LV11667B - Remedy for renewal of disordered function of immunomodulation and cell tissue reproduction adjustors - Google Patents

Abstract

Agents for restoration of malfunctioning immuno-modulating operations and regulation system of cell woof reproduction as a natural substance contains quicksilver bichloride or potassium arsenate 0.05-1.5% of volume, or natrium arsenate and thinner up to 100% of the volume. The offered agent as a thinner mainly contains natural grape white wine with content of sugar 3-4% of the volume or milk whey with content of sugar 3-4% of the volume.

Description

1 EN 11667 CPEflCTBO HMMyHOMOflyJIHPym {ErO flEHCTBHfl H BOCCTAHABJIHBAILOOROUS HAPPYHHOE 4 > YHKIlHOHHPOBAHHE CHCTEMH PEryJIHIlHH ΡΑ3ΜΗ0ΧΕΗΗΗ KJIETOK TKAHH 06JiaCTb ΤΘΧΗΗΚΗ

HacToanee Η3θ6ρβτθΗΗβ othochtch k MejmmHHe, a TOHHee κ ηοβομυ cpencTBy HMMy η ομοαυ she Hpyiome r ο ηβήστΒΗ a h

BoccTaHaBnHBaiomero HapymeHHoe $ yHKiiHOHHpoBaHHe cHCTemi peryjiiiiiHH pa3MHO * ehhh κϋβτοκ τκβηη · npejņnecTBjromHft ypoeeHb τθχηηκη ΙΙΐΗροκο H3BecTHH pa3JiHHHHe JieKapcTB € HH £ ie npenapaTH, MOfleJiHpyiomiie npoiļeccM HMMyHHTeTa · Tak, e.g. cnOCo6HOCTbIO CTHMyJIHpOBaTb ΗΜΜγΗΗΗβ peaiuļHH opraHH3Ma (a tack * e jiefīKono33) o6jia, qaiOT npoH3BOflHtie ΗγκιιβΜΗΟΒΟΗ KHciroTBi; οποοο6ηοοτβιο σπβΐίΗφΗΗβσκΗ βκτηβηροββτβ ΗΜΜγΗΟΚΟΜΠβΤβΗΤΗΗβ KJieTKH (T- Η Β-.ΠΗΜφθΙ1ΗΤΗ) o6jiaHaK) T npenapTBi miporeHan, npof1HrH03aH h apyrHe. EtoBecTeH npenapTaBaMH30Ji [(-) 2,3,5,6-TeTparimpo-6- [HHJ] HMHna30- (2,1-b) -Tna30J and rHEpoxiopnn] (M.fl.ManncoBCKHii, " JleKapcTBeHHLie cpe; qc: TBa " MockBa, " MeflHiUiHa " 1992 τ.2, CTP. 169-170) oČJianaiomHH cnoco6HocTbio H36HpaTeJibHo CTHMyJTHpOBaTb perynHTOpHyiO φγΗΚΙΪΗΗ) Τ-πΗΜφοΐ1ΗτθΒ, cnocoČHOCTbio ycHJiHBaTb c Jia6ym peaiOļHio κλθτοηηογο 0MMyHHTeTa, ocjia6ji5iTL · h CHJibHyio He neftcTBOBaTb Ha HopMajibHyio peaiuļHio. 03BecTeH Tax * e THMajiHH technology '(technology', npencTaBJiiiKimHH co6oft KOMnneKc ηοπΗΠβητΗΗΗΗΧ φρΒΚΐίΗϊί, BMfleneHHHx H3 βμιιο ^ χοβοη xejie3H KpynHoro poraToro CKOTa) /M.fl.MainKOBCKHH, " JIexapcTBeHHHe cpejļCTBa ", MockBa, " MejļHiļHHa ", 1992 τ.2 , CTp.171); ΠρΗΗβΗίποτ yKa3aHHHH technology 'b ^ That ecTBe HMMyHocTHMynsTopa h 6HocTHMyjiiiTopa npn 3a6oneBaHHJix, COnpOBO * "aiomHXCH ΠΟΗΗΧβΗΗΘΜ Κ, ΠβΤΟΗΗΟΓΟ HMMyHHTeTa, B TOM MHCjie npn οοτρΗχ xpoHHHecxHX γηοηηηχ npoijeccax H BOcnajiHTejtbHwx 3a6ojieBaHHHx, npn omoroBoft 6οηβ3ΗΗ, npn 2

II γΓΗβΤΘΗΗΗ HMMYHHTEt Η ΚρΟΒβΤΒΟρΗΟή φγΗΚΙ1ΗΗ nOCJie ϋγΗβΒΟΗ HJIH XHMHOTepanHH y ΟΗΚΟΠΟΓΗΗΘΟΚΗΧ δοΠΒΗΗΧ.

OnHaKO, Bce BHmeyKa3aHHHe npenapaTBi xapaKTepH3yioTCH H36HpTeJIbHOCTBIO fleaCTBHH, TOKCHHHOCTb », ΗΜβΜΤ ρΗΙ * 5 ΠΟδΟΗΗΜΧ HBJieHHH Μ ΠρθΤΗΒΟΠΟΚ333ΗΗΗ K ΠρΗΜβΗΘΗΗΙΟ. H3B6CTHO, ΗΤΟPemaiHM 3TanOM Β03ΗΗΚΗ0ΒβΗΗΗ HOBoo6pa30BaHHft (onyxojiea) HBJtHeTCH HapynieHHe cHCs PerYyHH HeJieHHa (pa3MHoxeHHe) κπβτοκ. H3BecTHH pa3JiHHHHe npoTHBoonyxojieBBie cpencTBa, 10 κοτορκβ npenCTaBJIiDOT Co6oH COEHHHeHHH pa3JHHHOH ΧΗΜΗΗβοκοβ CTpyKTypM. TaKHe Compound MoryT 6htb noJiyneHH, XAX χημημθοκημ πγτβΜ, Tax η πγτβΜ ΒΗΟβπβΗΗίΐ eHOJIOrHHeCKH aKTHBHMX BeņeCTB H3 CMpbH paCTHTenbHOrO H SHBOTHOrO npOHCXO * īīeHHH (M. .ΜβΙΠΧΟΒΟΚΗβ, " Jl € KapCTB6HHHe 15 cpeflCTBa ", MockBa, " MenmļHHa ", 1992 T .2, ατρ. 423-468). H3BecTHH TaKHe προτΗΒΟοπγχοπβΒΜβ cpencTBa, xax miKJi (α), αH, capKonH3HH, MycTapreH, KapHOJin3HH h cpyrne, b MexaHH3Me neacTBaa κοτορκχ cymecTBeHHyio pojib HrpaioT hx doorKHJiHyro cBoacTBa. Ohh ciiocočhh pearnpoBaTb c 20 HyK.Jieo < l) HJibHMMH lieHTpaMH δβπχοΒΗΧ MOJiexyji, Hapyma.a cnHTe3 ΠΗΚ, b pe3yjibTaTe nero HapymaeTCii * H3HefleHTejibHocTb κπβτοκ h δποκΗργβτοπ hx MHTOTHHSCKHe nejīeHHe. H3BecTHH Taxate προτκΒοοπγχοπβΒΗβ cpeflCTBa, conep * amHe rpynrra sTHJieHHMHHa, Taoe XAX ΤΗοφοοφβΜΗπ 25 flHIlHH, 6βΗ30Τ3φ Η ΛργΓΗβ, ΚΟΤΟρΗβ ΟΚΒ3ΒΙΒΒΙΟΤ iļHTOcTaTHHecKoe jjeacTBHe η γΓΗβτβιοτ pa3BHTne ΠρΟίΙΗφβρΗργΜίςββ, B TOM HHCJie 3JIOKaKeCTBeHHOa TKaHH. B M6xaHH3Me AeacTBHM 3ΤΗΧ cpjļcTB Ba * Hyro pojib HrpaeT HapymeHHe o6MeHa ΗγχπβΗΗΟΒΒΐχ khcjīot h 6jioxaHa 30 MHTOTHHecKoro fleneHHa κπβτοκ. ninpoKoe pacnpocTpaHeHae b Ka ^ ecTBe cpencTB, npOHBJīammHX ΠρΟΤΗΒΟΟΠγΧΟπβΒΟβ fleaCTBHe, ΠΟπγ ^ ίΜΠΗ ΗβΚΟΤΟρΒΙβ aHTH6HOTHKH, B HaCTHOCTH, ΠΟΠγΟΗΗΤβΤΗΊβΟΚΜβ ΠρθΗ3ΒΟΠΗΗβ C HCII0Jīb30BaHH6M ίϊΗβρ MOJieKyjI H3B6CTHHX 35 npOTHBOOnyXOJteBUX aHTH6HOTHXOB. MexaHH3M ΠβΗΟΤΒΗΛ 3ΤΗΧ npenapaTOB cB.S3aH c H36HpaTenbHMM ποπβΒπβΗΗβΜ flHK saBHCHHoro CHHTe3a PHK, mto πρΗΒΟΠΗΤ κ HapymeHtno CHHTe3a, 3 LV 11667

HyKJieHHOB £ IX 'KMCJIOT. OEHaKO, SoJlfelttHHCTBO yKa3aHHHX npoTHBOonyxoJieBHX npenapaTOB xapaKTepn3yioTCH bucokoS TOKCHsHOCTtyy, πο6οηηιικη neftcTBKflitH (yrHeTamT nponecc ΚρΟΒβΤΒΟρβΗΗίΐ). B JIHTepaTJTpe Ηβ OnHcaHil npOTHBOOnyxoneB £ ie cpencTBa, flefiCTBHe χοτορωχ HanpaBJieHo Ha BoccTaHOBJieHHe HapyineHHOrO φγΗΚηΗΟΗΗρΟΒΒΗΗΗ CHCTeMM peryJIBliMH pasMHojieHKii κπβτοκ τκ & ηη · ΠΙκροκο HSBecTHO πρκκβκβΗΗΘ b MeflKiļHHe npenapaTOB ρτγτΗ, b KacTHocTM nHXJiopHita pTyTH b KanecTBe aHTKcenTHHecKoro cpencTBa, a Tax * e npHMeHeHHe npenapaTOB Kann »NKA (apceHaTa ΗΒτρκκ κ apceHHTa KanHn aji «nNeReRiCeReMeCKHX 60Jt» HHX B CBfl3H C HX CBOftCTBOM BBiatlBaTb B036yxneHne apHTponoaTHHecKoft φγΗχηκκ κοοτηογο M03ra h yrHeTeHHe neBKonoo.

OpHaKo, πρκκβΗβΗΗβ yxa3aHHHX npenapTOB b KanecTBe cpeflCTB H30iyHOMonyJiHypyromic neftcTBHH, h cpencTBa nnn BOCCTaHOBIHHN AcidTeReHHO (pyKXnHOHHpOBaHH5i CHCTMM perYJlHH ρβ3ΜΗΟΧΘΗΗ.8 ΚίΤβΤΟΚ TKaHH HeHSBeCTHO ·

PacKptiTHe H3o6peTeHH.H B OGHOBy H3o6peTeHM.H noJio * eHa aanana co3jhHHji ηοβογο cpencTBa HMMyHOMonyJiHpyioniero «EtaTBH ^ h

BoccTaHaBJiKBaBmero HapymeHHoe φγΗκηΗ oHHp ο b aHH e cncTeMii perynjmH «pa3MH0 * eHHH κπβτοκ TKaHH, 6ροΚΗΚ ajβΚΤρΟΜ neftCTBHH. 3aflana pemeHa TEM, whereby to 3aHBJīneMoe cpencTBO HMMyHOMonyjiHpyiomero neftcTBKii h BoccTaHaB-riviBajoniero HapynieHHoe Φυηκβ; ηοηηροβηηηθ οηοτθμη perynHHHH pasMHO ^ eHHn κπβτοκ TKaHH, BKJUOHaiomee neftcTBymmee BemecTBo h paaSaBHTejiB, cornacHo H3o6peTeHim, b KanecTse neūCTBjTornero BeņecTBa conepaiKT ΠΗχηορκη ρτγτΗ hjih apceHHT KaUHit, hjih apceHaT sodium chloride to, NPH cnenyīomeM cooTHonieHHH ΗΟΧΟηΗΒΙΧ ΚΟΜΠΟΗβΗΤΟΒ, B MaC.%:

ΑΗΧηΟρΗΠ ρτγτκ HJIH apceHHT

KanHii, hjih apceHaT HaTpHH 0.0 1-1.5 pa36aBHTexib no 100.0 3anBJTneMoe cpencTao b KanecTBe pa36aBHTejiii 4 npennoHTHTeJibHo conep * HT HaTypajibHoe BHHorpaflHoe 6e; ioe bhho c coflepacaHHeM caxapa Mac 4% conep * aHHMM caxapa.

CoflepaantHecH B HaTypaJibHOM BMHorpaHHOM 6θιιομ βηηθ b He6oJibmoM κοιιηηθοτβθ očpaTHMO KoaryJiHpoBaHH £ ie paCTHTeJIBHHe 6ejIKH C BHCB06oHHBIIIHMHCH sulfate < L) rHnpHJIbHHMH rpynnaMH - SH, a Taksas o6paTHMO KoaryjiHpoBaHHLie 6eJiKH b COCTaBe ΜΟπΟΗΗΟή CHBOpOTKH O0paTHMO 6jIOKHpyiOTCH HOHaMH pTyTH hjih MHmbHKa, BCJiencTBHH nero ycTpaH5ieTCJi TOKCHHHOCTb 3aHBJIHeMOrO CpeflCTBa.

Caxapa, conepaiamHecH b KOJiHHecTBe 3-4 Mac.% B yxa3aHHHX βηηθ h mojiohhož cwBopoTxe cnoco6cTByioT noOTepaeaHHM khcjiož cpejņj nyTeM 6poxeHHH, yJiHinajoT BKycoBHe KanecTBa JieKapcTBeHHoro cpencTBa. 3asBjiHeMoe cpencTBo, cornacHO η3ο6ρθτθηηιο, npajjnoHTHTejibHO HcnoJib3yeTCH b BHne CJienyiomHX BapnaHTOB. 3aHBjineMoe cpencTBo hjih BHyTpeHHero h Hapy * Horo ΠρΗΜΘΗΘΗΗΗ, COCTOHT H3 ΟΠΘΠΥΜΠίΗΧ ΚΟΜΠΟΗΘΗΤΟΒ, B MaC.%!

Hhxjiophh pTyTH 0.01-0.1

HaTypajibHoe BHHorpanHoe 6eioe bhho c conep * aHHeM 3-4 Mac.% Caxapa hjih MOJioHHan CHBopoTc c conepacaHHeM caxapa 3-4 Mac.% No 100.0. 3 aHB JIH6MO e cpencTBO hjih BHyTpeHHero h Hapy * Horo πρημθηθηηη, conepxamee b KanecTBe pa36aBHTejiH cMecb cBHHoro * Hpa, Mesa HaTypajibHoro η βτηιιοβογο cnHpTa, coctoht 'H3 cJieny »iuHx κομποηθητοβ, b Mac.

HhxjiopHH pTyTH 0.03-0.13 CBHHOii * Hp 30.7-37.3 μθη HaTypajibHH 30.7-37.3 3THJIOBHŪ CnHpT HO 100.0. 3θηβπηθμοθ cpeHCTBo hjih BHyTpeHHero πρημθηθηηη, npennoHTHTejibHO HcnoJib3yeMoe hjih ιιθηθηηη οστρυχ η ΧρΟΗΗΗΘΟΚΗΧ ΗθήΚ030Β, COCTOHT H3 Β, Β Mac.

