3a6ojieBaHHH ΒΗγτρβΗΗΗΧ opraHOB h TKaHeft (paK npsraoH κηπικη , xejiynKa, πθηθηκ, HocorJioTKH, κόχη h np.) ; H3 onyxojieā no6poKaHecTBeHHOft npHponu, TaKne, KaK aneHOMa npencTaTejiBHoū χβπβ3Η, φκ6ροΜΗθΜ3 MāTKH, namuinoMa, KHCTa, MacTonaTHH mojiohhhx xejie3, ποιιηπ npsMOH κηπικη h npyrne.

Bo3pacTHoft κοητηηγ6ητ 6ojibhbix 20-60 JieT; epOKH JieneHHii 3aHBjiHeMHM cpencTBOM cocTaBJiiiJiH ot 0,5 no 2-x JieT h 6ojiee. 3 aHB JiHeMO e cpencTBO npHMeHHJiocB no BumeonHcaHHoū μθτοπηκθ: BHyTpt - πβρΒΗβ τρκ hhh no 5 mji 3 pa3a b neHB, nanee 10 mji x 3 pa3a b ηβΗΒ b τβνβΗΗβ Mecnna. napajuiejiBHO npneMy npenapaTa BHyTpB npoBOflHJiocB MecTHoe HapyxHoe

B03fleŪCTBHe 3 aHB JliieMHM CpenCTBOM B 3aBHCHHOCTH OT noKajiH3aiļHH npoiļecca 3a6ojieBaHHH. DpenapaT HapyxHO npHMeHHJTCH B BHfle ΠρΗΗΟΗβΚ, ΤΒΜΠΟΗΟΒ, CnpHHIļeBaHHH, KJIH3M. IIpenapaT HaHOCHJICH B somi Heo6xOHHMOrO B03fleHCTBHH - Ha κοπμηκ , naxoBue JIHMφoy sjih , nonMbimeHHjno o6jiacTB, Π03Β0Η0ΗΗΗΚ, CyCTaBU, JIOKaJIH30BaHHUe o6pa30BaHHH, ποκροΒΗΒιβ hjih koctho—cycTaBHHe τκβηη . AHanH3 pe3yjiBTaTOB JieneHHH 3aHBJiHeMBiM cpencTBOM, b TOM HHCJie OHKOJIOrHHeCKHX 6oJIBHBIX IV, m, Π CTaflHĀ 3a6ojieBaHHH (co cpoKaMH JieveHHJi: 6ojiee 0,5 rona, 6onee 1 rona, 6ojiee 2-χ πβτ), a Tamte nJiHTeJiBHan nonnepxHBaiomaiī Tepanna 3aHBjihombim cpencTBOM bbihbhjih ποηοχπτβιίΒΗΗΗ οφφβκτ jieaeHHa, KaK ajih ηθ πθηθηηηχ paHee, TaK η JieneHHHX paHee 6ojtbhhx .

HačJironaJiacB nojiHan perpeccnac onyxoJiH ( 3JIOKaHeCTBeHHOH) B 3aBHCHMOCTH OT BHHa 3a6oJieBaHHH, cTaflHH, οροκοΒ JieneHHH y 6ojibhhx no 34,3%; y 6ojibhhx c onyxojiiiMH HočpoKaaecTBeHHOH πρκροηΗ no 80,8%. Ύ pana 6ojibhhx HaēraonaJiacB CTa6HJiH3anH.sī nponecca, yMeHBmeHHe pa3Mepa onyxoJiH. Y Bcex 6ojibhhx OTMenajiocB ynyHineHHe o6mero cocTOHHHa. 28 flJiH jiyHinero ποηημηηηη HacTOjnņero Η3θ6ρβτβΗΗΗ npHBOBHTCH CJieHyiOmHe ΚΟΗΚρβΤΗΒΙβ npHMepU npHrOTOBJISHHH 3aHBJiaeMoro cpe^cTBa h ero KJiHHHHecKHx HcntiTaHHH. npHMep 1. 3aHBjiηθμόe cpejjcTBO cjie;ņyīomero cocTaBa: HHXJIOpH« pTyTH 0/01 Γ

HaTypajibHoe BHHorpajļHoe 6ejroe bhho c coflep*aHHeM caxapa 4 Mac.% 100 mji

3a5tBJiiieMoe cpejjcTBo γοτοβητ cjie;qyiomHM o6pa30M. Hhxjiophh pTyTH pacTBopiHOT b BHHorpajļHOM βηηθ b yxa3aHHHX

