LV10304A - Structured crystals are a new form of enzyme immobilization - Google Patents

Structured crystals are a new form of enzyme immobilization

Info

Publication number
LV10304A
LV10304A LV930807A LV930807A LV10304A LV 10304 A LV10304 A LV 10304A LV 930807 A LV930807 A LV 930807A LV 930807 A LV930807 A LV 930807A LV 10304 A LV10304 A LV 10304A
Authority
LV
Latvia
Prior art keywords
clecs
crystals
enzyme
new form
enzyme immobilization
Prior art date
Application number
LV930807A
Other languages
Latvian (lv)
Other versions
LV10304B (en
Inventor
Manuel A Navia
Nancy L St Clair
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of LV10304A publication Critical patent/LV10304A/en
Publication of LV10304B publication Critical patent/LV10304B/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6448—Elastases, e.g. pancreatic elastase (3.4.21.36); leukocyte elastase (3.4.31.37)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82—Asparaginase (3.5.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C12Q1/003—Functionalisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Liquid Crystal Substances (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Piezo-Electric Or Mechanical Vibrators, Or Delay Or Filter Circuits (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A method of immobilizing an enzyme by forming crystals of the enzyme and, generally, also cross-linking the resulting crystals through the use of a bifunctional reagent; crosslinked, immobilized enzyme crystals (CLECs) made by this method; lyophilization of CLECs made by this method; lyophilized crosslinked immobilized CLECs and a method of making a desired product by means of a reaction catalyzed by a CLEC or set of CLECs.
LVP-93-807A 1990-08-03 1993-06-30 Use of cross-linked crystals as a novel form of enzyme immobilization LV10304B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56228090A 1990-08-03 1990-08-03
PCT/US1991/005415 WO1992002617A1 (en) 1990-08-03 1991-07-30 Use of crosslinked crystals as a novel form of enzyme immobilization

Publications (2)

Publication Number Publication Date
LV10304A true LV10304A (en) 1994-10-20
LV10304B LV10304B (en) 1995-06-20

Family

ID=24245600

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-93-807A LV10304B (en) 1990-08-03 1993-06-30 Use of cross-linked crystals as a novel form of enzyme immobilization

Country Status (26)

Country Link
EP (2) EP0550450B1 (en)
JP (2) JPH05508549A (en)
AT (2) ATE240391T1 (en)
AU (1) AU662104B2 (en)
BR (1) BR9106732A (en)
CA (1) CA2087730C (en)
CZ (1) CZ12393A3 (en)
DE (2) DE69133521T2 (en)
DK (2) DK0861888T3 (en)
ES (2) ES2199933T3 (en)
FI (1) FI120099B (en)
HK (2) HK1023362A1 (en)
HU (2) HUT65904A (en)
IE (1) IE912767A1 (en)
IL (1) IL99046A (en)
LT (1) LT3366B (en)
LV (1) LV10304B (en)
MD (1) MD1592B2 (en)
NO (1) NO930360L (en)
PT (1) PT98564B (en)
RU (1) RU2124052C1 (en)
SG (1) SG70966A1 (en)
SK (1) SK283185B6 (en)
TJ (1) TJ210R3 (en)
UA (1) UA27035C2 (en)
WO (1) WO1992002617A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932212A (en) * 1996-05-24 1999-08-03 Altus Biologics, Inc. Crosslinked protein crystal formulations and their use as catalysts in organic solvents
WO1998013119A1 (en) * 1996-09-24 1998-04-02 Altus Biologics Inc. Crosslinked protein crystals as universal separation media
US6140475A (en) * 1997-04-11 2000-10-31 Altus Biologics Inc. Controlled dissolution crosslinked protein crystals
EP1009759B1 (en) * 1997-09-05 2008-05-28 Altus Pharmaceuticals Inc. Carbohydrate crosslinked glycoprotein crystals
US6500933B1 (en) 1997-09-05 2002-12-31 Altus Biologics Inc. Methods of preparing carbohydrate crosslinked glycoprotein crystals
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
GB9823334D0 (en) 1998-10-23 1998-12-23 Darwin Discovery Ltd Enzyme coupling
JP2004523240A (en) * 2001-02-16 2004-08-05 アイベックス テクノロジーズ Matrix stabilized enzyme crystals and methods of use
US7241272B2 (en) 2001-11-13 2007-07-10 Baxter International Inc. Method and composition for removing uremic toxins in dialysis processes
JP4799422B2 (en) * 2004-01-01 2011-10-26 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ Method for preparing crosslinked protein crystals
PT1729797E (en) 2004-03-22 2008-12-17 Solvay Pharm Gmbh Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants
PL2198880T3 (en) 2004-10-14 2017-04-28 Eli Lilly And Co. Compositions containing lipase, protease and amylase for treating pancreatic insufficiency
BRPI0614914A2 (en) 2005-07-29 2011-04-19 Solvay Pharm Gmbh Processes for Making Sterile Pancreatin Powder
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
JP5248676B2 (en) 2009-05-22 2013-07-31 サンヨー食品株式会社 Protein complex having asymmetric oxidation reaction and method for producing the same
BR112012005869A2 (en) 2009-09-15 2017-01-31 Althea Tech Inc protein a crystals, cross-linked crystals and methods of using them
WO2012026493A1 (en) * 2010-08-26 2012-03-01 アイシン精機株式会社 Electrode having enzyme crystals immobilized thereon, process for production of electrode having enzyme crystals immobilized thereon, and biological fuel cell and biosensor each equipped with electrode having enzyme crystals immobilized thereon
EP3003358B1 (en) 2013-06-07 2021-03-24 Allena Pharmaceuticals Inc. Compositions and devices for dialysis
WO2016126970A1 (en) 2015-02-04 2016-08-11 Abbvie Inc. Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency
AU2018285710A1 (en) * 2017-06-15 2020-01-23 The University Of Chicago Methods and compositions for treating cancer
WO2023194615A1 (en) * 2022-04-07 2023-10-12 Need4Health B.V. Method for determining insulin dosage