HaTypaJibHoe BHHorpaHHoe 6ejioe 5 LV 11667 bhho c cooep * aHHeM caxapa 3-4 Mac.

HJIH MOJIOHHaH CHBOpOT C COHPJKaHHeM caxapa 3-4 Mac.% No 100.0.

ΠρΗΜβΗβΗΗΘ 3aSBJISeMOrO CpeHCTBa SBJIHeTCS

πρβηΠΟΗΤΗΤβϋΒΗΜΜ JAL7IH ϋβΗβΗΗϋ OCTpMX H XpOHHHeCXHX theyHX030B, Tax xax ochobhhm not HaxoruieHHH MHmbHxa SBJIHeTCS KpOBfa. 3asBJiseMoe cpencTBO hii s Hapy * Horo πρκμθηθηηη, coctoht H3 cJienyiomHX κομποηθητοβ, b Mac.%: ΗΗχπορΗΠ ρτγτΗ 0.3-1.5

HaTypaJitHoe BHHorpanHoe 6enoe bhho c cojjepxaHHeM caxapa 3-4 Mac.% Hjih MOjiosHas CHBopoTKa c conepxaHHeM caxapa 3-4 Mac.% HO 100.0. 3asBJiseMoe cpencTBo He tokchhho, 6jiaro, ū [es CBoftcTBy HOHOB ρτγτΗ H MHmbHXa o6paTHMO 6jIOXHpOBaTb σγΠΒφΓΗΗρΗΠΒΗΜβ ΓργΠΠΗ, K ΧΟΤΟρΜΜ ΟΗΗ ΗΜβϊΟΤ CaMOe BMCOKOe cponcTBo Η3 Bcex peaxiļHOHHEix rpynn. 06nfHM CBOHCTBOM JALIS ΒΟβΧ OpraHH 3MOB h Bcex onyxoji eft SBJiseTcs pa3HHoxeHHe (neemie), npHxa3 o «ejieHHH nOnGeNeNeHHH MOJiexyjnj - pocTOBtie φ3ΧτορΗ sepe3 npyrne 6ejixoBHe MOJiexynu - ρβμβπτορΜ. ΟπβΐίΗφΗΗβοχΗΜ cbohctbom στργκτγρκ Mojiexyn Bcex φΒΚΤΟρΟΒ POCT H HMMyHOrJIo6yjIHHOB, ΙίΗΤΟΧΗΗΟΒ, peiļeiITOpOB ΠΗΜφθΙ1ΗΤΟΒ Η 3pHTpOIļHTOB Η ΗβΧΟΤΟρΜΧ ΓΟρΜΟΗΟΒ (HHCyjIHH, Ba30npecCHH Η ηρ.) SBJIHeTCS HaJIHHHe ηΗΟγΗΒφΗΠΗΗΧ CBS3eft, κοτορκβ o6jianaioT cnocoČHOCTbio rHnpojiH30BaTbcs (pa3pUBaTbCH) B npHCyTCTBHH HOHOB pTyTH, He3āBHCHMO OT HaJIHHHH npyrHX φγΗΚυ ( ΗΟΗΒΗΒΗ £ ΙΧ ΓργΠΠ. ΟπβΗΗφΗΗΘΟΧΗΜ CBOHCTBOM CTpoeHHH MOJiexyJI BCeX iļHTonjia3MOTHHecxHX ρβηβπτοροΒ h 6-one "Byx necsTXOB φβρΜβΗτοΒ (BxraoHas npoTeoJiHTHsecxHe) HBJiseTcs HaJiHHHe cBH3biBaK) iiļHx ysacTXOB cbo6ohhhx ογπΒφΓΗΗρκίίΒΗΒΐχ rpynn. 06paTHMHM 6jIOXHpOBaHHeM σγΛΒφΓΗβρΗΛΒΗΜΧ ΓργΠΠ ρβιχβπτοροΒ φΒΧΤοροΒ pocTa, peopoB στβροΗ ^ ΗΗΧ rapMOHOB h aflpeHeprHsecxHX peToBo hHcImh ρτγτΗ hjih Mfinnbsxa nPHOCTaHaBjiHBaeTcs pocT onyxojiH. 6

Hy6jiHpyioniaH npoTHBoonyxojieBa.a 3arņnTa o6ecneHHBaeTC5i 3a CNET pa3pMBa HHcyji £ »< L > HHHHX CBH3eft φaκτopoB POCT, HMMyHOrJIo6yjIHHOB, ρβΙίβΠΤΟρΟΒ JIHMtJjOIļHTOB H apHTpoiļHTOB B npHCyTCTBHH HOHOB pTyTH HJIH MUBbHKa. HBJieHHeP3ptIBa HHCyJII > $ HHHHX CBH3eZ HMMyHOrJi6yjIHHOB, ΗΘΚΟΤΟρΒΙΧ ΓΟρΜΟΗΟΒ (HHCyJIHH,

Ba30npeCCHH), ILLHTOKHHOB, pENTOTOPOB ΠΗΗφΟΙίΗΤΟΒ H BpHTPololHTOB očecneHHBaeT cbohctbo npenapaTa xax HMMyHOMOJiyJIHTOpa. 06paTHMoe 6jioKHpoBaHHeNePeTom cYJIbφΓHsHJHJJ > HBIX rpynn φθρΜθΗτοΒ η ρβιιβπτοροΒ o6ecneHHBaeT opraHH3My 3amHTyHHHiHOHHoro B03fleuCTBKH.

HCXOfliI H3 ΤΟΓΟ, HTO Ha ITOBepXHOCTH onyXOneBHX KJieTOK peiļenTopoB φ3κτοροΒ POCT b 20-100 Pa3 6oJibme, ηθμ Ha noBepxHocTH "pyrHX κπβτοκ, a φyHx ^ ^ noHa.πbHaί rpynnHpoBKa ρβιχβπτοροΒ φΒκτοροΒ POCT - ογιΐΗφΓΉ, ιηρΗΐΐΗΗΒίϊ rpynna, κ κοτοροή HOHBI pTyTH ΗΜβΙΟΤ Camo BHCOKOe CpOflCTBO, TO Βθ3ββήοτΒΗβ If onyxojieB £ ie κπθτκη b 20-100 pa3 cHJibHee.

HeficTBjnomee BemecTBO 3aHBJineMoro cpeflCTBa - HHxnopHH pTyTH πρκ pacTBopeHHH He npoBOflHT BJieKTpHHecKoro Tokai (HeHOHH3HpOBāHO) a ΗβΗΟΗΗ3ΗρθΒ3ΗΗΒΙβ ΜΟΠβΚγΠΜ ΠβΓΚΟ npOHHKaiOT Hepe3 MeM6paHH, B TOM HHCJie Η B Μ03Γ, a npoHHKHyB, nonaflaioT b iļHTonna3My c 6ojiee ΗΗ3κοή pH, B to * e BpeMH BCE naToreHHHe κπθτκη, βκπιοηθη onyxoneBMe, ημθιοτ aHOMaJIbHO HH3KHe ΒΘΠΗΗΗΗΗ pH, H BCJieflCTBHe ΠΟΒ & ΠΠΘΗΗ.Η khcjiothocth HM6HHO naToreHHHe KJieTKH nomamaiDT ρτγτι ", the ecTb o6ecneHHBaeTCH H36HpaTenbHoe B03fleūcTBHe He naToreHHHe κπθτκη. 3aHBJiHeMoe cpencTBO, 6jnjjjHHHHHOMY MexaHH3My Πθηοτβηη αποοο6ηοοτβμ BoccTaHaBJiHBaTb HapymeHHoe φγΗΚΗΗΟΗΗροΒθΗΗθ οηοτθμη perynHiHH pa3MHO * eHHH κπβτοκ TKHHH. 3aHBJiHeMoe cpencTBo o5jiaflaeT HMMyHOMOnynHpywmHM nežcTBHeM. Ποπ βπηηηηθμ 3aHBJiHeMoro cpencTBa προκοχοΛΗτ nepecTpoHKa BHyTpeHHHX perynHTopHHX MexaHH3MOB, o6beHHHHI0in, HX HMMHHHHEH ΘΗΗΗγίΟ CHCTeMy H HopMaji H3aHHi HMMyHOJiorHHecKHX RiaMeTpoB. 7 Ely EN 11667 JIyHfflHH Ba.pna.HT ocymecTBneHHH ΗΒοδρβτβΗΗΗ SaHBJiHeMoe cpejīCTBo, cornacHO Η3ο6ρβτθΗκπο, cojiepaiHT B KanecTBe neftCTBjromero BemecTBa hhxjiophh ρτγτκ hjih apcsHHT KaJTHH / hjih apceHaT sodium chloride to b KOJiHHecTBe 0.01 to 1.5 uac. % B COSETaHHH C $ APPLICATION BTHHeCKH ΠρΗΓΟΙΙΗΗΜ

to6aBHTejieM. Πρκ stom ajiji BHyTpeHHero h Hapy * Horo ΠρΗΜΘΗΘΗΗΗ CANDIDATE CpenCTBO NOHTHTE / IbHO ΟΟΑβρχΗΤ J3HXJIOp HJJ pTJTTH B KO JIHHeCTB e 0.01-0.1 Mac.% NpH

HcnojiBGOBaHHH b KanecTBe pa36aBHTeJiH HaTypanbHoro BHHorpanHoro 6eioro βηη3 c coaepxaHHeM caxapa 3-4 Mac.% Hjih μοβοηηοΗ cMBopoTKH c conepaeaHHeM caxapa 3-4 Mac.%;

HJIH COAepffHT HHXJIOpHH pTyTH B KOJIHHeCTBe 0.03 to 0.13 Mac. yxa3aHHtie KojiHHecTBa AKXJiopHna pTyTH b 3 asB JiiieHOM cpencTBe no, ao6paHti BKcnepHMeHTaJHH h o6ecneKHBaiOT οφφβκτκΒΗοοτΒ neftcTBKJi 3aHBJiHeMoro npenapaTa. CHioaeKHe conepsaHHHHHXJiopHna pTyTH ηηλθ yxaaaHHoro npecena hjih noBHmeHHe Bume 3aaB JieHHoro npenejia Heuejiecoo6pa3Ho, Tax KaK He očecneHHBaeT αοοτηχθηηη acejraeMoro pe3yjiE.Tara. IJeJiecoo6pa3HO, hjih πεπβΗΗίΐ οοτρΜΧ η χροΗΚΊβοκκχ jieftK030B HcnoJibaoBaTb aaHBJiHeiioe cpencTBo hjih BHyTpeHHero πρΗΜβΗβΗΗΗ, conepxamee b KasecTBe HeiicTByKimero BemecTBa apceHaT sodium chloride to hjih apceHHT KaJiHH b KoJiHHecTBe 0.05 to 0.15 Mac.% B coHeTaHHH c pa36aBHTejieM-HaTypaJibHiiM BHHorpanHLiM 6ejE & rM bhhom c cojjepjaaHHeM caxapa 3-4 Mac.% hjih mojiohhoH ctiBopoTKoft c coflepMaHHeM 3-4 Mac.%. yxa3aHHBie KojiHHecTBa neHCTByiomHx BemecTB Tajcce naAo6paHti OKcnepHMeHTaJibHO h o6ecneHHBajDT ΒφφεκτκΒΗΟοτΒ neTHBHH 3aHBJiHeMoro cpeflCTBa. 3aHBHjieMoe cpencTBo CTHMyjiHpyeT μηογηθ φyHκ ^ HH opraHH3Ma, ocjia6juieT OKHCJtHTejibHHe npoueccH h noBtunaeT ycBoeHHe aaoTa κ φοοφορ3, orpaHHHHBaH pacmeruieHHe δειτκοΒ, yjiyHmaeT o6MeH s KJieTKax η τκζηκχ, oKa3MBaa tskhm o6paaoM o6meTOHH3HpyBmee neftCTBHe, yJiyninaeT o6mee cocTOHHHe, yBejiHHHBaer npoueHT ΓβΜΟΓΤΙΟδΗΗβ H KOJIHHeCTBO ΟρΗΤρΟΙΙΗΤΟΒ B KpOBH. 3aHBJixeMoe cpencTBo hjih hapy * Horo πρημθηθηηη 8 conepatHT neiicTBjnomee BemecTBo-nHXJiopHn ρτγτΗ b KOJiHHecTBe 0,3-1,5 Mac.% B coHeTaHHH c pa36aBHTejieM - HaTypajibHHM BHHorpaflHHM 6eJīHM bhhom c conep * aHHeM caxapa 3-4 Mac.% Hjih mojiohhoh cuBopoTKoft c conepacaHHeM caxapa 3-4 Mac. B KanecTBe HaTypaJibHoro BHHorpanHoro 6eioro BHHa MOJKHO HCn0JIb30BaTb, HanpHMep OflHO H3 CJieHyOIIlHX MapoK BHH " MjriiBaHH, " COBHHbOH H HpyrHe. B HβΧΗΟΙΙΟΓΗΙΟ Η3ΓΟΤΟΒ11βΗΗΗ TaXHX BHH BXOflHT npOlcCC HarpeBaHHH ΠΟ 60 ° C ΗβοβΧΟΗΗΜΒΙΗ, hpe hpHHH c6pa * HBaHHH HacTH caxapoB. Πρκ yica3aHHOH TeMnepaType npoHcxonHT o6paTHMan Koaryji.smH.si pacTHTejibrooc 6eJIKOB, B ΗβδΟΧΙΒΙΠΟΜ KOJIHHeCTBe ΒΧΟΗΗΠξΗΧ B COCTaB BHHa, B pe3yjit > TaTe nero ocBo6oxnaiOTCH σγπΒφΓΗηρΗΐίΒΗΗβ rpynnti 6eJiKOB - SH, KOToptie o6paTHMo 6jioKHpyioTCiī ηοηβμη ρτγτκ hjih MumbHKa, BCJiencTBHe οτογο ycTpaHaeTca tokchhhoctb A solution. B COCTaB MOJIOHHOft CHBOpOTKH TČLKJK6 ΒΧΟΛΗΤ o6paTHMO KOaryjIHpOfiaHHHe 6eJIKH C BHCBo6oflHBIIIHMHCH sulfate rHHpHJIi $ »HBIMH rpynnaMH - SH, KOTOpHe OČpaTHMO 6jīOKHpyHJTCiI HOHaMH ρτγτκ HJIH HOHaMH MHmbHKa, BCJieflCTBHe ΗβΓΟ TOKCHHHOCTb solution of CHHiiaeTca of HyjiH. 3aHBJIHeMOe CpeHCTBO ΜΟ * βΤ ČHTb ρΚΟΜβΗ £ ΟΒΒΗΟ nJIH JieneHHH cjiayionHx 3a6ojieBaHHft: Bce bhjim no6poKaHecTBeHHHx onyxoJieft; Bce bhhh 3JioxaHecTBeHHHX οπγχοιιβκ; ΗΜΜγΗΟΗθφΗΗΗΤΗ pa3JIHHHOrO ΠρΟΗΟΧΟΧΗΘΗΗΗ; ρβΒΜΒΤΗ3Μ; peBMaTOHHHHe apTpuTH; nonHapTpHTH; 6poHXHaJibHaH acTMa; BOJinaHKa cHCTeMHaa KpacHaji; h3BH xenynKa; τροφΗΗβοκπβ h3bh; repnec; ncopnas; KHisHHaa ηηΦθκηηη; HeftponepMHTH h npyrHe 3a6oJieBaHHH. B 3aBHCHMOCTH OT φορΜΜ, CTaflHH 3a6oJieBaHHH, nepeHocHMocTH npenapaTOB h npyrnx HHHHBHHyajibHBix OCo6eHHOCTeft OpraHH3Ma, BH6op H HJIHTeJIbHOCTb ΠρΗΜβΗβΗΗΗ 3aHBJiHeMoro cpencTBa μοχθτ MeHHTbca, b to e * BpeMH cjienyeT npHnep * HBaTbCH onpenejieHHHx npHHiļHnoB jieHeHHH. Tax e.g. cJienyeT npHnepxHBaTbCH ηηθτηηθοχηχ OrpaHHHeHHH C HCKJIIOHeHHeM Τ3ΚΗΧ nponyKTOB ΠΗΤΒΗΗΗ, Kak mhco, pw6a, HHua, nocxojibKy NPH JieneHHH 3aHBJiHeMHM epeneTBOM 6jIOKHpyiOTCJI ΟγΐΙΒφΓΗηρΗΙΙΒΗΗΘ ΓργΠΠΜ B CHCT6M6 9 EN 11667 npOTeOJĪHTHHeCKHX φθρΜβΗΤΟΒ, TO eeTfa CHHXaeTCH B03M0XH0CTb opraHH3Ma ycBaHBaTb 6ejiKOByw nHmy. * Iame jieneHHe HaHHHaioT c npneMa 3aHBJiHeMoro cpencTBa BHyTps - nepBBie τρΗ ηηη from 5 mji (hjih 5 r) 3 pa3a β ηθηβ, Hajiee from 10 mji (hjih 10 r) x 3 pa3a b neHb β τθηθηηθ Mecca. napajiejiBHO npneMy npenapaTa BHyTpb hjih ηθ3Ββηοημο OT ΗβΓΟ OCymeCTBJIHWT M6CTHO6 B03fleThBe 3aIBiIiMBrM CpeHCTBOM B ΒΗΠβ ΠρΗΜΟΗβΚ, ΤόΙΜΠΟΗΟΒ, CnpHHIlBaHHa J KJH3M. Β 3aBHCHMOCTH OT JIOKaJIH3aiļHH npOIļeCCa ΒΒΐ6θρ 30HLI ΗβοδχΟΗΗΜΟΓΟ B03HeftCTBHH pa3JIHHeH - Ha κοπηηκ, naxoBHe JiHM $ oy3JiH, nonMHineHHjno o6jiacTb, πο3Βοηοηηηκ, cycTaBH, JI0KaJIH30BaHHE > These 06pa30BaHHH. ΠΟΚρΟΒΗΗβ HJIH KOCTHO-cycTaBHue tkbhh. Tax Hanpratep, πρκ JieneHHH 3a6oJieBaHHiI MOJIOHHOft JReJie3BI HJIH ΧβΗΟΚΟΗ ΠΟΟΙΟΒΟΗ ΗβρΗ Ha φΟΗΘ ΠρΗβΜβ 3aHBJiHeMoro cpeflCTBa BHyTpi > μοχηο HcnojiB30BaTb MecTmie npHMOHKH, a Taicse BJiarajiHuHHe TaMnoHU h kjih3MH. Πρκ JieHeHHH nopaxeHHH xejiynxa Ha φοΗβ npneMa 3aHBJiHeMoro Cpe ^ CTBa BHyTpb, ΠρΗΜΟΗΚΗ If ΠΟΗΜΒΠΠβΗΗΗβ OČJiaCTH Η ΚΟΠΗΗΚ hjih KJIH3MM. Πρκ nopaxeHHH npencTaTeJibHod xejie3H-3aHBJIHeMOe CpeflCTBO BHyTpb Η B BHfle ΠρΗΜΟΗβΚ Ha ΚΟΠΗΗΚ, naxoBHe h nojiMHnieHHbie JIHMφoy3JIH. Πρκ ΜΗβποπβΗκθ3β 3aHBJIHeMOe CpeflCTBO BHyTpb Η B BHJje ΠρΗΜΟΗβΚ Ha ΚΟΠΗΗΚ, rpynHyio nojiocTb naxoBHe h noflMHmeHHHe JIHMφoy3JIH / Π03Β0Η0ΗΗΗΚ, CyCTaBH. ΠρΗ ΠΟρβΧβΗΗΗ ΜΗΓΚΗΧ TKaHeŽ Η ΟΟΤβΟΓβΗΗΗΧ CapKOMaX -3aHBJIHeMOe CpeflCTBO BHyTpb Η B BHfle ΠρΗΜΟΗβΚ Ha ΚΟΠΗΗΚ, naxoBBie h πο, ΠΜΜίπβΗΗΗβ o6jiacTH, πο3βοηοηηηκ, o6jiacTb ostKKHHH. 3aHBJiHeMoe cpencTBO c ποββππθηηοη KOHueHTpaiļHeH pTyTH ΠρΗΜβΗΗβΤΟΗ ΠρΗ ΗβΗβΗΗΗ 3JIOKaHeCTBeHHMX 3a6oJieBaHHft JierKHX, NPH HaJIHHHH ΓΗΟΗ Η ΚρΟΒΗ Β ΜΟΚρΟΤβ, ΠρΗ ΙΙβΗβΗΗΗ nopajReHHH b 3anymeHHLix cjiyHaax.