KOJIHHeCTBaX B 06ΗΗΗΗΧ yCJIOBHHX ( īipH KOMHaTHOH

TeMnepaType) . nojiyHaioT npo3paHHUH pacTBop, cBeTjio-acejiToro i^BeTa (ρΗ=3/1). noJiyHSHHHH npenapaT xpaHHT b nocyHe H3 τθμηογο CTeKJia πρκ TeMnepaType He Βκαπβ 15 °C b τθμηομ MHecTe · Πρκ xpaHeHHH bū3mosho BHnafleHHe ocajtica coenHHeHHž bhhhoh khcjīoth , nosTOMy nepejj ynoTpe6jieHHeM pacTBop ηθοΘχοηημο B36ajiTBiBaTb. npenapaT npurofleH hjih BHyTpeHHero h HapyatHoro npHMeHemisi. ΠρΗΜβρ 2. 3aiīBJiiieMoe cpencTBo cjiejīyx>mero cocTaBa: ΛΗχηορχΛ pTyTH 0,06 r

HaTypaJibHoe BHHorpajmoe 6ejxoe bhho c conepaiaHHeM caxapa 3 Mac.% 100 mji npHroTaBJiHBaioT cpeflCTBO aHajiorHHHo npHMepy 1. nojiyHaioT npo3paHHUū pacTBop, acejiTOBaToro ijBeTa, pH=3,3. npenapaT npHroneH hjiji BHyTpeHHero h Hapy*Horo πρΗΜθΗβΗΗΗ. ΠρΗΜβρ 3. 3axBJiiīeMoe cpencTBo cjiejjjnomero cocTaBa: ΗΗχηορΗΗ pTyTH 0,1 r

MOJIOHHaH CBIBOpOTKa c 4 Mac.%-hhm conepxaHHeM caxapa 100 mji npHroTaBJiHBaMT cpeflCTBo aHanorHHHO npHMepy 1. nojiyHax>T npo3paHHHū pacTBop, cBeTJio-KpeMOBoro UBeTa. HpenapaT npHrofleH bjih BHyTpeHHero h Hapy*Horo πρΗΜβΗβΗΗΛ. 29 LV 11667 ΠρΗΜβρ 4. 3aHBJiaeMoe cpeflCTBO cneflyiomero cocTaBa: AHXJIOpHH pTyTH 0,3 Γ

HaTypajibHoe BHHorpanHoe 6ejroe bhho c coxepxaHHeM caxapa 3 Mac.% 100 mji ĪIpHroTaBJiHBaioT cpencTBO aHanorHMHo πρΗΜβργ 1. IIoJTyMaiOT npo3pa*īHUH pacTBop, cBeTJio-xejrroro iļBeTa, pH=3,2. IIpenapaT npHroneH βπη HapyxHoro πρημθηθηηα. ΠρΗΜβρ 5. 3aaBJiHeMoe cpencTBo cjienyiomero cocTaBa: HHXJIOpHfl ρτγΤΗ 1,5 Γ

MOJIOHHaH CHBOpOTKa c 3 Mac.%-hum conep*aHHeM caxapa 100 mji

IlpnroTaBJiHBaioT cpencTBo aHaJiorHHHO πρΗΜβργ 1. IIojiyHaioT npo3paHHHH pacTBop σΒβτπο-κρβΜΟΒΟΓο iļBeTa. IIpenapaT πρΗΓοπβΗ ηπχ HapyxHoro πρΗΜβΗβΗΗΗ. ΠρΗΜβρ 6· 3asBJiHeMoe cpencTBo cjiejiyioinero cocTaBa: ΗΗΧΠΟρΗΗ ρτγτΗ 0,25 r CBHHOŪ ΧΗρ 230 Γ ΜβΗ HaTypajiE>HKū 240 r cnHpT 96° no 750 r.

