LU87201A1 - Complexes a base d'anthraline et d'un sterol,leur procede d'obtention et leur utilisation en therapeutique et cosmetique - Google Patents
Complexes a base d'anthraline et d'un sterol,leur procede d'obtention et leur utilisation en therapeutique et cosmetique Download PDFInfo
- Publication number
- LU87201A1 LU87201A1 LU87201A LU87201A LU87201A1 LU 87201 A1 LU87201 A1 LU 87201A1 LU 87201 A LU87201 A LU 87201A LU 87201 A LU87201 A LU 87201A LU 87201 A1 LU87201 A1 LU 87201A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- anthralin
- complex
- cholesterol
- sterol
- melting point
- Prior art date
Links
- NUZWLKWWNNJHPT-UHFFFAOYSA-N anthralin Chemical compound C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O NUZWLKWWNNJHPT-UHFFFAOYSA-N 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 7
- 239000002537 cosmetic Substances 0.000 title claims description 5
- 239000003814 drug Substances 0.000 title description 2
- 229960002311 dithranol Drugs 0.000 claims abstract description 45
- 238000002844 melting Methods 0.000 claims abstract description 22
- 230000008018 melting Effects 0.000 claims abstract description 22
- 239000000470 constituent Substances 0.000 claims abstract description 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 17
- 235000012000 cholesterol Nutrition 0.000 claims description 15
- 229930182558 Sterol Natural products 0.000 claims description 13
- 150000003432 sterols Chemical class 0.000 claims description 13
- 235000003702 sterols Nutrition 0.000 claims description 13
- 229920001296 polysiloxane Polymers 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
- INBGSXNNRGWLJU-UHFFFAOYSA-N 25epsilon-Hydroxycholesterin Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(CCCC(C)(C)O)C)C1(C)CC2 INBGSXNNRGWLJU-UHFFFAOYSA-N 0.000 claims description 7
- 239000000839 emulsion Substances 0.000 claims description 7
- 229940032091 stigmasterol Drugs 0.000 claims description 7
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 claims description 6
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 claims description 6
- HZYXFRGVBOPPNZ-UHFFFAOYSA-N UNPD88870 Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)=CCC(CC)C(C)C)C1(C)CC2 HZYXFRGVBOPPNZ-UHFFFAOYSA-N 0.000 claims description 6
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 claims description 6
- 239000002674 ointment Substances 0.000 claims description 6
- 235000016831 stigmasterol Nutrition 0.000 claims description 6
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 claims description 6
- XUGISPSHIFXEHZ-UHFFFAOYSA-N 3beta-acetoxy-cholest-5-ene Natural products C1C=C2CC(OC(C)=O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 XUGISPSHIFXEHZ-UHFFFAOYSA-N 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000000377 silicon dioxide Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000000945 filler Substances 0.000 claims description 3
- -1 polyvinyldimethylsiloxane Polymers 0.000 claims description 3
- 239000002562 thickening agent Substances 0.000 claims description 3
- 239000013543 active substance Substances 0.000 claims description 2
- 150000002170 ethers Chemical class 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000006317 isomerization reaction Methods 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 abstract description 5
- 210000004761 scalp Anatomy 0.000 abstract description 3
- 201000004624 Dermatitis Diseases 0.000 abstract description 2
- 208000000260 Warts Diseases 0.000 abstract description 2
- 208000010668 atopic eczema Diseases 0.000 abstract description 2
- 230000004968 inflammatory condition Effects 0.000 abstract description 2
- 201000010153 skin papilloma Diseases 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 7
- 238000002156 mixing Methods 0.000 description 5