3aHBJiHeMoe cpencTBO c neHCTBjnomHM BenecTBOM HHXJiopHn pTyTH χοροιπο 3apeKOMeHHOBJioCeNCiJieneHHH κοχηηχ 3a6ojieBaHHft, τβκηχ, KaK ncopHa3 h ΗβΗροπβρΜΗΤ. 3to CBH3aHO B OCHOBHOM, ΠΟ-BHflHMOMy, C HSOtyHOMOUTH HUNNONHMH CBoiicTBaMH 3aHBJiHeMoro cpeflCTBa, κοτοροθ npH Hapy * HOM 10 πρΗΜβΗβΗΗΗ npoHBJiaeT Tax * e npoTHBOBOcnaJiHTejiBHoe H penapaTHBHoe cbooo. ΠρΗΜβΗβΗΗβ 3aHBJiaeMOro CpeflCTBa C HeftCTByiOmHM BemeCTBOM - ΑΗΧπορκη ρτγτκ ΠρΗ ΠΘΗβΗΗΗ ΤρΟφΗΗΘΟΚΗΧ H3b ηηχηηχ κοΗθΗΗοοτβϋ noKa3ajio ποποχΗτβπΒΗΕΐθ pe3yjibTaTH πρκ Ha3HaH6HHH cpencTBa BHyTpb of očņeft in Scheme h hapy * HO b BHfle πρΗΜΟΗβκ. Kypc JieneHHB: cocTaBJLHeT 1 Mecnn. ΠρΗ Heo6xoflHMOCTH nocjie μθοηηηογο nepepuBa xypc πθηθηηβ: Μοχετ 6hTB ΠΟΒΤσρβΗ. 3aHBJiseMoe cpencTBo npHroTaBJiHBaiOT of Η3ΒβοτΗθή ΜβτοΗΗΚβ nyTeM cMemeHHH hcxo «hhx κομποηθητοβ. 3aHBJi.seMoe cpencTBo 6mjxo H3yneHo b sKcnepnHeHe Ha ΧΗΒΟΤΗΗΧ H HCnHTaHO B KJIHHHXaX Ha, ΙΠΟΗίϊΧ. H3yHeHH eοοροή tokchhhocth 3aHBJiaeMoro cpencTBa 6hjxo προΒβηβΗΟ Ha 192 3AopoB i ix 6ecnopoAHHX Kp α α α-caMixx Maccož 180-220 r. 3a 24 naca no HcmrraHHH h bo BpeMH hx npoBeneHHH χηβοτηηθ HaxonHJiHCB b noMenjehhh BHBapHH c nocToHHHOH TeMnepaTypoft η ΒβΗΤΗπηηΗβή. 3a 2 naca from Hanana HcraiTaHH jkhbothhm npeKpamaJiH nany bosu h Kopma.

OnpenejieHHe napaMeTpa οοτροή tokchhhocth (Jlfl ^) Ka * noft H3 JieXapCTBeHHHX φορΜ npOBOnHJIH ΜβΤΟηΟΜ JĪHT ^ HJina h ynjiKOKcoHa πρκ nepopaJīBHOH nyTH BBeneHHa, cooTBeTCTBjnomeM HaaHaHeHmo h BHyTpn6pioniHHHOM, oSecneHHBaromeM ηοοτΗχβΗΗβ βηοοκογο τοκοηηθοκογο 3φφβκτ3.

nTeM oT6p η B3BemHBaHHH 6hjih BtinejieHH 10 rpynn κρΗΟ nJtH BBeneHHa 3aaBnneMOro npenapTa (b BHne BapnaHTOB - * HnKaH φΟρΜΒ If ΒΗΗβ H Ha ΜΟΟΧΟΗΗΟή CHBOpOTKe). ^ Ihcjio χηβοτηηχ b KaxnoH rpynne paBHHJioct. 6. ΠρΗ BHyTpH6piomHHHOM nyTH ΒΒβΠβΗΗΗ COOTBeTCTByKmHM rpynnaM κρκο ββοαηπη 5; 4; 3; 2 η 1 κπ 3aHBJiaeMoro cpencTBa, hto cooTBeTCTBOBajio no3aH nefiCTByomero BemecTBa - 1/65; 1/32; 0/99; 0.66 h 0.33 μγ / κγ. non-yiHB * e

BBOnHJIH 2; 1/5; 1 H 0/5 ΜΠ, B COOTBeTCTBOBaJIO n03aM neHCTByomero BemecTBa - 0.66; 0.495; 0.33 h 0.165 μγ / κγ.

B BEHALT ΧΗΒΟΤΗΜΜ BB onHJIH COOTBeTCTBJTOmHe paCTBOpHTeJIH - HaTypajii »Hoe BHHorpaflHoe 6enoe βηηο h mojiohhjtio 11 II! LV 11667 CHBOpOTKy.

Ha6jIK3fleHHH 3a ΧΗΒΟΤΗΜΜΗ npOBOflHJIH B ΤβΗβΗΗβ 14 HHea nocjie ΒΒβΗβΗΗΗ 3aHBJiHeMoro cpeflCTBa. ΠρΗ otom oiļeHHBaJiH o6nee coctoshhs tosηβοτημχ, ηχ ποΒβπβΗΗβ h Maccy Tena. nocjie ΒΒβΗβΗΗΗ yKa3aHH £ ix no3 3ajiBJi5ieMoro npenapaTa y Kpnc Ha6jiK) HaJiH cHHseHHe HBHraTejibHOH aKTHBHOCTH, COHJIHBOCTb. 3TH 5IBJleHH.il CHNJIH Chojie ΒΜρβΧβΗΜ npH BHyTpH6pfflfflHHHOM ΒΒβΗβΗΗΗ. ΟΠΗβΚΟ CJiyHaeB CMepTHOCTH ΧΗΒΟΤΗΜΧ B ΠβρΒΝβ HeCKOJTBKO ΠΗβ0 IOCOC MβHβΗΗΗ Ηβ OTMeHaJIH. ΚρΟΜβ ΤΟΓΟ, npH nepopJIBHOM ΒΒβΗβΗΗΗ 3aHBJi5ieMoro cpencTBa (b βηηθ BapnaHTOB Ha ΒΗΗβ η ΜοατοπΗοή CHBopoTKe) cjiynaeB βΜβρτΗοβτκ Ηβ Ha5JiionaJiH h b naJibHeftnieM B ΤβΗβΗΗβ Bcero cpOKa Ha6jIK) nonHHH. TρΗ 3TOM pa3JIHHHH B Macce Tejia, οθιςβΜ coctohhhh η ποΒβπβΗΗΗ χηβοτηηχ β CpaBHeHHH C KOHTPOJE ΒΗΗΒΠβΗΟ Ηβ 6mjio. AHajiorHHHHe pe3yni »Tatham 6hjih noJiyHeHH η πρκ BHyTpH6piOfflHHHOM ΒΒβΗβΗΗΗ 3aHBJIHeMOrO cpencTBa {BapnaHT Ha ΒΗΗβ) CJiyHaeB CMepTHOCTH Ηβ Ha6jTI0naJIH H pa3JTHHHH c KOHTpOJieM β ποΒβπβΗΗΗ h BejiHHHHax MaccM a missing o6Hapy * echo Ηβ 6hjio. OTcyTCTBHe cJiynaeB CMepTHOCTH πρκ nepopajibHOM ΒΒβΗβΗΗΗ Η ΠρΗ BHyTpH6piOfflHHHOM ΒΒβΗβΗΗΗ 3 aHBΗΗβΜΟ Γ O npenapaTa (sHHKaa φορΜβ Ha ΒΗΗβ), HecMOTpn If ΒΒβπβΗΗβ MaKCHMaJIbHO HOnyCTHMMX ΗΧ οβίβΜΟΒ, Ηβ n03B0JIHJI0

paccHHTaTb ochobho0 napaKeTp οστροή tokchhhocth · HTO jnca3HBaeT Ha HH3Kym tokchhhoctb οτηχ φορΜ npn yxa3aHHHX nyTax ΒΒβπβΗΗΗ h Hcnojib3yeMux no3ax. FlρΗ BHyTpH6p »fflHHHOM ΒΒβΗβΗΗΗ 3βΗΒΠΗβΜΟΓΟ CpeflCTBa (JKHHKaΗ φορΜΒ Ha MOJIOHHO0 CHBOPOTKe) 6HJIH BMHBJieHM CJiyHaH CMepTHOCTH Kpuc Ha 5, 6, Ί, 8h9 cyTKH nocjie ΒΒβΗβΗΗΗ. ΠρΗ 3TOM y ΧΗΒΟΤΗΜΧ ΠβρβΗ rH6eJIbH) OTMeHiHiHHHXX, polarJiHH 3aHHHX κοΗβΜΗοστβζ, Taxxe o6HapyxHJiH HapyraeHHH mepCTHOro ΠΟΚρΟΒβ. P ΒΜΧΗΒΠΙΗΧ KpMC 3TH HBJT6HHH 6hjih MaJIO BMpaxeHH η κ 14 cyTxaM from ποΒβπβΗΗΐο h noxa3aTejno Maccu Tejia OHH Ηβ OTJlHHaJIHCb ΟΤ KOHTPOJIH. AHaJIH3 HaCTOTH CMepTHOCTH ΧΗΒΟΤΗΜΧ, ΟΒρΟΒβΗβΗΗΜή ΜβΤΟΗΟΜ ΙίΗΤΗφΗηΠβ H yHJIXOKCOHa, n03BOJIHJI paCHHTaTb - ^ 50 12 jiji 3a5iBJiïeMoro cpeflCTBa (BapnaHT Ha mojiohhou οωΒοροτκβ) ΠρΗ HX BHyTpH6pwmHHHOM ΒΒΘ «βΗΗΗ.

BeJIHHHHa Jlflg y KpbIC npH BHyTpH6pwniHHHOM BBefleHHH 3aaBJiaceMoro cpencTBa (MHU) <

Ehjih npoBefleHH HccjiaoBaHHH npoTHBOonyxoJieBoS aKTHBHocTH 3aHBJiHeMoro cpencTBa Ha onyxojieBtix nepeBHBaeMHX xyji & Typax.

