LU505148B1 - Subcutaneous wireless communication system for interventional brain-computer interface - Google Patents
Subcutaneous wireless communication system for interventional brain-computer interface Download PDFInfo
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- LU505148B1 LU505148B1 LU505148A LU505148A LU505148B1 LU 505148 B1 LU505148 B1 LU 505148B1 LU 505148 A LU505148 A LU 505148A LU 505148 A LU505148 A LU 505148A LU 505148 B1 LU505148 B1 LU 505148B1
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- 238000007920 subcutaneous administration Methods 0.000 title claims abstract description 86
- 238000004891 communication Methods 0.000 title claims abstract description 49
- 210000004731 jugular vein Anatomy 0.000 claims abstract description 21
- 230000005540 biological transmission Effects 0.000 claims abstract description 15
- 238000005516 engineering process Methods 0.000 claims abstract description 12
- 238000004146 energy storage Methods 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 14
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 230000033001 locomotion Effects 0.000 claims description 9
- 210000003205 muscle Anatomy 0.000 claims description 8
- 238000000338 in vitro Methods 0.000 claims description 7
- 230000003321 amplification Effects 0.000 claims description 5
- 238000005259 measurement Methods 0.000 claims description 5
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 5
- 210000001562 sternum Anatomy 0.000 claims description 5
- 210000003109 clavicle Anatomy 0.000 claims description 4
- 210000000115 thoracic cavity Anatomy 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 230000003044 adaptive effect Effects 0.000 claims description 3
- 230000006835 compression Effects 0.000 claims description 3
- 238000007906 compression Methods 0.000 claims description 3
- 238000013507 mapping Methods 0.000 claims description 3
- 230000035515 penetration Effects 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims description 3
- 230000000740 bleeding effect Effects 0.000 abstract description 6
- 208000015181 infectious disease Diseases 0.000 abstract description 5
- 210000004556 brain Anatomy 0.000 description 11
- 210000004204 blood vessel Anatomy 0.000 description 6
- 208000032843 Hemorrhage Diseases 0.000 description 5
- 208000034158 bleeding Diseases 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 230000008054 signal transmission Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04B—TRANSMISSION
- H04B14/00—Transmission systems not characterised by the medium used for transmission
- H04B14/02—Transmission systems not characterised by the medium used for transmission characterised by the use of pulse modulation
- H04B14/04—Transmission systems not characterised by the medium used for transmission characterised by the use of pulse modulation using pulse code modulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/271—Arrangements of electrodes with cords, cables or leads, e.g. single leads or patient cord assemblies
- A61B5/273—Connection of cords, cables or leads to electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
- A61B5/293—Invasive
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
- A61B5/37—Intracranial electroencephalography [IC-EEG], e.g. electrocorticography [ECoG]
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04B—TRANSMISSION
- H04B1/00—Details of transmission systems, not covered by a single one of groups H04B3/00 - H04B13/00; Details of transmission systems not characterised by the medium used for transmission
- H04B1/38—Transceivers, i.e. devices in which transmitter and receiver form a structural unit and in which at least one part is used for functions of transmitting and receiving
- H04B1/3827—Portable transceivers
- H04B1/385—Transceivers carried on the body, e.g. in helmets
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04B—TRANSMISSION
- H04B14/00—Transmission systems not characterised by the medium used for transmission
- H04B14/02—Transmission systems not characterised by the medium used for transmission characterised by the use of pulse modulation
- H04B14/06—Transmission systems not characterised by the medium used for transmission characterised by the use of pulse modulation using differential modulation, e.g. delta modulation
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L12/00—Data switching networks
- H04L12/02—Details
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
- A61B5/0006—ECG or EEG signals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
- H02J2310/00—The network for supplying or distributing electric power characterised by its spatial reach or by the load
- H02J2310/10—The network having a local or delimited stationary reach
- H02J2310/20—The network being internal to a load
- H02J2310/23—The load being a medical device, a medical implant, or a life supporting device
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
- H02J50/00—Circuit arrangements or systems for wireless supply or distribution of electric power
- H02J50/10—Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
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Abstract
The present invention belongs to the technical field of brain-computer interfaces, and more particularly relates to a subcutaneous wireless communication system for an interventional brain- computer interface. The system can realize the wireless transmission of electroencephalograms collected by the interventional brain-computer interface technology directly from a human subcutaneous layer to a computer or other external devices. Meanwhile, the problems of bleeding and infection caused by the withdrawal of a wire from an internal jugular vein are solved by implanting a venous catheter in the wall of the internal jugular vein.