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3664926A (en) 1970-02-26 1972-05-23 Merck & Co Inc Crystallization of l-asparaginase
DE2857828C2 (en) 1977-01-27 1990-06-07 Toyo Soda Mfg. Co., Ltd., Shinnanyo, Yamaguchi, Jp
US4373023A (en) * 1980-10-14 1983-02-08 Massachusetts Institute Of Technology Process for neutralizing heparin
DE3381980D1 (en) * 1982-04-23 1990-12-13 Wako Pure Chem Ind Ltd METHOD FOR THE SEMI-SYNTHESIS OF HUMAN INSULIN AND ALKALINE PROTEASE TO BE USED FOR THIS.
US4411996A (en) * 1982-06-30 1983-10-25 Nabisco Brands, Inc. Process for isomerizing glucose
AU3889685A (en) * 1984-01-20 1985-08-09 Eye Products Ltd. Partnership Method for cleaning contact lenses
FR2566798B1 (en) * 1984-06-27 1986-12-12 Centre Nat Rech Scient LUCIFERASE CARRIER MEMBRANE FOR ATP ASSAY AND PROCESS FOR PRODUCING THE SAME
US4650758A (en) * 1984-09-21 1987-03-17 Cetus Corporation Stabilization of enzymes useful in the production of glucosone and other enzymatic processes
JPS6317691A (en) * 1986-07-09 1988-01-25 Agency Of Ind Science & Technol Immobilized enzyme for producing aspartame
FI85285C (en) * 1988-05-13 1992-03-25 Stabra Ag Crosslinked, water-insoluble glucose isomerase and process for its preparation