HccjieflOBaHHe npoBOflHJiH Ha nepeBHBaeMHX JieAxolHTapH i ix onyxoneBHX xyjiBTypax jihhhh L-41.

KyjiE > THBHpoBaHHe Kyni »Typ npoBOHHJiH no o6menpHHHTOMy MeTony. IlJtoTHocTb noceBa κηβτοκ cocTaBJtHJia -1.10 ^ κπβτοκ b 1 mji cpenM. B KanecTBe nHTaTeJibHoHpp Hcnojib30BaJiHb paBH £ ix cooTHomeHHfflt cpefly 199 h cpeny Urna c no6aBJieHHeM 10% 6MHE > eH CbIBOpOTKH H aHTH6HOTHKOB J 100 efl. nonHHIHJIJIHHa H 50 ej. cTpenTOMHiHHa Ha 1 mJ cpenBi. 3aHBJiHeMoe cpencTBO h OTflejibHO pa36aBHTeJib - bhho " SpeTH " h neuTBjromee BemecTBo - ΗΗχηορΗΠ pTyTH pa3BOAHJin Ha 6e36ejixoBOH nHTaTeJIBHOH Cpene H BHOCHJIH HX B pa3JIHHH £ IX COPYLHHX B 3-4 KyjibTypM hjih COTE c κπβτοπΗΗΜ MOHoejioeM. Tax XAX aeūcTBjrcomHM BenjecTBOM b 3aflBοιηθμομ cpencTBe ηβιγηθτοη BHXJIOpHn pTyTH, TO MH B npeflBapHTejibHOM onHTe HJIH CpaBHeHHH yCTaHOBHJIH, HTO Eflso HHXJIOpHIia pTyTH, TopM03smaH POCT onyxojieBHX Kyjii "Typ L-41 cocTaBJiHeT MeHee 10 ηκγ / ml. Ha BTopae cyTKH nocjie nocTaHOBKH omrra npoH3BonHJiH MHKpocKonHHecKjno oijeHKy fleHCTBHH technology '4-x 6ajitHOH οΗοτβΜθ h KOJiHHecTBSHHoe onpenejieHHe conepataHHH 6ejixa KyjitTyp of MeTony JIoypH b MOHH < L > HKaiļHH OHMa h Hrjia.

KpHTepHii alphaTocTaTHHecKOH aKTHBHocTH npenapaTa -nponeHT τορμολθηηη pocTa Kyji £ »Typ of yrHeTeHHK > CHHTe3a 6ejixa. flaHHMe onuTa nTeBJieHM b Ta6jiHie 1.

CorJiacHO cymecTByiomHM CTanapTHHM MeTOflaM OT6op npoTHBOonyxoJieBHX npenapTOB - npenapaT HBJiaeTca βκτηβημμ ecjm difference EfíQ MeHbme hjih paBHbi 100 μκγ / mji.

HccjieHOBaHHH noxa3ajiH, hto Eflgg 3aHB JineMoro cpencTBa cocTaBJineT _10 μκγ / mji, hto b 10 pa3 npeBsnnaeT CTaHnapT h 13 EN 11667

cBHfleTeJii > cTByeT o Difference Btip ax hh om olHTocTaTHHecicoM neftcTBHH Ha οπγχοπβΒΗΧ KyjiBTypax.

Ta6jiHeli 1

CpaBHHTeJiBHoe H3yneHHe 6HOJiorHHecK.oft εκτηβηοοτη 3aaBJiiieMoro cpefccTBa, pa36aBHTejia (HaTypajii > Hoe BHHorpaflHoe čejioe bhho c coHepacaHueM caxapa 4 Mac.%) H neacTBjnomero BemecTBa-i * HXJiopHna pTyTH Ha nepeBHBaeMOH onyxojieBoa KyJibType jihhhh L-41 IIpenapaT ΚΟΗΙίβΗ-% NCO co ^ ep * aHHe ΠρθΙ1βΗΤ flocTOBep- TepaiHH nep * a- 6eixa b TopMose- HOCTB flHXJIO- pHFl pTyTH B ΜΧΓ / MJI HH SL cnap- Ta μκγ / mJ HHH HJIH CTHMyjIH-IHH poc-Ta xyni > - Typ,% P 1 2 3 4 5 6 294.0 ± 10.4 - 1 .KOHTpOJIb-2.3 aHB jiaeMo e cpencTBO 1.1 3.3aHBJTheMeo cpencTBO 3.3 4.3aHBJi5ieMoe cpeflCTBO 4.8 5.3aHBJiHeMoe cpeflCTBO 6.6 6.3aHBJiHeMoe cpencTBO 9.9 0.03 318 , 0 ± 0 7.5 cth-MyJIHLHH 0.1 238.3 ± 9.1 18.9 τορ- MoaeHHH 0.15 224.0 ± 23.8 τορ- ΜΟΧΘΗΗΗ > 0.05 > 0.05 0.2 214.0 ± 0 27.2 τορ- ΜΟΛβΗΗΗ > 0.05 0.3 144.0 ± 0 51.0 τορ- > 0.05 ΜΟΧβΗΗΗ 14 1 2 3 4 5 6 7.Bhho 6eJioe HaTypaJii & gt Hoe BHHorpanHoe - 0.03 316.0 ± 25.1 6.9 cth-8.B hho 6ejioe HaTypaJiī »Hoe BHHorpajļHoe - 0.1 MyJIJmHH 318.0 ± 0 7.5 cth- 9.Bhho 6ejioe HaTypaJiBHoe BHHorpaflHoe - 0.15 MynSIJHH 318.0 ± 0 7.5 cth- 10.Bhho 6ejioe HaTypaJiE > - 0.2 MyjIHlHH 322.5 ± 5.8 8.8 cth-11.Bhho 6ejioe HaTypaji & Hoe BHHorpanHoe - 0.3 MyjIHB [HH 307.0 ± 13.8 4.2 cth-12.ΗΗΧπορΗΗ pTyTH 1, 0 MyjIHlHH 390.3 ± 2.6 1.2 τορΜΟ- < 0.05 13.fHXnopHH pTyTH 3.3 ΧΘΗΗΗ 279.0 ± 27.3 5.1 τορ- > 0.05 14. flHXJIOpHH pTyTH 5.0 ΜΟΧβΗΗΗ 256.0 ± 5.2 12.9 τορ- > 0.05 15.Ηηχπορηη pXyXH 8.0 ΜΟΧβΗΗΗ 154.0 + 5.0 47.6 τορ- > 0.05 ιιιι : EN 11667 15 03 ΠρΗΒβΟβΗΗΗΧ flaHHHX BHflHO, hTO 3aHBJIJīeMOe cpeHCTBO OKasMBaeT eupaseHHoe TopM03anee neftCTBHe Ha onyxojieB & ie xyjii »typus b KOHijeHTpaiļHH 9.9 μχγ / ml, hto h cociaBMeT ero Eflso / HHXJiopHna pTyTH cocTaBJineT πρΗΜβρΗο 8 μκγ / ml. Bhho 5 b nccjiaoBaHHBix KOHIHiHaHH [X oKa3HBeT Ha KyjibTypw He3HaHHTJibHoe cTHMyjiHpyiomee B03needTBHe b npenejiax 4.2-8.8%.

Bmjio npoBejieHo H3yHeHne HMMyHo < t < / RTI > apMaCiOrHHecKHx CBOHCTB 3aHBJIHeMOrO ChelCTBa. 10 ΠροΒβηβΗο HccneAOBaHHe bjihhhhh SYMPHUUIEMoro cpencTBa

If Maccy οοηοβηβιχ opraHOB HMMyHod CHCTeMH. ΟΠΗΤΗ npOBOflHJTH Ha iannax JIHHHH CBA, C57B1H rn6pHHax ΠβρΒΟΓΟ SHOCKHHH 3ΤΗΧ jihhhū. 3aHBJiHeMoe cpencTBo (b BHne HByx BapHaHTOB: 15 pa36aBHTenb - bhho h pa36aBHTejib - mojiohhčih cHBopoTKa) BBOflHJIH MLimaM JIHHHH C57B1 Η ΓΗ6ΗΠΗΠΗΠΜΜΠΒΟΓΟΒΟΓΟΒΟΓΟ Π ΟΚΟ JI ih jihhhh CBAxC57Bl b τβΗθΗΗβ 10 µHež. ^ epe3 cyTKH nocjie nocjiaHero ββθπθηηη 3aHBJiHeMoro cpencTBa χηβοτηηχ B3BeūIHBaJIH, 3a6HBaJIH, H3BJieKajIH C6JI636HKH Η ΟΠρβΠβΙΙίΙΙΙΗ HX 20 Maccy.

Pe3yjibTaTH Β3Β6πιηββηηη h noncHeTa MaccoBLix κο3φφΗΐ1ΗθΗΤθΒ npeflCTaBJieHH b Ta6jiHi;

It

Ta6jiHeli 2

Maccu cejie3eHOK npH ηθηοτβηη 3aHBJiHeMoro cpeflCTBa

N / π DpenapaT Kojih— Macca cejie3eHKn 5 ΜβΟΤΒΟ SHBOT- OC flocto- Macco-flocTOBep- ΗΗΧ B Bep- BHH HOCTb (P) rpynne HOCTt Κ03φ- OTJTHHH (P) OT- φΗΙ1ΗβΗΤ 15 1 2 3 4 5 6 7 JlHHHH C57B1 1 LOCATION 23 86 0.55 2 3aHBJiHeMoe 20 cpeflCTBO (pa3-6aBHTejib-MO-JIOHHaH CBIBO - PoTK) 9 90 > 0.05 0.56 > 0.05 3 3aHBJiHeMoe 25 cpeflCTBO (pa36aBHTejib-BHHO) 10 87 > 0.05 0.51 > 0.05 Γη6ρη «nepBoro 30 DOCUMENTSHHH1HHHH CBAxC57Bl 1 LOCATION 25 114 0.46 2 3aHBJiHeMoe cpeflCTBO 11 112 > 0.05 0.48 > 0.05 3 5 (pa36aBHTejib- MOJIOHHaH CH-BopoT) 17

JE LV 11667 1 2 3 4 5 6 7 3 3aiiBJiaeMoe cpencTBo (pa36aBHTeJibbhho) 12,114 > 0.05 0.46 > 0.05

HaHHbie 3thx οπβιτοβ noCastBaioT, hto 3aBJiHeMoe cpeflCTBO Ηβ BJiHHeT If Maccy ceJie3eHKH h MaccoBMU κο3φφΗΐ1ΗθΗτ 3Toro opraHa πρΗ ββθηθηηη npenapaTOB b ΤβΗβΗΗβ 10 ΠΗθή. B cJienyiomHX 3KcnepHMeHTax 3aaBJiaeMoe cpeflCTBo BBOJlHJIH B ΤβΗΘΗΗβ 30 ΠΗβή H 3aTeM nPOBOOLHJIH Β3Β6ΠΙΗΒΒΗΗβ THMycoB; b om, iTax Hcnonb30BajiH μβππθη jihhhh CBA. ΡΪ3 pe3yjibTaTOB, npencTaBJieHHHX b Ta6jmiLe 3, cJieHyeT, hto Ha Bec THMyca npenapT b HaHHHX 3KcnepnMeHTajibHHx yCJIOBHHX ΗΘ BJIHHJI ·

Ta6nHielis 3

Macca THMyca h cejie3eHKH npH JayHorTBHH 3JiBJiHeMoro ChipCTB (pa36aBHTeJib-BHHO)

Dawn of KonHHecTBo Macca THMyca JKHBOTHBIX _ b rpynne ηγ P otjihhhž ot KOHTpojia

CODEbb 8 174 3aHBJiHeMoe cpe £ CTBO 7,170 > 0.05

Perfection HccjieaoBaHO BJiHHHHe 3aHBJi5ieMoro cpencTBa Ha   " TpaHcnJiaHTaT προτΗΒ xo3SHHa " . 3TH HCCJieHOBaHHH npOBOflHJIH ΠΟ CJieHyiomeH ΜβΤΟΠΗΚβ.

Minna * - rn6pnHaM nepBoro noKOJieHHH jihhhū CBA n C57B1 18 B nonynieMKy OffHOii 3βΑΗβή JianKH ΠΟίΙΧΟΧΗΟ BBOflHJIH KJieTKH JiHM (L) aTHHecKHX y3JTOB Munreii jihhhh C57B1 b xoHTpjiaTepajii > Hyīo Jianye bboahjih to xe κοπηηθοτβο οηηγθηηηχ κπβτοχ jihm $ oy3jiob rn6pHHOB. Ha BoefaMLie ογτκκ nocjie nepeBHBKH κίΐβτοχ JīHM $ aTHHecKHX y3JioB noHopoB onpeneJiHJiH Maccy ποηκολθηηηχ JYHM $ aTHHeCKHX y3JIOB οδβΗΧ Jian ρβΙζΗΠΗβΗΤΟΒ. ChiOrHiOuHHBajiH from ΗΗββκογ mainHH / HP /, pacHHTaHHOMy from φορΜγπβ:

Bec JiHM (en > oy3Jia πρη ΒΒβηβΗΗΗ κπβτοκ C57B1 HP --------------------------------------- ---------

Bec JiHM (L > oy3Jia πρη BBeneHHH κπβτοκ ΓηδρηποΒ 3aHBJiHeMoe cpencTBO (b AByx BapnaHTax: pa36aBHTeni > -MOJTOMHaH CHBOpOTKa H pa36aBHTeJII > - BHHO) BBOHHJIOCI "b τβΗβΗΗβ 10 ηΗβή η 20 nHevi noHopaM h penHnneHTaM.

Pe3yjibTaTH θτηχ HccjieflOBaHHfi npencTaBJieHH b Ta6jtniļax 4-5.

