LV11525A - Piperidine Pyrrolidines and Hexahydroazepines with Growth Hormone Purification - Google Patents

Piperidine Pyrrolidines and Hexahydroazepines with Growth Hormone Purification

Info

Publication number
LV11525A
LV11525A LV960151A LV960151A LV11525A LV 11525 A LV11525 A LV 11525A LV 960151 A LV960151 A LV 960151A LV 960151 A LV960151 A LV 960151A LV 11525 A LV11525 A LV 11525A
Authority
LV
Latvia
Prior art keywords
hexahydroazepines
pyrrolidines
piperidine
growth hormone
hormone purification
Prior art date
Application number
LV960151A
Other languages
Latvian (lv)
Other versions
LV11525B (en
Inventor
Gregori J Morriello
Arthur A Patchett
Lihu Yang
Meng H Chen
Ravi Nargund
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/323,994 external-priority patent/US5494919A/en
Priority claimed from US08/323,998 external-priority patent/US5492920A/en
Priority claimed from US08/323,988 external-priority patent/US5492916A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of LV11525A publication Critical patent/LV11525A/en
Publication of LV11525B publication Critical patent/LV11525B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
LVP-96-151A 1993-11-09 1996-05-22 Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone LV11525B (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US14944193A 1993-11-09 1993-11-09
US16514993A 1993-12-10 1993-12-10
US17344993A 1993-12-23 1993-12-23
US08/323,994 US5494919A (en) 1993-11-09 1994-10-17 2-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
US08/323,998 US5492920A (en) 1993-12-10 1994-10-17 Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone
US08/323,988 US5492916A (en) 1993-12-23 1994-10-17 Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
PCT/US1994/012816 WO1995013069A1 (en) 1993-11-09 1994-11-07 Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone

Publications (2)

Publication Number Publication Date
LV11525A true LV11525A (en) 1996-10-20
LV11525B LV11525B (en) 1997-02-20

Family

ID=27558364

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-96-151A LV11525B (en) 1993-11-09 1996-05-22 Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone

Country Status (16)

Country Link
EP (1) EP0739204A4 (en)
JP (1) JPH10506091A (en)
KR (1) KR960705808A (en)
CN (1) CN1174504A (en)
AU (1) AU1172995A (en)
BG (1) BG100555A (en)
BR (1) BR9408019A (en)
CA (1) CA2175218A1 (en)
CZ (1) CZ134296A3 (en)
FI (1) FI961951A (en)
HU (1) HUT74733A (en)
LV (1) LV11525B (en)
NO (1) NO961865L (en)
PL (1) PL322706A1 (en)
SK (1) SK56296A3 (en)
WO (1) WO1995013069A1 (en)

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Also Published As

Publication number Publication date
FI961951A0 (en) 1996-05-08
CZ134296A3 (en) 1996-12-11
SK56296A3 (en) 1997-02-05
HUT74733A (en) 1997-02-28
EP0739204A1 (en) 1996-10-30
WO1995013069A1 (en) 1995-05-18
CN1174504A (en) 1998-02-25
EP0739204A4 (en) 2000-03-15
NO961865D0 (en) 1996-05-08
HU9601230D0 (en) 1996-07-29
KR960705808A (en) 1996-11-08
FI961951A (en) 1996-05-08
BR9408019A (en) 1997-08-26
JPH10506091A (en) 1998-06-16
BG100555A (en) 1996-10-31
PL322706A1 (en) 1998-02-16
NO961865L (en) 1996-07-08
CA2175218A1 (en) 1995-05-18
AU1172995A (en) 1995-05-29
LV11525B (en) 1997-02-20

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