Description
SUBCUTANEOUS WIRELESS COMMUNICATION SYSTEM FOR INTERVENTIONAL
BRAIN-COMPUTER INTERFACE 0505148
The present invention belongs to the technical field of brain-computer interfaces, and more particularly relates to a subcutaneous wireless communication system for an interventional brain-computer interface.
The brain-computer interface technology is a technology capable of making a human brain interact with an external device and capable of directly extracting signals from the human brain and converting the signals into a form that can be recognized by a computer or other devices.
This technology is widely used in the fields of neuroscience research, exercise rehabilitation and neural prosthesis.
The brain-computer interfaces can be classified into non-invasive brain-computer interfaces, invasive brain-computer interfaces and interventional brain-computer interfaces according to the collection modes of electroencephalograms. The invasive brain-computer interfaces collect the electroencephalograms by implanting electrodes in the brain, which can obtain high temporal resolution signals, but the surgical risk is high. In addition, the quality of the — electroencephalograms detected by the electrodes is gradually reduced due to biological rejection. The non-invasive brain-computer interfaces use external sensors to collect the electroencephalograms on a scalp surface, which is safer and more convenient. However, due to the complexity of the electroencephalograms on the scalp surface and the existence of noise interference, the signal quality obtained by the non-invasive brain-computer interfaces is poor.
The interventional brain-computer interface is a novel brain-computer interface technology different from the invasive and non-invasive brain-computer interfaces, and records the neural activity on the surface of the cerebral cortex by introducing stent electrodes into the blood vessels in the brain. Compared with the invasive brain-computer interfaces, the interventional brain-computer interfaces have lower risk and longer stability. Compared with the non-invasive brain-computer interfaces, the interventional brain-computer interfaces have higher signal quality and lower noise interference.
In the current interventional brain-computer interface technology, the electroencephalograms are generally transmitted to an external computer or other devices by the traditional wired transmission mode after being collected. Because the stent electrode needs to be retained in the body for a long time, wired signal transmission is easy to cause the stent electrode to move in the blood vessel and the long-time withdrawal of wires from the internal jugular vein is easy to cause bleeding and infection, which makes the current interventional brain-computer interface technology have problems of stability and safety. In addition, the wired signal transmission also has defects in portability, which greatly limits the LU505148 application scenarios and application ranges of the interventional brain-computer interfaces.
Therefore, the present invention provides a subcutaneous wireless communication system for an interventional brain-computer interface. The system can realize the wireless transmission of the electroencephalograms collected by the interventional brain-computer interface technology directly from the human subcutaneous layer to the computer or other external devices. Meanwhile, the problems of bleeding and infection caused by the withdrawal of a wire from the internal jugular vein are solved by implanting a venous catheter in the wall of the internal jugular vein.
The present invention can solve the problem of inconvenient communication in the interventional brain-computer interface, and improve the safety of withdrawal of the wires from the wall of the internal jugular vein. The present invention avoids the safety risks brought by the traditional wired communication mode, and improves the adaptability of the interventional brain- computer interface electroencephalograms in multiple environments. In addition, the present invention also improves the portability of the interventional brain-computer interface, and enables people to use the technology for a long time without affecting normal life.
