RU93005166A - STRUCTURED CRYSTALS AS A NEW TYPE OF ENZYME IMMOBILIZATION - Google Patents

STRUCTURED CRYSTALS AS A NEW TYPE OF ENZYME IMMOBILIZATION

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Publication number
RU93005166A
RU93005166A RU93005166/13A RU93005166A RU93005166A RU 93005166 A RU93005166 A RU 93005166A RU 93005166/13 A RU93005166/13 A RU 93005166/13A RU 93005166 A RU93005166 A RU 93005166A RU 93005166 A RU93005166 A RU 93005166A
Authority
RU
Russia
Prior art keywords
crystals
enzyme
new type
clec
enzyme immobilization
Prior art date
Application number
RU93005166/13A
Other languages
Russian (ru)
Other versions
RU2124052C1 (en
Inventor
А.Нэвиа Мануэль
Л.Ст.Клэр Нэнси
Original Assignee
Вертекс Фармасьютикалз Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вертекс Фармасьютикалз Инкорпорейтед filed Critical Вертекс Фармасьютикалз Инкорпорейтед
Publication of RU93005166A publication Critical patent/RU93005166A/en
Application granted granted Critical
Publication of RU2124052C1 publication Critical patent/RU2124052C1/en

Links

Claims (1)

Изобретение касается способа иммобилизации фермента посредством образования кристаллов этого фермента, а также структурированием полученных кристаллов посредством использования бифункционального реагента, способа изготовления лиофилизированных структурированных кристаллов иммобилизованного фермента (CLEC), лиофилизации CLEC кристаллов, полученных согласно изобретению; лиофилизированных структурированных кристаллов иммобилизованных ферментов и способа получения желаемого продукта посредством реакции, катализируемой CLEC - ферментом или набором CLEC - ферментов.The invention relates to a method of immobilizing an enzyme through the formation of crystals of this enzyme, as well as structuring the crystals obtained using a bifunctional reagent, a method of making lyophilized structured crystals of an immobilized enzyme (CLEC), freeze-drying CLEC crystals obtained according to the invention; lyophilized structured crystals of immobilized enzymes and a method of obtaining the desired product through a reaction catalyzed by CLEC - an enzyme or a set of CLEC - enzymes.
RU93005166A 1990-08-03 1991-07-30 Crystal of protein cross-linked with multifunctional cross-linking age (versions), device containing this crystal, and method for preparing aspartame RU2124052C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US562280 1983-12-16
US56228090A 1990-08-03 1990-08-03
US562.280 1990-08-03

Publications (2)

Publication Number Publication Date
RU93005166A true RU93005166A (en) 1995-12-10
RU2124052C1 RU2124052C1 (en) 1998-12-27

Family

ID=24245600

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93005166A RU2124052C1 (en) 1990-08-03 1991-07-30 Crystal of protein cross-linked with multifunctional cross-linking age (versions), device containing this crystal, and method for preparing aspartame

Country Status (26)

Country Link
EP (2) EP0550450B1 (en)
JP (2) JPH05508549A (en)
AT (2) ATE323158T1 (en)
AU (1) AU662104B2 (en)
BR (1) BR9106732A (en)
CA (1) CA2087730C (en)
CZ (1) CZ12393A3 (en)
DE (2) DE69133258T2 (en)
DK (2) DK0550450T3 (en)
ES (2) ES2263187T3 (en)
FI (1) FI120099B (en)
HK (2) HK1023362A1 (en)
HU (2) HUT65904A (en)
IE (1) IE912767A1 (en)
IL (1) IL99046A (en)
LT (1) LT3366B (en)
LV (1) LV10304B (en)
MD (1) MD1592B2 (en)
NO (1) NO930360L (en)
PT (1) PT98564B (en)
RU (1) RU2124052C1 (en)
SG (1) SG70966A1 (en)
SK (1) SK283185B6 (en)
TJ (1) TJ210R3 (en)
UA (1) UA27035C2 (en)
WO (1) WO1992002617A1 (en)