Also Published As

Publication number Publication date
DK0550450T3 (en) 2003-09-08
HK1023362A1 (en) 2000-09-08
WO1992002617A1 (en) 1992-02-20
IL99046A (en) 1998-09-24
HU9300275D0 (en) 1993-04-28
MD1592B2 (en) 2001-01-31
IL99046A0 (en) 1992-07-15
NO930360L (en) 1993-04-02
FI930454A0 (en) 1993-02-02
DK0861888T3 (en) 2006-08-14
DE69133521T2 (en) 2006-12-07
ES2199933T3 (en) 2004-03-01
UA27035C2 (en) 2000-02-28
IE20040113A1 (en) 2004-05-05
HK1012411A1 (en) 1999-07-30
JP2004000230A (en) 2004-01-08
FI930454A (en) 1993-02-02
CA2087730A1 (en) 1992-02-04
AU8315491A (en) 1992-03-02
PT98564A (en) 1992-06-30
JPH05508549A (en) 1993-12-02
EP0550450B1 (en) 2003-05-14
EP0550450A1 (en) 1993-07-14
BR9106732A (en) 1993-08-17
EP0861888A1 (en) 1998-09-02
DE69133258D1 (en) 2003-06-18
SK5993A3 (en) 1993-07-07
PT98564B (en) 1999-01-29
HUT65904A (en) 1994-07-28
TJ210R3 (en) 1998-11-14
LV10304B (en) 1995-06-20
IE912767A1 (en) 1992-02-12
EP0861888B1 (en) 2006-04-12
LT3366B (en) 1995-07-25
RU2124052C1 (en) 1998-12-27
FI120099B (en) 2009-06-30
CZ12393A3 (en) 1993-10-13
DE69133521D1 (en) 2006-05-24
ATE240391T1 (en) 2003-05-15
ES2263187T3 (en) 2006-12-01
CA2087730C (en) 1999-07-20
HU211521A9 (en) 1995-11-28
AU662104B2 (en) 1995-08-24
SK283185B6 (en) 2003-03-04
DE69133258T2 (en) 2004-03-18
LTIP1077A (en) 1995-04-25
SG70966A1 (en) 2000-03-21
ATE323158T1 (en) 2006-04-15
NO930360D0 (en) 1993-02-02

Similar Documents

Publication Publication Date Title
LV10304A (en) Structured crystals are a new form of enzyme immobilization
DE3785485D1 (en) ELECTRODES WITH IMMOBILIZED ENZYMES.
DE3668964D1 (en) VALVE SYSTEM FOR CONTROLLABLE, HYDRAULIC VIBRATION DAMPERS.
DE3789591D1 (en) Acoustic range finding system.
RU93005166A (en) STRUCTURED CRYSTALS AS A NEW TYPE OF ENZYME IMMOBILIZATION
DE3776089D1 (en) ENZYMATIC PERSAEURE BLENDER SYSTEM.
DE68908835D1 (en) Bioreactor.
DK0676414T3 (en) Lipases immobilized in sol-gel-processed hydrophobic materials
NL1006056A1 (en) Enzyme immobilizing carrier and immobilized lipase.
DK0875585T3 (en) Process for preparing isomaltooligosaccharide-rich syrups.
DE68916740D1 (en) Improved methatee catalyst system for the polymerisation of dicyclopentadiene.
ATE114713T1 (en) BIOMASS FOR PRODUCTION OF VIRUS/VIRUS ANTIGEN.
DK362185A (en) BIOCATALYSTATOR AND PROCEDURE FOR PREPARING IT
DE68917597D1 (en) CATALYTIC HYDROFLUORATION PROCESS.
DE3888437D1 (en) Immobilized antibodies.
DE3878388D1 (en) BELLOW MECHANICAL SEAL WITH INACTIVE MEMBRANES.
DE68909598D1 (en) CATALYZED HYDROFLUORATION PROCESS.
NL7810986A (en) PROCEDURE FOR THE IMMOBILIZATION OF ENZYMES ON AN INORGANIC CARRIER AND APPLICATION OF THE ENZYME IMMOBILIZATION FOR SELECTIVE ENZYMATIC APPLICATION OF N-ACYL-AMINO ACIDS.
DE68916301D1 (en) Immobilized FTF enzymes.
IT8722389A0 (en) PROCEDURE FOR THE CHEMICAL IMMOBILIZATION OF BIOLOGICALLY ACTIVE SUBSTANCES ON SILICA.
DE3771229D1 (en) METHOD FOR PRODUCING AN IMMOBILIZED CONJUGATE OF AN ENZYME-CONTAINING CELL, AND THE IMPROVED IMMOBILIZED CONJUGATE.
DE58906674D1 (en) Process for the selection of productive, amino acid-excreting strains of microorganisms.
NO911564L (en) IMMOBILIZATION OF LIGANDS WITH RADIO-DERIVATED POLYMERS.
IT8621596A0 (en) PROCEDURE FOR THE MANUFACTURE OF ARTICLES BASED ON ELASTOMERIC POLYMERS.