To achieve the above purpose, the present invention adopts the following technical solution:
A subcutaneous wireless communication system for an interventional brain-computer interface comprises: a venous catheter implanted in an internal jugular vein; a subcutaneous signal generator, a subcutaneous energy storage device, an electrode stent and a wire with an insulating layer, which are implanted in a subcutaneous layer; and a signal receiver and a wireless charger which are in vitro; the electrode stent is connected to the subcutaneous signal generator by the wire; the subcutaneous signal generator receives electroencephalograms detected by the stent electrode and transmits the electroencephalograms through radio waves; the signal receiver is used for receiving a wireless communication signal transmitted by the subcutaneous signal generator, and transmitting the signal to a computer or other external devices; the subcutaneous energy storage device is used for powering the subcutaneous signal generator; and the wireless charger is used for transmitting a wireless power signal in vitro to achieve wireless charging of the subcutaneous energy storage device.
To further optimize the technical solution, the venous catheter is implanted in the internal jugular vein to allow the wire to withdraw from the internal jugular vein through the venous catheter; and a three-way valve is arranged inside the venous catheter.
To further optimize the technical solution, the subcutaneous signal generator comprises: a generating end processor and a generating end transmitter; the generating end processor is used for amplifying the electroencephalograms collected by the stent electrode, converting the electroencephalograms into wireless communication signals, and transmitting the wireless LU505148 communication signals to the generating end transmitter; and the generating end transmitter is used for transmitting the wireless communication signals.
To further optimize the technical solution, the wire penetrates through the venous catheter and connects the electrode stent of the interventional brain-computer interface to the generating end processor on the subcutaneous signal generator, so as to transmit the electroencephalograms detected by the stent electrode to the generating end processor.
To further optimize the technical solution, the generating end processor uses a biopotential measurement chip with analog-to-digital conversion accuracy not less than 16 bits to achieve signal sampling and amplification.
To further optimize the technical solution, the subcutaneous signal generator is implanted in a human subcutaneous position having infrequent movement and little muscle, and the human subcutaneous position having infrequent movement and little muscle comprises, but not limited to, an auricle back, a clavicle middle and a thoracic central sternum.
To further optimize the technical solution, the electroencephalograms are subjected to lossless compression by a differential pulse code modulation technology.
To further optimize the technical solution, the specific process of the differential pulse code modulation comprises: firstly, conducting encoding transmission of the interpolations of each sample value of a digital signal obtained by analog-to-digital conversion and a previous sample value; and for prediction of a left side, a differential encoding formula is: e(n) = x(n) — x(n) wherein e(n) is a differential error, x(n) is the current sample value, and x(n) is a predicted value of the previous sample value; then quantizing the differential error, that is, mapping the continuous error value to a discrete quantized value; and quantizing by bit, with a formula as follows: e(n) + 2671 qn) = [1 wherein g(n) is a quantized value, and [J represents downward rounding; then encoding the quantized value by using adaptive Huffman encoding; and after converting the discrete quantized value into a binary code, transmitting the binary code as a wireless communication signal through the generating end transmitter.
To further optimize the technical solution, the frequency range of the wireless communication signal is 3 kHz-300 GHz, which has anti-interference performance and penetrability on the basis of ensuring a transmission rate. The formula for the radio waves to penetrate through human skin is as follows:
I =Ie wherein / is the intensity of the radio waves after penetration, /, is the intensity of incident 5051 18 radio waves, u is an absorption coefficient of the human skin, and x is the thickness of the human skin.
Different from the prior art, the above technical solution has the following beneficial effects: 1. The portability and the safety of the interventional brain-computer interface are improved. 2. The interventional brain-computer interface can adapt to different physical environments, thereby improving the environmental adaptability and practicability of the device. 3. The risks of bleeding and infection caused by the wire that penetrates directly through the venous wall are reduced, and the safety is improved. 4. The problems of safety hidden hazards and signal quality degradation caused by signal line dragging in the wired signal transmission of the interventional brain-computer interface are solved, and the safety and the anti-interference ability of the signal are improved.
The influence on the daily life of users that use the interventional brain-computer interface is reduced and the user experience is improved.
Fig. 1 is a structural schematic diagram of a subcutaneous wireless communication system for an interventional brain-computer interface;
Fig. 2 is a schematic diagram of implantation of a subcutaneous signal generator;
Fig. 3 is a schematic diagram of a human subcutaneous position having infrequent movement and little muscle;
Fig. 4 is a flow chart of electroencephalogram transmission;
Fig. 5 is a schematic diagram of ADS1299 wiring;
Fig. 6 is a schematic diagram of implantation of a venous catheter in the internal jugular vein.