npHroTaBJiHBaioT cpencTBo cjienyiomHM o6pa30M. flHXJIOpHH ρτγτΗ paCTBOpHIOT B 3THJIOBOM ΟΠΗρΤβ. npeflBapHTeJibHO pa3MsirMeHHHH cbhhoh χκρ CMemHB aioT c MenoM HaTypajiĒ,HHM B yxa3aHHHx xojiHHecTBax. 3βτβΜ pacTBop HHXJIOpHHa ρτγτΗ cyMMH B 3THJIOBOM ΟΠΗρΤβ He6ojIfemHMH nopuļHMMH, TiņaTenbHo pacTHpaii, bhocsit b CMect οβηηογο xnpa C ΜΘΠΟΜ. nojiyHaioT 3aHBJiiieMoe cpencTBo b βηηθ KpeMOo6pa3Horo nponyxTa, CBeTJio-xejiToro iļBeTa. npenapaT πρκΓΟΗβΗ ηπχ ΒΗγτρβΗΗβτο h HapyxHoro ΠρΗΜΘΗΘΗΗΗ. 30 II. ΠρΗΜβρ 7 . 3aHBjiaeMoe cpencTBO cnejijromero cocTaBa: apceHHT KaJiHH 0,05 r

HaTypaJibHoe BHHorpaflHoe 6eJioe bhho c conep*aHHeM caxapa 4 Mac.% no 100 mji. 3aaBJiHeMoe cpencTBo γοτοβητ πγτβΜ pacTBopeHHH apceHHTa KanHH b HaTypajibHOM BHHorpaflHOM 6ejioM βηηθ b yKa3aHHHX KOJiHHecTBax. IIojiyHaioT npo3paHHHft pacTBop, οΒβτπο-χβπτοΓο iļBeTa, pH=3,2. IIpenapaT npnroneH hjih ΒΗγτρβΗΗβΓο πρημθηθηηη. ΠρΗΜβρ 8. 3afīBJifieMoe cpescTBo cjienyiomero cocTaBa: apceHaT HaTpHH 0,15 MOJIOHHaS CMBOpOTKa c coflepsaHHeM caxapa 3 Mac.% flo 100 mji.

3aHBJĪHSMO€ CpeflCTBO ΓΟΤΟΒΒΤ ΠγΤβΜ paCTBOpeHHH apceHaTa HaTpna b MonoHHOft CMBopoTKe c conepsaHHeM caxapa 3 Mac.% b jnca3aHHMx KOJiHHecTBax. IIoJiyHaH)T npo3paHHHīi pacTBop, CBeTno-xejiToro UBeTa. IIpenapaT πρΗΓΟΗβΗ hjih BHjrrpeHHero πρκΗβΗβΗΗΗ. IIpHMep 9.

EfcIJIH npOBeneHH KJIHHHHeCKHe HCnLITaHHJI 3 aHB JIHeMO Γ o cpe^cTBa Ha 99 oHKOJiorHHecKHX 6ojibhhx, k3 hhx: 67 6ojibhhx

- HMeJiH 3jīOKaHecTBeHHbie onyxojiH, 32 6ojibhhx ημθ,πη onyxoJiH no6poKaHecTBeHHO0 πρκροπΜ. 03 rpynnH 67 6ojibhbix - 32 npomjiH xypc npenBapHTeJH>Horo jieneHHH (onepaiļHfi, nojiHXHMHOTepanH.fi, raMMa-Tepanaa) , 3 5- He nonsepraJiMci» paHee πθηθηκο. EOJIBmHHCTBO OHKOJIOrHHeCKHX 6oJIbH£IX: 21 ΗβίΙΟΒβΚ HMeJIH IV cTaHHM 3a6oJieBaHHH, 18 6ojibhbix - ΠΙ; Π cTaflHa 3a6ojieBaHHfi OTMeHeHa y 6 6οπβηβιχ. fljiH 22 6ojibhhx cTaflHH 3a6ojieBaHHH He onpejjeJieHa. Κοητηηγθητ ohxo6ojibhbix no B03pacTy: ot 40 no 60 ηβτ - 39 ΗβηοΒβχ. Οτ 20 no 40 πβτ - 7 ΗβηοΒβκ, CTapme 60 ηβτ 31 LV 11667 - 14 HejioBeK. Πο noJiy: 11 MyatHHH, 56 - χθηπιηη.