QiHiIi 4 Βπηηηηθ 3anBJineMoro cpencTBa (pa36aBHTejiB-MOJioHHasi cHBopoTKa) Ha Maccy ποπκολθηηηχ JiHM $ oy3JioB b headKijHH " TpaHcnJiaHTaT προτΗΒ xo3SHHa "

CxeMa BseneHHn * lHCJIO MaCCH JHM $ Oy3JOB HHfleKC 3anBJiJieMoro SHBOT-headKiHHH cpencTBa ΗΗΧ B LOCALBY- ΟΠΕΙΤΗΟϋ rpynne HOft JianKH peiHnH- noHopan JianKH θητβμ / μγ / / «hh / 1 2 3 4 5 6 35 14 10 9 7.2 7.7 1.10 14 20 10 11.5 13.3 1.24 LOCATION 11 3.3 3.1 2.4 14 9 5.2 6.6 1.3 19 LV 11667 1 2 3 4 5 6 - 10 10 6.0 7/0 1/3 14 10 10 5/2 6.6 1/4

Ta6jnma 5 BJiHHHHe 3aaBJiHeMoro cpeacTBa (pa36aBHTeJtb - bhho) Ha Maccy ποπκοπβΗΗΗΧ πΗΜφογ3ποΒ b mainstreamHH TpaHcIiaHaT npOTHB X03HHHa

CxeMa BBeneHHH ^ HCJIO MaCCH ϋΗΜφθγ3ίΙΟΒ HHHeKC 3aHBJijieMoro cTBa * HBOT-ΗΗΧ B LOCAL-ΟΠΒΙΤΗΟΗ HEALTHKHH ρβΙίΗΠΗ- JOHOHOpaM / HHH / hhh / rpynne HOft jianKH / μγ / JianKH 1 2 3 4 5 6 LOCAL 11 3/3 7,1 2,4 14 - 9 6.7 8.2 1.3 - 10 10 4.6 6.2 1.4 14 10 9 5/1 6.3 1.2 Kax cnenyeT H3 flaHHBIX, npeHCTaBJieHHiix b Ta6jiHuax 4 h

5 3aHBJiHeMoe cpencTBo OK3HBeT MonjHoe βιϊηηηηθ Ha KJieTOHHHft ΗΜΜγΗΗΤΘΤ B HeadKIHH " TpaHCIIJsHaT npOTHB X03HHHa ". CBoeo6pa3He neftcTBHH 3a.HBJi5ieMoro cpejjCTBa

3aKHHDHaeTCiī b τομ, ητο 3φφθκτ jjocTHraeTCH xax πρκ ββθπθηηη npenapaTa peiļHnHeHTaM, TaK h HOHopaM. Bo Bcex cJiyHaHx npoHcxojiHT yBenHHeHHe Macca JiHM $ aTHHecKHX y3JiOB npn nepecanxe κπβτοκ toh * e jihhhh Mtmie. 3th " KOHTpojibHHe " itHM $ oy3 for flocTHraioT pa3MepoB " οπητηηχ ", to ecTb τβχ, headKIlHIO B ΚΟΤΟρΜΧ OCymeCTBJIiDOT ΠΗΜφΟΗΗΗΗβ KJieTKH 20 pOflHTeJIbCKOft JIHHHH ΠρΟΤΗΒ KJISTOK ΓβΗΟΤΗΠΒ ΓΗΑρΗΑΟΒ. MaCCa 3ΤΗΧ " οπητηηχ " ΛΗΜφογ3ΛθΒ npaxTHHecxn OflHHaxOBa Bcex rpynnax ληβοτηβιχ, BXJiioHaH ΜΗΐπβή, He nonyHaBūiHX 3aHBAiieMoe cpencTBO. CjieAOBaTejibHO, 3aūBJixeMoe cpencTBO πρκ ββθα € ηηη 5 B τβκβΗΗβ 10 jļHeH XAX AOHopaM, Tax h peAHnHeHTaM He BJmsieT Ha Maccy τβχ πκΜφβτΗΗβοχΗΧ y3JioB / b χοτορκχ h npoTexaeT peaxiļHH πΗΜφοΑΗΤΟΒ noHopoB προτΗΒ χπβτοχ ny * epoAHoro reHOTHna, ho ycHJiHBaeT peaxijnīo πΗΜφοΑΗΤΟΒ προτΗΒ χπβτοχ co6cTBeHHoro reHOTHna. Πρκ TaKOM xapaxTepe 10 πθηοτβηη npenapaTa HHnexc peaxuHH hanHin »He3HaHHTeni» Ho npeBtnnaeT 1 b οπητηηχ rpynnax.

Πρκ yBeJiHHeHHH xypca ββθαθηηη 3aHBJineMoro cpencTBa HOHOpaM AO 20 ΑΗβΗ B03paCTeT Maeca o6oHX πHMφoy3πOB / " ΟΠΗΤΗΗΧ " H " KOHTpOJIbHHX " H CTaHOBHTCfl ΒΒΠΠΘ, ΗβΜ B 15 rpynne χηβοτηηχ, He nonyHaBineft aasBJiaeMoro cpeACTBa / Ta6jiHAa 4 /. 0AHaxo, Me * Ay co6oft 3TH πHMφoy3πH otjihhcUotch He3HaHHTenbHO η ηηαθχο peaxAHH paeeH 1.24.

KccJieAOBaHO βηηηηηθ 3aaBJiaeMoro cpeACTBa Ha KojiHHecTBo po3eTXOo6pa3yiomHX χπβτοχ b cene3eHxax μηοπθη.

20 IIonyjTHAHH po3eTxoo6pa3yK > MHX χπβτοχ ΗΒππβτοπ CMemaHHoft, ho npaxTHxa noxa3HBaeT, ητο ηχ οηρβΑβπβΗΗβ πΒππβτοπ oahhm H3 ηάκ6ο Jiee vyBCTBHTenbHHX τθοτοβ NPH HccneAOBaHHH HMMyHHOTponHOrO AeiiCTBHH CcLMHX p03H006pa3HHX ΧΗΜΗΜβΟΧΗΧ ΟΟβΑΗΗβΗΗή. 25? KypcH ΒΒβΑβΗΗΗ 3aūBJiHeMoro cpeACTBa paanHHHOii AJIHTeJIliHOCTH HaHHHanH npOBOAHTb AO HMMyHH3aiļHH Χ5ΗΒΟΤΗΗΧ 30 Tect-aHTHreHOM η ηροΑοπχβπΗ enie πητβ αηθη nocjie HMMyHH3aiļHH · H ceAfaMae cyTXH Nocni βητηγθηηογο cTHMyna MLimeH 3a6HBanH h b cene3eHxax οπρβηβπππΗ KonnnecTBO χπβτοχ, CBH3HBaiomHX ορκτροΑΗΤΗ 6apaHa. IIonyHeHH £ ie AaHHMe cBHAeTenbCTByioT, whereby to 3aHBHiieMoe cpeACTBO b TepaneBTHHecxoft A ° 3e Nocni 10 h 20 αηθη nepopanbHoro ββθαθηηη MHmaM yMeHbmaeT KOJiHHecTBO aHTHreHCBH3HBaiomHX χπβτοχ b cene3eHxax MtnneH XAX bbicoko 35 21 ΙΕ EN 11667

TaK η HHaKOOTBeHajonei jihhhh. Πρπ stom b cjiyHae HH3KOOTBeHaiOmeii JIHHHH ΧΗΒΟΤΗΗΧ ΟΗΗΒΙβΗΗβ HHTeHCHBHOCTH HMMyhhoro oTBee 6ojiee 3aMeTHo.

BjiHHHHe 3aHBJiHeMoro cpencTBa Ha hhcjio aHTHTejioo6pa3yiomHX κπβτοκ b cejie3eHxax μεππθη npoBOflHJiH, HCCJienyH ηβήοτΒΗβ cpeflCTBa Ha hhcjio

RHYMHHHHYPHYHyHyYMHX KJieTOK B 3TOM opraHe «ΗΒΟΤΗΒΙΧ, HMMyHH3HpOBaHHUX BpHTpOUHTaMH 6s. KypCM ΒΒββΘΗΗΗ 3aHBJI «eMOrO CpenCTBa pa3JIHHHOH HJIHTeJIbHOCTH HaHHHJJH nPOBOlHHHHHHYHH3aIHH ΧΗΒΟΤΏΙΧ ΤβΟΤ - ΒΗΤΗΓΘΗΟΜ H npoflOJiacajiH ņ e κ κ κ κ κ κ κ κ h h h h h h h oc oc oc M M HMMyHH3aijHH. IIpenapaT BBOflHJIH SHBOTHBEM Non-YiBHO B Π03θ, SKBHBaJieHTHOH TepaneBTHHecKoft, eacenHeBHo. Ha 5 cyTHH nocjie HMMyHH3AlHH MLirnea 3pHTpolylHaMH 6aHa jkhbothbix 3a6HBaJiH h b cene3eHKax is a PENJiHYiHiOnTBo KJieTOK, nPNeRiMiHHX aHTHTejia. IIojiyHeHHHe nahhh, noKa3ajiH, whereby to 3aBJiaeMoe cpencTBO yMeHi > niaeT KOJinnecTBo aHTHTejioo6pa3yiomHx KJieTOK b cejie3eHKax MHinefi CEC hh3ko, TAK h BHCOKooTBeHaiomHX jihhhh ΠρΗ HMMyHH3aiIHH ΗΗΒΟΤΗΗΧ 3pHTpOIļHT AMH 6apaHa B KaneCTBe Tect-aHTHreHa. Πρπ stom CTeneHt οηηχθηηη HHCJia reMOJIH3HHnponyiEHpyiOmHX KJieTOK 3aBHCHT OT HJlHTeJIbHOCTH Kypca BBefleHHH npenapTa. Πρκ ββθαθηηη 3aHBJiHeMoro cpencTBa β τβπβΗΗβ 20 η «βή sto cHHseHHe οτβηοβητβοη CTaTHCTHHeCKH 3HaHHMHM y« ΗΒΟΤΗΗΧ6βΗΧ JIHHHH.

BjiHHHHe 3aHBJiaeMoro cpencTBa Ha KOJinnecTBo IlHpKyJIHpyOIIIHX B KpOBH αHTHTeI nPOBOHHJIH Hepe3 10 H 20 ΠΗβή nocjie BBejteHHH npenapTa h nepe3 7 ηκβή nocjie HMMyHH3aHH ΜΗΙΠβή 3pHTpOIHHTMH 6? KypCH BBeneHHH3aHBJI5ieMOro cpencTBa pa3JHHHOHHJIHTJIbHOCTH HaHHHaJIH npOBOnHTb no HMMyHH3AlHH ΛΗΒΟΤΗΗΧ ΤβΟΤ-3ΗΤΗΓβΗΟΜ H nponent * aJiH em πητβ ηΗβή nocjie HMMyHH3anHH. IIojīyHeHHKe pe3yjibTaTH noKa3aJiH, hto hh y bhcoko, hh y HH3KOOTBeHaiOmHX ΧΗΒΟΤΗΒΙΧ 3aHBJIHeMOe CpenCTBO He BJIHHJIO Ha 3Ty peaKiļHH) ryMopaJibHoro KMMyHHTeTa NPH HccJienoBaHHH noKa3aTejieii hhtshchbhocth HMMyHHoro oTBeTa nocjie 10 h 20 ηΗβή nepopaoibHoro BBeneHHH technology 'b TepaneBTHHecKoū 22 Ηθ3β. ItKHM o6pa30M, KOJiHHecTBO aHTHThey, HaH6oiiee HHTerpyfHHH noKa3aTeJib hhtshchbhocth ημμυηηογο οτβθτβ, πρκ BulbHHH 3ajiBJHeMoro cpencTBa coxpaHaeTCH b npenejiax HOpManbHOrO / KOHTpOJIBHOro / ypOBH5X.

HccajanoBajioci »TaKxe βληηηηθ 3aHBληθμοro cpjļCTBa Ha jJJHyHiHocTb reKceHajioBoro CHa KaK noKa3aTena $ yHKIlHOHaJlbHOrO COCTU5IHHS MOHOOKCHreHa3HOft CHCT6MBI OpraHH3Ma. Οπβιτβι npoBOHHJiH Ha 6ecnopoflHHX MHmax-ca * max, Maccoii 20-22. Χηβοτηβιμ bbohhjih cpencTBo essayHeBHo nepopJibHO b ΤβΗβΗΗβ OHHOH Η Tpex HeneJIb; COPYBEHHMM ΓργΠΠβΜ ΒΒΟΠΗΠΗ τοτ * e ο6βθμ $ H3HOJiorHHecxoro pacTBopa. TecT-MeTa6ojiHT (ReCaEHan) BoHyHiHiHiBiJIH JYYTHTeJIbHOCTb HAPKOTHHeCoCo COCTOHHHa ΜΒΠΠβΗ. ΠοτιγΗθΗΗΒΐβ pe3yjibTaTBi noKa3ajiH, ητο ββθχχθηηθ 3aHBJiH6Moro cpejjCTBa b TepaneBTHHecicož fl03e b τθηθηηθ οηΗΟή hjih τρβχ Henejib He Βπκκβτ Ha flJiHTeJibHOCTb MeTa6ojiH3Ma reKceHajia, whereby to CBHjnsTejibCTByeT 06 otcytctbhh

CymeCTBeHHBIX MAINTENANCE CO CTOPOHBI MHKpOCOMaJlbHOYHCcHuCs φβρΜβΗΤΟΒ opraHH3Ma πρκ fleūcTBHH θτογο npenapaTa.

TaKKM o6pa30M Ha ocHOBaHHH npoBeneHHoro HCCJieHOBaHHH ΗβΚΟΤΟρΒΙΧ HMMy Ηθφ3ρΜ3ΚΟ JIΟΓΗΗΘ CKHX CBOHCTB 3aHBJĪiieMOrO cpeHCTBa BBIHBJīeHO 3Η3ΊΗΤ6ΠΒΗ06 ΗΜΜγΗΟΤρΟΠΗΟβ ΗβήοτΒΗβ ero b οτηοπιθηηη peaiciiHH κπβτοΗΗΟΓο ημμυηητθτβ -peaKijHH " TpaHcnjiaHTaT προτΗΒ χο3ηηη3 " . Πθ £ βχτηηηηθμ 3aHBJIHeMOTO CpeHCTBa npOHCXOJXHIta CTHMyJIimHH ΟΪΗΜφΟΙίΗΤΟΒ XAX b oTHomeHHH peaKiļHž προτΗΒ ΗγκβροπΗΗχ κίΐβτοκ (πρκ BBefleHHH technology 'b τθηθηηθ 3 HeneJIb), TAK η b οτηοπιθημη κχιβτοκ τογο xe reHOTHna, ho HaxoftSBHHXCH b npyroā ocočh (πρκ BBensHHH technology' 10 h 20 ΠΗβή). 3τκ pe3yjibTaTBi 6bijth nonyHeHBi KaK πρκ ββθηθηηη 3aHBJiaeMoro cpencTBa peiHnHeHTSLM, TaK h npH BBeHHH hx jjoHopaM. B ycjtoBHHX 3KcnepHMeHTOB npenapT HHrH6HpoBaji ημμυηηοθ po3eTKoo6pa30BaHHe h cHHxaji KOJiHHecTBO aHTHTejioo6pa3y *) ^ x κπβτοκ b cejie3eHKax ΜΒππβή. O ^ HaKO, HHTerpaJyHBie πoκa3aτeIIκ ryMopajibHoro ΗΜΜγΗκτβτβ - τκτρπ 23 LV 11667 IlHpKyJIHpyiOmHX. B KpOBH aHTHTeJI, - OCTaBaJIHCb B ΟΠΒΙΤΗΗΧ rpynnax If ypoBHe bthx xapaxTepHCTHx y KOHTpoJibHbix ΧΗΒΟΤΗΒΙΧ. B TepaneBTHHecKHX no3ax 3aHBJi5ieMoe cpeflCTBo He oxa3HBajio BJiHHHHe Ha φyHK ^ HOHaπfaHyn aKTHBHOCTb MOHOOKCHreHa3HOH φβρΜβΗΤΗΟή CHCTeMH, ΒΜβΟΤβ C HMMyHHOft HBJiHMņeiicjī nacTbio eflHHož CHCTeMH opraHH3Ma, o6ecneHHBaīomeft ero οτβθτ Ha BHemHHe B03neftCTBHH. 3to TaKJKe CBHneTenbCTByeT ο μηγκομ HMMyHOTponHOM does not teachTBHH 3aHBJiHeMoro cpeflCTBa.