In the figures: 1-computer or other external device, 2-signal receiver, 3-wireless charger, 4- human skin, 5-subcutaneous signal generator, 6-subcutaneous energy storage device, 7- electrode stent, 8-stent electrode, 9-auricle back, 10-clavicle middle, 11-thoracic central sternum, 12-internal jugular vein, 13-three-way valve, and 14-venous catheter.
In order to explain the technical content, structural features and achieved purposes and effects of the technical solution in detail, the present invention is described in detail below in combination with specific embodiments and the drawings.
The present invention proposes a subcutaneous wireless communication system for an interventional brain-computer interface, comprising: a venous catheter 14 implanted in an internal jugular vein 12; a subcutaneous signal generator 5 and a subcutaneous energy storage device 6 which are implanted in a subcutaneous layer; and a signal receiver 2 and a wireless charger 3 which are in vitro. The subcutaneous signal generator 5 receives LU505148 electroencephalograms detected by a stent electrode 8 and transmits the electroencephalograms through radio waves. The signal receiver 2 is used for receiving a wireless communication signal transmitted by the subcutaneous signal generator 5, and 5 transmitting the signal to a computer or other external devices 1. The subcutaneous energy storage device 6 is used for powering the subcutaneous signal generator 5; and the wireless charger 3 is used for transmitting a wireless power signal in vitro to achieve wireless charging of the subcutaneous energy storage device 6.
Embodiments of the present application provide a venous catheter 14. The venous catheter 14 is implanted in the internal jugular vein 12 to allow the wire to withdraw from the internal jugular vein 12 through the venous catheter 14, to reduce the risks of bleeding and infection caused by the wire that penetrates directly through the internal jugular vein 12. A three-way valve 13 is arranged inside the venous catheter 14, which can prevent blood backflow, reduce the risk of bleeding and ensure that the venous catheter 14 is smooth.
Embodiments of the present application provide a subcutaneous signal generator 5 for transmitting detected electroencephalograms. The subcutaneous signal generator 5 comprises: a generating end processor and a generating end transmitter; the generating end processor is used for amplification, filtering and analog-to-digital conversion of the electroencephalograms collected by the stent electrode 8, converting the electroencephalograms into wireless communication signals, and transmitting the wireless communication signals to the generating end transmitter; and the generating end transmitter is used for transmitting the wireless communication signals.
The subcutaneous signal generator 5 is implanted in a human subcutaneous position having infrequent movement and little muscle to avoid electromyographic signal interference caused by muscle activity. The human subcutaneous position having infrequent movement and little muscle comprises, but not limited to, an auricle back 9, a clavicle middle 10 and a thoracic central sternum 11.
A wire with an insulating layer penetrates through the venous catheter 14, and connects the electrode stent 7 of the interventional brain-computer interface to tha generating end processor onthe subcutaneous signal generator 5 in order to fransmit the electroencephalograms detected by the sient electrode 8 to the generating end processor.
The generating end processor uses a biopotential measurement chip with analog-to-digital conversion accuracy not less than 16 bits to achieve signal sampling and amplification. For example, a biopotential measurement chip with analog-to-digital conversion accuracy of 24 bits is used for the following conversion of the detected electroencephalograms: y Gin — Vrer) out 7 523 wherein J, is output voltage, V,, is input voltage, G is an amplification gain, and V,, is LU505148 reference voltage.
In addition, the generating end processor also uses a bandpass filter to filter out high- frequency noise and direct current components in the system. The formula can be expressed as: y[n] = box[n] + b,x[n — 1] + bax[n — 2] — a,y[n — 1] — aay[n — 2] wherein x[»] is a current sample of the input signal and [x] is the output of the filter. b,, b, and A, are the leading coefficients of the filter, and a, and a, are the feedback coefficient of the filter.