CpOKH JieHeHHH ČOJIbHBDC 3 aHB JīileMHM CpeHCTBOM cocTaBJiHJiH: 6ojiee 0,5 rona 28 6ojibhhx (41,8%), 6oJiee 1 rona 3 6ojibhhx (4,5%), 6oJiee 2-χ πβτ 19 6ojibhhx (28,3%). fljiHTejibHas nonnep*HBaromaa: TepanM 3a5iBJiHeMHM cpencTBOM npoBOHHJiacb y 17 6ojibHHX (25,4%). npeHMynieCTBeHH£IMH 3a6oJieBaHHHMH HBJIHJIHCb: 3JiOKaMecTBeHHue onyxojin (paK mojio^hoū xejie3H, pax Tena, meāKH MaTKH, paK hhhhhkob , pax πρΗΜΟή κηπικη , *ejiynxa, ΠβΗβΗΗ, HOCOrJIOTKH, ΚΟΧΗ; 3a6oJieBaHHH ΚρΟΒβΤΒΟρΗΟΗ CHCTeMSI - JHD®ļ)0rpaHyjieMaT03, ΙΙΗΜφ0ΙΙθίίΚ03 , ΟΟΤρΗή ΙΙΗΜφοδJiaCTHBIH JieHK03 , MHeJIOMHaJī 6oJie3Hb) , Η3 onyxojiež Ho6poicaHecTBeHHOH πρπρο,ηΗ (aneHOHa npeflCTaTeJibHoft xejie3H, φπδροΜΗΟΜΗ HaTKH, nanHJiJioMa, KHCTa, MacTonaTHH mojiohhhx XeJie3 , nOJĪHIĪBI ΠρΗΜΟΗ κηπικη ) .

Hjiji ΟΗκοποΓΗΗβοκΗΧ 6ojibhbix (paHee ηθ noflBepraBinHXCH JieneHHio) - 35 ηθποβθκ (100%) noJiyneHH cjienyiomHe pe3yjibTaTBi: nojiHan perpeccHH onyxojiH (chhth c yneTa y OHKOJiora) , npaKTHHecKH 3βοροΒΗ 12 ΗβποΒβκ (34,3%). 3a6ojieBaHHSi: paK mojiohhoh senesu ΠΙ-lV ct., φΗδρο3Ηο-KHCT03HaH MacTonaTHH (3JioxaHecTBeHHaB: φορΜ3), paK MaTKH, pax shhhhkob,. ocTeoreHHaa capKOMa, MeJiaHOMa, ΠΗΜφ0ΠβΗΚ03). - CTa6HJiH3aiļHH npoiļecca Ha6jnonajiacb y 12 6οηβηηχ (34,3%). (3a6oJieBaHH5i: paK ΜοποΗΗΟή xejie3H ΙΠ-IV ct., aneHOKapiļHHOMa mojiohhhx xejie3, aneHOKapijHHOMa npocTaTti, IV ct (M€TacTa3U B JierKHe) , paK npaMoft κηπικη, IV ct. , paK HOCOrJIOTKH (MeTaCTa3H B Μ03Γ, Π03ΒΟΗΟΊΗΗΚ) , 6jiaCTOMa ΗΗΧΗΘΗ HaCTH ΠΗΠ*βΒΟΠ& (3JIOKaHeCTBeHHa.il φθρΜ3, ΙΠ CT. , ) . - ΥΜθΗΒΠιβΗΗβ pa3Mepa onyxojiH y 9 6ojibHHX (25,8%). (3a6oneBaHHe : paK mojiohhoh xejie3H) . - yjiyHineHHe o6njero coctohhhh y 1-ro 6ojibHoro (2,8%). flajībHeHinee nporpeccnpoBaHHe npoiļecca HMeJio MecTO y 1-ro 6ojibHoro (2,8%).

Hjih OHKOJiorHHecKHx 6ojibHHX, πθηθηηηχ paHee HejioeeKa (100%) pe3yjibTaTM JieneHHH cjienyiomHe: 32 32 ĪIoJiHaii perpeccHH onyxojin. Chhtbi c yneTa y oHKOJiora. IIpaKTHMecKH 3HopoBBi - 6 6ojte>hi>ix (18,8%). (3a6oJieBaHHJī: pax mojiohhoh *exte3H III—IV ct., pax shhhhkob, IV ct. , oSteMHoe o6pa30BaHHe npaBOft nojiH πθηθηη (3JīOKaHecTBeHHaH $opMa), 6a3ajiHOMa yniHo8 paKOBHHH). - CTa6HJiH3aiļH5i npouecca Ha6jnooajiacb y 12 6ojibhhx (37,6%). (3a6oJieBaHH5i: pax mojiohhoh xejie3U 6onacTOMa mojiohhoh *βπβ3Η, IV ct. (3JioKaHecTBeHHaH $opMa), pax meftKH MaTKH, pax γιιοτκη, ΙΠ ct., pax npaBoH hojih neneHH, pax πρΗΜΟή κηιπκη, ροτογποτκη, *ejiyHKa, nofl*eJiyjļOHHoft XeJie3M, ΧρΟΗΗΗβΟΚΗή ΛΗΜφ0ΛβΗΚ03 ΠΙ CT. , OCTpHft

