LTIP839A - Memantine-containing solid pharmaceutical dosage forms having an extended two-stage release profile and production thereof - Google Patents

Memantine-containing solid pharmaceutical dosage forms having an extended two-stage release profile and production thereof

Info

Publication number
LTIP839A
LTIP839A LTIP839A LTIP839A LTIP839A LT IP839 A LTIP839 A LT IP839A LT IP839 A LTIP839 A LT IP839A LT IP839 A LTIP839 A LT IP839A LT IP839 A LTIP839 A LT IP839A
Authority
LT
Lithuania
Prior art keywords
memantine
solid pharmaceutical
extended
production
dosage forms
Prior art date
Application number
LTIP839A
Other languages
Lithuanian (lt)
Inventor
Eberhard Nurnberg
Erhard Seiller
Stefan Ritsert
Original Assignee
Merz Pharma Gmbh & Co. Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Co. Kgaa filed Critical Merz Pharma Gmbh & Co. Kgaa
Publication of LTIP839A publication Critical patent/LTIP839A/en
Publication of LT3201B publication Critical patent/LT3201B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Šis išradimas apima kietas farmacines kompozicijas dozuotoje formoje, turinčias aktyvų ingredientą arba pagrindą, ypač memantiną, kurios įgyvendinta prailgintą dviejų fazių vaisto išskyrimą, ir kurios yra charakterizuojamos buvimu matricoje dviejų - vandenyje tirpios ir vandenyje netirpios kazeino druskos, ypač natrio ir kalcio kazeinatų plačiose proporcijų ribose , o jų bendras kiekis kompozicijoje yra tarp 5 ir 98 masės %, ir jų gavimo būdą.The present invention relates to solid pharmaceutical compositions in dosage form comprising an active ingredient or a base, in particular memantine, which is provided by extended release of the two-phase drug, and which are characterized by the presence in the matrix of two - water-soluble and water-insoluble casein salts, in particular in the broad proportions of sodium and calcium caseinates, in particular in the broad proportions. and their total content in the composition is between 5 and 98% by weight, and the method of preparation.

LTIP839A 1992-08-04 1993-08-04 Memantine-containing solid pharmaceutical dosage forms having an extended two-stage release profile and production thereof LT3201B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4225730A DE4225730C2 (en) 1992-08-04 1992-08-04 Process for the preparation of solid dosage forms with protracted 2-stage release

Publications (2)

Publication Number Publication Date
LTIP839A true LTIP839A (en) 1994-08-25
LT3201B LT3201B (en) 1995-03-27

Family

ID=6464804

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP839A LT3201B (en) 1992-08-04 1993-08-04 Memantine-containing solid pharmaceutical dosage forms having an extended two-stage release profile and production thereof

Country Status (17)

Country Link
US (1) US5382601A (en)
EP (1) EP0582186B1 (en)
JP (1) JP3560244B2 (en)
CN (1) CN1086708A (en)
AT (1) ATE176866T1 (en)
AU (1) AU669731B2 (en)
CA (1) CA2141691C (en)
DE (2) DE4225730C2 (en)
DK (1) DK0582186T3 (en)
ES (1) ES2128369T3 (en)
GR (1) GR3030227T3 (en)
IL (1) IL106580A (en)
LT (1) LT3201B (en)
LV (1) LV10182B (en)
MX (1) MX9304675A (en)
WO (1) WO1994003158A1 (en)
ZA (1) ZA935614B (en)

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Also Published As

Publication number Publication date
ATE176866T1 (en) 1999-03-15
AU4706993A (en) 1994-03-03
LT3201B (en) 1995-03-27
CA2141691A1 (en) 1994-02-17
JP3560244B2 (en) 2004-09-02
DK0582186T3 (en) 1999-09-27
IL106580A (en) 1998-02-08
DE4225730C2 (en) 2003-04-30
WO1994003158A1 (en) 1994-02-17
GR3030227T3 (en) 1999-08-31
US5382601A (en) 1995-01-17
IL106580A0 (en) 1993-12-08
DE59309388D1 (en) 1999-04-01
MX9304675A (en) 1994-03-31
EP0582186B1 (en) 1999-02-24
EP0582186A1 (en) 1994-02-09
JPH07509479A (en) 1995-10-19
DE4225730A1 (en) 1994-02-10
AU669731B2 (en) 1996-06-20
LV10182A (en) 1994-10-20
CN1086708A (en) 1994-05-18
CA2141691C (en) 2002-04-09
ES2128369T3 (en) 1999-05-16
LV10182B (en) 1995-04-20
ZA935614B (en) 1995-02-03

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Legal Events

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TK9A Rectifications: patents

Free format text: MERZ + CO. GMBH & CO., ECKENHEIMER LANDSTRASSE 100-104, D-6000 FRANKFURT AM MAIN 1, DE, 19951128

PD9A Change of patent owner

Owner name: MERZ PHARMA GMBH & CO. KGAA,DE

Effective date: 20021017

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Effective date: 20130804