Pl3yHeHHe cnoco6HocTH 3asBMeMoro cpencTBa HHnIlHpoBaTB reHHbie MyTanHH Ha CTaHHapTHHX TecT-niTaMMax S. typhimurium TA 100 / TA 98, TA 1537 MeTOflOM 3ftMca, noKa3aio, hto 3aHBJiHeMoe cpencTBO ηθ o6jianaeT MyTareHHoft aKTHBHOCTbH

Ebiji ΠρΟΒβΗΘΗΟ KJIHHHHeCKOe H3yHeHHe HMMyHOTpOIIHbIX cbohctb 3aHBJiHeMoro cpencTBa. Et3yHeHHe npoBOflHJioct Ha Ho6poBOJibu; ax (78 nalHeHTOB): cp3JiHHHHMH onyxoJtBHMH 3a6oXXBBHHHMH - 56 ΗβΠΟΒβΚ; peBMaTOHHHHM apTpHTOM (Π-1Π peHTreHOJiorHHecxHe CTHh η Π-ΠΙ cTeneHb aKTHBHocTH) 22

HejTOBexa.

BbiJiH HccjieHOBaHbicJienyiomHe noKa3aJiH: o6qee KOJiHHecTBO ΠΗΜφΟΗΗΤΟΒ, HHCJIO B-ΠΗΜφθΗΗΤΟΒ Η Τ-ΠΗΜφθΙ1ΗΤΟΒ, cooTHomeHHe Τ-χβππβροΒ h T-cynpeccopoB, conepataHHe HMMyHOrJIo6yjIHHOB C / M / A Η EH IļHpKyJlHpytOmHX HMMyHHbIX KOMnJieKCOB, φyHX ^ ^ HOHaJIbHa5 aKTHBHOCTb Τ-ΠΗΜφΟΗΗΤΟΒ {T χβππβροΒ h T-cynpeccopoB) η Β-πΗΜφοακτοΒ b mainHHx 6ϋ3αΤΤρ3ΗαφσρΜ3ΙίΗΗ C 3HYHHHMH ΜΗΤΟΓΘΗβΜΗ, φ3ΓΟΙ1ΗΤ3ρΗόΙΗ aKTHBHOCTb H HHTOXHMHHeCK3LH XapaKTepHCTHKa φβρΜβΗΤΒΤΗΒΗΟϋ aKTHBHOCTH HMMyHOKOMneTeHTHHX KJieTOK. JTeHeHHe 3 aHB ηθμβιμ cpencTBOM npoBORHJiocb b COOTB6TCTBMH C ΠρΗΜΘΗΗβΜΟΗ CXeMOH. 0MMyHOJIorHHeCKHe o6cJie "oBaHHH ocymecTBJiHJiH nepefl HanajioM ηθηθηκη, b npoiļecce πθηθηηη: nocjie nepBux HByx HeneJib πρΗΜβΗβΗΗΗ technology 'h nocjie οαηογο Kypca (HeTHpe HeneJiH c HanaJia JieneHHH) / - h cnycTH 2-3 Mecmja nocjie οκοηηηηηη npHeMa technology'. B ΗβκοτορΗΧ cnyHanx onpenejreHHe 24 HMMyHOJiorHHecKHX noKa3aThey npoBonnjin πρη ποβτορηηχ Kypcax ββθηθηηη cpencTBa n cnycTH 6 MecsmeB nocjie Hanajia npneMa 3aBjiHeMoro cpeflCTBa. iiHHaMHKa ΤβηβΗΗΗ OCHOBHOrO 3a6oJieBaHHi [npH ΠΘΗΘΗΗΗ 5 3aHBJIH € MbIM CpeHCTBOM B flaHHHX HCCJieflOBaHHHX CTaHOBHJiaCb nojio

Cy6teKTHBHO oHKOJiornHecKne SojibHHe nocjie xypcoBoro npneMa 3anBJineMoro cpencTBa OTMeHaJin 3HaHHTejibHoe yjiyHineHHe o6mero caMOHyBCTBna. 06ϊ > βκτΗΒΗθ - 6bijih οτμθηθηβι 10 cjiyHan yMeHbmeHnn pa3Mepoe onyxoJin n nnM $ oy3JioB,

BoccTaHOBJieHne προχοηηΜΟοτη KnmenHHKa. Eocjie npoBeneHnn HByx-Tpex xypcoB JieHeHHH 3aHBJiHeMHM npenapTOM 6ojibHue nojio * nTejibHo oneHHBaJin caMonyBCTBne, coxpaHnnn

Tpynocnoco6HocTb; HeKOTopyw cna6ocTb CBH3iiBajin c 15 Heo6xojn; HMocTbio co6juoneHHn πηθτη. y 6oJIbmHHCTBa 6oJibHHX peBMaTOHHHHM apTpHTOM BpaHH οτμθτηπη nojiOMHTeJibHyio HHHaMHKy cycTaBHoro CHHnpoMa b Bnne yueHbmeHHH cKOBaHHOCTH nocjie οηηογο xypca Tepann npenapaTOM. B θτηχ ycjioBnnx 6hjio o6Hapy®eHO ncne3HOBeHne 20 φηδροΜΗ Hapy * Hbix ποποββιχ opraHOB y ohhou H3 6οπβηηχ. Πρη očcjieflOBaHHH 6ojibHHX from non-mitm 3aHBjmeMBiM cpeflCTBOM oTMenaeTcn M03annHHft xapaxTep Η3ΜβΗβΗηή nMMyHOJiornHecKoro CTaTyca KaK y 6ολβηηχ pa3JiHHHHMH 3a6oneBaHHflMn, Taic n y 6ojie »hhx isHoft rpynnH. Πρη Otomo 25 BejrnnnHH nccjienoBaHHHx napaMeTpoB nMMyHHTeTa He bbkobhjih 3a paMxn cpenHe- (L > H3noJiornHecKnx noxa3aTejīeft y npaKTnnecKH 3JHopoBbix juoneft. OnHaxo, y 3HaHHTejibHoro nncjia ΟΗΚοποΓΗΗβοκηχ 6ojibhhx 6hjio HapymeHO οοοτΗοπιβΗΗβ cy6nonyjiHnnū T-xejinepoB: T cynpeccopoB. 30 EnnHCTBeHHHM noxa3aTejieM, onHOHanpaBJieHHO Η3Μθηθηηβιμ y Bcex nanneHTOB, HBJiHeTcn κοατηΜβοτΒο nnpKyjinpyiomHx nMMyHHHXKNB, κοτορυβ yBejiHHeHH ny οηκοπογηηθοκηχ 6οίιβηηχ, nyNanneHTOB cTpanaK > mnx peBMaTonnHHM apTpnTOM.

Hepe3 nBe Henen nocjie HanaJia npneMa 3anBJi5ieMoro 35 cpencTBa npn nccjiaoBaHnn noKa3aTeTeS HMMyHaNaN HANB 6bnia o6Hapy * eHa 3HaHHTejibHan headKnnn HMMyHHon CHCTeMU. 25 E 11667 y 6oJii »mHHCTBa 6ojti» hbix o6enx rpynn Ha6jixmaitoc b cHHaeHHe o6ņero HHCJia ΠΗΜφοιίΗτοΒ, οηηχθηηθ T η B ΠΗΜφομΗΤΟΒ, CHHXeHHS Τ-ΧβϋΠβρΟΒ H 3aMeTHOe CHHX6HH6 T-cy npeccopoB, η3μθηθηηθ KOJinnecTBa HMMyHorJio6yjiHHOB pa3JiHHHBix KJiaccoB hochjio pa3HOHanpaBJieHHHtf xapaxTep y pa3HHx nOpHaToB, y oHKOJiornHecicnx 6ojibhhx οτμθηθηο yBeJiHHeHHe φaΓo ^ nτapHoή axTHBHocTH mohoiihtob h jieftKololHTOB. KojiH ^ ecTBO * e i nn iNpKymipynmnx HMMyHHHx KOMiiJieKCOB yMeHtmanoci »h y οηκοπογηηθοκηχ 6ojibmix h y 6oJIbHBIX peBMaTOHHHHM apTpHTOM.

Ba * HO ΟΤΜΘΤΗΤΒ, HTO y OHKJiOrH'tieCKHX 60JIbHBIX puck

HapymeHHK cooTHomeHHJi T-xeJinepoB: T-cynpeccopoB πρκ CHHSeHHH HHCJia Τ-ΙΙΗΜφΟΙίΗΤΟΒ, JHMHHIHHH HHCJieHHOCTH HX cy6nonyjiHiiHi npoHcxonHiio b pa3HoT CTeneHH. 3a σπβτ θτογο nocTHrajīoci »BoccTaHOBJieHHe cootkoh6Hhx T-xennepoB: T-cynpeccopoB, χοτη h If hh3kom φyHK ^ HOHa.πbHOM ypoBHe. Ρΐ3ΜΘΗβΗΗβ COHep * αHHH ΠΗΜφΟΙΙΗΤΟΒ-HCC06eHH0 pHHHOBH3HHHH IX IX KJiaccoB HOCHJIH HeperynHpHHH xapaKTep.

HaHHMe H3yHeHHJĪ ΠρΟΙΙΗφβρΒΤΗΒΗΟίί āKTHBHOCTH ϋΗΜφοΐ1ΗτοΒ b peaxiiH.sx 6 > π3θττρΒΗαφορΜΒΐΐΗΗ nonTBep * FLAIS ΒΗΒΟΠ O 3HaHHTeJIbHOft peaKIļHH HMMyHHOft CHCTeMH NPH BBefleHHH 3aHBJiHeMoro cpeflCTBa η o cymecTBeHHLix HHnHBHnyaJIbHHX 0C06eHH0CT5IX 3TOŽ peaKITHH noCJie nByx nepBtix HeneJib npHeMa technology '. Πο OKOHHaHHH ΠβρΒΟΓΟ Kypca JieneHHH CpenH Η3ΜβΗβΗΗΗ noxa3aTeJieiHMMHyHaTeTeMe Ha ce6K BHHMaHHe 3ausTHoe yMeHbmeHHe u; Πρκ BceM pa3HOHanpaBJieHHOM xapaKTepe KOJie6aHHft ocTaJibHHx HMMyHojiorHHecxHx hubMeTpoB Heo6xonnMo οτμθτητβ τοτ φ3κτ, HTO OHH He BUXOHHT 3a rpaHHLTM φΗ3ΗθπθΓΗΗθαΚΟΗ HOpMH. AHaJiorHHHaii KapTHHa coxpaHaeTCii πρκ HccneflOBaHHH HMMyHOJiorHHecKHX noxa3aTeJiea y naHeHTOB Hepe3 2-3 Mecima nocite oKOHHaHHii nepBoro xypca Teparinn nepejr Βτοροή cepaeii npneMa npenapaTa. B τBHηθηηθ noBTopHoro xypca HHHHBHjiyajibHHe Η3ΜβΗβΗΗΗ HMMyHojiorHHecKHx napaMeTpoB y 6ojibHHXHitht τοτ xe xapaxTep, hto h npn nepBOM xypce 26

TepanHH, HO Mβ HMeioT eflHHoro BeKTopa HanpaBJieHHocTH y Bcex 6ojibhhx. B nlolecce HccjiaoBaHHft ntiTaJTHCb ο6ί »θπηηητβ 6oJIBHBIX B rpynnBi na THnaM Η3ΗβΗβΗΗΗ, CBH3aTb 3TH Η3ΜΘΗΘΗΗΗ C rpjnLMH KpOBH OJļaa KOKOΗ 3aKOHOMepHOCTefit ββμβητβ He ynajiocb. Jepea 6 MecaneB nocne nysee 2-3 xypcoB JieneHHSi 3ΒϋΒΠΗβΜ £ ΙΗ CpejļCTBOM ΟΤΜΘΗβΗ3 nOJIOJKHTEJIbHaH JJHHaMHKa H3yMaeMHX noxa3aTejieft.

ΠρΗ aHajiH3e Bcex, npencTaBJieHHHX κ paccMOTpeHHio pe3yJIBTaTOB KJIHHHHeCKHX HCCJieJiOBaHHft HMMyHOTpOnH £ IX cbožctb 3aHBJiaeMoro cpeacTBa, o6pamaeT Ha ce6s BHHMaHHe b BBicmeft οτβπβΗΗ ηηπηβHnyajit > Heihei xapaxTep peaKiļHH HMMyHHOH CHCTeMU Kasnoro 6ojibHoro. B M M pea pea pea pea a a a a a pea pea pea pea pea pea pea pea pea pea pea pea pea pea pea pea pea pea pea peaρ ρ pea IlepBaH - xapaxTepH3yeTCH HeHanpaBJieHHHMH K3MeHeHHHHH HMMyHOJTOrHxieCKHX noka3aTeJieŽ. OHeBHflHO, non BJTHSHHeM 3aseBJisMoro cpencTBa npoHcxonnT non-targeting BHyTpeHHHX [TOpHHX HexaHH3HOB, o6be, nHHHIomHX HMMyHHBie KJieTKH b eHHHyw cHCTeMy. BTopan $ a3a - < t > a3a HopMaxin3AlHH HMMyHOJiornHecKHx napaMeTpoB. 06π1ημη 3jiecb hbjiūiotch nea θφφβκτβ: yMeHbineHHe conepjKaHHii nnpicyiiHpyīoiaHx hmmjthhbdc

KOMiineKCOB; HopMaiH3anHH cooTHomeHHH cy6nonyjiHXiHu T-xeJinepoB: T-cynpeccopoB. 06a Ha6jiBHaeMHX stBJieHHii μμθϊοτ nojTo * HTejibHoe nporHocTHHecxoe 3HaHeHHe, Tax xax CBHHeTeJIbCTBYoO HHMiHHiHHOH COCtIHHi HMMyHHOH CHCTeMH. Υμθηβπιθηηθ nHpKyjiHpyiomHX nwMyHHHx κομππθκοοβ Ha6jiMHaeTCH y ecex 6ojibHi > ix (οΗχοιιοΓΗΗβοκΗΧ h cTpanaiomnx peBMaTOHHHLIM apTpHTOM) HOpMaJIM3aiļHJI COOTHOmeHHiī cy6nonyjisiļHft πΗΜφοηΗΤΟΒ xapaKTepHa nnn 6ojibmHHCTBa naiļHeHTOB ηβηηβιχ rpynn. 3aHBJiiieMoe cpeflCTBO 6bijio HcnHTaHo b KJiHHHKax 6ojiee ηθμ Ha 250 6ojibHMX. IIpopThe HcraiTaHHH πρκ πθηθηηη cjiayH) mHX 3a6oylBaHHu: 3JiooxaHecTBeHHBie h floepoKaHecTBeHHHe onyxonH, peBMaTH3M, peBaTOHfHiHiPtHT? IIpeHMymeCTBeHHMMH OHKOJIOrHHeCKHMH 3a6oJieBaHHHMH HBJiHJiHCb: 3a6ojieBaHHH * eHCKHX opraHOB (pax mojiohhož 27 EN 11667 xejie3u Pak Rehn h ιπθηκη μ3τκη Pak hhmhhkob) 3a6oJieBaHHH ΚρΟΒβΤΒΟρΗΟή ΟΗΟΤβΜΜ (ΛΗΜφ0Γρ3ΗγπβΜ3Τ03, ΙΙΗΜφ0ΧΙΘΗΚ03, OCTpMft ΠΗΜφοβ ^ ΟΤΗΗΪΪ ΠΘΗΚ03, MHeJĪOMHaH 6ojie3Hb) 3a6ojieBaHHH ΒΗγτρβΗΗΗΧ opraHOB h TKaHeft (paK npsraoH κηπικη, xejiynKa, πθηθηκ, HocorJioTKH, κόχη h np.); H3 onyxojie no6poKaHecTBeHHOft npHponu, TaKne, KaK aneHOMa npencTaTejiBHoU χβπβ3Η, φκ6ροΜΗθΜ3 MāTKH, namuinoMa, KHCTa, MacTonaTHH mojiohhhx xejie3, ποιιηπ npsMOH κηπικη h npyrne.