Jira^OČJiaCTHHH JieĀX03 ) . - ΥΜθΗΒΐπβΗΗβ pa3Mepa onyxoJiH y 2-x 6ojibhhx (6,2%). (3a6ojieBaHHe: paK mojiohhoh *ejie3w) , naHH£ix no peiļHnHBy He o6HapyxeHo y 4 6ojtbhhx (12,5%) . - yjiyHmeHne o6mero coctohhhh y 4-x 6ojibhhx (12,5%). - PeMHccnii y 2-x 6ojibhhx (6,2%). - CocTOHHne yHOBJTeTBopHTejiBHoe y 1 6ο.πβηογο (3,l%)io - flajīBHežniee nporpeccHpoBaHHe npoiļecca ΗΜβπο hscto y 1-ro 6ojibHoro (3,1%). ΠοαΐΟ*ΗΤθηΐ»ΗΗΗ θφφθΚΤ JieHeHHH ΟΗΚΟΠΟΓΗΗβσΚΗΧ 6ojibhhx (paHee πθηθηηβιχ η ΗβηβΗβΗΗΗΧ) aaHBJiHeMHM cpeflCTBOM cocTaBJiHeT - 79%. OTcyTcTBHe 3φφβκτ3 - y οπηογο 6oJiBHoro (2,9%).

Pe3yjibTaTH JieneHHH onyxojieft HoGpoKaHecTBeHHOiī npHpoflj.1 (paHee He JieH€HH&ix 6ojibhbix) - 26 ΗβηοΒβκ (100%): IIoJiHaH perpeccHH onyxcmH, chhth c yneTa y OHKOJiora, npaKTHHecKH 3flopoBM - 21 6ojibhoū (80,8%). (3a6oJieBaHHJi: φκ6ρο3ΗθΗθΜ3 μοποηηηχ xene3, MacTonaTHH, φΗβρΟΜΒ, φΗδρΟΜΗΟΜΒ MaTKH, ΠΟ.ΠΗΠ ΠρΗΜΟΗ ΚΗΙΠΚΗ, ΠΟ.ΠΗΠ ΠΙβΗΚΗ MaTKH, nOJIHKHCT03, rHOHHaH OnyXOJIB HHHHHKOB, JIHHfOāneHHT H HpyrHe) . - CTa6HJiH3aiiHH npoijecca Ha6.monajiacb y 2-x 6oJibHŠix (7,7%). (3a6oJieBaHHiī: ocTa mojiohhoū xejie3īi, BHyTpHnpoTOKOBaH nanHJiJioMa mojiohhoū *ejie3Bi) . Υμθηβπιθηηθ pa3Mepa onyxojiH, yjiyHmeHHe o6mero 33 ΙΕ LV 11667 COCTOHHHJI y 2-x 6ojii»hhx (7,6%).

CocTOiīHHe ynoBJieTBopHTejītHoe y 1-ro 6oJibHoro (3,8). Pe3ynbTaTH jieneHU-a 6oJibHBix (paHee πθηθηημχ) - 6 πβποΒθκ (100%).

IlpaKTHHecKH 3^opoB - 1 6ojibHoft (16,7%). (3a6oneBaHHe: MacTonaTHH). - CocTOHHHe xopomee y 3 6οιιβηηχ (49,9%). - Be3 peutnnHBOB y 1 6ojibHoro (16,7%). - PeMHccM y 1 6ojibHoro (16,7%). ΠΟΠΟΧΗΤβΠΒΗΗή ΒφφβΚΤ Jie^eHHS 6oJTbHHX C 3a6oneBaHHHMH He oHXOJīorHHecxoro xapaxTepa (onyxoJTH no6poKaHecTBeHHoft npHpoiīBi) cocTaBJiiieT - 81%. IIpHMep 10.