In order to ensure the real-time transmission of the electroencephalograms by the system and reduce the data amount of the electroencephalograms stored in a wireless transmission device, the electroencephalograms are subjected to lossless compression by a differential pulse code modulation (DPCM) technology. The specific process comprises: firstly, conducting encoding transmission of the interpolations of each sample value of a digital signal obtained by analog-to-digital conversion and a previous sample value; and for prediction of a left side, a differential encoding formula is: e(n) = x(n) — x(n) wherein e(n) is a differential error, x(n) is the current sample value, and x(n) is a predicted value of the previous sample value; then quantizing the differential error, that is, mapping the continuous error value to a discrete quantized value; for example, if quantizing by z bit, a formula is as follows: e(n) + 2671 qm) = [=] wherein g(n) is a quantized value, and [J represents downward rounding; then encoding the quantized value by using adaptive Huffman encoding; and after converting the discrete quantized value into a binary code, transmitting the binary code as a wireless communication signal through the generating end transmitter.
The frequency range of the wireless communication signal is 3 kHz-300 GHz, which has anti-interference performance and penetrability on the basis of ensuring a transmission rate.
The formula for the radio waves to penetrate through human skin 4 is as follows: =e" wherein / is the intensity of the radio waves after penetration, I; is the intensity of incident radio waves, u is an absorption coefficient of the human skin 4, and x is the thickness of the human skin 4.
Embodiments of the present application provide a signal receiver 2 for receiving the electroencephalograms from the subcutaneous signal generator 5, and transmitting the electroencephalograms to a computer or other external devices 1. The signal receiver 2 LU505148 comprises a receiving end processor and a receiving end receiver. The receiving end processor converts the wireless communication signal into an external device communication signal, and simultaneously receives an external device power signal of the computer or other external devices 1. The external device power signal is used for powering the entire subcutaneous wireless communication system, The receiving end receiver is used for receiving the wireless communication signal transmitied by the subouianscus signal generator & and transmiting the signal to the receiving end processor.
The process of converting the wireless communication signal into the external device communication signal by the receiving end processor specifically comprises: firstly, decoding the binary code, and then dequantizing the quantized value after decoding. For k dequantizing, the formula is as follows: e'(n) = q'(n) x 2% — 261 wherein e'(n) is the error value after dequantization, and ¢'(n) is the quantized value after decoding; then conducting differential decoding, specifically. adding the error value and the predicted value of the previous sample value to obtain the reconsiructed value of the current sample. For the prediction of the left side, a differential decoding formula is as follows:
X'(n) = e'(n) + x'(n — 1) wherein TC} is the reconstructed value, that is, an original time domain electroencephalogram.
The externai device communication signal is the original time domain electroencephalogram, and the computer or other external devices 1 need to extract the frequency domain features before using the electroencephalogram.
Embodiments of the present application further provide a subcutaneous energy storage device 6 and a wireless charger 3. The subcutaneous energy storage device 6 is used for powering the subcutaneous signal generator 5 in the subcutaneous layer. The subcutaneous energy storage device © has an inductor coll that can receive the wireless power signal from the wireless charger 2 for charging. The wireless charger 2 is used for transmitting the wireless power signal to charge the subcutaneous energy storage device 5.
Embodiment 1:
Referring to Fig. 1, Fig. 3, Fig. 4, Fig. 5 and Fig. 7, the subcutaneous signal generator 5 is implanted in the auricle back 9. For the subcutaneous wireless communication system of the interventional brain-computer interface, the subcutaneous signal transmitter is connected with the electrode stent of the interventional brain-computer interface 7 through the wire with the insulating layer, and the signal receiver 2 is connected with the computer through a USB LU505148 interface.
After the stent electrode 8 detects the human electroencephalogram, the electroencephalogram is transmitted to the generating end processor on the subcutaneous signal generator 5 through the electrode stent 7 and the wire with the insulating layer; the generating end processor uses the ADS1299 biopotential measurement chip to sample and amplify the signal, then converts the signal into the wireless communication signal available to the generating end transmitter, and transmits the wireless communication signal through the generating end transmitter; the receiving end receiver on the signal receiver 2 receives the wireless communication signal and then transmits the signal to the receiving end processor; and the receiving end processor processes the wireless communication signal into a USB information signal, and transmits the time domain electroencephalogram to the computer or other external devices through the USB interface. The computer or other external devices may perform further actions according to the time domain electroencephalogram.