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US6140475A (en) * 1997-04-11 2000-10-31 Altus Biologics Inc. Controlled dissolution crosslinked protein crystals
US6500933B1 (en) 1997-09-05 2002-12-31 Altus Biologics Inc. Methods of preparing carbohydrate crosslinked glycoprotein crystals
DK1009759T3 (en) * 1997-09-05 2008-08-04 Altus Pharmaceuticals Inc Carbohydrate crosslinked glycoprotein crystals
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
GB9823334D0 (en) 1998-10-23 1998-12-23 Darwin Discovery Ltd Enzyme coupling
WO2002070646A2 (en) * 2001-02-16 2002-09-12 Ibex Technologies Matrix stabilized enzyme crystals and methods of use
US7241272B2 (en) 2001-11-13 2007-07-10 Baxter International Inc. Method and composition for removing uremic toxins in dialysis processes
US20090035828A1 (en) * 2004-01-01 2009-02-05 Tholath Emilia Abraham Method For the Preparation of Cross Linked Protein Crystals
ES2314646T3 (en) 2004-03-22 2009-03-16 Solvay Pharmaceuticals Gmbh PHARMACEUTICAL COMPOSITIONS VIA PRODUCTS CONTAINING LIPASE, IN PARTICULAR PANCREATIN, CONTAINING TENSIOACTIVE.
LT2198880T (en) 2004-10-14 2017-02-27 Eli Lilly And Co. Compositions containing lipase, protease and amylase for treating pancreatic insufficiency
EP1913138B1 (en) 2005-07-29 2016-08-24 Abbott Laboratories GmbH Processes for the manufacture of pancreatin powder with low virus content
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
US8852904B2 (en) 2009-05-22 2014-10-07 Sanyo Foods Co., Ltd. Protein complex having activity catalyzing asymmetric oxidation reaction and process for producing the same
US8921531B2 (en) * 2009-09-15 2014-12-30 Althea Technologies, Inc. Protein a crystals and cross-linked crystals and methods of use thereof
US9303255B2 (en) 2010-08-26 2016-04-05 Aisin Seiki Kabushiki Kaisha Electrode having enzyme crystals immobilized thereon, method for producing electrode having enzyme crystals immobilized thereon, and biological fuel cell and biosensor provided with electrode having enzyme crystals immobilized thereon
EP3003358B1 (en) 2013-06-07 2021-03-24 Allena Pharmaceuticals Inc. Compositions and devices for dialysis
WO2016126970A1 (en) 2015-02-04 2016-08-11 Abbvie Inc. Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency
EP3638293B1 (en) * 2017-06-15 2023-10-04 The University of Chicago Compositions for treating cancer
WO2023194615A1 (en) * 2022-04-07 2023-10-12 Need4Health B.V. Method for determining insulin dosage

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US3664926A (en) 1970-02-26 1972-05-23 Merck & Co Inc Crystallization of l-asparaginase
DE2801238C2 (en) 1977-01-27 1986-06-05 (Zaidanhojin) Sagami Chemical Research Center, Tokio/Tokyo Process for the preparation of salts from L, L-dipeptides and phenylalanine esters
US4373023A (en) * 1980-10-14 1983-02-08 Massachusetts Institute Of Technology Process for neutralizing heparin
EP0367302A3 (en) * 1982-04-23 1991-06-19 Wako Pure Chemical Industries, Ltd. Process for semi-synthesis of human insulin, water-soluble cross-linked achromobacter protease i for use therein and a process for preparing the same
US4411996A (en) * 1982-06-30 1983-10-25 Nabisco Brands, Inc. Process for isomerizing glucose
AU3889685A (en) * 1984-01-20 1985-08-09 Eye Products Ltd. Partnership Method for cleaning contact lenses
FR2566798B1 (en) * 1984-06-27 1986-12-12 Centre Nat Rech Scient LUCIFERASE CARRIER MEMBRANE FOR ATP ASSAY AND PROCESS FOR PRODUCING THE SAME
US4650758A (en) * 1984-09-21 1987-03-17 Cetus Corporation Stabilization of enzymes useful in the production of glucosone and other enzymatic processes
JPS6317691A (en) * 1986-07-09 1988-01-25 Agency Of Ind Science & Technol Immobilized enzyme for producing aspartame
FI85285C (en) * 1988-05-13 1992-03-25 Stabra Ag Crosslinked, water-insoluble glucose isomerase and process for its preparation

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