BbiJIH npOBeneHU KJIHHHHeCKHe HCntlT aHHH 3aHBJIHeMOrO cpencTBa Ha 157 6ojiī*hhx, H3 χοτορκχ 138 (87,9%) oHKOJiomHecxHe 6ojibHHe (onyxojiH 3JioxaHecTBeHHOH npnpojm); 19 (12,1%) - HMejiH onyxojiH nočpoKaHecTBeHHoii npHpoflM. 03 138 OHKOJiorHHecxHX 6ojie>hbix - 94 (68,1%) nponuiH xypc npenBapHTeJibHoro πθηθημη (onepaijHH, nojiHXHMnoTepannii,

raMMa-TepanHH) , 44 6ο.πβηηχ (31,8%) He nonBeprajincb TaxoMy JieHeHHio · OHKOnorHHecKHe 3a6oneBaHHH (onyxojiH 3JioKaHecTBeHHOfi npnpo;nji) BKJīioHaioT: 1- 3a6oJieBaHHH jishckhx opraHOB (pax MOJionHoa *ejie3H, pax Tejia h pax meaxH μβτχη , pax hhhhhkob) - 72 6ojībHMx. Π - pax ΚρΟΒβΤΒΟρΗΟΗ CHCTeMH (HHM(ļ)OrpaHyneMaTOB, JIHM$o6naCTHaH JIHMC|>OMa, JĪSHK03BI: XpOHHHeCKHii JIHM$o6jiaCTHMH JieāX03, OCTpMH MHeJlOHflHHft JieftX03)- 14 6oJIbHHX. ΙΠ - OHKOJiorHHecxne 3a6oneBaHHiī BHyTpeHHHX opraHOB h TKaHeft (pax xejiy£xa, pax Jierxoro, pax πρκΜΟΗ χηπιχη, pax neneHH, pax μοηθβογο ny3Brp5i, pax npeflcTaTejibHOH *ejie3H h HpyrHe) - 52 6ojibHux.

B pe3yjibTaTe JieHeHHH 6ojibHHX 3 aHB JiiieMHH cpencTBOM 6mjih nojiyHeHH cjienywmHe pe3yjībTaTH. fljiH rpyuim oHxoJiora*iecxnx 6ojibHHX (onyxojiH 3JtOKaHecTBeHHoa npHpoflM) Π, ΙΠ, IV cTajuia - 138 ΗβποΒβκ (100%) ycTaHOBjxeHO: - IIojiHaH perpeccHū onyxojīH y 5 6oxtbHiix (3,6%); 34 II. - yMeHbmeHHe pa3Mepa onyxoJiH y 32 6οπβηηχ (23,5); - CTa6HJiH3auHH pocTa 3JioKaHecTBeHHoft onyxojiH y 61 6ojibHHX (44,2); - yjiyHineHHe o6iņero coctohhhh y 28 6ojiī»hlīx (20,3%); 5 - flajībHežniee nporpeccHpoBaHHe npoijecca y 12 6ojibhhx (8,7%). fljin rpynnu Θοπβηηχ c onyxojiHMH no6poKaHecTBeHHoft npHpom»! - 19 ΗβποΒβκ (100%) ycTaHOBJieHo: - PerpeccHH onyxoJiH y 8 6ojibhhx (42,1%); 10 - CTa6HJiH3aijH5ī npoijecca y 5 6ojibHtix (26,2%); - yMeHbmeHHe pa3MepoB onyxoxiH y 4 6oJibHux (21,1%); - yuyHmeHHe o6ņero coctohhhh y 2 6οηβηηχ (10,5%). IIpOMUfflJieHHaH npHMeHHMOCTL· 3aHBJIHeMOe CpeflCTBO H3XOflHT ΠρΗΜΘΗβΗΗβ B MeflHIJHHe 15 unH JieneHHH HMMyHOHe$HIļHTOB pa3JIHHHOrO npOHCXOameHHH, H3IH πβΗβΗΗΗ Bcex bhsob 3HOKanecTBeHHHX h Ho6poicaHecTBeHHHX onyxojieii, peBMaTH3Ma, peBMaTOHflHoro apTpHTa, nojmapTpHTa, 6poHXHaJIbHOŽ aCTMH, BOJIHaHKH CHCTeMHOŽ KpaCHOā, H3BH *ejiynKa, repneca, τροφΗΗθσκκχ H3B, ncopnasa, κηπθηηηχ 20 ΗΗφβκΐίΗΗ, HeūpoflepMHTOB h apymx 3a6oiteBaHHft. 5 35 LV 11667 ΦΟΡΜΥΠΑ H30BPETEHH3 1. CpencTBO HMMyHOMonyjiHpy»mero neiīcTBHH h BoccTaHaBJiHBanmero HapymeHHoe 4>yHKUHOHHpoBaHHe cHCTeMU peryjiHiiHH paaMHOseHHH κιιετοκ TK.aHH, BKJUOHaiomee AeftcTBjrsomee BemecTBo h pa36aBHTejii>, xapaKTepH3ymmeecH τθμ , hto b KaMecTBe AeftcTBymmero semecTBa oho conepxHT ΑΗΧίίορκπ ρτγτκ ΗΒΗ apceHHT KajiHB, hjih apceHaT HaTpHH npH CJieAyKitn;eM cooTHomeHHH hcxohhhx χομποηθητοβ , b Mac. % : 10 AHXJIopHfl ρτγτκ ΗΒΗ apceHHT KajiHH, hjih apceHaT HaTpHH 0,01-1,5 pa36aBHTenb no 100,0. 15 2. Cpe«cTBo no n.l, xapaxTepn3yx3m:eecjī τβΜ, hto b KanecTBe paaāaBHTejiH oho οοπβρχκτ HaTypaji&Hoe BHHorpanHoe 6enoe bhho c conepxaHHeK caxapa 3-4 wac.% hjih μοποηηυ® οκΐΒοροτκγ c 3-4 Mac.% conepsaHHeM caxapa. 20 3. CpencTBo no n.l hjih ΒΗγτρβΗΗβΓο hjih HapyxHoro npHMeHeHHH, xapaxTepn3ywmeecH τβΜ, hto oho coctoht H3 cnenyioniHX κομποηθητοβ , b Mac. %: HHXJIopHH ρτγτκ 0,01-0,1