- 238000009472 formulation Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000004455 differential thermal analysis Methods 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- INBGSXNNRGWLJU-ZHHJOTBYSA-N 25-hydroxycholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](CCCC(C)(C)O)C)[C@@]1(C)CC2 INBGSXNNRGWLJU-ZHHJOTBYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- XUGISPSHIFXEHZ-VEVYEIKRSA-N cholesteryl acetate Chemical group C1C=C2C[C@@H](OC(C)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 XUGISPSHIFXEHZ-VEVYEIKRSA-N 0.000 description 2
- QBPFLULOKWLNNW-UHFFFAOYSA-N chrysazin Chemical compound O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O QBPFLULOKWLNNW-UHFFFAOYSA-N 0.000 description 2
- 239000003431 cross linking reagent Substances 0.000 description 2
- 239000007857 degradation product Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 235000019271 petrolatum Nutrition 0.000 description 2
- 239000006069 physical mixture Substances 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 206010054786 Skin burning sensation Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 150000001841 cholesterols Chemical class 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- UMNKXPULIDJLSU-UHFFFAOYSA-N dichlorofluoromethane Chemical compound FC(Cl)Cl UMNKXPULIDJLSU-UHFFFAOYSA-N 0.000 description 1
- 229940099364 dichlorofluoromethane Drugs 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000013213 extrapolation Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000010587 phase diagram Methods 0.000 description 1
- 108091008695 photoreceptors Proteins 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229940098458 powder spray Drugs 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 238000012205 qualitative assay Methods 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 238000004073 vulcanization Methods 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- XLOMVQKBTHCTTD-UHFFFAOYSA-N zinc oxide Inorganic materials [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229940105296 zinc peroxide Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Steroid Compounds (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU87201A LU87201A1 (fr) | 1988-04-14 | 1988-04-14 | Complexes a base d'anthraline et d'un sterol,leur procede d'obtention et leur utilisation en therapeutique et cosmetique |
| CA000596601A CA1315774C (fr) | 1988-04-14 | 1989-04-13 | Complexes a base d'anthraline et d'un sterol, leur procede d'obtention et leur utilisation en therapeutique et cosmetique |
| ES89401023T ES2017064A4 (es) | 1988-04-14 | 1989-04-13 | Complejos a base de antralina y de un esterol, su procedimiento de obtencion y su uso en terapeutica y cosmetica |
| DE8989401023T DE68900996D1 (de) | 1988-04-14 | 1989-04-13 | Komplexe des anthralins mit einem sterol, verfahren zu deren herstellung sowie deren verwendung in der therapie und kosmetik. |
| AT89401023T ATE73816T1 (de) | 1988-04-14 | 1989-04-13 | Komplexe des anthralins mit einem sterol, verfahren zu deren herstellung sowie deren verwendung in der therapie und kosmetik. |
| EP89401023A EP0337890B1 (de) | 1988-04-14 | 1989-04-13 | Komplexe des Anthralins mit einem Sterol, Verfahren zu deren Herstellung sowie deren Verwendung in der Therapie und Kosmetik |
| JP1096198A JP2621976B2 (ja) | 1988-04-14 | 1989-04-13 | アントラリン・ステロール錯体、その製法および治療・化粧用途 |
| DK178489A DK178489A (da) | 1988-04-14 | 1989-04-13 | Anthralin-sterol-komplekser, deres fremstilling og anvendelse |
| DE198989401023T DE337890T1 (de) | 1988-04-14 | 1989-04-13 | Komplexe des anthralins mit einem sterol, verfahren zu deren herstellung sowie deren verwendung in der therapie und kosmetik. |
| US07/337,800 US4961922A (en) | 1988-04-14 | 1989-04-13 | Complexes based on anthralin and a sterol, a process for obtaining them and their use in therapeutics and cosmetics |
| GR90300162T GR900300162T1 (en) | 1988-04-14 | 1991-09-27 | Complexes from anthralin and one sterol, process for their preparation and their use in therapeutics and cosmetics |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU87201A LU87201A1 (fr) | 1988-04-14 | 1988-04-14 | Complexes a base d'anthraline et d'un sterol,leur procede d'obtention et leur utilisation en therapeutique et cosmetique |