Atthe same time, the subcutaneous energy storage device 6 is connected to the generating end processor on the subcutaneous signal generator 5 through a wire to power the entire subcutaneous wireless generator. When the subcutaneous energy storage device 6 is out of power, the wireless charger 3 is used for wirelessly charging the subcutaneous energy storage device 6 in vitro.
Embodiment 2:
Referring to Fig. 2, the subcutaneous signal generator 5 is implanted into the clavicle middle 10 based on embodiment 1. The wire with the insulating layer led from the electrode stent 7 located in the internal jugular vein 12 is connected to the generating end processor on the subcutaneous signal generator 5. Other information transmission and power supply modes and processes are the same those of embodiment 1.
Embodiment 3:
Referring to Fig. 2, the subcutaneous signal generator 5 is implanted at the thoracic central sternum 11 based on embodiment 1. The wire with the insulating layer led from the electrode stent 7 located in the internal jugular vein 12 is connected to the generating end processor on the subcutaneous signal generator 5. Other information transmission and power supply modes and processes are the same as those of embodiment 1.
Embodiment 4:
Referring to Fig. 3, the computer or external devices are determined as a computer based on embodiment 1. The computer will read the electroencephalogram data detected by the stent electrode 8 and analyse the data. When the stent electrode 8 is introduced into the blood vessel near the visual area of the human brain, the vision-related data of the human brain can be read; 505148 when the stent electrode 8 is introduced into the blood vessel near the motion area of the human brain, the data related to the motion imagination of the human brain can be read; and when the stent electrode 8 is in the blood vessel near the sensory area of the human brain, the sensory related data of the human brain can be read. Other specific device use, information transmission and power supply modes and processes are the same as those of embodiment 1.
Embodiment 5:
Referring to Fig. 6, in the interventional brain-computer interface system, the stent electrode 8 detects the electroencephalogram in the corresponding brain regions of intracranial veins. The surface of the electrode stent 7 is coated with the insulating layer and connected with the wire; the wire is withdrawn from the internal jugular vein 12 through the implanted venous catheter 14, and a three-way valve 13 is arranged in the venous catheter 14 to organize the outflow of venous blood from the blood vessel.
It should be noted that relationship terms such as first and second herein are just used for differentiating one entity or operation from the other entity or operation, and do not necessarily require or imply any practical relationship or sequence between the entities or operations.
Moreover, terms of “comprise”, “include” or any other variant are intended to cover non- exclusive inclusion, so that a process, a method, an article or a terminal device which includes a series of elements not only includes such elements, but also includes other elements not listed clearly or also includes inherent elements in the process, the method, the article or the terminal device. Under the condition of no more limitation, the elements defined by a sentence “comprise...” or “include...” do not exclude additional elements in the process, the method, the article or the terminal device which includes the elements. In addition, “greater than”, “less than”, ‘more than”, etc. herein are understood to exclude this number; and “above”, “below”, “within”, etc. are understood to include this number.
Although the above embodiments are described, those skilled in the art can make additional alterations and amendments to the embodiments once knowing basic creative concepts.
Therefore, the above only describes the embodiments of the present invention, but is not intended to limit the patent protection scope of the present invention. Any equivalent structure or equivalent flow transformation made by using contents of the description and drawings of the present invention, or directly or indirectly used in other relevant technical fields shall be similarly included within the patent protection scope of the present invention.
Claims (9)
1. A subcutaneous wireless communication system for an interventional brain-computer interface, comprising:a venous catheter implanted in an internal jugular vein;a subcutaneous signal generator,a subcutaneous energy storage device, an electrode stent and a wire with an insulating layer, which are implanted in a subcutaneous layer; and a signal receiver and a wireless charger which are in vitro, wherein — the electrode stent is connected to the subcutaneous signal generator by the wire; — the subcutaneous signal generator receives electroencephalograms detected by the stent electrode and transmits the electroencephalograms through radio waves; — the signal receiver is used for receiving a wireless communication signal transmitted by the subcutaneous signal generator, and transmitting the signal to a computer or other external devices; — the subcutaneous energy storage device is used for powering the subcutaneous signal generator; and — the wireless charger is used for transmitting a wireless power signal in vitro to achieve wireless charging of the subcutaneous energy storage device.