Bo3pacTHoft κοητηηγ6ητ 6ojibhbix 20-60 JieT; epOKH JieneHHii 3aHBjiHeMHM cpencTBOM cocTaBJiiiJiH 0.5 or 2-x JieT h 6ojiee. 3 aHB JiHeMO e cpencTBO npHMeHHJiocB from BumeonHcaHHoU μθτοπηκθ: BHyTpt - πβρΒΗβ τρκ hhh from 5 mji 3 pa3a b neHB, nanee 10 mji x 3 pa3a b ηβΗΒ b τβνβΗΗβ Mecnna. napajuiejiBHO npneMy npenapaTa BHyTpB npoBOflHJiocB MecTHoe HapyxHoe

B03fle®CTBHe 3 aHB JliieMHM CpenCTBOM B 3aBHCHHOCTH OT fromCaEH3AlHH npollecca 3a6ojieBaHHH. DpenapaT HapyxHO nPHMeHHJTCH B BHfle ΠρΗΗΟΗβΚ, ΤΒΜΠΟΗΟΒ, CnpHHIlBaHHH, KJIH3M. IIpenapaT HaHOCHJICH B Finnish Heo6xOHHMOrO B03fleHCTBHH - Ha κοπμηκ, naxoBue JIHMφoy sjih, nonMbimeHHjno o6jiacTB, Π03Β0Η0ΗΗΗΚ, CyCTaBU, JIOKaJIH30BaHHUe o6pa30BaHHH, ποκροΒΗΒιβ hjih koctho-cycTaBHHe τκβηη. AHanH3 pe3yjiBTaTOB JieneHHH 3aHBJiHeMBiM cpencTBOM, b TOM HHCJie OHKOJIOrHHeCKHX 6oJIBHBIX IV, m Π CTaflHĀ 3a6ojieBaHHH (co cpoKaMH JieveHHJi: 0.5 6ojiee Rhone 6-one 1 Rhone 6ojiee 2-χ πβτ) a Tamtus nJiHTeJiBHan nonnepxHBaiomaiī Tepanna 3aHBjihombim cpencTBOM bbihbhjih ποηοχπτβιίΒΗΗΗ οφφβκτ taeaeHHa, KaK ajih ηθ πθηθηηηχ paHee, TaK η JieneHHHX paHee 6ojtbhhx.

HacJironaJiacB nojiHan perpeccnac onyxoJiH (3JIOKaHeCTBeHHOH) B 3aBHCHMOCTH OT BHHa 3a6OJieBaHHH, cTaflHH, οροκοΒ JieneHHH y 6ojibhhx no 34.3%; y 6ojibhhx c onyxojiiiMH HočpoKaaecTBeHHOH πρκροηΗ no 80.8%. Ύ pana 6ojibhhx HaeraonJiacB CTa6HJiH3anH.Si nponecca, yMeHBmeHHe pa3Mepa onyxoJiH. Y Bcex 6ojibhhx OTMenajiocB ynyHineHHe o6mero cocTOHHHa. 28 flJiH jiyHinero ποηημηηηη HacTOjnņero Η3θ6ρβτβΗΗΗ npHBOBHTCH CJieHyiOmHe ΚΟΗΚρβΤΗΒΙβ npHMepU npHrOTOBJISHHH 3aHBJiaeMoro cpe ^ cTBa h difference KJiHHHHecKHx HcntiTaHHH. npHMep 1. 3aHBjiηθμόe cpejjcTBO cjie; yyymom cocTaBa: HHXJIOpH «pTyTH 0/01 Γ

HaTypajibHoe BHHorpajHoe 6ejroe bhho c coflep * aHHeM caxapa 4 for Mac.

3a5tBJiiieMoe cpejjcTBo γοτοβητ cjie; qyiomHM o6pa30M. Hhxjiophh pTyTH pacTBopiHOT b BHHorpajhOM βηηθ b yxa3aHHHX

KOJIHHeCTBaX B 06ΗΗΗΗΧ yCJIOBHHX (short for KOMHaTHOH

TeMnepaType). nojiyHaioT npo3paHHUH pacTBop, cBeTjio-acejiToro i ^ BeTa (ρΗ = 3/1). noJiyHSHHHH technology 'xpaHHT b nocyHe H3 τθμηογο CTeKJia πρκ TeMnepaType He Βκαπβ 15 ° C for τθμηομ MHecTe · Πρκ xpaHeHHH bū3mosho BHnafleHHe ocajtica coenHHeHHž bhhhoh khcjīoth, nosTOMy nepejj ynoTpe6jieHHeM solution was ηθοΘχοηημο B36ajiTBiBaTb. npenapaT npurofleH hjih BHyTpeHHero h HapyatHoro npHMeHemiss. ΠρΗΜβρ 2. 3youBiYiMoe cpencTBo cjiejīyx > mero cocTaBa: ΛΗχηορχΛ pTyTH 0,06 r

HaTypaJibHoe BHHorpajmoe 6ejxoe bhho c conepaiaHHeM caxapa 3 Mac.% 100 mj npHroTaBJiHBaio cpeflCTBO aHajioHHHo npHMepy 1. nojiyHaio npo3paHHUU pacTBop, aceyTOBaToro ijBeTa, pH = 3.3. npenapaT npHroneH hjiji BHyTpeHHero h Hapy * Horo πρΗΜθΗβΗΗΗ. ΠρΗΜβρ 3. 3axBJiiiMoe cpencTBo cjiejjjnomero cocTaBa: ΗΗχηορΗΗ pTyTH 0,1 r

MOJIOHHaH CBIBOpOTK c 4 Mac.% - hhm conepxaHHeM caxapa 100 mj npHroTaBJiHBaMT cpeflCTBo aHanorHHHO npHMepy 1. nojiyHax > T npo3paHHHu pacTBop, cBeTJio-KpeMOBor UBeT HpenapaT npHrofleH bjih BHyTpeHHero h Hapy * Horo πρΗΜβΗβΗΗΛ. 29 EN 11667 ΠρΗΜβρ 4. 3aHBJiaeMoe cpeflCTBO cneflyiomero cocTaBa: AHXJIOpHH pTyTH 0.3 Γ

HaTypajibHoe BHHorpanHoe 6ejroe bhho c coxepxaHHeM caxapa 3 Mac.% 100 mIiPHroTaBJiHBaioT cpencTBO aHanorHMHo πρΗΜβργ 1. IIpenapaT npHroneH βπη HapyxHoro πρημθηθηηα. ΠρΗΜβρ 5. 3aaBJiHeMoe cpencTBo cjiayiomero cocTaBa: HHXJIOpHfl ρτγΤΗ 1,5 Γ

MOJIOHHaH CHBOPOTK c 3 Mac.% - hum conep * aHHeM caxapa 100 mji

BACKGROUND OF THE INVENTION cpencTBo aHaJiorHHHO πρΗΜβργ 1. IIojiyHaioT npo3paHHHH pacTBop σΒβτπο-κρβΜΟΒΟΓο BEBEAT. IIpenapaT πρΗΓοπβΗ ηπχ HapyxHoro πρΗΜβΗβΗΗΗ. ΠρΗΜβρ 6 · 3asBJiHeMoe cpencTBo cjiejiyioinero cocTaBa: ΗΗΧΠΟρΗΗ ρτγτΗ 0,25 r CBHHOU ΧΗρ 230 Γ ΜβΗ HaTypajiE HKu 240 r cnHpT 96 ° from 750 r.

npHroTaBJiHBaioT cpencTBo cjiayiomHM o6pa30M. flHXJIOpHH ρτγτΗ paCTBOpHIOT B 3THJIOBOM ΟΠΗρΤβ. npeflBapHTeJibHO pa3MsirMeHHHH cbhhoh χκρ CMemHB is a cc MenoM HaTypaye, HHM B yxa3aHHHx xojiHHecTBax. 3βτβΜ pacTBop HHXJIOpHHa ρτγτΗ cyMMH B 3THJIOBOM ΟΠΗρΤβ He6ojIfemHMH PatchHMMH, TinaTenbHo pacTHpaii, bhocsit b CMect οβηηογο xnpa C ΜΘΠΟΜ. nojiyHaioT 3aHBJiiieMoe cpencTBo b βηηθ KpeMOo6pa3Horo nponyxTa, CBeTJio-xejiToroBBeTa. npenapaT πρκΓΟΗβΗ ηπχ ΒΗγτρβΗΗβτο h HapyxHoro ΠρΗΜΘΗΘΗΗΗ. 30 II. ΠρΗΜβρ 7. 3aHBjiaeMoe cpencTBO cnejijromero cocTaBa: apceHHT KaJiHH 0.05 r

HaTypaJibHoe BHHorpaflHoe 6eJioe bhho c conep * aHHeM caxapa 4 for Mac. 3aaBJiHeMoe cpencTBo γοτοβητ πγτβΜ pacTBopeHHH apceHHTa KanHH b HaTypajibHOM BHHorpaflHOM 6eioM βηηθ b yKa3aHHHX KOJiHHecTBax. IIojiyHaioT npo3paHHHft pacTBop, οΒβτπο-χβπτοΓο BEBEAT, pH = 3.2. IIpenapaT npnroneH hjih ΒΗγτρβΗΗβΓο πρημθηθηηη. ΠρΗΜβρ 8. 3afīBJifieMoe cpescTBo cjiayiomero cocTaBa: apceHaT HaTpHH 0.15 MOJIOHHaS CMBOPOTK c coflepsaHHeM caxapa 3 Mac.% Flo 100 mji.

3aHBJHSMO € CpeflCTBO ΓΟΤΟΒΒΤ ΠγΤβΜ paCTBOpeHHH apceHaT HaTpna b MonoHHOft CMBopoTKe c conepsaHHeM caxapa 3 Mac.% B jnca3aHHMx KOJiHHecTBax. IIoJiyHaH) T npo3paHHHi pacTBop, CBeTno-xejiToro UBeTa. IIpenapaT πρΗΓΟΗβΗ hjih BHjrrpeHHero πρκΗβΗβΗΗΗ. IIpHMep 9.

EfcIJIH nPOBeneHH KJIHHHHeCKHe HCnLITAHHJI 3 aHB JIHeMO Γ o cpe ^ cTBa Ha 99 oHKOJiorHHecKHX 6ojibhhx, k3 hhx: 67 6ojibhhx

- HMeJiH 3JiKaHecTBeHHbie onyxojiH, 32 6ojibhhx ημθ, πη onyxoJiH no6poKaHecTBeHHO0 πρκροπΜ. 03 rpynnH 67 6ojibhbix - 32 npomjiH xypc npenBapHTeJH > Horo jieneHHH (onepaiHfi, nojiHXHMHOTepanH.fi, raMMa-Tepanaa), 3 5- He nonsepraJiMci »paHee πθηθηκο. EOJIBmHHCTBO OHKJIOHHeCKHX 6oJIbH £ IX: 21 ΗβίΙΟΒβΚ HMeJIH IV cTaHHM 3a6oJieBaHHH, 18 6ojibhbix - ΠΙ; Π cTaflHa 3a6ojieBaHHf OTMeHe y 6 6οπβηβιχ. fljiH 22 6ojibhhx cTaflHH 3a6ojieBaHHH He onpejjeJieHa. Κοητηηγθητ ohxo6ojibhbix of B03pacTy: ot 40 of 60 ηβτ - 39 ΗβηοΒβχ. Οτ 20 no 40 πβτ - 7 ΗβηοΒβκ, CTapme 60 ηβτ 31 EN 11667 - 14 HejioBeK. Πο noJiy: 11 MyatHHH, 56 - χθηπιηη.

CpOKH JieHeHHH ChOiHHBDC 3 aHB JileMHM CpeHCTBOM cocTaBJiHJiH: 6oye 0.5 rona 28 6ojibhhx (41.8%), 6oIe 1 rona 3 6ojibhhx (4.5%), 6oJiee 2-π ββτ 19 6ojibhhx (28.3%). fljiHTejibHas nonnep * HBaromaa: TepanM 3a5iBJiHeMHM cpencTBOM npoBOHHJiacb y17 6ojibHHX (25.4%). npeHMynieCTBeHH £ IMH 3a6oJieBaHHHMH HBJIHJIHCb: 3JiOKaMecTBeHHue onyxojin (PAK mol ^ Hou xejie3H, pax Tena meāKH MaTKH Pak hhhhhkob, pax πρΗΜΟή κηπικη * ejiynxa, ΠβΗβΗΗ, HOCOrJIOTKH, ΚΟΧΗ; 3a6oJieBaHHH ΚρΟΒβΤΒΟρΗΟΗ CHCTeMSI - JHD®ļ) 0rpaHyjieMaT03, ΙΙΗΜφ0ΙΙθίίΚ03, ΟΟΤρΗή ΙΙΗΜφοδJiaCTHBIH JieHK03, MHeJIOMHaJī 6oJie3Hb) Η3 onyxojiež Ho6poicaHecTBeHHOH πρπρο, ηΗ (aneHOHa npeflCTaTeJibHoft xejie3H, φπδροΜΗΟΜΗ HaTKH, nanHJiJioMa, KHCTa, MacTonaTHH mojiohhhx XeJie3, nOJĪHIĪBI ΠρΗΜΟΗ κηπικη).

Hjiji ΟΗκοποΓΗΗβοκΗΧ 6ojibhbix (paHee ηθ noflBepraBinHXCH JieneHHio) - 35 ηθποβθκ (100%) noJiyneHH cjiayiomHe pe3yjibTaTBi: nojiHan perpeccHH onyxojiH (chhth c yneTa y OHKOJiora), npaKTHHecKH 3βοροΒΗ 12 ΗβποΒβκ (34.3%). 3a6ojieBaHHSi: paK mojiohhoheenesu esu-lV ct., ΦΗδρο3Ηο-KHCT03HaH MacTonaTHH (3JioxaHecTBeHHaB: φορΜ3), paK MaTKH, pax shhhhkob ,. ocTeoreHHa capKOMa, MeJiaHOMa, ΠΗΜφ0ΠβΗΚ03). - CTa6HJiH3aHH npololecca Ha6jnonajiacb y 12 6οηβηηχ (34.3%). (3a6oJieBaHH5i Pak ΜοποΗΗΟή xejie3H ΙΠ-IV ct., AneHOKapiļHHOMa mojiohhhx xejie3, aneHOKapijHHOMa npocTaTti, IV ct (M € TacTa3U B JierKHe), Pak npaMoft κηπικη, IV ct. Pak HOCOrJIOTKH (MeTaCTa3H B Μ03Γ, Π03ΒΟΗΟΊΗΗΚ) 6jiaCTOMa ΗΗΧΗΘΗ HaCTH ΠΗΠ * βΒΟΠ & (3JIOKaHeCTBeHHa.il φθρΜ3, ΙΠ CT.,.) - ΥΜθΗΒΠιβΗΗβ pa3Mepa onyxojiHY 9 6ojibHHX (25.8% BaaHHe: paK mojiohhoh xejie3H). 8%) flajibHeHinee nporpeccnpoBaHHe npolylecca HMeJio MecTO y 1-ro 6ojibHoro (2.8%).