HaTypanbHoe BHHorpanHoe 6enoe bhho c conepacaHHeM caxapa 3-4 Mac.% 25

HJIH MOJIOHHaH CHBOpOTKa C conep*aHHeM caxapa 3-4 Mac.% no 100,0. 30

4. CpencTBo no n.l, hjih BHyTpeHHero hjih Hapy*Horo npuMeHeHHfl, xapaxTepH3ymmeecH τεχ, hto b KanecTBe pa36aBHTejiH oho conepMHT cMect cbhhoto «npa, wena HaTypanbHoro η 3Τηιιοβογο cnHpTa, npn cJienyiomeM COOTHOmeHHH HCXOHHHX ΚΟΜΠΟΗβΗΤΟΒ, Β Mac.%! HHXJIOpHH ρτγΤΗ CBHHOft SHp Men HaTypajibHHft STHJTOBblfl CnnpT 5. CpencTBo no 0,03-0 ,13 30.7- 37,3 30.7- 37,3 «o 100,0. n.l, hjih BHyTpeHHero πρκΜθΗβΗΗΗ, xapajcTepH3ymnieecH τβΜ HTO OHO COCTOHT H3 ΟΠβΗ$ΠΟΠΙΗΧ 35 36

ΚΟΜΠΟΗβΗΤΟΒ, Β Mac.% I apceHaT ΗβτρΗΗ hjth apceHHT KajiHH 0,05-0,15

HaTypan£>Hoe BHHorpanHoe 6eJioe bhho c conepataHHeM caxapa 3-4 Mac.% HJTH MOJIOHHČLH CHBOpOTKā C conepxaHHeM caxapa 3-4 Mac.% no 100,0 10 6. CpencTBO no n.l, ansi Hapy*Horo πρΗΜβΗβΗΗΗ, xapaKTepH3jnomeecH τβΜ, hto oho coctoht H3 cjienytomHX ΚΟΜΠΟΗβΗΤΟΒ, b Mac.%: ΠΗχηορκη pTyTH 0,3-1,5