| LU87201 | 1988-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU87201A1 true LU87201A1 (fr) | 1989-11-14 |
Family
ID=19731045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU87201A LU87201A1 (fr) | 1988-04-14 | 1988-04-14 | Complexes a base d'anthraline et d'un sterol,leur procede d'obtention et leur utilisation en therapeutique et cosmetique |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4961922A (de) |
| EP (1) | EP0337890B1 (de) |
| JP (1) | JP2621976B2 (de) |
| AT (1) | ATE73816T1 (de) |
| CA (1) | CA1315774C (de) |
| DE (2) | DE68900996D1 (de) |
| DK (1) | DK178489A (de) |
| ES (1) | ES2017064A4 (de) |
| GR (1) | GR900300162T1 (de) |
| LU (1) | LU87201A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2663850B1 (fr) * | 1990-07-02 | 1994-01-14 | Gird Galderma | Composition pharmaceutique ou cosmetique contenant en association un retinouide et un sterol. |
| FR2705030A1 (fr) * | 1993-05-11 | 1994-11-18 | Biodev | Utilisation de composés stéroliques pour la fabrication d'un médicament anti-inflammatoire. |
| DE19834812A1 (de) * | 1998-08-01 | 2000-02-03 | Beiersdorf Ag | Verwendung von Sterolderivaten in kosmetischen und dermatologischen Zubereitungen zur Stärkung der Barrierefunktion der Haut |
| WO2005020928A2 (en) | 2003-08-29 | 2005-03-10 | The Regents Of The University Of California | Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins |
| AU2008331808B2 (en) | 2007-03-16 | 2014-08-21 | The Regents Of The University Of California | Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling |
| CA2872751A1 (en) | 2012-05-07 | 2013-11-14 | The Regents Of The University Of California | Oxysterol analogue oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis |
| AU2014259672A1 (en) | 2013-05-02 | 2015-12-03 | The Regents Of The University Of California | Bone-selective osteogenic oxysterol-bone targeting agents |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4513011A (en) * | 1981-10-23 | 1985-04-23 | L'oreal | Composition in the form of a shampoo based on anthralin |
| GB2143433A (en) * | 1983-06-20 | 1985-02-13 | Hariprasad Manibhai Patel | Methotrexate ointment |
| FR2569561B1 (fr) * | 1984-08-30 | 1990-05-18 | Oreal | Composition stable d'anthraline dans des triglycerides d'acides gras satures d'origine vegetale ayant de 6 a 12 atomes de carbone |
| US4743597A (en) * | 1986-01-27 | 1988-05-10 | Javitt Norman B | Composition comprising an oxygenated cholesterol and use thereof for topical treatment of diseases |
-
1988
- 1988-04-14 LU LU87201A patent/LU87201A1/fr unknown
-
1989
- 1989-04-13 US US07/337,800 patent/US4961922A/en not_active Expired - Fee Related
- 1989-04-13 AT AT89401023T patent/ATE73816T1/de not_active IP Right Cessation
- 1989-04-13 JP JP1096198A patent/JP2621976B2/ja not_active Expired - Lifetime
- 1989-04-13 DK DK178489A patent/DK178489A/da not_active Application Discontinuation
- 1989-04-13 DE DE8989401023T patent/DE68900996D1/de not_active Expired - Fee Related
- 1989-04-13 ES ES89401023T patent/ES2017064A4/es active Pending
- 1989-04-13 DE DE198989401023T patent/DE337890T1/de active Pending
- 1989-04-13 CA CA000596601A patent/CA1315774C/fr not_active Expired - Fee Related
- 1989-04-13 EP EP89401023A patent/EP0337890B1/de not_active Expired - Lifetime
-
1991
- 1991-09-27 GR GR90300162T patent/GR900300162T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK178489A (da) | 1989-10-15 |
| EP0337890B1 (de) | 1992-03-18 |
| DE337890T1 (de) | 1990-12-20 |
| JP2621976B2 (ja) | 1997-06-18 |
| ES2017064A4 (es) | 1991-01-01 |
| DE68900996D1 (de) | 1992-04-23 |
| EP0337890A1 (de) | 1989-10-18 |
| CA1315774C (fr) | 1993-04-06 |
| DK178489D0 (da) | 1989-04-13 |
| ATE73816T1 (de) | 1992-04-15 |
| GR900300162T1 (en) | 1991-09-27 |
| JPH02204498A (ja) | 1990-08-14 |
| US4961922A (en) | 1990-10-09 |
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