Hjih OHKOJiorHHecKHx 6ojibHHX, πθηθηηηχ paHee HejioeeKa (100%) pe3yjibTaTM JieneHHH cjiayiomHe: 32 32 IHIiHaii perpeccHH onyxojin. Chhtbi c yneTa y oHKOJiora. IIpaKTHMecKH 3HopoBBi - 6 6ojte > hi > ix (18.8%). (3a6oJieBaHHJi: pax mojiohhoh * exte3H III-IV ct., Pax shhhhkob, IV ct., OSteMHoe o6pa30BaHHe npaBOft nojiH πθηθηη (3JīKaHecTBeHHaH $ opMa), 6a3ajiHOMa yniHo8 paKOBHHH). - CTa6HJiH3aHH5i npouecca Ha6jnooajiacb y 12 6ojibhhx (37.6%). (3a6oJieBaHH5i: pax mojiohhoh xejie3U 6onacTOMa mojiohhoh * βπβ3Η, IV ct. (3JioKaHecTBeHHaH $ opMa) pax meftKH MaTKH, pax γιιοτκη, ΙΠ ct., Pax npaBoH hojih neneHH, pax πρΗΜΟή κηιπκη, ροτογποτκη * ejiyHKa, nofl * eJiyjļOHHoft XeJie3M, ΧρΟΗΗΗβΟΚΗή ΛΗΜφ0ΛβΗΚ03 ΠΙ CT., OCTpHft

Jira ^ OČJiaCTHHH JieĀX03). - ΥΜθΗΒΐπβΗΗβ pa3Mepa onyxoJiH y 2-x 6ojibhhx (6.2%). (3a6ojieBaHHe: paK mojiohhoh * ejie3w), NaHH ix from peiHnHBy He o6HapyxeHo y 4 6ojtbhhx (12.5%). - yjiyHmeHne o6mero coctohhhh y 4-x 6ojibhhx (12.5%). - PeMHccnii y 2-x 6ojibhhx (6.2%). - CocTOHHne yHOBJTeTBopHTejiBHoe y 1 6ο.πβηογο (3, 1%) io - flajīBHežniee nporpeccHpoBaHHe npoiļecca ΗΜβπο hscto y 1-ro 6ojibHoro (3.1%). ΠοαΐΟ * ΗΤθηΐ »ΗΗΗ θφφθΚΤ JieHeHHH ΟΗΚΟΠΟΓΗΗβσΚΗΧ 6ojibhhx (paHee πθηθηηβιχ η ΗβηβΗβΗΗΗΧ) aaHBJiHeMHM cpeflCTBOM cocTaBJiHeT - 79%. OTcyTcTBHe 3φφβκτ3 - y οπηογο 6oJiBHoro (2.9%).

Pe3yjibTaTH JieneHHH onyxojieft HoGpoKaHecTBeHHOi npHpoflj.1 (PAH He JieH HH & ix 6ojibhbix) - 26 ΗβηοΒβκ (100%): IIoJaHaH perpeccHH onyxcmH, chhth c y OHKOORA, npaKTHHecKH 3flopoBM - 21 6ojibhou (80.8%). (3a6HiHhJi: φκ6ρο3ΗθΗθΜ3 μοποηηηχ xene3, MacTonaTHH, φΗβρΟΜΒ, φΗδρΟΜΗΟΜΒ MaTKH, ΠΟ.ΠΗΠ ΠρΗΜΟΗ ΚΗΙΠΚΗ, ΠΟ.ΠΗΠ ΠΙβΗΚΗ MaTKH, nOJIHKHCT03, rHOHHaHOnyXOJIBHHHHHKOB, JHHPHHHHHHHPHHe). - CTa6HJiH3aiiHH npoijecca Ha6.monajiacb y 2-x 6oJibHSix (7.7%). (3a6oJieBaHHii: ocTa mojiohhou xejie3ii, BHyTpHnpoTOKOBaH nanHJiJioMa mojiohhou * ejie3Bi). Υμθηβπιθηηθ pa3Mepa onyxojiH, yjiyHmeHHeO6mero 33 ΙΕ LV 11667 COCTOHHYJ y 2-x 6ojii hhx (7.6%).

CocTOiHHeYoBJieTBopHomeHoe y 1-ro 6oJibHoro (3.8). Pe3ynbTaTH jieneHU-6oJibHBix (paHee πθηθηημχ) - 6 πβποΒθκ (100%).

IlpaKTHHecKH 3 ^ opoB - 1 6ojibHoft (16.7%). (3a6oneBaHHe: MacTonaTHH). - CocTOHHHe xopomee y 3 6οιιβηηχ (49.9%). - Be3 peutnnHBOB y 1 6ojibHoro (16.7%). - PeMHccM y 1 6ojibHoro (16.7%). ΠΟΠΟΧΗΤβΠΒΗΗή ΒφφβΚΤ Jie ^ eHHS 6oJTbHHX C 3a6oneBaHHHMH He oHXOJiorHHecxoro xapaxTepa (onyxoJTH no6poKaHecTBeHHoft npHpyol) cocTaBJiiieT - 81%. IIpHMep 10.

BbiJIH npOBeneHU KJHHHHeCKHe HCntl aHHH 3aHBJIHeMOrO cpencTBa Ha 157 6thi * hhx, H3 χοτορκχ 138 (87.9%) OHHiHHxHe 6ojibHHe (onyxojiH 3JioxaHecTBeHHOH npnpojm); 19 (12.1%) - HMe H onyxojiH nočpoKaHecTBeHHoii npHpoflM. 03 138 OHKOJiorHHecxHX 6ojie   hbix - 94 (68.1%) npon for H xypc npenBapHTeJibHoro πθηθημη (onepaijHH, nojiHXHMnoTepannii,

Rammi-TepanHH) 6ο.πβηηχ 44 (31.8%) He nonBeprajincb TaxoMy JieHeHHio · OHKOnorHHecKHe 3a6oneBaHHH (onyxojiH 3JioKaHecTBeHHOfi npnpo; yl) BKJīioHaioT 1- 3a6oJieBaHHH jishckhx opraHOB (pax MOJionHoa * ejie3H, pax h a missing pax meaxH μβτχη, pax hhhhhkob) - 72 6ojibHMx. Pa - pax ΚρΟΒβΤΒΟρΗΟΗ CHCTeMH (HHM (δ) OrpaHyneMaTOB, JIHM $ o6naCTHaH JIHMC | >OMa; ΙΠ - OHKOJiorHHecxne 3a6oneBaHHiI BHyTpeHHHX opraHOB h TKaHeft (pax xejiy £ xa, pax jierx, pax πρκΜΟΗ χηπιχη, pax nHH, pax μοηcβογο ny3Brp5i, pax npeflcTaTejibHOH * ejie3H h HpyrHe) - 52 6ojibHux.

B pe3yjibTaTe JieHeHHH 6ojibHHX 3 aHB JiiieMHH cpencTBOM 6mjih nojiyHeHH cjiaywmHe pe3yjībTaTH. fljiH rpyuim oHxoJiora * nimxnx 6ojibHHX (onyxojiH 3JtOKaHecTBeHHoa npHpoflM) Π, ΙΠ, IV c. 34 II. - yMeHbmeHHe pa3Mepa onyxoJiH y 32 6οπβηηχ (23,5); - CTa6H1H3aHH pocTa 3JioKaHecTBeHHoft onyxojiHy 61 6ojibHHX (44.2); - yjiyHineHHe o6iņero coctohhhh y 28 6ojiī »hlīx (20.3%); 5 - flajieHeijnie nporpeccHpoBaHHe npoijecca y 12 6ojibhhx (8.7%). fljin rpynnu Θοπβηηχ c onyxojiHMH no6poKaHecTBeHHoft npHpom »! - 19 ΗβποΒβκ (100%) ycTaHOBJieHo: - PerpeccHH onyxoJiH y 8 6ojibhhx (42.1%); 10 - CTa6HJ1H3a7H5iOpoijecca y 6ojibHtix (26.2%); - µMeHbmeHHe pa3MepoB onyxoxyH 4 4OJibHux (21.1%); - yuyHmeHHe o6ņero coctohhhh y 2 6οηβηηχ (10.5%). IIpOMUfflJieHHaH npHMeHHMOCTL · 3aHBJIHeMOe CpeflCTBO H3XOflHT ΠρΗΜΘΗβΗΗβ B MeflHIJHHe 15 UNH JieneHHH HMMyHOHe $ HIļHTOB pa3JIHHHOrO npOHCXOameHHH, H3IH πβΗβΗΗΗ Bcex bhsob 3HOKanecTBeHHHX h Ho6poicaHecTBeHHHX onyxojieii, peBMaTH3Ma, peBMaTOHflHoro apTpHTa, nojmapTpHTa, 6poHXHaJIbHOŽ aCTMH, BOJIHaHKH CHCTeMHOŽ KpaCHOā, H3BH * ejiynKa, repneca, τροφΗΗθσκκχ H3b, ncopnasa, κηπθηηηχ 20 ΗΗφβκΐίΗΗ, HeūpoflepMHTOB h apymx 3a6oiteBaHHft. 5 35 E 11667 ΦΟΡΜΥΠΑ H30BPETEHH3 1 CpencTBO HMMyHOMonyjiHpy »Mero neiīcTBHH h BoccTaHaBJiHBanmero HapymeHHoe 4 > yHKUHOHHpoBaHHe cHCTeMU peryjiHiiHH paaMHOseHHH κιιετοκ TK.aHH, BKJUOHaiomee AeftcTBjrsomee BemecTBo h pa36aBHTejii >, xapaKTepH3ymmeecH τθμ, hto b KaMecTBe AeftcTBymmero semecTBa handled easily conepxHT ΑΗΧίίορκπ ρτγτκ ΗΒΗ apceHHT KajiHB, hjih apceHaT HaTpHH npH CJieAyKitn; eM cooTHomeHHH hcxohhhx χομποηθητοβ, b Mac. %: 10 AHXJIopHfl ρτγτκ ΗΒΗ apceHHT KajiHH, hjih apceHaT HaTpHH 0.01-1.5 pa36aBHTenb no 100.0. 15 2. cpBo n.l, xapaxTepn3yx3m: eecjī τβΜ, hto b KanecTBe GenerationBHTejiH oho οοπβρχκτ HaTypaji & Hoe BHHorpanHoe 6enoe bhho c conepxaHHeK caxapa 3-4 wac.% Hjih μοποηηυ® οκΐΒοροτκγ c 3-4 Mac.% ConepsaHHeM caxapa. 20 3. CpencTBo no hjih ΒΗγτρβΗΗβΓο hjih HapyxHoro npHMeHeHHH, xapaxTepn3ywmeecH τβΜ, hto oho coctoht H3 cnenyioniHX κομποηθητοβ, b Mac. %: HHXJIopHH ρτγτκ 0.01-0.1

HaTypanbHoe BHHorpanHoe 6enoe bhho c conepacaHHeM caxapa 3-4 Mac.% 25

HJIH MOJIOHHaH CHBOPOTK C conep * aHHMM caxapa 3-4 Mac.% No 100.0. 30

4 CpencTBo of n.l, hjih BHyTpeHHero hjih hapy * Horo npuMeHeHHfl, xapaxTepH3ymmeecH τεχ, hto b KanecTBe pa36aBHTejiH handled easily conepMHT cMect cbhhoto "NPA wena HaTypanbHoro η 3Τηιιοβογο cnHpTa, npn cJienyiomeM COOTHOmeHHH HCXOHHHX ΚΟΜΠΟΗβΗΤΟΒ, Β Mac.%! HHXJIOpHH ρτγΤΗ CBHHOft SHp Men HaTypajibHHft STHJTOBblfl CnnpT 5. CpencTBo no. 0.03-0, 13 30.7-37.3 30.7-37.3? O 100.0. n.l, hjih BHyTpeHHero πρκΜθΗβΗΗΗ, xapajcTepH3ymnieecH τβΜ HTO OHO COCTOHT H3 ΟΠβΗ $ ΠΟΠΙΗΧ 35 36

IβΗΤΟΒ, Β Mac.% I apceHaT ΗβτρΗΗ hjth apceHHT KajiHH 0.05-0.15

HaTypan £ > Hoe BHHorpanHoe 6eJioe bhho c conepataHHeM caxapa 3-4 Mac.% HJTH MOJIOHHCHLH CHBOOTOT C conepxaHHeM caxapa 3-4 Mac. oho coctoht H3 cjiaytomHX ΚΟΜΠΟΗβΗΤΟΒ, b Mac.%: ΠΗχηορκη pTyTH 0.3-1.5

HaTypajn »Hoe BHHorpaflHoe 6eioe bhho c conepacaHHeM caxapa 3-4 Mac.% Hjih MOJioHHaH cHBopoTKa c conepatahhsm caxapa 3-4 Mac.% No 100.0. 15 37 EN 11667 CPEflCTBO HHMyHOMOflyjnipyi) mErO flEftCTBHfl H BOCCTAHABJTHBAJDlUErO ACID TREATMENT KίΙΕ CKCTEMH ΡΕΓΥΠίΠίΐΠί PA3MHOKEHHH KJIETOK TKAHH ΡΕΦΕΡΑΤ 5 CpepcTBO HMMy HOKOHyjiHpyiome r o seCtBBH; h

BoccTaHaBJiHBčiBoinero HapymeHHoe "pyHKitHOHHpoBaHKe cHCTena peryJIHlļHH pa3MHO * eHHK KJieTOK TXaHH COCT0HT H3 neftcTBjaomero BemecTBa-ΑΗχπορΗθ pTyTH hjih apceHHT Kajima hjth apceHar ΗΛτρκπ b KojiucsecTBe 0.01 to 1.5 Mac.% H 10 paaSaBHTejiJi £ o 100 Mac.%. B KanecTBe GenerationBHTejiH 3aKBnxeuoe cpejjCTBo npenno ^ THTenBHo co ^ epMHT HaTjrpanbHoe BHHorpanHoe 6enoe bkho c conep * aHHeM caxapa 3-4 Mac.

Claims (6)

Invention 1. The immunomodulatory action and the restoration of the impaired functioning of the tissue cell multiplication regulatory system comprising the active ingredient and the diluent is characterized by the use of mercuric dichloride as the active substance. or potassium arsenite or sodium arsenate, with the following percentages by weight: mercury dichloride or potassium arsenite or sodium arsenate 0.05 - 1.5 diluter to 100.0 2. The product according to claim 1, characterized in that it contains, as a diluent, a natural white wine with a sugar content of 3 to 4% by weight or a milk whey with a sugar content of 3 to 4% by weight. 3. The agent according to claim 1 for oral or external use, consisting of the following components, by weight: mercury dichloride 0.01-0.1 natural grape white wine with II! 3-4 wt% sugar content or whey with 3 to 4 wt% sugar content up to 100.0 4. An oral or external agent according to claim 1, characterized in that it comprises a mixture of diluent pig fat, natural honey and ethyl alcohol, wherein the percentage by weight of these components is as follows: Mercury dichloride 0.03 to 0.13 pigs fat 30.7 - 37.3 natural honey 30.7 - 37.3 ethyl alcohol to 100.0 5. The oral formulation according to claim 1, comprising the following components, by weight: sodium arsenate or potassium arsenite 0.05 - 0.15 natural grape white wine with 3 to 4% by weight of sugar or milk whey with a sugar content of 3 to 4% by weight up to 100.0 6. An agent for external use according to claim 1, characterized in that it consists of the following components, by weight: mercury dichloride 0.3 -1.5 natural grape white wine with 3 to 4% by weight of sugar or milk whey with 3 - 4 wt% sugar content up to 100.0