HaTypajn»Hoe BHHorpaflHoe 6ejioe bhho c conepacaHHeM caxapa 3-4 Mac.% hjih MOJioHHaH cHBopoTKa c conepata- hhsm caxapa 3-4 Mac.% no 100,0. 15 37 LV 11667 CPEflCTBO HHMyHOMOflyjnipyī)mErO flEftCTBHfl H BOCCTAHABJTHBAJDlUErO HAPJTUEHHOE ΦΥΗΚΙΙΗΟΗΗΡΟΒΑΗίΙΕ CKCTEMH ΡΕΓΥΠίΠίΐΠί PA3MHOKEHHH KJIETOK TKAHH ΡΕΦΕΡΑΤ 5 CpepcTBO HMMy HOKOHyjiHpyiome r o seĀCTBHB; h

BoccTaHaBJiHBčiBoinero HapymeHHoe «pyHKitHOHHpoBaHKe cHCTena peryJIHlļHH pa3MHO*eHHK KJieTOK TXaHH COCT0HT H3 neftcTBjaomero BemecTBa-ΑΗχπορΗθ pTyTH hjih apceHHT Kajimi hjth apceHar ΗΛτρκπ b KojiucsecTBe 0,01-1,5 Mac.% h 10 paaSaBHTejiJi £o 100 Mac.%. B KanecTBe paafiaBHTejiH 3aKBnxeuoe cpejjCTBo npenno^THTenBHo co^epMHT HaTjrpanbHoe BHHorpanHoe 6enoe bkho c conep*aHHeM caxapa 3-4 Mac.% hjih KOJio«mys3 cHBopoTKy c conep*aHHeM caxapa 3-4 Mac.%.

Claims (6)

1. LV 11667 IMŪNOMODULĒJOŠAS DARBĪBAS UN AUDU ŠŪNU VAIROŠANĀS REGULĀCIJAS SISTĒMAS TRAUCĒTAS FUNKCIONĒŠANAS ATJAUNOŠANAS LĪDZEKĻI Izgudrojuma formula 1. Imūnomodulējošas darbības un audu šūnu vairošanās regulācijas sistēmas traucētas funkcionēšanas atjaunošanas līdzeklis, kas satur darbīgo vielu un atšķaidītāju, atšķiras ar to, ka kā darbīgā viela tiek izmantoti dzīvsudraba dihlorīds vai kālija arsenīts vai nātrija arsenāts, pie kam masas % attiecība ir sekojoša: dzīvsudraba dihlorīds vai kālija arsenīts vai nātrija arsenāts 0,05 -1,5 atšķaidītājs līdz 100,0
2. 2. Līdzeklis saskaņā ar 1.punktu, atšķiras ar to, ka satur kā atšķaidītāju dabīgo vīnogu baltvīnu ar 3 - 4 masas % cukura saturu vai piena sūkalas ar 3 - 4 masas % cukura saturu.
3. 3. Līdzeklis saskaņā ar 1 .punktu iekšķīgai vai ārīgai lietošanai, atšķiras arto, ka sastāv no sekojošiem komponentiem, masas % : dzīvsudraba dihlorīds 0,01-0,1 dabīgais vīnogu baltvīns ar II! 3-4 masas % cukura saturu vai piena sūkalas ar 3 - 4 masas % cukura saturu līdz 100,0
4. 4. Līdzeklis saskaņā ar 1.punktu iekšķīgai vai ārīgai lietošanai, atšķiras ar to, ka satur kā atšķaidītāju cūku tauku, dabīgā medus un etilspirta maisījumu, pie kam šo komponentu masas % attiecība ir sekojoša: dzīvsudraba dihlorids 0,03 - 0,13 cūku tauki 30,7 - 37,3 dabīgais medus 30,7 - 37,3 etilspirts līdz 100,0
5. 5. Līdzeklis saskaņā ar 1 .punktu iekšķīgai lietošanai, atšķiras ar to, ka sastāv no sekojošiem komponentiem, masas %: nātrija arsenāts vai kālija arsenīts 0,05 - 0,15 dabīgais vīnogu baltvīns ar 3 - 4 masas % cukura saturu vai piena sūkalas ar 3 - 4 masas % cukura saturu līdz 100,0
6. 6. Līdzeklis saskaņā ar 1.punktu ārīgai lietošanai, atšķiras ar to, ka sastāv no sekojošiem komponentiem, masas %: dzīvsudraba dihlorids 0,3 -1,5 dabīgais vīnogu baltvīns ar 3 - 4 masas % cukura saturu vai piena sūkalas ar 3 - 4 masas % cukura saturu līdz 100,0