2. The subcutaneous wireless communication system for the interventional brain-computer interface according to claim 1, wherein — the venous catheter is implanted in the internal jugular vein to allow the wire to withdraw from the internal jugular vein through the venous catheter; and — a three-way valve is arranged inside the venous catheter.
3. The subcutaneous wireless communication system for the interventional brain-computer interface according to claim 1, wherein the subcutaneous signal generator comprises a generating end processor and a generating end transmitter, wherein — the generating end processor is used for amplifying the electroencephalograms collected by the stent electrode, converting the electroencephalograms into wireless communication signals, and transmitting the wireless communication signals to the generating end transmitter; and — the generating end transmitter is used for transmitting the wireless communication signals.
4. The subcutaneous wireless communication system for the interventional brain-computer interface according to claim 3, wherein the wire penetrates through the venous catheter and connects the electrode stent of the interventional brain-computer interface to the generating end processor on the subcutaneous signal generator, so as to transmit the LU505148 electroencephalograms detected by the stent electrode to the generating end processor.
5. The subcutaneous wireless communication system for the interventional brain-computer interface according to claim 3, wherein the generating end processor uses a biopotential measurement chip with analog-to-digital conversion accuracy not less than 16 bits to achieve signal sampling and amplification.
6. The subcutaneous wireless communication system for the interventional brain-computer interface according to claim 1, wherein the subcutaneous signal generator is implanted in a human subcutaneous position having infrequent movement and little muscle, and the human subcutaneous position having infrequent movement and little muscle comprises, but not limited to, an auricle back, a clavicle middle and a thoracic central sternum.
7. The subcutaneous wireless communication system for the interventional brain-computer interface according to claim 1, wherein the electroencephalograms are subjected to lossless compression by a differential pulse code modulation technology.
8. The subcutaneous wireless communication system for the interventional brain-computer interface according to claim 7, wherein the process of the differential pulse code modulation comprises: — firstly, conducting encoding transmission of the interpolations of each sample value of a digital signal obtained by analog-to-digital conversion and a previous sample value; and for prediction of a left side, the differential encoding formula is: e(n) = x(n) — x(n) wherein e(n) is a differential error, x(n) is the current sample value, and x(n) is a predicted value of the previous sample value; — then quantizing the differential error, that is, mapping the continuous error value to a discrete quantized value; and quantizing by x bit, with a formula as follows: e(n) + 2“71 qm) = [=r] wherein g(n) is a quantized value, and [J represents downward rounding; — then encoding the quantized value by using adaptive Huffman encoding; and after converting the discrete quantized value into a binary code, transmitting the binary code as a wireless communication signal through the generating end transmitter.
9. The subcutaneous wireless communication system for the interventional brain-computer LU505148 interface according to claim 1, wherein — the frequency range of the wireless communication signal is 3 kHz-300 GHz, which has anti-interference performance and penetrability on the basis of ensuring a transmission rate; and — the formula for the radio waves to penetrate through human skin is as follows: I =Ie wherein / is the intensity of the radio waves after penetration, /, is the intensity of incident radio waves, u is an absorption coefficient of the human skin, and x is the thickness of the human skin.
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|---|---|---|---|
| CN202310852273.8A CN117220692A (en) | 2023-07-12 | 2023-07-12 | Interventional brain-computer interface subcutaneous wireless communication system |
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| LU505148B1 true LU505148B1 (en) | 2024-03-22 |
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| LU505148A LU505148B1 (en) | 2023-07-12 | 2023-09-22 | Subcutaneous wireless communication system for interventional brain-computer interface |
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| CN (1) | CN117220692A (en) |
| LU (1) | LU505148B1 (en) |
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